TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona
Curated by ChEMBL
The University Of Arizona
Curated by ChEMBL
Affinity DataIC50: 0.0100nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC4R expressed in HEK293 cells after 40 mins by gamma counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0600nMAssay Description:Binding affinity against human Melanocortin-4 receptorMore data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona
Curated by ChEMBL
The University Of Arizona
Curated by ChEMBL
Affinity DataIC50: 0.0740nMAssay Description:Antagonist activity at human MC1R transfected in HEK293 cells co-transfected with GScAMP22F assessed as decrease in alpha-MSH induced cAMP level in p...More data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona
Curated by ChEMBL
The University Of Arizona
Curated by ChEMBL
Affinity DataIC50: 0.0741nMAssay Description:Antagonist activity at human MC1R transfected in HEK293 cells co-transfected with GScAMP22F assessed as decrease in alpha-MSH induced cAMP level in p...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0900nMAssay Description:Binding affinity against human Melanocortin-4 receptorMore data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona
Curated by ChEMBL
The University Of Arizona
Curated by ChEMBL
Affinity DataIC50: 0.100nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human MC1R expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: <0.100nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.150nMAssay Description:Displacement of [125I]NDPalphaMSH from human cloned MC4R expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.150nMAssay Description:Displacement of [125I]NDP-a-MSH from human recombinant MC4 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.150nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human recombinant MC4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona
Curated by ChEMBL
The University Of Arizona
Curated by ChEMBL
Affinity DataIC50: 0.150nMAssay Description:Displacement of [125I]NDPalphaMSH from human cloned melanocortin receptor 1b expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.160nMAssay Description:Inhibition of human recombinant melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.160nMAssay Description:Binding affinity against human Melanocortin-4 receptorMore data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona
Curated by ChEMBL
The University Of Arizona
Curated by ChEMBL
Affinity DataIC50: 0.160nMAssay Description:Inhibition of [125I]NDP-MSH binding to Melanocortin 1 receptor expressed in HEK293 cells; (N = 4)More data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona
Curated by ChEMBL
The University Of Arizona
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Displacement of [125I]NDP-alphaMSH from human MC1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona
Curated by ChEMBL
The University Of Arizona
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona
Curated by ChEMBL
The University Of Arizona
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibitory activity against hMC1R transfected in HEK293 cellsMore data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona
Curated by ChEMBL
The University Of Arizona
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Displacement of [125I]NDPalphaMSH from human MC1R expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona
Curated by ChEMBL
The University Of Arizona
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Agonist activity at human MC1R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelMore data for this Ligand-Target Pair
Affinity DataIC50: 0.210nMAssay Description:Displacement of [125I]NDP-alpha -MSH from human recombinant MC4 receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 0.230nMAssay Description:Binding affinity against human Melanocortin-4 receptorMore data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona
Curated by ChEMBL
The University Of Arizona
Curated by ChEMBL
Affinity DataIC50: 0.25nMAssay Description:Inhibitory concentration against human Melanocortin 1 receptor (hMC1R)More data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Agonist activity at human MC4 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Evaluated for binding affinity against Melanocortin-4 receptor by displacing [125I]-NDP-alpha-MSH radioligand expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona
Curated by ChEMBL
The University Of Arizona
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Agonist activity at human MC1R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation measured after 3 minsMore data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona
Curated by ChEMBL
The University Of Arizona
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of [125I]NDP-MSH binding to Melanocortin 1 receptor expressed in HEK293 cells; (N = 4)More data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona
Curated by ChEMBL
The University Of Arizona
Curated by ChEMBL
Affinity DataIC50: 0.350nMAssay Description:Inhibitory concentration against human Melanocortin 1 receptor (hMC1R)More data for this Ligand-Target Pair
Affinity DataIC50: 0.370nMAssay Description:Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC4R expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human melanocortin 4 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodMore data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona
Curated by ChEMBL
The University Of Arizona
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC4R expressed in HEK293 cells after 40 mins by gamma counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of [125I]NDP-MSH binding to Melanocortin 4 receptor expressed in HEK293 cells; (N = 4)More data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona
Curated by ChEMBL
The University Of Arizona
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of [125I]NDP-MSH binding to Melanocortin 1 receptor expressed in HEK293 cells; (N = 4)More data for this Ligand-Target Pair
Affinity DataIC50: 0.410nMAssay Description:Inhibition of human MC4 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.430nMAssay Description:Inhibition of human MC4 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.480nMAssay Description:Binding affinity against human Melanocortin-4 receptorMore data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona
Curated by ChEMBL
The University Of Arizona
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of [125I]NDP-MSH binding to Melanocortin 1 receptor expressed in HEK293 cells; (N = 4)More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Evaluated for binding affinity against Melanocortin-4 receptor by displacing [125I]-NDP-alpha-MSH radioligand expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona
Curated by ChEMBL
The University Of Arizona
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:The concentration that inhibits 50% specific binding was determined against the Melanocortin 1 receptorMore data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona
Curated by ChEMBL
The University Of Arizona
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:The concentration that inhibits 50% specific binding was determined against the Melanocortin 1 receptorMore data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona
Curated by ChEMBL
The University Of Arizona
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Agonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsMore data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona
Curated by ChEMBL
The University Of Arizona
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Agonist activity at human MC1R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Binding affinity against human Melanocortin-4 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC4 receptor expressed in HEK293 cells after 40 mins by luminescence countingMore data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona
Curated by ChEMBL
The University Of Arizona
Curated by ChEMBL
Affinity DataIC50: 0.510nMAssay Description:Inhibitory concentration against human Melanocortin 1 receptor (hMC1R)More data for this Ligand-Target Pair
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona
Curated by ChEMBL
The University Of Arizona
Curated by ChEMBL
Affinity DataIC50: 0.510nMAssay Description:Displacement of [125I]NDP-MSH from Melanocortin 1 receptor at 10 uMMore data for this Ligand-Target Pair
Affinity DataIC50: 0.510nMAssay Description:Binding affinity against human Melanocortin-4 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.530nMAssay Description:Displacement of [125I]-NDP-R-MSH from human MC4R expressed in CHO cells after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 0.560nMAssay Description:Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC4R expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Displacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair