TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataEC50: 3.30E+3nMAssay Description:Inhibition of KDM4A in human KYSE-150 cells assessed as increase in H3K9me3 levelMore data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataEC50: 3.80E+3nMAssay Description:Inhibition of human Flag-tagged KDM4A expressed in human HeLa cells assessed as increase in H3K9me3 level after 24 hrs by DAPI staining based immunof...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataEC50: 4.70E+3nMAssay Description:Inhibition of FLAG tagged full length wild type human KDM4A transfected in HeLa cells assessed as decrease in demethylation of H3K9Me3 measured after...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataEC50: 5.90E+3nMAssay Description:Inhibition of FLAG tagged full length wild type human KDM4A transfected in HeLa cells assessed as decrease in demethylation of H3K9Me3 measured after...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataEC50: 8.50E+3nMAssay Description:Inhibition of FLAG tagged full length wild type human KDM4A transfected in HeLa cells assessed as decrease in demethylation of H3K9Me3 measured after...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataEC50: 9.00E+3nMAssay Description:Inhibition of full-length FLAG-tagged KDM4A (unknown origin) expressed in human HeLa cells assessed as increase in H3K9me3 level after 24 hrs by DAPI...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataEC50: 1.00E+4nMAssay Description:Inhibition of KDM4A in human KYSE-150 cells assessed as increase in H3K9me3 levelMore data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataEC50: 1.04E+4nMAssay Description:Inhibition of FLAG tagged full length wild type human KDM4A transfected in HeLa cells assessed as decrease in demethylation of H3K9Me3 measured after...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataEC50: 1.20E+4nMAssay Description:Inhibition of KDM4A in human MCF7 cells assessed as increase in H3K9me3 level after 24 hrs by DAPI staining based immunofuorescence assayMore data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataEC50: 3.03E+4nMAssay Description:Inhibition of FLAG tagged full length wild type human KDM4A transfected in HeLa cells assessed as decrease in demethylation of H3K9Me3 measured after...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataEC50: 4.05E+4nMAssay Description:Inhibition of KDM4A in human KYSE-150 cells assessed as increase in H3K9me3 levelMore data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of full length FLAG-tagged KDM4A (unknown origin) expressed in human HeLa cells assessed as increase in H3K9me3 levels after 24 hrs by DAP...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of full length FLAG-tagged KDM4A (unknown origin) expressed in human HeLa cells assessed as increase in H3K9me3 levels after 24 hrs by DAP...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of full length FLAG-tagged KDM4A (unknown origin) expressed in human HeLa cells assessed as increase in H3K9me3 levels after 24 hrs by DAP...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of full length FLAG-tagged KDM4A (unknown origin) expressed in human HeLa cells assessed as increase in H3K9me3 levels after 24 hrs by DAP...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of full length FLAG-tagged KDM4A (unknown origin) expressed in human HeLa cells assessed as increase in H3K9me3 levels after 24 hrs by DAP...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of full length FLAG-tagged KDM4A (unknown origin) expressed in human HeLa cells assessed as increase in H3K9me3 levels after 24 hrs by DAP...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of full length FLAG-tagged KDM4A (unknown origin) expressed in human HeLa cells assessed as increase in H3K9me3 levels after 24 hrs by DAP...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of full length FLAG-tagged KDM4A (unknown origin) expressed in human HeLa cells assessed as increase in H3K9me3 levels after 24 hrs by DAP...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of full length FLAG-tagged KDM4A (unknown origin) expressed in human HeLa cells assessed as increase in H3K9me3 levels after 24 hrs by DAP...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of full length FLAG-tagged KDM4A (unknown origin) expressed in human HeLa cells assessed as increase in H3K9me3 levels after 24 hrs by DAP...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataEC50: 8.70E+4nMAssay Description:Inhibition of human Flag-tagged KDM4A expressed in human HeLa cells assessed as increase in H3K9me3 level after 24 hrs by DAPI staining based immunof...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Stabilization of FLAG-tagged KDM4A (1 to 1064 residues) (unknown origin) expressed in human U2OS cells measured after 3 hrs by CETSAMore data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataEC50: 1.05E+5nMAssay Description:Inhibition of binding of H3K4Me3 to KDM4A tudor domain (unknown origin) measured by NanoBRET-based cellular proximity assayMore data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataEC50: 1.05E+5nMAssay Description:Inhibition of NanoLuc-KDM4A-TUDOR domain (unknown origin) binding to Histone H3.3-HaloTag expressed in 293T cells incubated for 18 hrs by Nano-BRET b...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataEC50: 1.22E+6nMAssay Description:Inhibition of NanoLuc-KDM4A-TUDOR domain (unknown origin) binding to Histone H3.3-HaloTag expressed in 293T cells incubated for 18 hrs by Nano-BRET b...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Binding affinity to KDM4A (unknown origin)More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataKi: 3nMAssay Description:Binding affinity to KDM4A (unknown origin)More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataKi: 3nMAssay Description:Binding affinity to KDM4A (unknown origin)More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Binding affinity to KDM4A (unknown origin)More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Binding affinity to KDM4A (unknown origin)More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Binding affinity to KDM4A (unknown origin)More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Binding affinity towards KDM4A (unknown origin)More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataKi: 5nMAssay Description:Binding affinity to KDM4A (unknown origin)More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataKi: 26nMAssay Description:Binding affinity to KDM4A (unknown origin)More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataKi: 420nMAssay Description:Competitive inhibition of recombinant His6-tagged KDM4A (1 to 359 residues) (unknown origin) expressed in Escherichia coli BL21 cells using methylsta...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataKi: 420nMAssay Description:Inhibition of His6-tagged recombinant human KDM4A (1 to 359 residues) measured by fluorescence polarization based competitive binding assayMore data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataKi: 420nMAssay Description:Inhibition of His6-tagged recombinant human KDM4A (1 to 359 residues) measured by fluorescence polarization based competitive binding assayMore data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataKi: 420nMAssay Description:Inhibition of His6-tagged recombinant human KDM4A (1 to 359 residues) measured by fluorescence polarization based competitive binding assayMore data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataKi: 520nMAssay Description:Competitive inhibition of recombinant His6-tagged KDM4A (1 to 359 residues) (unknown origin) expressed in Escherichia coli BL21 cells using methylsta...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataKi: 1.94E+3nMAssay Description:Competitive inhibition of human KDM4A (1 to 359 residues) expressed in competent Escherichia coli BL21-CodonPlus-RIL cells using 2-oxoglutarate as su...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataKi: 3.02E+3nMAssay Description:Competitive inhibition of recombinant His6-tagged KDM4A (1 to 359 residues) (unknown origin) expressed in Escherichia coli BL21 cells using methylsta...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataKi: 5.50E+3nMAssay Description:Competitive inhibition of recombinant human KDM4A (1 to 347 aa) expressed in Escherichia coli using H3K9me3 peptide as substrate after 30 mins by dou...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataKi: 1.70E+5nMAssay Description:Inhibition of H3(1-10)K4me3 peptide binding to thrombin cleavable N-terminal 6His tagged and 13C-IVLM labeled human KDM4A tandem TUDOR domain (897 to...More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMpH: 7.5Assay Description:Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMpH: 7.5Assay Description:Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMpH: 7.5Assay Description:Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMpH: 7.5Assay Description:Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o...More data for this Ligand-Target Pair
Affinity DataIC50: 4.30E+4nMpH: 7.5Assay Description:Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair