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Compile Data Set for Download or QSAR

Found 313 hits of ic50 data for polymerid = 5184,5184   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50177318
PNG
(2-(4-(7-(4-tetradecylbenzoyl)cyclopenta[d][1,2]oxa...)
Show SMILES CCCCCCCCCCCCCCc1ccc(cc1)C(=O)c1ccc2c(nocc12)-c1ccc(OCC(O)=O)cc1
Show InChI InChI=1S/C36H43NO5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-27-15-17-29(18-16-27)36(40)32-24-23-31-33(32)25-42-37-35(31)28-19-21-30(22-20-28)41-26-34(38)39/h15-25H,2-14,26H2,1H3,(H,38,39)
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n/an/a 150n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibitory activity against CD45 phosphatase


Bioorg Med Chem Lett 16: 499-502 (2005)


Article DOI: 10.1016/j.bmcl.2005.10.062
BindingDB Entry DOI: 10.7270/Q2319VFG
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099692
PNG
(CHEMBL51314 | N-(9,10-Dioxo-9,10-dihydro-phenanthr...)
Show SMILES CC(C)(C)C(=O)Nc1ccc-2c(c1)C(=O)C(=O)c1ccccc-21
Show InChI InChI=1S/C19H17NO3/c1-19(2,3)18(23)20-11-8-9-13-12-6-4-5-7-14(12)16(21)17(22)15(13)10-11/h4-10H,1-3H3,(H,20,23)
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n/an/a 200n/an/an/an/an/an/a



AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50094938
PNG
(5-Isopropoxy-2-(4-methylsulfanyl-pyridin-2-ylmetha...)
Show SMILES CSc1ccnc(CS(=O)c2nc3ccc(OC(C)C)cc3[nH]2)c1
Show InChI InChI=1S/C17H19N3O2S2/c1-11(2)22-13-4-5-15-16(9-13)20-17(19-15)24(21)10-12-8-14(23-3)6-7-18-12/h4-9,11H,10H2,1-3H3,(H,19,20)
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n/an/a 280n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
The compound was evaluated for its inhibitory activity towards Protein tyrosine phosphatase of CD45


Bioorg Med Chem Lett 10: 2657-60 (2000)


Article DOI: 10.1016/s0960-894x(00)00539-4
BindingDB Entry DOI: 10.7270/Q2MK6C54
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50262986
PNG
(CHEMBL515797 | [5-Hydroxy-3',5'-bis-trifluoromethy...)
Show SMILES OC(=O)COc1c(O)cc(cc1OCc1cccc(c1)C(F)(F)F)-c1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C24H15F9O5/c25-22(26,27)15-3-1-2-12(4-15)10-37-19-8-14(7-18(34)21(19)38-11-20(35)36)13-5-16(23(28,29)30)9-17(6-13)24(31,32)33/h1-9,34H,10-11H2,(H,35,36)
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n/an/a 280n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of CD45 (unknown origin)


Bioorg Med Chem 16: 7399-409 (2008)


Article DOI: 10.1016/j.bmc.2008.06.014
BindingDB Entry DOI: 10.7270/Q2PC325T
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50303173
PNG
(2-(5-((3-(4-(2-chlorobenzyloxy)phenyl)-1-phenyl-1H...)
Show SMILES OS(=O)(=O)CCN1C(=S)S\C(=C/c2cn(nc2-c2ccc(OCc3ccccc3Cl)cc2)-c2ccccc2)C1=O
Show InChI InChI=1S/C28H22ClN3O5S3/c29-24-9-5-4-6-20(24)18-37-23-12-10-19(11-13-23)26-21(17-32(30-26)22-7-2-1-3-8-22)16-25-27(33)31(28(38)39-25)14-15-40(34,35)36/h1-13,16-17H,14-15,18H2,(H,34,35,36)/b25-16-
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Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant CD45


J Med Chem 52: 6716-23 (2009)


Article DOI: 10.1021/jm901016k
BindingDB Entry DOI: 10.7270/Q2VX0GK3
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM22857
PNG
(1,2-Dione-Based Compound, 14 | 9,10-dihydrophenant...)
Show SMILES O=C1C(=O)c2ccccc2-c2ccccc12
Show InChI InChI=1S/C14H8O2/c15-13-11-7-3-1-5-9(11)10-6-2-4-8-12(10)14(13)16/h1-8H
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n/an/a 300n/an/an/an/an/an/a



United States Army Medical Research Institute of Infectious Diseases



Assay Description
Protein phosphatases were purchased from Upstate Biotechnology (Lake Placid, NY).


J Biol Chem 284: 12874-85 (2009)


Article DOI: 10.1074/jbc.M809633200
BindingDB Entry DOI: 10.7270/Q2J67FJV
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099700
PNG
(CHEMBL51776 | N-[7-(3-Methoxycarbonyl-propionylami...)
Show SMILES COC(=O)CCC(=O)Nc1ccc-2c(c1)C(=O)C(=O)c1cc(NC(=O)CCC(=O)OC)ccc-21
Show InChI InChI=1S/C24H22N2O8/c1-33-21(29)9-7-19(27)25-13-3-5-15-16-6-4-14(26-20(28)8-10-22(30)34-2)12-18(16)24(32)23(31)17(15)11-13/h3-6,11-12H,7-10H2,1-2H3,(H,25,27)(H,26,28)
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration against CD45 protein-tyrosine phosphatase using lck-10 mer as substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099772
PNG
(2-Bromo-phenanthrene-9,10-dione | CHEMBL52491)
Show SMILES Brc1ccc-2c(c1)C(=O)C(=O)c1ccccc-21
Show InChI InChI=1S/C14H7BrO2/c15-8-5-6-10-9-3-1-2-4-11(9)13(16)14(17)12(10)7-8/h1-7H
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099730
PNG
(CHEMBL51781 | N-(9,10-Dioxo-9,10-dihydro-phenanthr...)
Show SMILES COC(=O)CCC(=O)Nc1ccc2C(=O)C(=O)c3ccccc3-c2c1
Show InChI InChI=1S/C19H15NO5/c1-25-17(22)9-8-16(21)20-11-6-7-14-15(10-11)12-4-2-3-5-13(12)18(23)19(14)24/h2-7,10H,8-9H2,1H3,(H,20,21)
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099746
PNG
(CHEMBL51579 | N-(9,10-Dioxo-9,10-dihydro-phenanthr...)
Show SMILES COC(=O)CCC(=O)Nc1cccc2-c3ccccc3C(=O)C(=O)c12
Show InChI InChI=1S/C19H15NO5/c1-25-16(22)10-9-15(21)20-14-8-4-7-12-11-5-2-3-6-13(11)18(23)19(24)17(12)14/h2-8H,9-10H2,1H3,(H,20,21)
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099737
PNG
(2-Amino-phenanthrene-9,10-dione | CHEMBL417727 | U...)
Show SMILES Nc1ccc-2c(c1)C(=O)C(=O)c1ccccc-21
Show InChI InChI=1S/C14H9NO2/c15-8-5-6-10-9-3-1-2-4-11(9)13(16)14(17)12(10)7-8/h1-7H,15H2
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099692
PNG
(CHEMBL51314 | N-(9,10-Dioxo-9,10-dihydro-phenanthr...)
Show SMILES CC(C)(C)C(=O)Nc1ccc-2c(c1)C(=O)C(=O)c1ccccc-21
Show InChI InChI=1S/C19H17NO3/c1-19(2,3)18(23)20-11-8-9-13-12-6-4-5-7-14(12)16(21)17(22)15(13)10-11/h4-10H,1-3H3,(H,20,23)
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United States Army Medical Research Institute of Infectious Diseases



Assay Description
Protein phosphatases were purchased from Upstate Biotechnology (Lake Placid, NY).


J Biol Chem 284: 12874-85 (2009)


Article DOI: 10.1074/jbc.M809633200
BindingDB Entry DOI: 10.7270/Q2J67FJV
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50335865
PNG
(6-Hydroxy-2-(4-methoxyphenyl)-3-(1-(4-(naphthalen-...)
Show SMILES COc1ccc(cc1)-c1oc2cc(O)c(cc2c1-c1cn(CCCC(=O)Nc2cccc3ccccc23)nn1)C(O)=O
Show InChI InChI=1S/C32H26N4O6/c1-41-21-13-11-20(12-14-21)31-30(24-16-23(32(39)40)27(37)17-28(24)42-31)26-18-36(35-34-26)15-5-10-29(38)33-25-9-4-7-19-6-2-3-8-22(19)25/h2-4,6-9,11-14,16-18,37H,5,10,15H2,1H3,(H,33,38)(H,39,40)
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n/an/a 410n/an/an/an/an/an/a



Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of CD45


J Med Chem 54: 562-71 (2011)


