Compile Data Set for Download or QSAR
maximum 50k data
Found 1501 of ic50 data for polymerid = 6546,6547
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50250586(CHEMBL4093140)
Affinity DataIC50:  0.0100nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC4R expressed in HEK293 cells after 40 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50121268(21-(2-Acetylamino-hexanoylamino)-7-[3-(diaminometh...)
Affinity DataIC50:  0.0600nMAssay Description:Binding affinity against human Melanocortin-4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50134946(CHEMBL2370964 | H-Tyr-Val-Nle-Gly-His-D-Nal(2')-Ar...)
Affinity DataIC50:  0.0740nMAssay Description:Antagonist activity at human MC1R transfected in HEK293 cells co-transfected with GScAMP22F assessed as decrease in alpha-MSH induced cAMP level in p...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50134946(CHEMBL2370964 | H-Tyr-Val-Nle-Gly-His-D-Nal(2')-Ar...)
Affinity DataIC50:  0.0741nMAssay Description:Antagonist activity at human MC1R transfected in HEK293 cells co-transfected with GScAMP22F assessed as decrease in alpha-MSH induced cAMP level in p...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50121267(5-(2-Acetylamino-hexanoylamino)-19-[3-(diaminometh...)
Affinity DataIC50:  0.0900nMAssay Description:Binding affinity against human Melanocortin-4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50184359((3S,6S,9R,12S,15S,23S)-15-((S)-2-acetylamino-hexan...)
Affinity DataIC50:  0.100nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human MC1R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50138293((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Affinity DataIC50: <0.100nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50211392(Ac-Nle4-cyclo(Asp5-Pro6-D-4,4'-Bip7-Pro8-Trp9-Lys1...)
Affinity DataIC50:  0.150nMAssay Description:Displacement of [125I]NDPalphaMSH from human cloned MC4R expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50017181(CHEMBL441738)
Affinity DataIC50:  0.150nMAssay Description:Displacement of [125I]NDP-a-MSH from human recombinant MC4 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50017181(CHEMBL441738)
Affinity DataIC50:  0.150nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human recombinant MC4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50211392(Ac-Nle4-cyclo(Asp5-Pro6-D-4,4'-Bip7-Pro8-Trp9-Lys1...)
Affinity DataIC50:  0.150nMAssay Description:Displacement of [125I]NDPalphaMSH from human cloned melanocortin receptor 1b expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50128358(CHEMBL3629347)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of human recombinant melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50121266(21-(2-Acetylamino-hexanoylamino)-7-[3-(diaminometh...)
Affinity DataIC50:  0.160nMAssay Description:Binding affinity against human Melanocortin-4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50163144(CHEMBL414778 | H-Tyr-Val-Nle-Gly-His-D-Nal(2'')-Ar...)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of [125I]NDP-MSH binding to Melanocortin 1 receptor expressed in HEK293 cells; (N = 4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50184359((3S,6S,9R,12S,15S,23S)-15-((S)-2-acetylamino-hexan...)
Affinity DataIC50:  0.200nMAssay Description:Displacement of [125I]NDP-alphaMSH from human MC1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50027084(Melatonan)
Affinity DataIC50:  0.200nMAssay Description:Displacement of [125I][Nle4,D-Phe7]alpha-MSH from human MC1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50184359((3S,6S,9R,12S,15S,23S)-15-((S)-2-acetylamino-hexan...)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory activity against hMC1R transfected in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50205745((3S,6S,9R,12S,15S,23S)-15-[(2S)-2-aminohexanamido]...)
Affinity DataIC50:  0.200nMAssay Description:Displacement of [125I]NDPalphaMSH from human MC1R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50184359((3S,6S,9R,12S,15S,23S)-15-((S)-2-acetylamino-hexan...)
Affinity DataIC50:  0.200nMAssay Description:Agonist activity at human MC1R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM392076(US10301272, Example 7/9)
Affinity DataIC50:  0.210nMAssay Description:Displacement of [125I]NDP-alpha -MSH from human recombinant MC4 receptor after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50121261(5-(2-Acetylamino-hexanoylamino)-19-[3-(diaminometh...)
Affinity DataIC50:  0.230nMAssay Description:Binding affinity against human Melanocortin-4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50184359((3S,6S,9R,12S,15S,23S)-15-((S)-2-acetylamino-hexan...)
Affinity DataIC50:  0.25nMAssay Description:Inhibitory concentration against human Melanocortin 1 receptor (hMC1R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50119367((3R)-N-[(2R)-3-(4-chlorophenyl)-1-{4-cyclohexyl-4-...)
Affinity DataIC50:  0.300nMAssay Description:Agonist activity at human MC4 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50119367((3R)-N-[(2R)-3-(4-chlorophenyl)-1-{4-cyclohexyl-4-...)
