Compile Data Set for Download or QSAR
maximum 50k data
Found 102 of ic50 data for polymerid = 3667
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM30185(CHEMBL226403 | Pyrrolopyridine, 16)
Affinity DataIC50:  81nMpH: 7.5 T: 2°CAssay Description:Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50365798(CHEMBL1956685)
Affinity DataIC50:  88nMAssay Description:Inhibition of MAPKAPK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM30185(CHEMBL226403 | Pyrrolopyridine, 16)
Affinity DataIC50:  100nMAssay Description:Inhibition of MAPKAPK5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  129nMAssay Description:Inhibition of human MAPKAPK5 using KKLNRTLSVA as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM30178(Pyrrolopyridine, 9)
Affinity DataIC50:  140nMpH: 7.5 T: 2°CAssay Description:Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50365797(CHEMBL1956684)
Affinity DataIC50:  148nMAssay Description:Inhibition of MAPKAPK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50365801(CHEMBL1956682)
Affinity DataIC50:  195nMAssay Description:Inhibition of MAPKAPK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM30192(Pyrrolopyridine, 23)
Affinity DataIC50:  210nMpH: 7.5 T: 2°CAssay Description:Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50365797(CHEMBL1956684)
Affinity DataIC50:  227nMAssay Description:Inhibition of MAPKAPK5 in syonovial fibroblast from rheumatoid arthritis patient assessed as inhibition of TNF-alpha-induced MMP1 expression incubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50365795(CHEMBL1956574)
Affinity DataIC50:  239nMAssay Description:Inhibition of MAPKAPK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50365799(CHEMBL1956686)
Affinity DataIC50:  290nMAssay Description:Inhibition of MAPKAPK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  295nMAssay Description:Inhibition of human MAPKAPK5 using KKLNRTLSVA as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50365794(CHEMBL1956573)
Affinity DataIC50:  327nMAssay Description:Inhibition of MAPKAPK5 in syonovial fibroblast from rheumatoid arthritis patient assessed as inhibition of TNF-alpha-induced MMP1 expression incubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM558875(US11370770, Compound 6z)
Affinity DataIC50:  350nMAssay Description:Kinase activity of recombinant active full-length human MEK4 (Carna Biosciences) was measured using the ADP-Glo assay (Promega) with 3 μM recomb...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50365788(CHEMBL1956567)
Affinity DataIC50:  390nMAssay Description:Inhibition of MAPKAPK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50365791(CHEMBL1956570)
Affinity DataIC50:  392nMAssay Description:Inhibition of MAPKAPK5 in syonovial fibroblast from rheumatoid arthritis patient assessed as inhibition of TNF-alpha-induced MMP1 expression incubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50365794(CHEMBL1956573)
Affinity DataIC50:  437nMAssay Description:Inhibition of MAPKAPK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50365801(CHEMBL1956682)
Affinity DataIC50:  445nMAssay Description:Inhibition of MAPKAPK5 in syonovial fibroblast from rheumatoid arthritis patient assessed as inhibition of TNF-alpha-induced MMP1 expression incubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM27344(2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyri...)