Article DOI: 10.1021/jm101004d
BindingDB Entry DOI: 10.7270/Q2N016T4
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM28879
PNG
(2-[(5Z)-5-[(3-{4-[(4-chlorophenyl)methoxy]phenyl}-...)
Show SMILES OS(=O)(=O)CCN1C(=S)S\C(=C/c2cn(nc2-c2ccc(OCc3ccc(Cl)cc3)cc2)-c2ccccc2)C1=O
Show InChI InChI=1S/C28H22ClN3O5S3/c29-22-10-6-19(7-11-22)18-37-24-12-8-20(9-13-24)26-21(17-32(30-26)23-4-2-1-3-5-23)16-25-27(33)31(28(38)39-25)14-15-40(34,35)36/h1-13,16-17H,14-15,18H2,(H,34,35,36)/b25-16-
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Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant CD45


J Med Chem 52: 6716-23 (2009)


Article DOI: 10.1021/jm901016k
BindingDB Entry DOI: 10.7270/Q2VX0GK3
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50303174
PNG
(2-(5-((3-(4-(2-fluorobenzyloxy)phenyl)-1-phenyl-1H...)
Show SMILES OS(=O)(=O)CCN1C(=S)S\C(=C/c2cn(nc2-c2ccc(OCc3ccccc3F)cc2)-c2ccccc2)C1=O
Show InChI InChI=1S/C28H22FN3O5S3/c29-24-9-5-4-6-20(24)18-37-23-12-10-19(11-13-23)26-21(17-32(30-26)22-7-2-1-3-8-22)16-25-27(33)31(28(38)39-25)14-15-40(34,35)36/h1-13,16-17H,14-15,18H2,(H,34,35,36)/b25-16-
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Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant CD45


J Med Chem 52: 6716-23 (2009)


Article DOI: 10.1021/jm901016k
BindingDB Entry DOI: 10.7270/Q2VX0GK3
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099704
PNG
(CHEMBL301801 | [(9,10-Dioxo-9,10-dihydro-phenanthr...)
Show SMILES OC(=O)CNC(=O)c1ccc2C(=O)C(=O)c3ccccc3-c2c1
Show InChI InChI=1S/C17H11NO5/c19-14(20)8-18-17(23)9-5-6-12-13(7-9)10-3-1-2-4-11(10)15(21)16(12)22/h1-7H,8H2,(H,18,23)(H,19,20)
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099742
PNG
(4-Nitro-phenanthrene-9,10 dione | 4-Nitro-phenanth...)
Show SMILES [O-][N+](=O)c1cccc2C(=O)C(=O)c3ccccc3-c12
Show InChI InChI=1S/C14H7NO4/c16-13-9-5-2-1-4-8(9)12-10(14(13)17)6-3-7-11(12)15(18)19/h1-7H
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099700
PNG
(CHEMBL51776 | N-[7-(3-Methoxycarbonyl-propionylami...)
Show SMILES COC(=O)CCC(=O)Nc1ccc-2c(c1)C(=O)C(=O)c1cc(NC(=O)CCC(=O)OC)ccc-21
