Compile Data Set for Download or QSAR
maximum 50k data
Found 5715 of ic50 data for polymerid = 2112
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM602735((5Z)-5-[[1-(3-chlorophenyl)pyrazol-4-yl]methylene]...)
Affinity DataIC50:  0nMAssay Description:Among the compounds of the Examples 1-1 to 1-61, compounds that showed excellent inhibitory activity (inhibitory activity of 85% or more at 20 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM116089(US8633183, E-238)
Affinity DataIC50:  0.0700nMAssay Description:The mTOR kinase TR-FRET assay utilizes a physiologically relevant protein substrate for mTOR (4E-BP1, labeled with an acceptor fluorophore (Green Flu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM35595(pyrazolo pyrimidine, 28)
Affinity DataIC50:  0.0800nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM36609(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of mTOR kinase expressed in human HEK293 cells by western blot analysisMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM36609(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of mTOR in HEK293 cellsMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50315080(4-(3-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50303282(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-et...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human Flag-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50303298(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-et...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human Flag-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50303299(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-et...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human Flag-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50316254(CHEMBL1098245 | methyl 4-(6-(4-(3-(4-(2-hydroxyeth...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50300067(CHEMBL573157 | methyl 4-(4-(8-oxa-3-azabicyclo[3.2...)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of Flag-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50306624(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-is...)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50306640(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1...)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50306639(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1...)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50348452(AZD-8055 | CHEMBL1801204 | US9102670, 1a)
Affinity DataIC50:  0.130nMAssay Description:Inhibition of recombinant FLAG-tagged mTOR (1362 to 2549) (unknown origin) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50315071(4-(3-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6...)
Affinity DataIC50:  0.140nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM174595(US9102670, 14a)
Affinity DataIC50:  0.150nMT: 2°CAssay Description:The assay used AlphaScreen technology (Gray et al., Analytical Biochemistry, 2003, 313: 234-245) to determine the ability of test compounds to inhibi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50300072(CHEMBL573202 | methyl 4-(4-(3-oxa-8-azabicyclo[3.2...)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of Flag-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50306638(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1...)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50300077(CHEMBL578645 | ethyl 4-(6-(4-(3-ethylureido)phenyl...)
Affinity DataIC50:  0.170nMAssay Description:Inhibition of Flag-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50315056(1-(4-(4,6-di(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-...)
Affinity DataIC50:  0.180nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50145416(GSK2126458 | Omipalisib)
Affinity DataIC50:  0.180nMAssay Description:Competitive inhibition of human mTOR using 4EBP1 as substrate in presence of [33gammaP]-ATP after 120 mins by filter binding methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50300070(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(2...)
Affinity DataIC50:  0.190nMAssay Description:Inhibition of Flag-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50306620(CHEMBL606423 | isopropyl 4-(4-(8-oxa-3-azabicyclo[...)
Affinity DataIC50:  0.190nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50341056(5-(1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-1H-benz...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of mTOR assessed as inhibition of phosphorylation of 4EBP1 by Lantha-Screen enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50300074(1-(4-(4-morpholino-1-(2,2,2-trifluoroethyl)-1H-pyr...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of mTOR in HEK293 cells by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50316255(CHEMBL1095932 | Isopropyl 4-(6-(4-(3-Methylureido)...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50089318(CHEMBL3577911)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of mTOR (unknown origin) using GFP-4E-BP1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50303280(4-(3-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human Flag-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50303281(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-et...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human Flag-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM116093(US8633183, E-242)
Affinity DataIC50:  0.200nMAssay Description:The mTOR kinase TR-FRET assay utilizes a physiologically relevant protein substrate for mTOR (4E-BP1, labeled with an acceptor fluorophore (Green Flu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50303295(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-et...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human Flag-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM35592(pyrazolo pyrimidine, 24)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of Flag-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50300071(CHEMBL577137 | methyl 4-(4-(8-oxa-3-azabicyclo[3.2...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of Flag-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50300075(1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-1-(2...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of Flag-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM35592(pyrazolo pyrimidine, 24)
Affinity DataIC50:  0.200nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50303292(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(2...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human Flag-tagged mTOR expressed in HEK293 cells after 2 hrs by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM116143(US8633183, E-297)
Affinity DataIC50:  0.210nMAssay Description:The mTOR kinase TR-FRET assay utilizes a physiologically relevant protein substrate for mTOR (4E-BP1, labeled with an acceptor fluorophore (Green Flu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50306633(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1...)
Affinity DataIC50:  0.210nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50300078(CHEMBL574012 | methyl 4-(4-(3-oxa-8-azabicyclo[3.2...)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of Flag-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50300066(CHEMBL568259 | methyl 4-(4-(8-oxa-3-azabicyclo[3.2...)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50300066(CHEMBL568259 | methyl 4-(4-(8-oxa-3-azabicyclo[3.2...)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of Flag-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50306636(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1...)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50306637(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1...)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50306627(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(4...)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50300074(1-(4-(4-morpholino-1-(2,2,2-trifluoroethyl)-1H-pyr...)
Affinity DataIC50:  0.230nMAssay Description:Inhibition of Flag-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50300069(1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(2...)
Affinity DataIC50:  0.230nMAssay Description:Inhibition of Flag-tagged human mTOR by DELFIA methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50306628(CHEMBL610630 | trans-1-(4-(4-(8-oxa-3-azabicyclo[3...)
Affinity DataIC50:  0.240nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM50341209(9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Medicinal Bioconvergence Research Center

US Patent
LigandPNGBDBM116092(US8633183, E-241)
Affinity DataIC50:  0.25nMAssay Description:The mTOR kinase TR-FRET assay utilizes a physiologically relevant protein substrate for mTOR (4E-BP1, labeled with an acceptor fluorophore (Green Flu...More data for this Ligand-Target Pair
In DepthDetails US Patent
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