Affinity DataEC50: 34nMAssay Description:Antagonist activity against recombinant human P2X purinoceptor 7 (P2X7)More data for this Ligand-Target Pair
Affinity DataEC50: 158nMAssay Description:Antagonist activity at P2X7 receptor in human whole blood assessed as inhibition of BzATP-induced IL-1beta release preincubated for 30 mins followed ...More data for this Ligand-Target Pair
Affinity DataEC50: 158nMAssay Description:Antagonist activity at P2X7 receptor in human whole blood assessed as inhibition of BzATP-induced IL-1beta release preincubated for 30 mins followed ...More data for this Ligand-Target Pair
Affinity DataEC50: 400nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 7 (P2X7)More data for this Ligand-Target Pair
Affinity DataEC50: 2.19E+3nMAssay Description:Negative allosteric modulation activity at human P2X7 receptor expressed in human 1321N1 cells assessed as ATP induced calcium response by measuring ...More data for this Ligand-Target Pair
Affinity DataEC50: 6.08E+3nMAssay Description:Negative allosteric modulation activity at human P2X7 receptor expressed in human 1321N1 cells assessed as ATP induced calcium response by measuring ...More data for this Ligand-Target Pair
Affinity DataEC50: 6.62E+3nMAssay Description:Negative allosteric modulation activity at human P2X7 receptor expressed in human 1321N1 cells assessed as ATP induced calcium response by measuring ...More data for this Ligand-Target Pair
Affinity DataEC50: 8.31E+3nMAssay Description:Antagonist activity against human P2X7R stably transfected in human 1321N1 cells assessed as BzATP EC50 at 0.05 uM incubated for 30 mins by Fura-2 AM...More data for this Ligand-Target Pair
Affinity DataEC50: 9.14E+3nMAssay Description:Antagonist activity against human P2X7R stably transfected in human 1321N1 cells assessed as BzATP EC50 at 0.2 uM incubated for 30 mins by Fura-2 AM ...More data for this Ligand-Target Pair
Affinity DataEC50: 9.44E+3nMAssay Description:Antagonist activity against human P2X7R stably transfected in human 1321N1 cells assessed as BzATP EC50 at 0.1 uM incubated for 30 mins by Fura-2 AM ...More data for this Ligand-Target Pair
Affinity DataEC50: 1.66E+4nMAssay Description:Agonist activity at human P2X7R expressing HEK293 cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followed b...More data for this Ligand-Target Pair
Affinity DataEC50: 2.24E+4nMAssay Description:Agonist activity at human P2X7R expressed in HEK293 cells assessed as reduction in YO-PRO-1 iodide dye uptake preincubated for 30 mins followed by YO...More data for this Ligand-Target Pair
Affinity DataEC50: 5.20E+4nMAssay Description:Antagonist activity against recombinant human P2X purinoceptor 7 (P2X7)More data for this Ligand-Target Pair
Affinity DataEC50: 6.20E+4nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 7 (P2X7)More data for this Ligand-Target Pair
Affinity DataEC50: 9.20E+4nMAssay Description:Antagonist activity against recombinant human P2X purinoceptor 7 (P2X7)More data for this Ligand-Target Pair
Affinity DataEC50: <1.00E+5nMAssay Description:Agonist activity at human P2X7R expressing HEK293 cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followed b...More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+5nMAssay Description:Antagonist activity against recombinant human P2X purinoceptor 7 (P2X7)More data for this Ligand-Target Pair
Affinity DataEC50: <1.00E+5nMAssay Description:Agonist activity at human P2X7R expressed in HEK293 cells assessed as reduction in YO-PRO-1 iodide dye uptake preincubated for 30 mins followed by YO...More data for this Ligand-Target Pair
Affinity DataEC50: 7.80E+5nMAssay Description:Antagonist activity against recombinant human P2X purinoceptor 7 (P2X7)More data for this Ligand-Target Pair