Compile Data Set for Download or QSAR
maximum 50k data
Found 324 of ic50 data for polymerid = 49000732
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50379862(CHEMBL2011870)
Affinity DataIC50:  0.900nMAssay Description:Antagonist activity at rat mGluR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50177100(3-Cycloheptyl-9-dimethylamino-3H-pyrido[3',2':4,5]...)
Affinity DataIC50:  1nMAssay Description:Inhibition of rat mGluR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50177080(3-azepan-1-yl-9-dimethylamino-3H-pyrido[3',2':4,5]...)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at rat mGluR1 expressed in 1321N1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50163617((2,3-Dihydro-thieno[2,3-b]quinolin-6-yl)-(4-methox...)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50163592((3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-(4-met...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50231750((3-ethyl-2-methylquinolin-6-yl)(4-methoxycyclohexy...)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50177053(9-Dimethylamino-3-(4-ethyl-phenyl)-3H-pyrido[3',2'...)
Affinity DataIC50:  3nMAssay Description:Inhibition of rat mGluR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50163590((2,3-Diethyl-quinolin-6-yl)-(4-methoxy-cyclohexyl)...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50163592((3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-(4-met...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50163590((2,3-Diethyl-quinolin-6-yl)-(4-methoxy-cyclohexyl)...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50301804(5-(1-(2,4-difluorophenyl)-5-methyl-1H-1,2,3-triazo...)
Affinity DataIC50:  3.60nMAssay Description:Antagonist activity at rat mGluR1 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FLIP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50163607(3-ethyl-6-[(4-methoxycyclohexyl)carbonyl]quinoline...)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50177063(3-(4-Bromo-phenyl)-9-dimethylamino-3H-pyrido[3',2'...)
Affinity DataIC50:  4nMAssay Description:Inhibition of rat mGluR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50129227(3-Methyl-1H-pyrrole-2,4-dicarboxylic acid 2-isopro...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibition of rat metabotropic glutamate receptor 1 in CHO cells using the CDP-DAG accumulation method.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50163613((2,3-Dihydro-1H-cyclopenta[b]quinolin-7-yl)-(4-met...)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50163589((4-Methoxy-cyclohexyl)-(2-propyl-quinolin-6-yl)-me...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50163616((2-Chloro-3-ethyl-quinolin-6-yl)-(4-methoxy-cycloh...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50231744(CHEMBL399160 | NPS 2390 | quinoxaline-2-carboxylic...)
Affinity DataIC50:  5nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50163616((2-Chloro-3-ethyl-quinolin-6-yl)-(4-methoxy-cycloh...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50177085(3-Cyclopentyl-9-dimethylamino-3H-pyrido[3',2':4,5]...)
Affinity DataIC50:  5nMAssay Description:Inhibition of rat mGluR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50177097(9-Dimethylamino-3-p-tolyl-3H-pyrido[3',2':4,5]thie...)
Affinity DataIC50:  5nMAssay Description:Inhibition of rat mGluR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50177053(9-Dimethylamino-3-(4-ethyl-phenyl)-3H-pyrido[3',2'...)
Affinity DataIC50:  5nMAssay Description:Antagonist activity at rat mGluR1 expressed in 1321N1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50231749(6-ethyl-5-methyl-3-(1,2,4,5-tetrahydrobenzo[d]azep...)
Affinity DataIC50:  6nMAssay Description:Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50163606(1-(3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-2-ph...)
Affinity DataIC50:  6nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50163609((4-Methoxy-cyclohexyl)-(2-methyl-3-propyl-quinolin...)
Affinity DataIC50:  7nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50163611(1-(3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-2-th...)
Affinity DataIC50:  7nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50163615((4-Methoxy-cyclohexyl)-(1-methyl-1,2,3,4-tetrahydr...)
Affinity DataIC50:  8nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50177055(9-Dimethylamino-3-(3-ethyl-phenyl)-3H-pyrido[3',2'...)
Affinity DataIC50:  9nMAssay Description:Inhibition of rat mGluR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50177080(3-azepan-1-yl-9-dimethylamino-3H-pyrido[3',2':4,5]...)
