Affinity DataIC50: 9.20nM Kd: 2.80nMAssay Description:In vitro kinase assay profiled against a panel of different kinase binding assay using Ambit kinomeScan technology. Biochemical IC50 values were det...More data for this Ligand-Target Pair
Affinity DataKd: 3.10nMAssay Description:In vitro kinase assay profiled against a panel of different kinase binding assay using Ambit kinomeScan technology. Biochemical IC50 values were det...More data for this Ligand-Target Pair
Affinity DataKd: 3.10nMAssay Description:Binding affinity to N-terminal 6xHis-tagged human recombinant FGFR1 (458 to 765) by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Affinity DataKd: 5.80nMAssay Description:Binding affinity to N-terminal 6xHis-tagged human recombinant FGFR1 (458 to 765) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
Affinity DataKd: 17nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan® technologyMore data for this Ligand-Target Pair
Affinity DataKd: 17nMAssay Description:FGFR1: In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...More data for this Ligand-Target Pair
Affinity DataKd: 44nMAssay Description:Binding constant for FGFR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 47nMAssay Description:Binding constant for FGFR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 53nMAssay Description:Binding constant for FGFR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 54nMAssay Description:FGFR1: In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...More data for this Ligand-Target Pair
Affinity DataKd: 54nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan® technologyMore data for this Ligand-Target Pair
Affinity DataKd: 60nMAssay Description:Average Binding Constant for FGFR1; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 62nMAssay Description:Binding constant for FGFR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 68nMAssay Description:Binding affinity to N-terminal 6xHis-tagged human recombinant FGFR1 (458 to 765) by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Affinity DataKd: 69nMAssay Description:Binding affinity to N-terminal 6xHis-tagged human recombinant FGFR1 (458 to 765) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
Affinity DataKd: 76nMAssay Description:Binding affinity to wild-type human partial length FGFR1 (P357 to V669 residues) expressed in bacterial expression system by Kinomescan method relati...More data for this Ligand-Target Pair
Affinity DataKd: 79nMAssay Description:FGFR1: In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...More data for this Ligand-Target Pair
Affinity DataKd: 79nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan® technologyMore data for this Ligand-Target Pair
Affinity DataKd: 90nMAssay Description:Binding constant for FGFR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 90nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 90nMAssay Description:Binding constant for FGFR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 92nMAssay Description:Binding constant for FGFR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 99nMAssay Description:Binding constant for FGFR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 141nMAssay Description:FGFR1: In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) is incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01...More data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info
Affinity DataKd: 150nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 150nMAssay Description:Binding constant for FGFR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 150nMAssay Description:Binding constant for FGFR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 268nMAssay Description:Binding affinity to recombinant N-terminal His-FLAG-GST-tagged FGFR1 (unknown origin) (396 to 820 residues) expressed in baculovirus infected Sf9 ins...More data for this Ligand-Target Pair
Affinity DataKd: 280nMAssay Description:Binding constant for FGFR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 310nMAssay Description:Binding constant for FGFR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 310nMAssay Description:Binding affinity to FGFR1More data for this Ligand-Target Pair
Affinity DataKd: 311nMAssay Description:Binding affinity to N-terminal 6xHis-tagged human recombinant FGFR1 (458 to 765) by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Affinity DataKd: 314nMAssay Description:FGFR1: In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.0...More data for this Ligand-Target Pair
Affinity DataKd: 314nMAssay Description:Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan® technologyMore data for this Ligand-Target Pair
Affinity DataKd: 331nMAssay Description:FGFR1: In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) is incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01...More data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info
Affinity DataKd: 370nMAssay Description:Binding constant for FGFR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 380nMAssay Description:Binding constant for FGFR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 380nMAssay Description:Binding affinity to wild-type human partial length FGFR1 (P357 to V669 residues) expressed in bacterial expression system by Kinomescan assayMore data for this Ligand-Target Pair
Affinity DataKd: 447nMAssay Description:Binding affinity to N-terminal 6xHis-tagged human recombinant FGFR1 (458 to 765) by isothermal titration calorimetric analysisMore data for this Ligand-Target Pair
Affinity DataKd: 520nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 520nMAssay Description:Binding constant for FGFR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 520nMAssay Description:Binding affinity to FGFR1More data for this Ligand-Target Pair
Affinity DataKd: 520nMAssay Description:Binding constant for FGFR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 550nMAssay Description:Binding constant for FGFR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 550nMAssay Description:Binding constant for FGFR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 550nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 560nMAssay Description:Binding constant for FGFR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 560nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 560nMAssay Description:Binding constant for FGFR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 570nMAssay Description:Binding constant for FGFR1 kinase domainMore data for this Ligand-Target Pair