Compile Data Set for Download or QSAR
maximum 50k data
Found 586 Enz. Inhib. hit(s) with Target = 'Complement C1'
TargetComplement C1s subcomponent(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50201566(CHEMBL2220483)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human C1s esterolytic activity using benzyloxycarbonyl-Lys-thiobenzyl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50063698(4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...)
Affinity DataIC50:  29nMAssay Description:Inhibition of human serum C1s using AGLME as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50201566(CHEMBL2220483)
Affinity DataIC50:  46nMAssay Description:Inhibition of human serum C1s-mediated lysis of rabbit Ab-sensitized sheep erythrocytes after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50063698(4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...)
Affinity DataIC50:  140nMAssay Description:Compound was evaluated for inhibitory activity against C1s serine protease .More data for this Ligand-Target Pair
In DepthDetails Article
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063701(2-(2-Iodo-phenylamino)-naphtho[2,3-d][1,3]oxazin-4...)
Affinity DataIC50:  200nMAssay Description:Inhibition of 50% of human C1r Serine Protease by initially using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50147046(5-Methylsulfanyl-4-[4-(5-propoxy-1-pyridin-2-yl-1H...)
Affinity DataIC50:  300nMAssay Description:Inhibitory activity of the compound against human Complement C1s subcomponent in erythrocyte hemolytic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM32672(MLS000097371 | N-[4-(1H-1,2,3-benzotriazol-1-ylcar...)
Affinity DataIC50:  380nMAssay Description:Molecular Library Screening Center Network (MLSCN) Penn Center for Molecular Discovery (PCMD) Assay Provider: Dr. Scott L. Diamond, University of Pen...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063726(7-Chloro-2-(2,6-dichloro-phenylamino)-benzo[d][1,3...)
Affinity DataIC50:  400nMAssay Description:Inhibition of 50% of human C1r Serine Protease by initially using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063745(2-(2-Iodo-phenylamino)-7-trifluoromethyl-benzo[d][...)
Affinity DataIC50:  400nMAssay Description:Compound was evaluated in vitro for inhibitory activity against purified human C1r protease proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063745(2-(2-Iodo-phenylamino)-7-trifluoromethyl-benzo[d][...)
Affinity DataIC50:  400nMAssay Description:Inhibition of 50% of human C1r Serine Protease by initially using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063722(6,7-Dichloro-2-(2-iodo-phenylamino)-benzo[d][1,3]o...)
Affinity DataIC50:  500nMAssay Description:Inhibition of 50% of human C1r Serine Protease by initially using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50462100(CHEMBL4247936)
Affinity DataIC50:  600nMAssay Description:Inhibition of human plasma C1r using Cbz-Gly-Arg-S-Bzl as substrate preincubated for 10 mins followed by substrate addition and measured after 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063711(7-Chloro-2-(2-iodo-phenylamino)-benzo[d][1,3]oxazi...)
Affinity DataIC50:  700nMAssay Description:Inhibition of 50% of human C1r Serine Protease by initially using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50289007(2-(2-Iodo-phenyl)-naphtho[2,3-d][1,3]oxazin-4-one ...)
Affinity DataIC50:  700nMAssay Description:Inhibition of C1r serine proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50075982(4-Methoxy-N-methyl-N-(4-oxo-4H-benzo[d][1,3]oxazin...)
Affinity DataIC50:  700nMAssay Description:In vitro inhibition of purified human C1r protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063698(4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...)
Affinity DataIC50:  800nMAssay Description:Inhibition of human serum C1r using AAME as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063723(2-(2-Iodo-phenylamino)-7-methyl-benzo[d][1,3]oxazi...)
Affinity DataIC50:  800nMAssay Description:Inhibition of 50% of human C1r Serine Protease by initially using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063721(2-(2-Iodo-phenylamino)-7-nitro-benzo[d][1,3]oxazin...)
Affinity DataIC50:  800nMAssay Description:Inhibition of 50% of human C1r Serine Protease by initially using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063717(7-Chloro-2-(2-chloro-phenylamino)-benzo[d][1,3]oxa...)
Affinity DataIC50:  800nMAssay Description:50% inhibition of human C1r serine protease after 60 mins using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063717(7-Chloro-2-(2-chloro-phenylamino)-benzo[d][1,3]oxa...)
Affinity DataIC50:  800nMAssay Description:Inhibition of 50% of human C1r Serine Protease by initially using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM32801(1,3-benzodioxol-5-yl(1-benzotriazolyl)methanone | ...)
Affinity DataIC50:  850nMAssay Description:Molecular Library Screening Center Network (MLSCN) Penn Center for Molecular Discovery (PCMD) Assay Provider: Dr. Scott L. Diamond, University of Pen...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetComplement C1s subcomponent(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM32671(3-(2-furyl)-5-(methylthio)-1-(2-thienylcarbonyl)-1...)
Affinity DataIC50:  880nMAssay Description:Molecular Library Screening Center Network (MLSCN) Penn Center for Molecular Discovery (PCMD) Assay Provider: Dr. Scott L. Diamond, University of Pen...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063724(2-(2,6-Dichloro-phenylamino)-benzo[d][1,3]oxazin-4...)
Affinity DataIC50:  900nMAssay Description:Inhibition of 50% of human C1r Serine Protease by initially using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063724(2-(2,6-Dichloro-phenylamino)-benzo[d][1,3]oxazin-4...)
