Compile Data Set for Download or QSAR
maximum 50k data
Found 1476 of ic50 data for polymerid = 2129,49000132,49000137,49000138,49000139,49000144,5536,5768
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM50149598(CHEMBL3770679)
Affinity DataIC50:  0.0295nMAssay Description:Agonist activity at human Adenosine A1 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(BOVINE)
TBA

Curated by ChEMBL
LigandPNGBDBM50020986(CHEMBL11002 | N-(2-Dimethylamino-ethyl)-4-(2,6-dio...)
Affinity DataIC50:  0.0500nMAssay Description:Binding affinity against bovine brain adenosine A1 receptor by using N6-[3H]- cyclohexyladenosineChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(BOVINE)
TBA

Curated by ChEMBL
LigandPNGBDBM82013(8-(2-Amino-4-chloro-phenyl)-1,3-dipropyl-3,7-dihyd...)
Affinity DataIC50:  0.0500nMAssay Description:Binding affinity against bovine brain adenosine A1 receptor by using N6-[3H]- cyclohexyladenosineChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50550819(CHEMBL4796077)
Affinity DataIC50:  0.0670nMAssay Description:Displacement of [3H]DPCPX from rat brain cortical membrane A1AR in absence of GTP by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(BOVINE)
TBA

Curated by ChEMBL
LigandPNGBDBM50021010(CHEMBL545362 | N-(4-Dimethylamino-butyl)-4-(2,6-di...)
Affinity DataIC50:  0.0700nMAssay Description:Binding affinity against bovine brain adenosine A1 receptor by using N6-[3H]- cyclohexyladenosineChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50550824(CHEMBL4797181)
Affinity DataIC50:  0.0756nMAssay Description:Displacement of [3H]DPCPX from rat brain cortical membrane A1AR in absence of GTP by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50550824(CHEMBL4797181)
Affinity DataIC50:  0.0763nMAssay Description:Displacement of [3H]DPCPX from rat brain cortical membrane A1AR in presence of 100 uM of GTP by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(BOVINE)
TBA

Curated by ChEMBL
LigandPNGBDBM50021008(CHEMBL11036 | N-(3-Dimethylamino-propyl)-4-(2,6-di...)
Affinity DataIC50:  0.0800nMAssay Description:Binding affinity against bovine brain adenosine A1 receptor by using N6-[3H]- cyclohexyladenosineChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50550819(CHEMBL4796077)
Affinity DataIC50:  0.0840nMAssay Description:Displacement of [3H]DPCPX from rat brain cortical membrane A1AR in presence of 100 uM of GTP by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50550832(CHEMBL4764086)
Affinity DataIC50:  0.0929nMAssay Description:Displacement of [3H]DPCPX from rat brain cortical membrane A1AR in absence of GTP by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50550832(CHEMBL4764086)
Affinity DataIC50:  0.0981nMAssay Description:Displacement of [3H]DPCPX from rat brain cortical membrane A1AR in presence of 100 uM of GTP by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM474233(5-[5-amino-7-(4-fluorophenyl)-2-[(3-fluoropyrid in...)
Affinity DataIC50:  0.100nMAssay Description:Binding affinity and specificities of the compounds against different subtype of human adenosine receptors (hA1, hA2A, hA2B and hA3) were characteriz...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM474233(5-[5-amino-7-(4-fluorophenyl)-2-[(3-fluoropyrid in...)
Affinity DataIC50:  0.100nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM50375517(CHEMBL411245)
Affinity DataIC50:  0.120nMAssay Description:Agonist activity at adenosine A1 receptor assessed as inhibition of isoproterenol-stimulated cAMP accumulation in DDT1MF-2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM50517299(CHEMBL4533718)
Affinity DataIC50:  0.140nMAssay Description:Agonist activity at human A1A adenosine receptor expressed in HEK cells assessed as inhibition of forskolin-stimulated cAMP production after 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(BOVINE)
TBA

