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Found 119 Enz. Inhib. hit(s) with Target = 'AMP deaminase'
TargetAMP deaminase 2(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM154583(6-[4-({[(1S)-1-(isoquinolin-8-yl)ethyl]amino}methy...)
Affinity DataIC50:  16nMpH: 7.4Assay Description:AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 1(Mus musculus (Mouse))
Astrazeneca R&D

LigandPNGBDBM154584(4-[4-({[(1R)-1-(isoquinolin-8-yl)ethyl]amino}methy...)
Affinity DataIC50:  20nMpH: 7.4Assay Description:AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAMP deaminase 1(Rattus norvegicus (Rat))
Astrazeneca R&D

LigandPNGBDBM154584(4-[4-({[(1R)-1-(isoquinolin-8-yl)ethyl]amino}methy...)
Affinity DataIC50:  20nMpH: 7.4Assay Description:AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAMP deaminase 1(Mus musculus (Mouse))
Astrazeneca R&D

LigandPNGBDBM154583(6-[4-({[(1S)-1-(isoquinolin-8-yl)ethyl]amino}methy...)
Affinity DataIC50:  24nMpH: 7.4Assay Description:AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 1(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM154584(4-[4-({[(1R)-1-(isoquinolin-8-yl)ethyl]amino}methy...)
Affinity DataIC50:  24nMpH: 7.4Assay Description:AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAMP deaminase 1(Rattus norvegicus (Rat))
Astrazeneca R&D

LigandPNGBDBM154583(6-[4-({[(1S)-1-(isoquinolin-8-yl)ethyl]amino}methy...)
Affinity DataIC50:  27nMpH: 7.4Assay Description:AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 1(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM154583(6-[4-({[(1S)-1-(isoquinolin-8-yl)ethyl]amino}methy...)
Affinity DataIC50:  38nMpH: 7.4Assay Description:AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 1(Oryctolagus cuniculus)
Agrevo

Curated by ChEMBL
LigandPNGBDBM50004698(CHEMBL1160282)
Affinity DataIC50:  70nMAssay Description:Inhibition of Oryctolagus cuniculus (rabbit) muscle adenylate deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 3(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM154583(6-[4-({[(1S)-1-(isoquinolin-8-yl)ethyl]amino}methy...)
Affinity DataIC50:  75nMpH: 7.4Assay Description:AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase(Arabidopsis thaliana)
Agrevo

Curated by ChEMBL
LigandPNGBDBM50004698(CHEMBL1160282)
Affinity DataIC50:  100nMAssay Description:Inhibition of Pisum sativum (pea) adenylate deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 2(Rattus norvegicus (Rat))
Astrazeneca R&D

LigandPNGBDBM154584(4-[4-({[(1R)-1-(isoquinolin-8-yl)ethyl]amino}methy...)
Affinity DataIC50:  300nMpH: 7.4Assay Description:AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAMP deaminase 3(Rattus norvegicus (Rat))
Astrazeneca R&D

LigandPNGBDBM154583(6-[4-({[(1S)-1-(isoquinolin-8-yl)ethyl]amino}methy...)
Affinity DataIC50:  400nMpH: 7.4Assay Description:AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 1(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM50096172(1-Bromo-4-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5...)
Affinity DataIC50:  500nMAssay Description:Inhibition of human skeletal muscle AMPD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 2(Rattus norvegicus (Rat))
Astrazeneca R&D

LigandPNGBDBM154583(6-[4-({[(1S)-1-(isoquinolin-8-yl)ethyl]amino}methy...)
Affinity DataIC50:  570nMpH: 7.4Assay Description:AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 1(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM154581(6-[4-({[(1R)-1-(naphthalen-1-yl)ethyl]amino}methyl...)
Affinity DataIC50:  620nMpH: 7.4Assay Description:AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 3(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM50385586(CHEMBL2042530)
Affinity DataIC50:  900nMAssay Description:Inhibition of human recombinant AMPD3-1b expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 1(Mus musculus (Mouse))
Astrazeneca R&D

LigandPNGBDBM154582(6-[4-({[(1R)-1-(isoquinolin-8-yl)ethyl]amino}methy...)
Affinity DataIC50:  4.50E+3nMpH: 7.4Assay Description:AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 1(Rattus norvegicus (Rat))
Astrazeneca R&D

LigandPNGBDBM154582(6-[4-({[(1R)-1-(isoquinolin-8-yl)ethyl]amino}methy...)
Affinity DataIC50:  5.80E+3nMpH: 7.4Assay Description:AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 3(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM154582(6-[4-({[(1R)-1-(isoquinolin-8-yl)ethyl]amino}methy...)
Affinity DataIC50:  7.30E+3nMpH: 7.4Assay Description:AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 1(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM154582(6-[4-({[(1R)-1-(isoquinolin-8-yl)ethyl]amino}methy...)
Affinity DataIC50:  9.20E+3nMpH: 7.4Assay Description:AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 2(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM154582(6-[4-({[(1R)-1-(isoquinolin-8-yl)ethyl]amino}methy...)
Affinity DataIC50:  3.20E+4nMpH: 7.4Assay Description:AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 2(Rattus norvegicus (Rat))
Astrazeneca R&D

LigandPNGBDBM154582(6-[4-({[(1R)-1-(isoquinolin-8-yl)ethyl]amino}methy...)
Affinity DataIC50:  3.20E+4nMpH: 7.4Assay Description:AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 3(Rattus norvegicus (Rat))
Astrazeneca R&D