Affinity DataIC50:  0.300nMAssay Description:Evaluated for binding affinity against Melanocortin-4 receptor by displacing [125I]-NDP-alpha-MSH radioligand expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50134946(CHEMBL2370964 | H-Tyr-Val-Nle-Gly-His-D-Nal(2')-Ar...)
Affinity DataIC50:  0.300nMAssay Description:Agonist activity at human MC1R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation measured after 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50163145(CHEMBL413439 | H-Tyr-Val-Nle-Gly-His-D-Nal(2'')-Ar...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of [125I]NDP-MSH binding to Melanocortin 1 receptor expressed in HEK293 cells; (N = 4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50454555(CHEMBL2115441)
Affinity DataIC50:  0.350nMAssay Description:Inhibitory concentration against human Melanocortin 1 receptor (hMC1R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50168724(1-[(R)-2-[((1S,2S)-1-Amino-1,2,3,4-tetrahydro-naph...)
Affinity DataIC50:  0.370nMAssay Description:Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC4R expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human melanocortin 4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50250586(CHEMBL4093140)
Affinity DataIC50:  0.400nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC3R expressed in HEK293 cells after 40 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50250591(CHEMBL4072387)
Affinity DataIC50:  0.400nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC4R expressed in HEK293 cells after 40 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50017181(CHEMBL441738)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of [125I]NDP-MSH binding to Melanocortin 4 receptor expressed in HEK293 cells; (N = 4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50029747((4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of [125I]NDP-MSH binding to Melanocortin 1 receptor expressed in HEK293 cells; (N = 4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50329956(((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrol...)
Affinity DataIC50:  0.410nMAssay Description:Inhibition of human MC4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50329959((6-chloro-5-methyl-3-(2-(1-methyl-1H-1,2,4-triazol...)
Affinity DataIC50:  0.430nMAssay Description:Inhibition of human MC4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50121258(9-(2-Acetylamino-hexanoylamino)-23-[3-(diaminometh...)
Affinity DataIC50:  0.480nMAssay Description:Binding affinity against human Melanocortin-4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50163146(Ac-Tyr-Val-Nle-Gly-His-D-Phe-Arg-Trp-Asp-Arg-Phe-G...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of [125I]NDP-MSH binding to Melanocortin 1 receptor expressed in HEK293 cells; (N = 4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50119371(1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ...)
Affinity DataIC50:  0.5nMAssay Description:Evaluated for binding affinity against Melanocortin-4 receptor by displacing [125I]-NDP-alpha-MSH radioligand expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50184359((3S,6S,9R,12S,15S,23S)-15-((S)-2-acetylamino-hexan...)
Affinity DataIC50:  0.5nMAssay Description:The concentration that inhibits 50% specific binding was determined against the Melanocortin 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50029748((2R,3R)-15-(2-Acetylamino-hexanoylamino)-9-benzyl-...)
Affinity DataIC50:  0.5nMAssay Description:The concentration that inhibits 50% specific binding was determined against the Melanocortin 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50268806(Ac-Tyr-Val-Nle-Gly-His-DPhe-Arg-Trp-Asp-Arg-Phe-Gl...)
Affinity DataIC50:  0.5nMAssay Description:Agonist activity at human MC5R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50268806(Ac-Tyr-Val-Nle-Gly-His-DPhe-Arg-Trp-Asp-Arg-Phe-Gl...)
Affinity DataIC50:  0.5nMAssay Description:Agonist activity at human MC1R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50121259(6-(3-Guanidino-propyl)-3-(1H-indol-3-ylmethyl)-9-n...)
Affinity DataIC50:  0.5nMAssay Description:Binding affinity against human Melanocortin-4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50112984(CHEMBL3601428)
Affinity DataIC50:  0.5nMAssay Description:Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC4 receptor expressed in HEK293 cells after 40 mins by luminescence countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataIC50:  0.510nMAssay Description:Inhibitory concentration against human Melanocortin 1 receptor (hMC1R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
The University Of Arizona

Curated by ChEMBL
LigandPNGBDBM82411(CAS_75921-69-6 | NDP-MSH)
Affinity DataIC50:  0.510nMAssay Description:Displacement of [125I]NDP-MSH from Melanocortin 1 receptor at 10 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50121264(8-(2-Acetylamino-hexanoylamino)-22-[3-(diaminometh...)
Affinity DataIC50:  0.510nMAssay Description:Binding affinity against human Melanocortin-4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50348579(CHEMBL1801215)
Affinity DataIC50:  0.530nMAssay Description:Displacement of [125I]-NDP-R-MSH from human MC4R expressed in CHO cells after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50168725(1-[2-[((R)-3-Amino-1,2,3,4-tetrahydro-naphthalene-...)
Affinity DataIC50:  0.560nMAssay Description:Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC4R expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50121268(21-(2-Acetylamino-hexanoylamino)-7-[3-(diaminometh...)
Affinity DataIC50:  0.600nMAssay Description:Displacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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