Curated by ChEMBL
LigandPNGBDBM50021004(8-(2,4-Diamino-phenyl)-1,3-dipropyl-3,7-dihydro-pu...)
Affinity DataIC50:  0.150nMAssay Description:Binding affinity against bovine brain adenosine A1 receptor by using N6-[3H]- cyclohexyladenosineChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM474222(5-(5-amino-2-(2,6-difluorobenzyl)-7-(4- fluorophen...)
Affinity DataIC50:  0.200nMAssay Description:Binding affinity and specificities of the compounds against different subtype of human adenosine receptors (hA1, hA2A, hA2B and hA3) were characteriz...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM474222(5-(5-amino-2-(2,6-difluorobenzyl)-7-(4- fluorophen...)
Affinity DataIC50:  0.200nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataIC50:  0.209nMAssay Description:Agonist activity at human Adenosine A1 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(BOVINE)
TBA

Curated by ChEMBL
LigandPNGBDBM50020979(4-[4-(2,6-Dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H...)
Affinity DataIC50:  0.240nMAssay Description:Binding affinity against bovine brain adenosine A1 receptor by using N6-[3H]- cyclohexyladenosineChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM50375516(CHEMBL258759)
Affinity DataIC50:  0.300nMAssay Description:Agonist activity at adenosine A1 receptor assessed as inhibition of isoproterenol-stimulated cAMP accumulation in DDT1MF-2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM25400((2R,3R,4S,5R)-2-[6-(cyclopentylamino)-9H-purin-9-y...)
Affinity DataIC50:  0.320nMAssay Description:Evaluated for binding affinity against Adenosine A1 receptorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM25400((2R,3R,4S,5R)-2-[6-(cyclopentylamino)-9H-purin-9-y...)
Affinity DataIC50:  0.350nMAssay Description:Binding affinity to adenosine A1 receptor of rat brain membranes without NaCl by inhibition of [125-I]-labeled aminobenzyl adenosine bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(BOVINE)
TBA

Curated by ChEMBL
LigandPNGBDBM50020974(8-(2-Amino-4-chloro-phenyl)-1,3-dimethyl-3,7-dihyd...)
Affinity DataIC50:  0.350nMAssay Description:Binding affinity against bovine brain adenosine A1 receptor by using N6-[3H]- cyclohexyladenosineChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM50385957(CHEMBL2042297)
Affinity DataIC50:  0.360nMAssay Description:Agonist activity at human adenosine A1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM50149597(CHEMBL3771184)
Affinity DataIC50:  0.398nMAssay Description:Agonist activity at human Adenosine A1 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50020974(8-(2-Amino-4-chloro-phenyl)-1,3-dimethyl-3,7-dihyd...)
Affinity DataIC50:  0.400nMAssay Description:Binding affinity against adenosine A1 receptor in rat brain membrane preparations using N6-[3H]-cyclohexyladenosine as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM21173(1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...)
Affinity DataIC50:  0.5nMAssay Description:Displacement of [3H]DPCPX from human recombinant adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM21173(1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...)
Affinity DataIC50:  0.5nMAssay Description:Displacement of [3H]DPCPX from human recombinant adenosine receptor A1 expressed in CHO cells measured after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataIC50:  0.501nMAssay Description:Agonist activity at human Adenosine A1 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50452317(CHEMBL2094085)
Affinity DataIC50:  0.520nMAssay Description:Potency against rat brain adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50287703((E)-1-[(S)-2-(2-Hydroxy-ethyl)-piperidin-1-yl]-3-(...)
Affinity DataIC50:  0.560nMAssay Description:Inhibition of adenosine induced negative inotropic activity against guinea-pig atria (Adenosine A1 receptor)More data for this Ligand-Target Pair
In DepthDetails Article
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM50327343(2-(4-(8-fluoroquinoxalin-6-yl)-3-methyl-1-o-tolyl-...)
Affinity DataIC50:  0.600nMAssay Description:Antagonist activity at adenosine A1 receptor by cAMP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  0.610nMAssay Description:Displacement of [3H]-DPCPX from human recombinant adenosine A1 receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50452315(CHEMBL2094086)
Affinity DataIC50:  0.620nMAssay Description:Potency against rat brain adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM50149594(CHEMBL3771208)
Affinity DataIC50:  0.676nMAssay Description:Agonist activity at human Adenosine A1 receptor transfected in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production after 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(BOVINE)
TBA