Affinity DataIC50:  10nMAssay Description:Inhibition of rat mGluR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50163604(1-(3-Ethyl-2-methyl-quinolin-6-yl)-2-phenyl-ethano...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50163599(Bicyclo[2.2.1]hept-2-yl-(3-ethyl-2-methyl-quinolin...)
Affinity DataIC50:  13nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50163584((3-Ethyl-2-iodo-quinolin-6-yl)-(4-methoxy-cyclohex...)
Affinity DataIC50:  13nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50177059(3-Cyclooctyl-9-dimethylamino-3H-pyrido[3',2':4,5]t...)
Affinity DataIC50:  13nMAssay Description:Inhibition of rat mGluR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50301520(4-fluoro-N-(4-(6-(isopropylamino)pyrimidin-4-yl)th...)
Affinity DataIC50:  13.9nMAssay Description:Displacement of 4-[18F]fluoro-N-[4-(6-(isopropylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl]-N-methylbenzamide from mGluR1 in Sprague-Dawley rat brain hom...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50163620((3-Ethyl-2-hydroxy-quinolin-6-yl)-(4-methoxy-cyclo...)
Affinity DataIC50:  15nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50163598(1-(3-Ethyl-2-methyl-quinolin-6-yl)-2-(4-methoxy-cy...)
Affinity DataIC50:  16nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50177076(3-(4-Chloro-phenyl)-9-dimethylamino-3H-pyrido[3',2...)
Affinity DataIC50:  16nMAssay Description:Inhibition of rat mGluR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50204428((S)-4-(3,3-dimethylbutan-2-yl) 2-propyl 3,5-dimeth...)
Affinity DataIC50:  16nMAssay Description:Antagonist activity at rat mGluR1a expressed in CHO cells assessed as inhibition of intracellular calcium ion mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50422815(CHEMBL383107)
Affinity DataIC50:  16nMAssay Description:Inhibition of rat mGluR1a in CHO cells by CDP-DAG accumulation methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50177065(9-Dimethylamino-3-(2,4-dimethyl-phenyl)-3H-pyrido[...)
Affinity DataIC50:  17nMAssay Description:Inhibition of rat mGluR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50129246(3-Methyl-1H-pyrrole-2,4-dicarboxylic acid 2-tert-b...)
Affinity DataIC50:  17nMAssay Description:In vitro inhibition of rat metabotropic glutamate receptor 1 in CHO cells using the CDP-DAG accumulation method.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50163586((3-Ethyl-2-methoxy-quinolin-6-yl)-(4-methoxy-cyclo...)
Affinity DataIC50:  19nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50163586((3-Ethyl-2-methoxy-quinolin-6-yl)-(4-methoxy-cyclo...)
Affinity DataIC50:  19nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50422824(CHEMBL204802)
Affinity DataIC50:  20nMAssay Description:Inhibition of rat mGluR1a in CHO cells by CDP-DAG accumulation methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50177079(9-dimethylamino-3-phenyl-3H-pyrido[3',2':4,5]thien...)
Affinity DataIC50:  20nMAssay Description:Inhibition of rat mGluR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50422826(CHEMBL377503)
Affinity DataIC50:  20nMAssay Description:Inhibition of rat mGluR1a in CHO cells by CDP-DAG accumulation methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50422825(CHEMBL444359)
Affinity DataIC50:  20nMAssay Description:Inhibition of rat mGluR1a in CHO cells by CDP-DAG accumulation methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50190236(9-dimethylamino-3-(3-fluoro-4-methyl-phenyl)-3H-py...)
Affinity DataIC50:  21nMAssay Description:Antagonist activity at rat mGluR1 expressed in 1321N1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50177078(9-Dimethylamino-3-(4-fluoro-phenyl)-3H-pyrido[3',2...)
Affinity DataIC50:  23nMAssay Description:Inhibition of rat mGluR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50422817(CHEMBL380698)
Affinity DataIC50:  25nMAssay Description:Inhibition of rat mGluR1a in CHO cells by CDP-DAG accumulation methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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