Show InChI InChI=1S/C24H22N2O8/c1-33-21(29)9-7-19(27)25-13-3-5-15-16-6-4-14(26-20(28)8-10-22(30)34-2)12-18(16)24(32)23(31)17(15)11-13/h3-6,11-12H,7-10H2,1-2H3,(H,25,27)(H,26,28)
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099697
PNG
(7-(9,10-Dioxo-9,10-dihydro-phenanthren-2-ylcarbamo...)
Show SMILES COC(=O)CCCCCCC(=O)Nc1ccc2-c3ccccc3C(=O)C(=O)c2c1
Show InChI InChI=1S/C23H23NO5/c1-29-21(26)11-5-3-2-4-10-20(25)24-15-12-13-17-16-8-6-7-9-18(16)22(27)23(28)19(17)14-15/h6-9,12-14H,2-5,10-11H2,1H3,(H,24,25)
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099722
PNG
(2-Benzyloxy-N-(9,10-dioxo-9,10-dihydro-phenanthren...)
Show SMILES O=C(COCc1ccccc1)Nc1ccc-2c(c1)C(=O)C(=O)c1ccccc-21
Show InChI InChI=1S/C23H17NO4/c25-21(14-28-13-15-6-2-1-3-7-15)24-16-10-11-18-17-8-4-5-9-19(17)22(26)23(27)20(18)12-16/h1-12H,13-14H2,(H,24,25)
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099771
PNG
(3-Nitro-phenanthrene-9,10-dione | CHEMBL50973)
Show SMILES [O-][N+](=O)c1ccc2C(=O)C(=O)c3ccccc3-c2c1
Show InChI InChI=1S/C14H7NO4/c16-13-10-4-2-1-3-9(10)12-7-8(15(18)19)5-6-11(12)14(13)17/h1-7H
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099708
PNG
(1-(4-Carbamoyl-2-{[1-(4-carbamoyl-2-{4-carboxy-2-[...)
Show SMILES NC(=O)CCC(NC(=O)C(CCC(O)=O)NC(=O)c1ccc2C(=O)C(=O)c3ccccc3-c2c1)C(=O)N1CCCC1C(=O)NC(CCC(N)=O)C(=O)N1CCCC1C(O)=O
Show InChI InChI=1S/C40H45N7O13/c41-30(48)14-11-26(38(57)46-17-3-7-28(46)37(56)45-27(12-15-31(42)49)39(58)47-18-4-8-29(47)40(59)60)44-36(55)25(13-16-32(50)51)43-35(54)20-9-10-23-24(19-20)21-5-1-2-6-22(21)33(52)34(23)53/h1-2,5-6,9-10,19,25-29H,3-4,7-8,11-18H2,(H2,41,48)(H2,42,49)(H,43,54)(H,44,55)(H,45,56)(H,50,51)(H,59,60)
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099713
PNG
(CHEMBL50878 | N-(9,10-Dioxo-9,10-dihydro-phenanthr...)
Show SMILES Fc1ccccc1C(=O)Nc1ccc-2c(c1)C(=O)C(=O)c1ccccc-21
Show InChI InChI=1S/C21H12FNO3/c22-18-8-4-3-7-16(18)21(26)23-12-9-10-14-13-5-1-2-6-15(13)19(24)20(25)17(14)11-12/h1-11H,(H,23,26)
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibitory concentration against CD45 protein-tyrosine phosphatase pNPP