Curated by ChEMBL
LigandPNGBDBM82025(1,3-Dipropyl-8-phenylxanthine | 8-Phenyl-1,3-dipro...)
Affinity DataIC50:  0.700nMAssay Description:Binding affinity against bovine brain adenosine A1 receptor by using N6-[3H]- cyclohexyladenosineChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(BOVINE)
TBA

Curated by ChEMBL
LigandPNGBDBM50020976(8-(2-Amino-phenyl)-1,3-dipropyl-3,7-dihydro-purine...)
Affinity DataIC50:  0.75nMAssay Description:Binding affinity against bovine brain adenosine A1 receptor by using N6-[3H]- cyclohexyladenosineChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(BOVINE)
TBA

Curated by ChEMBL
LigandPNGBDBM50020981(8-(4-Bromo-phenyl)-1,3-dimethyl-3,7-dihydro-purine...)
Affinity DataIC50:  0.75nMAssay Description:Binding affinity against bovine brain adenosine A1 receptor by using N6-[3H]- cyclohexyladenosineChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(BOVINE)
TBA

Curated by ChEMBL
LigandPNGBDBM50020961(8-(4-Ethyl-phenyl)-1,3-dimethyl-3,7-dihydro-purine...)
Affinity DataIC50:  0.800nMAssay Description:Binding affinity against bovine brain adenosine A1 receptor by using N6-[3H]- cyclohexyladenosineChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM474230(5-(5-amino-7-(4-fluorophenyl)-2-((3-fluoropyrid in...)
Affinity DataIC50:  0.800nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM474237(5-(5-amino-7-(3-chlorophenyl)-2-((3-fluoropyrid in...)
Affinity DataIC50:  0.800nMAssay Description:Binding affinity and specificities of the compounds against different subtype of human adenosine receptors (hA1, hA2A, hA2B and hA3) were characteriz...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM474237(5-(5-amino-7-(3-chlorophenyl)-2-((3-fluoropyrid in...)
Affinity DataIC50:  0.800nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A1(BOVINE)
TBA

Curated by ChEMBL
LigandPNGBDBM50020963(1,3-Diallyl-8-(2-amino-4-chloro-phenyl)-3,7-dihydr...)
Affinity DataIC50:  0.800nMAssay Description:Binding affinity against bovine brain adenosine A1 receptor by using N6-[3H]- cyclohexyladenosineChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(BOVINE)
TBA

Curated by ChEMBL
LigandPNGBDBM50020966(8-(2-Amino-4-chloro-phenyl)-1,3-diethyl-3,7-dihydr...)
Affinity DataIC50:  0.800nMAssay Description:Binding affinity against bovine brain adenosine A1 receptor by using N6-[3H]- cyclohexyladenosineChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50020988(8-(4-Chloro-phenyl)-1,3-dimethyl-3,7-dihydro-purin...)
Affinity DataIC50:  0.800nMAssay Description:Binding affinity against adenosine A1 receptor in rat brain membrane preparations using N6-[3H]-cyclohexyladenosine as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(BOVINE)
TBA

Curated by ChEMBL
LigandPNGBDBM50020988(8-(4-Chloro-phenyl)-1,3-dimethyl-3,7-dihydro-purin...)
Affinity DataIC50:  0.800nMAssay Description:Binding affinity against bovine brain adenosine A1 receptor by using N6-[3H]- cyclohexyladenosineChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM474230(5-(5-amino-7-(4-fluorophenyl)-2-((3-fluoropyrid in...)
Affinity DataIC50:  0.800nMAssay Description:Binding affinity and specificities of the compounds against different subtype of human adenosine receptors (hA1, hA2A, hA2B and hA3) were characteriz...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A1(BOVINE)
TBA

Curated by ChEMBL
LigandPNGBDBM50020969(1,3-Dimethyl-8-p-tolyl-3,7-dihydro-purine-2,6-dion...)
Affinity DataIC50:  0.800nMAssay Description:Binding affinity against bovine brain adenosine A1 receptor by using N6-[3H]- cyclohexyladenosineChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50020969(1,3-Dimethyl-8-p-tolyl-3,7-dihydro-purine-2,6-dion...)
Affinity DataIC50:  0.800nMAssay Description:Binding affinity against adenosine A1 receptor in rat brain membrane preparations using N6-[3H]-cyclohexyladenosine as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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