Affinity DataIC50:  500nMpH: 7.5 T: 2°CAssay Description:Compounds were evaluated as inhibitors of kinase by measuring their effect on kinase induced phosphorylation of substrate. IC50 values were reported ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50413752(CHEMBL2012519 | L-783277)
Affinity DataIC50:  640nMAssay Description:Inhibition of MK5 by TR-FRET based LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50365795(CHEMBL1956574)
Affinity DataIC50:  676nMAssay Description:Inhibition of MAPKAPK5 in syonovial fibroblast from rheumatoid arthritis patient assessed as inhibition of TNF-alpha-induced MMP1 expression incubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50365798(CHEMBL1956685)
Affinity DataIC50:  702nMAssay Description:Inhibition of MAPKAPK5 in syonovial fibroblast from rheumatoid arthritis patient assessed as inhibition of TNF-alpha-induced MMP1 expression incubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50365800(CHEMBL1956687)
Affinity DataIC50:  816nMAssay Description:Inhibition of MAPKAPK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50365782(CHEMBL1956561)
Affinity DataIC50:  829nMAssay Description:Inhibition of MAPKAPK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50365788(CHEMBL1956567)
Affinity DataIC50:  871nMAssay Description:Inhibition of MAPKAPK5 in syonovial fibroblast from rheumatoid arthritis patient assessed as inhibition of TNF-alpha-induced MMP1 expression incubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50365799(CHEMBL1956686)
Affinity DataIC50:  871nMAssay Description:Inhibition of MAPKAPK5 in syonovial fibroblast from rheumatoid arthritis patient assessed as inhibition of TNF-alpha-induced MMP1 expression incubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50365785(CHEMBL1956564)
Affinity DataIC50:  914nMAssay Description:Inhibition of MAPKAPK5 in syonovial fibroblast from rheumatoid arthritis patient assessed as inhibition of TNF-alpha-induced MMP1 expression incubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50192071((13R,15S)-13-methyl-16-oxa-8,9,12,22,24-pentaazahe...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PRAKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50070942((-)-Epigallocatechin gallate | (-)-Epigallocatechi...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of PRAK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Protein kinase PRAKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50365785(CHEMBL1956564)
Affinity DataIC50:  1.37E+3nMAssay Description:Inhibition of MAPKAPK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50536679(CHEMBL4568087)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of full-length recombinant human His-tagged MAPKAPK5 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50365791(CHEMBL1956570)
Affinity DataIC50:  1.42E+3nMAssay Description:Inhibition of MAPKAPK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50365784(CHEMBL1956563)
Affinity DataIC50:  1.49E+3nMAssay Description:Inhibition of MAPKAPK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50363167(CHEMBL1945559)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of MK5 using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50126829((E)-1-(6-(3-acetyl-2,4,6-trihydroxy-5-methylbenzyl...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of His-tagged human PRAK expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50126829((E)-1-(6-(3-acetyl-2,4,6-trihydroxy-5-methylbenzyl...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of p38-regulated activated kinase (PRAK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50365787(CHEMBL1956566)
Affinity DataIC50:  2.39E+3nMAssay Description:Inhibition of MAPKAPK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50365800(CHEMBL1956687)
Affinity DataIC50:  2.61E+3nMAssay Description:Inhibition of MAPKAPK5 in syonovial fibroblast from rheumatoid arthritis patient assessed as inhibition of TNF-alpha-induced MMP1 expression incubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50365792(CHEMBL1956571)
Affinity DataIC50:  2.82E+3nMAssay Description:Inhibition of MAPKAPK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50365782(CHEMBL1956561)
Affinity DataIC50:  2.82E+3nMAssay Description:Inhibition of MAPKAPK5 in syonovial fibroblast from rheumatoid arthritis patient assessed as inhibition of TNF-alpha-induced MMP1 expression incubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50365793(CHEMBL1956572)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of MAPKAPK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50157880(CHEMBL3787112)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of MAPKAPK5 (unknown origin) in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50365802(CHEMBL1956683)
Affinity DataIC50:  3.73E+3nMAssay Description:Inhibition of MAPKAPK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM175242(US11844801, Compound (M)-I | US9115089, 49)
Affinity DataIC50:  8.10E+3nMpH: 7.5Assay Description:The ability of compounds to inhibit activated phospho-p38alpha is evaluated using a p38alpha /MK2 and a p38alpha /PRAK cascade assay format. The kina...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM175242(US11844801, Compound (M)-I | US9115089, 49)
Affinity DataIC50:  8.10E+3nMAssay Description:Inhibition of MK2 and PRAK by Compound (P)-I and (M)-I, respectively, was investigated to understand selectivity of Compound (P)-I and/or Compound (M...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  9.60E+3nMAssay Description:Inhibition of full-length recombinant human His-tagged MAPKAPK5 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50001733(CHEMBL3133821)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human MAPKAPK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50031747(CHEMBL3360318)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MAPKAPK5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50135286(CHEMBL3745885)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human MAPKAPK5 using [KKLNRTLSVA] as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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