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099713
PNG
(CHEMBL50878 | N-(9,10-Dioxo-9,10-dihydro-phenanthr...)
Show SMILES Fc1ccccc1C(=O)Nc1ccc-2c(c1)C(=O)C(=O)c1ccccc-21
Show InChI InChI=1S/C21H12FNO3/c22-18-8-4-3-7-16(18)21(26)23-12-9-10-14-13-5-1-2-6-15(13)19(24)20(25)17(14)11-12/h1-11H,(H,23,26)
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099757
PNG
(4-(Carboxymethyl-carbamoyl)-4-{[1-(2-{2-[(9,10-dio...)
Show SMILES NC(=N)NCCCC(NC(=O)c1ccc2-c3ccccc3C(=O)C(=O)c2c1)C(=O)NC(CCCNC(N)=N)C(=O)N1CCCC1C(=O)NC(CCC(O)=O)C(=O)NCC(O)=O
Show InChI InChI=1S/C39H49N11O11/c40-38(41)44-15-3-8-25(47-33(57)20-11-12-22-21-6-1-2-7-23(21)31(55)32(56)24(22)18-20)35(59)49-27(9-4-16-45-39(42)43)37(61)50-17-5-10-28(50)36(60)48-26(13-14-29(51)52)34(58)46-19-30(53)54/h1-2,6-7,11-12,18,25-28H,3-5,8-10,13-17,19H2,(H,46,58)(H,47,57)(H,48,60)(H,49,59)(H,51,52)(H,53,54)(H4,40,41,44)(H4,42,43,45)
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099764
PNG
(4-(Carboxymethyl-carbamoyl)-4-{[1-(2-{2-[(9,10-dio...)
Show SMILES OC(=O)CCC(NC(=O)C1CCCN1C(=O)CNC(=O)CNC(=O)c1ccc-2c(c1)C(=O)C(=O)c1ccccc-21)C(=O)NCC(O)=O
Show InChI InChI=1S/C31H31N5O11/c37-23(13-33-29(45)16-7-8-18-17-4-1-2-5-19(17)27(43)28(44)20(18)12-16)32-14-24(38)36-11-3-6-22(36)31(47)35-21(9-10-25(39)40)30(46)34-15-26(41)42/h1-2,4-5,7-8,12,21-22H,3,6,9-11,13-15H2,(H,32,37)(H,33,45)(H,34,46)(H,35,47)(H,39,40)(H,41,42)
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099707
PNG
(CHEMBL49992 | [(9,10-Dioxo-9,10-dihydro-phenanthre...)
Show SMILES CC(C)(C)OC(=O)CNC(=O)c1ccc2-c3ccccc3C(=O)C(=O)c2c1
Show InChI InChI=1S/C21H19NO5/c1-21(2,3)27-17(23)11-22-20(26)12-8-9-14-13-6-4-5-7-15(13)18(24)19(25)16(14)10-12/h4-10H,11H2,1-3H3,(H,22,26)
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099747
PNG
(1-{4-Carbamoyl-2-[2-(4-carbamoyl-2-{4-carboxy-2-[(...)
Show SMILES NC(=O)CCC(NC(=O)C(CCC(O)=O)NC(=O)c1ccc2C(=O)C(=O)c3ccccc3-c2c1)C(=O)NCC(=O)NC(CCC(N)=O)C(=O)N1CCCC1C(O)=O
Show InChI InChI=1S/C37H41N7O13/c38-27(45)12-9-23(34(53)40-17-29(47)41-25(10-13-28(39)46)36(55)44-15-3-6-26(44)37(56)57)43-35(54)24(11-14-30(48)49)42-33(52)18-7-8-21-22(16-18)19-4-1-2-5-20(19)31(50)32(21)51/h1-2,4-5,7-8,16,23-26H,3,6,9-15,17H2,(H2,38,45)(H2,39,46)(H,40,53)(H,41,47)(H,42,52)(H,43,54)(H,48,49)(H,56,57)
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099752
PNG
(CHEMBL54131 | [(9,10-Dioxo-9,10-dihydro-phenanthre...)
Show SMILES CC(C)(C)OC(=O)CNC(=O)c1ccc2C(=O)C(=O)c3ccccc3-c2c1
Show InChI InChI=1S/C21H19NO5/c1-21(2,3)27-17(23)11-22-20(26)12-8-9-15-16(10-12)13-6-4-5-7-14(13)18(24)19(15)25/h4-10H,11H2,1-3H3,(H,22,26)
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50303175
PNG
(2-(5-((3-(4-(benzyloxy)phenyl)-1-phenyl-1H-pyrazol...)
Show SMILES OS(=O)(=O)CCN1C(=S)S\C(=C/c2cn(nc2-c2ccc(OCc3ccccc3)cc2)-c2ccccc2)C1=O
Show InChI InChI=1S/C28H23N3O5S3/c32-27-25(38-28(37)30(27)15-16-39(33,34)35)17-22-18-31(23-9-5-2-6-10-23)29-26(22)21-11-13-24(14-12-21)36-19-20-7-3-1-4-8-20/h1-14,17-18H,15-16,19H2,(H,33,34,35)/b25-17-
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Institute for Medical Research

