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Found 461 Enz. Inhib. hit(s) with Target = 'Lysine-specific demethylase 4A'
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50598654(CHEMBL5169996)
Affinity DataEC50:  3.30E+3nMAssay Description:Inhibition of KDM4A in human KYSE-150 cells assessed as increase in H3K9me3 levelMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50158888(CHEMBL3785984)
Affinity DataEC50:  3.80E+3nMAssay Description:Inhibition of human Flag-tagged KDM4A expressed in human HeLa cells assessed as increase in H3K9me3 level after 24 hrs by DAPI staining based immunof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50513343(CHEMBL4449500)
Affinity DataEC50:  4.70E+3nMAssay Description:Inhibition of FLAG tagged full length wild type human KDM4A transfected in HeLa cells assessed as decrease in demethylation of H3K9Me3 measured after...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50513360(CHEMBL4573390)
Affinity DataEC50:  5.90E+3nMAssay Description:Inhibition of FLAG tagged full length wild type human KDM4A transfected in HeLa cells assessed as decrease in demethylation of H3K9Me3 measured after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50151923(CHEMBL3774537)
Affinity DataEC50:  8.50E+3nMAssay Description:Inhibition of FLAG tagged full length wild type human KDM4A transfected in HeLa cells assessed as decrease in demethylation of H3K9Me3 measured after...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50158849(CHEMBL3785164)
Affinity DataEC50:  9.00E+3nMAssay Description:Inhibition of full-length FLAG-tagged KDM4A (unknown origin) expressed in human HeLa cells assessed as increase in H3K9me3 level after 24 hrs by DAPI...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50598655(CHEMBL5178246)
Affinity DataEC50:  1.00E+4nMAssay Description:Inhibition of KDM4A in human KYSE-150 cells assessed as increase in H3K9me3 levelMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50513361(CHEMBL4567766)
Affinity DataEC50:  1.04E+4nMAssay Description:Inhibition of FLAG tagged full length wild type human KDM4A transfected in HeLa cells assessed as decrease in demethylation of H3K9Me3 measured after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50158849(CHEMBL3785164)
Affinity DataEC50:  1.20E+4nMAssay Description:Inhibition of KDM4A in human MCF7 cells assessed as increase in H3K9me3 level after 24 hrs by DAPI staining based immunofuorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50513345(CHEMBL4438830)
Affinity DataEC50:  3.03E+4nMAssay Description:Inhibition of FLAG tagged full length wild type human KDM4A transfected in HeLa cells assessed as decrease in demethylation of H3K9Me3 measured after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50088376(CHEBI:49005 | Deferasirox | Exjade | ICL670A | US1...)
Affinity DataEC50:  4.05E+4nMAssay Description:Inhibition of KDM4A in human KYSE-150 cells assessed as increase in H3K9me3 levelMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50454848(CHEMBL4205285)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of full length FLAG-tagged KDM4A (unknown origin) expressed in human HeLa cells assessed as increase in H3K9me3 levels after 24 hrs by DAP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50454855(CHEMBL4215000)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of full length FLAG-tagged KDM4A (unknown origin) expressed in human HeLa cells assessed as increase in H3K9me3 levels after 24 hrs by DAP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50454850(CHEMBL4206582)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of full length FLAG-tagged KDM4A (unknown origin) expressed in human HeLa cells assessed as increase in H3K9me3 levels after 24 hrs by DAP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50454849(CHEMBL4218675)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of full length FLAG-tagged KDM4A (unknown origin) expressed in human HeLa cells assessed as increase in H3K9me3 levels after 24 hrs by DAP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50454844(CHEMBL4204694)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of full length FLAG-tagged KDM4A (unknown origin) expressed in human HeLa cells assessed as increase in H3K9me3 levels after 24 hrs by DAP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50454858(CHEMBL4218774)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of full length FLAG-tagged KDM4A (unknown origin) expressed in human HeLa cells assessed as increase in H3K9me3 levels after 24 hrs by DAP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50454856(CHEMBL4208277)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of full length FLAG-tagged KDM4A (unknown origin) expressed in human HeLa cells assessed as increase in H3K9me3 levels after 24 hrs by DAP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50454854(CHEMBL4209038)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of full length FLAG-tagged KDM4A (unknown origin) expressed in human HeLa cells assessed as increase in H3K9me3 levels after 24 hrs by DAP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50454851(CHEMBL4209558)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of full length FLAG-tagged KDM4A (unknown origin) expressed in human HeLa cells assessed as increase in H3K9me3 levels after 24 hrs by DAP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50454852(CHEMBL4208111)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of full length FLAG-tagged KDM4A (unknown origin) expressed in human HeLa cells assessed as increase in H3K9me3 levels after 24 hrs by DAP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataEC50:  8.70E+4nMAssay Description:Inhibition of human Flag-tagged KDM4A expressed in human HeLa cells assessed as increase in H3K9me3 level after 24 hrs by DAPI staining based immunof...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50454847(CHEMBL4203936)
Affinity DataEC50: >1.00E+5nMAssay Description:Stabilization of FLAG-tagged KDM4A (1 to 1064 residues) (unknown origin) expressed in human U2OS cells measured after 3 hrs by CETSAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50598662(CHEMBL5181544)
Affinity DataEC50:  1.05E+5nMAssay Description:Inhibition of binding of H3K4Me3 to KDM4A tudor domain (unknown origin) measured by NanoBRET-based cellular proximity assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50457513(CHEMBL4212908)
Affinity DataEC50:  1.05E+5nMAssay Description:Inhibition of NanoLuc-KDM4A-TUDOR domain (unknown origin) binding to Histone H3.3-HaloTag expressed in 293T cells incubated for 18 hrs by Nano-BRET b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50457514(CHEMBL4204908)
Affinity DataEC50:  1.22E+6nMAssay Description:Inhibition of NanoLuc-KDM4A-TUDOR domain (unknown origin) binding to Histone H3.3-HaloTag expressed in 293T cells incubated for 18 hrs by Nano-BRET b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50513345(CHEMBL4438830)
Affinity DataKi:  2nMAssay Description:Binding affinity to KDM4A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50513361(CHEMBL4567766)
Affinity DataKi:  3nMAssay Description:Binding affinity to KDM4A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50151923(CHEMBL3774537)
Affinity DataKi:  3nMAssay Description:Binding affinity to KDM4A (unknown origin)More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50513344(CHEMBL4447515)
Affinity DataKi:  4nMAssay Description:Binding affinity to KDM4A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50513343(CHEMBL4449500)
Affinity DataKi:  4nMAssay Description:Binding affinity to KDM4A (unknown origin)More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50513348(CHEMBL4585876)
Affinity DataKi:  4nMAssay Description:Binding affinity to KDM4A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50513343(CHEMBL4449500)
Affinity DataKi:  4nMAssay Description:Binding affinity towards KDM4A (unknown origin)More data for this Ligand-Target Pair
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50513360(CHEMBL4573390)
Affinity DataKi:  5nMAssay Description:Binding affinity to KDM4A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50513346(CHEMBL4525269)
Affinity DataKi:  26nMAssay Description:Binding affinity to KDM4A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50158852(CHEMBL3785340)
Affinity DataKi:  420nMAssay Description:Competitive inhibition of recombinant His6-tagged KDM4A (1 to 359 residues) (unknown origin) expressed in Escherichia coli BL21 cells using methylsta...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50158853(CHEMBL3786188)
Affinity DataKi:  420nMAssay Description:Inhibition of His6-tagged recombinant human KDM4A (1 to 359 residues) measured by fluorescence polarization based competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50158851(CHEMBL3786265)
Affinity DataKi:  420nMAssay Description:Inhibition of His6-tagged recombinant human KDM4A (1 to 359 residues) measured by fluorescence polarization based competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50598657(CHEMBL600353 | GNF-Pf-1339)
Affinity DataKi:  420nMAssay Description:Inhibition of His6-tagged recombinant human KDM4A (1 to 359 residues) measured by fluorescence polarization based competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50158851(CHEMBL3786265)
Affinity DataKi:  520nMAssay Description:Competitive inhibition of recombinant His6-tagged KDM4A (1 to 359 residues) (unknown origin) expressed in Escherichia coli BL21 cells using methylsta...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50158850(CHEMBL3785434)
Affinity DataKi:  1.94E+3nMAssay Description:Competitive inhibition of human KDM4A (1 to 359 residues) expressed in competent Escherichia coli BL21-CodonPlus-RIL cells using 2-oxoglutarate as su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50158853(CHEMBL3786188)
Affinity DataKi:  3.02E+3nMAssay Description:Competitive inhibition of recombinant His6-tagged KDM4A (1 to 359 residues) (unknown origin) expressed in Escherichia coli BL21 cells using methylsta...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50047962(CHEMBL1966136)
Affinity DataKi:  5.50E+3nMAssay Description:Competitive inhibition of recombinant human KDM4A (1 to 347 aa) expressed in Escherichia coli using H3K9me3 peptide as substrate after 30 mins by dou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50457513(CHEMBL4212908)
Affinity DataKi:  1.70E+5nMAssay Description:Inhibition of H3(1-10)K4me3 peptide binding to thrombin cleavable N-terminal 6His tagged and 13C-IVLM labeled human KDM4A tandem TUDOR domain (897 to...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A [1-973](Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM50193145(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
Affinity DataIC50: >2.00E+4nMpH: 7.5Assay Description:Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A [1-973](Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM103842(4HQ derivative 4)
Affinity DataIC50: >1.00E+5nMpH: 7.5Assay Description:Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A [1-973](Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM103843(4HQ derivative 6)
Affinity DataIC50:  1.00E+5nMpH: 7.5Assay Description:Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A [1-973](Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM103844(4HQ derivative 7)
Affinity DataIC50: >1.00E+5nMpH: 7.5Assay Description:Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A [1-973](Homo sapiens (Human))
University Of Oxford

LigandPNGBDBM103845(4HQ derivative 8)
Affinity DataIC50:  4.30E+4nMpH: 7.5Assay Description:Inhibition assays were carried out in 384-well white ProxiPlates(PerkinElmer) in 10 μL of reaction volume. Standard reaction mixturesconsisted o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM191598(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)
Affinity DataIC50:  600nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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