Affinity DataIC50:  900nMAssay Description:50% inhibition of human C1r serine protease after 60 mins using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM32796(MLS000115326 | SMR000092470 | [3-(2-furanyl)-5-(me...)
Affinity DataIC50:  900nMAssay Description:Molecular Library Screening Center Network (MLSCN) Penn Center for Molecular Discovery (PCMD) Assay Provider: Dr. Scott L. Diamond, University of Pen...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetComplement C1s subcomponent(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50462100(CHEMBL4247936)
Affinity DataIC50:  900nMAssay Description:Inhibition of human plasma C1s using Cbz-Gly-Arg-S-Bzl as substrate preincubated for 10 mins followed by substrate addition and measured after 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063711(7-Chloro-2-(2-iodo-phenylamino)-benzo[d][1,3]oxazi...)
Affinity DataIC50:  900nMAssay Description:50% inhibition of human C1r serine protease after 60 mins using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063726(7-Chloro-2-(2,6-dichloro-phenylamino)-benzo[d][1,3...)
Affinity DataIC50:  900nMAssay Description:50% inhibition of human C1r serine protease after 60 mins using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063732(2-(2-Chloro-phenylamino)-7-methyl-benzo[d][1,3]oxa...)
Affinity DataIC50:  900nMAssay Description:50% inhibition of human C1r serine protease after 60 mins using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063698(4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity against C1r serine proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063698(4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...)
Affinity DataIC50:  1.04E+3nMAssay Description:Inhibitory activity against C1r serine proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetComplement C1s subcomponent(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50063703(2-(2-Iodo-phenyl)-benzo[d][1,3]oxazin-4-one | CHEM...)
Affinity DataIC50:  1.25E+3nMAssay Description:Compound was evaluated for inhibitory activity against C1s serine protease .More data for this Ligand-Target Pair
In DepthDetails Article
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063703(2-(2-Iodo-phenyl)-benzo[d][1,3]oxazin-4-one | CHEM...)
Affinity DataIC50:  1.37E+3nMAssay Description:Inhibitory activity against C1r serine proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063704(2-[(2-Iodo-phenyl)-methyl-amino]-benzo[d][1,3]oxaz...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of 50% of human C1r Serine Protease by initially using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063703(2-(2-Iodo-phenyl)-benzo[d][1,3]oxazin-4-one | CHEM...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibitory activity against C1r serine proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063732(2-(2-Chloro-phenylamino)-7-methyl-benzo[d][1,3]oxa...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of 50% of human C1r Serine Protease by initially using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063720(2-(2-Chloro-phenylamino)-7-nitro-benzo[d][1,3]oxaz...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of 50% of human C1r Serine Protease by initially using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063740(2-(2,6-Dichloro-phenylamino)-7-trifluoromethyl-ben...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of 50% of human C1r Serine Protease by initially using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063723(2-(2-Iodo-phenylamino)-7-methyl-benzo[d][1,3]oxazi...)
Affinity DataIC50:  1.50E+3nMAssay Description:50% inhibition of human C1r serine protease after 60 mins using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50075992(4-Guanidino-N-methyl-N-(4-oxo-4H-benzo[d][1,3]oxaz...)
Affinity DataIC50:  1.50E+3nMAssay Description:In vitro inhibition of purified human C1r protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063708(7-Fluoro-2-(2-iodo-phenylamino)-benzo[d][1,3]oxazi...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of 50% of human C1r Serine Protease by initially using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50288998(6,7-Dichloro-2-(2-iodo-phenyl)-benzo[d][1,3]oxazin...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibitory activity against C1r serine proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063697(2-(2,5-Dichloro-phenylamino)-benzo[d][1,3]oxazin-4...)
Affinity DataIC50:  2.00E+3nMAssay Description:50% inhibition of human C1r serine protease after 60 mins using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063697(2-(2,5-Dichloro-phenylamino)-benzo[d][1,3]oxazin-4...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of 50% of human C1r Serine Protease by initially using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063730(6,7-Dichloro-2-(2-chloro-phenylamino)-benzo[d][1,3...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of 50% of human C1r Serine Protease by initially using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM32778(MLS000081703 | SMR000062919 | [2-(2-cyanoethyl)-5-...)
Affinity DataIC50:  2.14E+3nMAssay Description:Molecular Library Screening Center Network (MLSCN) Penn Center for Molecular Discovery (PCMD) Assay Provider: Dr. Scott L. Diamond, University of Pen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PCBioAssay
TargetComplement C1s subcomponent(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM32669((3,4-dimethoxyphenyl)-[3-(2-furanyl)-5-(methylthio...)
Affinity DataIC50:  2.37E+3nMAssay Description:Molecular Library Screening Center Network (MLSCN) Penn Center for Molecular Discovery (PCMD) Assay Provider: Dr. Scott L. Diamond, University of Pen...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50075978(2-Bromo-N-methyl-N-(4-oxo-4H-benzo[d][1,3]oxazin-2...)
Affinity DataIC50:  2.80E+3nMAssay Description:In vitro inhibition of purified human C1r protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50063708(7-Fluoro-2-(2-iodo-phenylamino)-benzo[d][1,3]oxazi...)
Affinity DataIC50:  2.80E+3nMAssay Description:50% inhibition of human C1r serine protease after 60 mins using CbzGly-Arg-S-Bzl as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50289016(5-Chloro-2-(2-iodo-phenyl)-benzo[d][1,3]oxazin-4-o...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibitory activity against C1r serine proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
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