Curated by ChEMBL


Assay Description
Inhibition of recombinant CD45


J Med Chem 52: 6716-23 (2009)


Article DOI: 10.1021/jm901016k
BindingDB Entry DOI: 10.7270/Q2VX0GK3
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50335868
PNG
(6-Hydroxy-3-(1-(4-(naphthalen-1-ylamino)-4-oxobuty...)
Show SMILES Cc1ccc(cc1)-c1oc2cc(O)c(cc2c1-c1cn(CCCC(=O)Nc2cccc3ccccc23)nn1)C(O)=O
Show InChI InChI=1S/C32H26N4O5/c1-19-11-13-21(14-12-19)31-30(24-16-23(32(39)40)27(37)17-28(24)41-31)26-18-36(35-34-26)15-5-10-29(38)33-25-9-4-7-20-6-2-3-8-22(20)25/h2-4,6-9,11-14,16-18,37H,5,10,15H2,1H3,(H,33,38)(H,39,40)
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Sanford-Burnham Medical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of CD45


J Med Chem 54: 562-71 (2011)


Article DOI: 10.1021/jm101004d
BindingDB Entry DOI: 10.7270/Q2N016T4
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099773
PNG
(1-{4-Carbamoyl-2-[2-(4-carboxy-2-{2-[(9,10-dioxo-9...)
Show SMILES NC(=O)CCC(NC(=O)CNC(=O)C(CCC(O)=O)NC(=O)CNC(=O)c1ccc2C(=O)C(=O)c3ccccc3-c2c1)C(=O)N1CCCC1C(O)=O
Show InChI InChI=1S/C34H36N6O12/c35-25(41)11-9-23(33(50)40-13-3-6-24(40)34(51)52)39-27(43)16-37-32(49)22(10-12-28(44)45)38-26(42)15-36-31(48)17-7-8-20-21(14-17)18-4-1-2-5-19(18)29(46)30(20)47/h1-2,4-5,7-8,14,22-24H,3,6,9-13,15-16H2,(H2,35,41)(H,36,48)(H,37,49)(H,38,42)(H,39,43)(H,44,45)(H,51,52)
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099768
PNG
(4-(2-{2-[1-(Carboxymethyl-carbamoyl)-4-guanidino-b...)
Show SMILES NC(=N)NCCCC(NC(=O)C1CCCN1C(=O)CNC(=O)C(CCC(O)=O)NC(=O)c1ccc2-c3ccccc3C(=O)C(=O)c2c1)C(=O)NCC(O)=O
Show InChI InChI=1S/C35H40N8O11/c36-35(37)38-13-3-7-23(32(52)40-17-28(47)48)42-34(54)25-8-4-14-43(25)26(44)16-39-33(53)24(11-12-27(45)46)41-31(51)18-9-10-20-19-5-1-2-6-21(19)29(49)30(50)22(20)15-18/h1-2,5-6,9-10,15,23-25H,3-4,7-8,11-14,16-17H2,(H,39,53)(H,40,52)(H,41,51)(H,42,54)(H,45,46)(H,47,48)(H4,36,37,38)
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099784
PNG
(4-{[1-(4-Carbamoyl-2-{2-[(9,10-dioxo-9,10-dihydro-...)
Show SMILES NC(=O)CCC(NC(=O)CNC(=O)c1ccc-2c(c1)C(=O)C(=O)c1ccccc-21)C(=O)N1CCCC1C(=O)NC(CCC(O)=O)C(=O)NCC(O)=O
Show InChI InChI=1S/C34H36N6O12/c35-25(41)11-9-23(34(52)40-13-3-6-24(40)33(51)39-22(10-12-27(43)44)32(50)37-16-28(45)46)38-26(42)15-36-31(49)17-7-8-19-18-4-1-2-5-20(18)29(47)30(48)21(19)14-17/h1-2,4-5,7-8,14,22-24H,3,6,9-13,15-16H2,(H2,35,41)(H,36,49)(H,37,50)(H,38,42)(H,39,51)(H,43,44)(H,45,46)
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099766
PNG
(1-(4-Carbamoyl-2-{[1-(4-carbamoyl-2-{4-carbamoyl-2...)
Show SMILES NC(=O)CCC(NC(=O)c1ccc2C(=O)C(=O)c3ccccc3-c2c1)C(=O)NC(CCC(N)=O)C(=O)N1CCCC1C(=O)NC(CCC(N)=O)C(=O)N1CCCC1C(O)=O
Show InChI InChI=1S/C40H46N8O12/c41-30(49)14-11-25(44-35(54)20-9-10-23-24(19-20)21-5-1-2-6-22(21)33(52)34(23)53)36(55)45-26(12-15-31(42)50)38(57)47-17-3-7-28(47)37(56)46-27(13-16-32(43)51)39(58)48-18-4-8-29(48)40(59)60/h1-2,5-6,9-10,19,25-29H,3-4,7-8,11-18H2,(H2,41,49)(H2,42,50)(H2,43,51)(H,44,54)(H,45,55)(H,46,56)(H,59,60)
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50118096
PNG
(2,2'-(4,4'-(1,4-phenylenebis(methylene))bis(oxy)bi...)
Show SMILES OC(=O)C(=O)c1ccc(OCc2ccc(COc3ccc(cc3)C(=O)C(O)=O)cc2)cc1
Show InChI InChI=1S/C24H18O8/c25-21(23(27)28)17-5-9-19(10-6-17)31-13-15-1-2-16(4-3-15)14-32-20-11-7-18(8-12-20)22(26)24(29)30/h1-12H,13-14H2,(H,27,28)(H,29,30)
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Brown University

Curated by ChEMBL


Assay Description
Concentration required for 50% Inhibition of activity against Yersinia Protein-tyrosine phosphatase


J Med Chem 45: 3946-52 (2002)


