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Compile Data Set for Download or QSAR

Found 11 hits of kon data for polymerid = 10485,10592,10684,5408,5579,5638,945,10485,10592,10684,5408,5579,5638,945   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243476
PNG
(US9427440, 24)
Show SMILES CN1CCCCN(C)S(=O)(=O)NC(=O)c2ccc3c(C4CCCCC4)c4-c5cc(Cl)ccc5C=C(Cn4c3c2)C1=O
Show InChI InChI=1S/C31H35ClN4O4S/c1-34-14-6-7-15-35(2)41(39,40)33-30(37)22-11-13-25-27(17-22)36-19-23(31(34)38)16-21-10-12-24(32)18-26(21)29(36)28(25)20-8-4-3-5-9-20/h10-13,16-18,20H,3-9,14-15,19H2,1-2H3,(H,33,37)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/an/a 0.00370 4.80E+37.425



Janssen Ireland

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...


US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243481
PNG
(US9427440, 38)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)NCCCCN(C)S(=O)(=O)NC5=O
Show InChI InChI=1S/C31H36N4O5S/c1-34-15-7-6-14-32-30(36)23-16-22-17-24(40-2)11-13-25(22)29-28(20-8-4-3-5-9-20)26-12-10-21(18-27(26)35(29)19-23)31(37)33-41(34,38)39/h10-13,16-18,20H,3-9,14-15,19H2,1-2H3,(H,32,36)(H,33,37)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/an/a 0.0000410 5.30E+37.425



Janssen Ireland

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...


US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243480
PNG
(US9427440, 28)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCCCN(C(C)C)S(=O)(=O)NC5=O
Show InChI InChI=1S/C34H42N4O5S/c1-22(2)38-17-9-8-16-36(3)34(40)26-18-25-19-27(43-4)13-15-28(25)32-31(23-10-6-5-7-11-23)29-14-12-24(20-30(29)37(32)21-26)33(39)35-44(38,41)42/h12-15,18-20,22-23H,5-11,16-17,21H2,1-4H3,(H,35,39)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/an/a 0.0000660 7.30E+37.425



Janssen Ireland

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...


US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243469
PNG
(US9427440, 17)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=C(C)c2c1)C(=O)N(C)CCCCN(C)S(=O)(=O)NC5=O
Show InChI InChI=1S/C33H40N4O5S/c1-21-27-19-24(42-4)13-15-25(27)31-30(22-10-6-5-7-11-22)26-14-12-23-18-29(26)37(31)20-28(21)33(39)35(2)16-8-9-17-36(3)43(40,41)34-32(23)38/h12-15,18-19,22H,5-11,16-17,20H2,1-4H3,(H,34,38)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/an/a 0.000160 8.70E+37.425



Janssen Ireland

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...


US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243479
PNG
(US9427440, 27)
Show SMILES CN1CCCCCNC(=O)C2=Cc3ccc(Cl)cc3-c3c(C4CCCCC4)c4ccc(cc4n3C2)C(=O)NS1(=O)=O
Show InChI InChI=1S/C31H35ClN4O4S/c1-35-15-7-3-6-14-33-30(37)23-16-21-10-12-24(32)18-26(21)29-28(20-8-4-2-5-9-20)25-13-11-22(17-27(25)36(29)19-23)31(38)34-41(35,39)40/h10-13,16-18,20H,2-9,14-15,19H2,1H3,(H,33,37)(H,34,38)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/an/a 0.00380 9.50E+37.425



Janssen Ireland

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...


US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243456
PNG
(US9427440, 1)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O
Show InChI InChI=1S/C32H38N4O6S/c1-34-13-15-42-16-14-35(2)43(39,40)33-31(37)22-9-11-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)10-12-26(23)30(36)29(27)21-7-5-4-6-8-21/h9-12,17-19,21H,4-8,13-16,20H2,1-3H3,(H,33,37)
PDB

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MCE
PC cid
PC sid
UniChem
US Patent
n/an/an/a 4.40n/a 0.0000900 2.00E+47.425



Janssen Ireland

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...


US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243470
PNG
(US9427440, 18)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCCCN(C)S(=O)(=O)NC5=O
Show InChI InChI=1S/C32H38N4O5S/c1-34-15-7-8-16-35(2)42(39,40)33-31(37)22-11-13-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)12-14-26(23)30(36)29(27)21-9-5-4-6-10-21/h11-14,17-19,21H,4-10,15-16,20H2,1-3H3,(H,33,37)
PDB

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PC cid
PC sid
PDB
UniChem
PDB
US Patent
n/an/an/an/an/a 0.0000480 2.00E+47.425



Janssen Ireland

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...


US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (strain HC-J4) (HCV))
BDBM243456
PNG
(US9427440, 1)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O
Show InChI InChI=1S/C32H38N4O6S/c1-34-13-15-42-16-14-35(2)43(39,40)33-31(37)22-9-11-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)10-12-26(23)30(36)29(27)21-7-5-4-6-8-21/h9-12,17-19,21H,4-8,13-16,20H2,1-3H3,(H,33,37)
PDB

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MCE
PC cid
PC sid
UniChem
US Patent
n/an/an/a 5.20n/a 0.000100 2.00E+47.425



Janssen Ireland

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...


US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243456
PNG
(US9427440, 1)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O
Show InChI InChI=1S/C32H38N4O6S/c1-34-13-15-42-16-14-35(2)43(39,40)33-31(37)22-9-11-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)10-12-26(23)30(36)29(27)21-7-5-4-6-8-21/h9-12,17-19,21H,4-8,13-16,20H2,1-3H3,(H,33,37)
PDB

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Purchase

MCE
PC cid
PC sid
UniChem
US Patent
n/an/an/an/an/a 0.0000900 2.00E+47.425



Janssen Ireland

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...


US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243468
PNG
(US9427440, 16)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=C(C)c2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O
Show InChI InChI=1S/C33H40N4O6S/c1-21-27-19-24(42-4)11-13-25(27)31-30(22-8-6-5-7-9-22)26-12-10-23-18-29(26)37(31)20-28(21)33(39)35(2)14-16-43-17-15-36(3)44(40,41)34-32(23)38/h10-13,18-19,22H,5-9,14-17,20H2,1-4H3,(H,34,38)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/an/a 0.0000360 2.20E+47.425



Janssen Ireland

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...


US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair
Genome polyprotein [2420-3010]


(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
BDBM243477
PNG
(US9427440, 25)
Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCCCNS(=O)(=O)NC5=O
Show InChI InChI=1S/C31H36N4O5S/c1-34-15-7-6-14-32-41(38,39)33-30(36)21-10-12-26-27(18-21)35-19-23(31(34)37)16-22-17-24(40-2)11-13-25(22)29(35)28(26)20-8-4-3-5-9-20/h10-13,16-18,20,32H,3-9,14-15,19H2,1-2H3,(H,33,36)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/an/a 0.000310 2.90E+47.425



Janssen Ireland

US Patent


Assay Description
All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...


US Patent US9427440 (2016)


BindingDB Entry DOI: 10.7270/Q2DN43Z6
More data for this
Ligand-Target Pair