LigandPNGBDBM154582(6-[4-({[(1R)-1-(isoquinolin-8-yl)ethyl]amino}methy...)
Affinity DataIC50:  4.40E+4nMpH: 7.4Assay Description:AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 3(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM50385587(CHEMBL2042529)
Affinity DataIC50:  3.70E+5nMAssay Description:Inhibition of human recombinant AMPD3-1b expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 3(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM50096172(1-Bromo-4-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5...)
Affinity DataKi:  2nMAssay Description:Inhibition of recombinant human E-type adenylate deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 3(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM50096172(1-Bromo-4-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5...)
Affinity DataKi:  2nMAssay Description:Inhibition of human recombinant AMPD3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 3(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM50096166(1-Benzyloxy-4-[2-(8-hydroxy-7,8-dihydro-6H-imidazo...)
Affinity DataKi:  9nMAssay Description:Inhibition of recombinant human E-type adenylate deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 3(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM50096165(4-[2-(8-Hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]...)
Affinity DataKi:  15nMAssay Description:Inhibition of recombinant human E-type adenylate deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 3(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM50096165(4-[2-(8-Hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]...)
Affinity DataKi:  15nMAssay Description:Inhibition of human recombinant AMPD3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 3(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM50096169(4-[2-(8-Hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]...)
Affinity DataKi:  20nMAssay Description:Inhibition of recombinant human E-type adenylate deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 3(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM50087401(2-[4-(8-Hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]...)
Affinity DataKi:  29nMAssay Description:Inhibitory activity against porcine heart or recombinant human E-type AMPDAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 3(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM50096170(4-[2-(8-Hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]...)
Affinity DataKi:  30nMAssay Description:Inhibition of recombinant human E-type adenylate deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 3(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM50096167(4-[2-(8-Hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]...)
Affinity DataKi:  40nMAssay Description:Inhibition of recombinant human E-type adenylate deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 3(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM50087407(2-[4-(8-Hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]...)
Affinity DataKi:  40nMAssay Description:Inhibitory activity against porcine heart or recombinant human E-type AMPDAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 3(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM50087409(2-[4-(8-Hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]...)
Affinity DataKi:  41nMAssay Description:Inhibitory activity against porcine heart or recombinant human E-type AMPDAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 3(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM50096164(1,3-Dichloro-4-[2-(8-hydroxy-7,8-dihydro-6H-imidaz...)
Affinity DataKi:  50nMAssay Description:Inhibition of recombinant human E-type adenylate deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 3(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM50096171(4-[2-(8-Hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]...)
Affinity DataKi:  90nMAssay Description:Inhibition of recombinant human E-type adenylate deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 3(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM50087411(2-Benzyl-2-[4-(8-hydroxy-7,8-dihydro-6H-imidazo[4,...)
Affinity DataKi:  170nMAssay Description:Inhibitory activity against porcine heart or recombinant human E-type AMPDAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 3(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM50096175(4-[2-(8-Hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]...)
Affinity DataKi:  220nMAssay Description:Inhibition of recombinant human E-type adenylate deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 3(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM50087408(2-[4-(8-Hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]...)
Affinity DataKi:  250nMAssay Description:Inhibitory activity against porcine heart or recombinant human E-type AMPDAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 3(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM50096168(1-Benzyloxy-4-[2-(8-hydroxy-7,8-dihydro-6H-imidazo...)
Affinity DataKi:  300nMAssay Description:Inhibition of recombinant human E-type adenylate deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 3(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM50096162(1,3-Dichloro-4-[2-(8-hydroxy-7,8-dihydro-6H-imidaz...)
Affinity DataKi:  300nMAssay Description:Inhibition of recombinant human E-type adenylate deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 2(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM50087295(2-(2-Bromo-benzyl)-6-(8-hydroxy-7,8-dihydro-6H-imi...)
Affinity DataKi:  300nMAssay Description:Evaluated for the inhibition of porcine heart or human L-type Adenosine 5'-monophosphate deaminase (AMPDA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 3(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM50087414(2-[4-(8-Hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]...)
Affinity DataKi:  360nMAssay Description:Inhibitory activity against porcine heart or recombinant human E-type AMPDAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 3(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM50087405(2-[4-(8-Hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]...)
Affinity DataKi:  360nMAssay Description:Inhibitory activity against porcine heart or recombinant human E-type AMPDAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 2(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM50087332(2-Benzyl-6-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d...)
Affinity DataKi:  410nMAssay Description:Evaluated for the inhibition of porcine heart or human L-type Adenosine 5'-monophosphate deaminase (AMPDA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 3(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM50087332(2-Benzyl-6-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d...)
Affinity DataKi:  410nMAssay Description:Inhibition of recombinant human E-type adenylate deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 3(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM50087377(3-[2-(8-Hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]...)
Affinity DataKi:  500nMAssay Description:Inhibition of recombinant human E-type adenylate deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 3(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM50096157(1,3-Dichloro-4-[2-(8-hydroxy-7,8-dihydro-6H-imidaz...)
Affinity DataKi:  500nMAssay Description:Inhibition of recombinant human E-type adenylate deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAMP deaminase 2(Homo sapiens (Human))
Astrazeneca R&D

LigandPNGBDBM50087328(2-(3-Bromo-benzyl)-6-(8-hydroxy-7,8-dihydro-6H-imi...)
Affinity DataKi:  790nMAssay Description:Evaluated for the inhibition of porcine heart or human L-type Adenosine 5'-monophosphate deaminase (AMPDA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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