Article DOI: 10.1021/jm020093q
BindingDB Entry DOI: 10.7270/Q2F76BW4
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099767
PNG
(4-(1-{2-[3-Carboxy-1-(carboxymethyl-carbamoyl)-pro...)
Show SMILES NC(=N)NCCCC(NC(=O)C(CCC(O)=O)NC(=O)c1ccc2-c3ccccc3C(=O)C(=O)c2c1)C(=O)N1CCCC1C(=O)NC(CCC(O)=O)C(=O)NCC(O)=O
Show InChI InChI=1S/C38H44N8O13/c39-38(40)41-15-3-7-26(37(59)46-16-4-8-27(46)36(58)44-24(11-13-28(47)48)34(56)42-18-30(51)52)45-35(57)25(12-14-29(49)50)43-33(55)19-9-10-21-20-5-1-2-6-22(20)31(53)32(54)23(21)17-19/h1-2,5-6,9-10,17,24-27H,3-4,7-8,11-16,18H2,(H,42,56)(H,43,55)(H,44,58)(H,45,57)(H,47,48)(H,49,50)(H,51,52)(H4,39,40,41)
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099739
PNG
(7-(9,10-Dioxo-9,10-dihydro-phenanthren-3-ylcarbamo...)
Show SMILES COC(=O)CCCCCCC(=O)Nc1ccc2C(=O)C(=O)c3ccccc3-c2c1
Show InChI InChI=1S/C23H23NO5/c1-29-21(26)11-5-3-2-4-10-20(25)24-15-12-13-18-19(14-15)16-8-6-7-9-17(16)22(27)23(18)28/h6-9,12-14H,2-5,10-11H2,1H3,(H,24,25)
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099703
PNG
(1-(4-Carbamoyl-2-{[1-(4-carboxy-2-{2-[(9,10-dioxo-...)
Show SMILES NC(=O)CCC(NC(=O)C1CCCN1C(=O)C(CCC(O)=O)NC(=O)CNC(=O)c1ccc2C(=O)C(=O)c3ccccc3-c2c1)C(=O)N1CCCC1C(O)=O
Show InChI InChI=1S/C37H40N6O12/c38-28(44)13-11-25(36(53)43-16-4-8-27(43)37(54)55)41-34(51)26-7-3-15-42(26)35(52)24(12-14-30(46)47)40-29(45)18-39-33(50)19-9-10-22-23(17-19)20-5-1-2-6-21(20)31(48)32(22)49/h1-2,5-6,9-10,17,24-27H,3-4,7-8,11-16,18H2,(H2,38,44)(H,39,50)(H,40,45)(H,41,51)(H,46,47)(H,54,55)
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099749
PNG
(5-{2-[3-Carbamoyl-1-(carboxymethyl-carbamoyl)-prop...)
Show SMILES NC(=O)CCC(NC(=O)C1CCCN1C(=O)C(CCC(O)=O)NC(=O)CNC(=O)c1ccc-2c(c1)C(=O)C(=O)c1ccccc-21)C(=O)NCC(O)=O
Show InChI InChI=1S/C34H36N6O12/c35-25(41)11-9-22(32(50)37-16-28(45)46)39-33(51)24-6-3-13-40(24)34(52)23(10-12-27(43)44)38-26(42)15-36-31(49)17-7-8-19-18-4-1-2-5-20(18)29(47)30(48)21(19)14-17/h1-2,4-5,7-8,14,22-24H,3,6,9-13,15-16H2,(H2,35,41)(H,36,49)(H,37,50)(H,38,42)(H,39,51)(H,43,44)(H,45,46)
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM22857
PNG
(1,2-Dione-Based Compound, 14 | 9,10-dihydrophenant...)
Show SMILES O=C1C(=O)c2ccccc2-c2ccccc12
Show InChI InChI=1S/C14H8O2/c15-13-11-7-3-1-5-9(11)10-6-2-4-8-12(10)14(13)16/h1-8H
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099715
PNG
(CHEMBL51257 | N-(9,10-Dioxo-9,10-dihydro-phenanthr...)
Show SMILES CCCC(=O)Nc1ccc2-c3ccccc3C(=O)C(=O)c2c1
Show InChI InChI=1S/C18H15NO3/c1-2-5-16(20)19-11-8-9-13-12-6-3-4-7-14(12)17(21)18(22)15(13)10-11/h3-4,6-10H,2,5H2,1H3,(H,19,20)
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099693
PNG
(5-{2-[1-(Carboxymethyl-carbamoyl)-4-guanidino-buty...)
Show SMILES NC(=N)NCCCC(NC(=O)C1CCCN1C(=O)C(CCC(O)=O)NC(=O)CNC(=O)c1ccc2-c3ccccc3C(=O)C(=O)c2c1)C(=O)NCC(O)=O
Show InChI InChI=1S/C35H40N8O11/c36-35(37)38-13-3-7-23(32(52)40-17-28(47)48)42-33(53)25-8-4-14-43(25)34(54)24(11-12-27(45)46)41-26(44)16-39-31(51)18-9-10-20-19-5-1-2-6-21(19)29(49)30(50)22(20)15-18/h1-2,5-6,9-10,15,23-25H,3-4,7-8,11-14,16-17H2,(H,39,51)(H,40,52)(H,41,44)(H,42,53)(H,45,46)(H,47,48)(H4,36,37,38)
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099698
PNG
(4-(1-{2-[1-(Carboxymethyl-carbamoyl)-4-guanidino-b...)
Show SMILES NC(=N)NCCCC(NC(=O)C1CCCN1C(=O)C(CCCNC(N)=N)NC(=O)C(CCC(O)=O)NC(=O)c1ccc2-c3ccccc3C(=O)C(=O)c2c1)C(=O)NCC(O)=O
Show InChI InChI=1S/C39H49N11O11/c40-38(41)44-15-3-8-25(34(58)46-19-30(53)54)48-36(60)28-10-5-17-50(28)37(61)27(9-4-16-45-39(42)43)49-35(59)26(13-14-29(51)52)47-33(57)20-11-12-22-21-6-1-2-7-23(21)31(55)32(56)24(22)18-20/h1-2,6-7,11-12,18,25-28H,3-5,8-10,13-17,19H2,(H,46,58)(H,47,57)(H,48,60)(H,49,59)(H,51,52)(H,53,54)(H4,40,41,44)(H4,42,43,45)
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099762
PNG
(2-(2-Fluoro-phenyl)-phenanthrene-9,10-dione | CHEM...)
Show SMILES Fc1ccccc1-c1ccc-2c(c1)C(=O)C(=O)c1ccccc-21
Show InChI InChI=1S/C20H11FO2/c21-18-8-4-3-5-13(18)12-9-10-15-14-6-1-2-7-16(14)19(22)20(23)17(15)11-12/h1-11H
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099777
PNG
(4-(9,10-Dioxo-9,10-dihydro-phenanthren-3-ylcarbamo...)
Show SMILES COC(=O)CCCC(=O)Nc1ccc2C(=O)C(=O)c3ccccc3-c2c1
Show InChI InChI=1S/C20H17NO5/c1-26-18(23)8-4-7-17(22)21-12-9-10-15-16(11-12)13-5-2-3-6-14(13)19(24)20(15)25/h2-3,5-6,9-11H,4,7-8H2,1H3,(H,21,22)
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099717
PNG
(CHEMBL300241 | [(9,10-Dioxo-9,10-dihydro-phenanthr...)
Show SMILES OC(=O)CNC(=O)c1ccc-2c(c1)C(=O)C(=O)c1ccccc-21
Show InChI InChI=1S/C17H11NO5/c19-14(20)8-18-17(23)9-5-6-11-10-3-1-2-4-12(10)15(21)16(22)13(11)7-9/h1-7H,8H2,(H,18,23)(H,19,20)
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099689
PNG
(4-Amino-phenanthrene-9,10-dione | CHEMBL49236)
Show SMILES Nc1cccc2C(=O)C(=O)c3ccccc3-c12
Show InChI InChI=1S/C14H9NO2/c15-11-7-3-6-10-12(11)8-4-1-2-5-9(8)13(16)14(10)17/h1-7H,15H2
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099714
PNG
(CHEMBL50846 | N-(9,10-Dioxo-9,10-dihydro-phenanthr...)
Show SMILES CCCC(=O)Nc1ccc2C(=O)C(=O)c3ccccc3-c2c1
Show InChI InChI=1S/C18H15NO3/c1-2-5-16(20)19-11-8-9-14-15(10-11)12-6-3-4-7-13(12)17(21)18(14)22/h3-4,6-10H,2,5H2,1H3,(H,19,20)
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM50099723
PNG
(2-Thiophen-3-yl-phenanthrene-9,10-dione | CHEMBL51...)
Show SMILES O=C1C(=O)c2cc(ccc2-c2ccccc12)-c1ccsc1
Show InChI InChI=1S/C18H10O2S/c19-17-15-4-2-1-3-13(15)14-6-5-11(9-16(14)18(17)20)12-7-8-21-10-12/h1-10H
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AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate


J Med Chem 44: 1777-93 (2001)


Article DOI: 10.1021/jm000447i
BindingDB Entry DOI: 10.7270/Q2X34WQQ
More data for this
Ligand-Target Pair
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