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Found 849 Enz. Inhib. hit(s) with Target = 'Myosin light chain kinase'
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM6760((+)-K-252a | CHEMBL281948 | K-252a | methyl (15S,1...)
Affinity DataIC50:  0.0200nMAssay Description:Inhibition of Smooth muscle myosin light chain kinase of chicken gizzardMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  10nMpH: 7.2 T: 2°CAssay Description:The activity of MLCK is measured by its ability to transfer 32P from [gamma-32P]ATP to myosin light-chain.More data for this Ligand-Target Pair
In DepthDetails Article
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  10nMAssay Description:In vitro for inhibitory activity against myosin light-chain kinase from chicken gizzard (M-kinase)More data for this Ligand-Target Pair
In DepthDetails Article
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50058332(CHEMBL299496 | methyl 10,23-di(ethylsulfanylmethyl...)
Affinity DataIC50: >10nMAssay Description:Inhibition of Smooth muscle myosin light chain kinase of chicken gizzardMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Tumor Biology Center

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  10nMAssay Description:Tested for inhibition of Myosin light chain kinase from chicken gizzardMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMyosin light chain kinase 2, skeletal/cardiac muscle(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  13.9nMAssay Description:Inhibition of human MLCK2 using KKLNRTLSFAEPG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase 2, skeletal/cardiac muscle(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  15.5nMAssay Description:Inhibition of human MLCK2 using KKLNRTLSFAEPG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Tumor Biology Center

LigandPNGBDBM199250(US9221808, 1bo | US9221808, 1bo-HCl | US9221808, 1...)
Affinity DataIC50:  16nMAssay Description:Inhibition of MLCK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Tumor Biology Center

LigandPNGBDBM3040(23-(3-aminopropyl)-3-methyl-3,13,23-triazahexacycl...)
Affinity DataIC50:  18nMAssay Description:Tested for inhibition of Myosin light chain kinase from chicken gizzardMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM3040(23-(3-aminopropyl)-3-methyl-3,13,23-triazahexacycl...)
Affinity DataIC50:  18nMpH: 7.2 T: 2°CAssay Description:The activity of MLCK is measured by its ability to transfer 32P from [gamma-32P]ATP to myosin light-chain.More data for this Ligand-Target Pair
In DepthDetails Article
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Tumor Biology Center

LigandPNGBDBM6760((+)-K-252a | CHEMBL281948 | K-252a | methyl (15S,1...)
Affinity DataIC50:  22nMAssay Description:Inhibition of Myosin light chain kinase 1 (MLCK1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Tumor Biology Center

LigandPNGBDBM50118955(CHEMBL94678 | Compound K-252a(epi))
Affinity DataIC50:  25nMAssay Description:Inhibition of Myosin light chain kinase 1 (MLCK1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Tumor Biology Center

LigandPNGBDBM3035(3-{7,19-dihydroxy-23-methyl-14-oxo-3,13,23-triazah...)
Affinity DataIC50:  30nMAssay Description:Tested for inhibition of Myosin light chain kinase from chicken gizzardMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM3035(3-{7,19-dihydroxy-23-methyl-14-oxo-3,13,23-triazah...)
Affinity DataIC50:  30nMpH: 7.2 T: 2°CAssay Description:The activity of MLCK is measured by its ability to transfer 32P from [gamma-32P]ATP to myosin light-chain.More data for this Ligand-Target Pair
In DepthDetails Article
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM3038(23-[3-(dimethylamino)propyl]-7,19-dihydroxy-3,13,2...)
Affinity DataIC50:  31nMpH: 7.2 T: 2°CAssay Description:The activity of MLCK is measured by its ability to transfer 32P from [gamma-32P]ATP to myosin light-chain.More data for this Ligand-Target Pair
In DepthDetails Article
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM3047(4-{19-methoxy-23-methyl-12,14-dioxo-3,13,23-triaza...)
Affinity DataIC50:  32nMpH: 7.2 T: 2°CAssay Description:The activity of MLCK is measured by its ability to transfer 32P from [gamma-32P]ATP to myosin light-chain.More data for this Ligand-Target Pair
In DepthDetails Article
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Tumor Biology Center

LigandPNGBDBM50284317(3-(9-methoxy-13-methyl-5,7-dioxo-6,7,12,13-tetrahy...)
Affinity DataIC50:  32nMAssay Description:Tested for inhibition of Myosin light chain kinase from chicken gizzardMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50074653(CHEMBL385812 | R-K-K-Y-(Ach)-Y-R-R-K-NH2)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity against MLCK (smooth muscle myosin light chain kinase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Tumor Biology Center

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  43.2nMAssay Description:Inhibition of human MLCK using KKLNRTLSFAEPG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM3044(3-{7-methoxy-23-methyl-12,14-dioxo-3,13,23-triazah...)
Affinity DataIC50:  49nMpH: 7.2 T: 2°CAssay Description:The activity of MLCK is measured by its ability to transfer 32P from [gamma-32P]ATP to myosin light-chain.More data for this Ligand-Target Pair
In DepthDetails Article
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Tumor Biology Center

LigandPNGBDBM3045(3-{19-methoxy-23-methyl-12,14-dioxo-3,13,23-triaza...)
Affinity DataIC50:  49nMAssay Description:Tested for inhibition of Myosin light chain kinase from chicken gizzardMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50074638(CHEMBL443574 | R-K-K-Y-K-Y-R-R-K-NH2)
Affinity DataIC50:  50nMAssay Description:Inhibitory activity against MLCK (smooth muscle myosin light chain kinase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Tumor Biology Center

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  51.3nMAssay Description:Inhibition of human MLCK using KKLNRTLSFAEPG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase family member 4(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  52.9nMAssay Description:Inhibition of human MYLK4 using KKRPQRRYSNVF as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase family member 4(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  54.5nMAssay Description:Inhibition of human MYLK4 using KKRPQRRYSNVF as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM3043(3-{23-methyl-12,14-dioxo-3,13,23-triazahexacyclo[1...)
Affinity DataIC50:  55nMpH: 7.2 T: 2°CAssay Description:The activity of MLCK is measured by its ability to transfer 32P from [gamma-32P]ATP to myosin light-chain.More data for this Ligand-Target Pair
In DepthDetails Article
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Tumor Biology Center

LigandPNGBDBM3043(3-{23-methyl-12,14-dioxo-3,13,23-triazahexacyclo[1...)
Affinity DataIC50:  55nMAssay Description:Tested for inhibition of Myosin light chain kinase from chicken gizzardMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMyosin light chain kinase family member 4(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM597774(US11608319, Compound 20 | US11608319, Compound 21)
Affinity DataIC50:  55nMAssay Description:Table 4: Assay for Inhibitory Effect on Myosin Light Chain Kinase 4 (MYLK-4). The experimental procedure referred to the LanthaScreen Eu Kinase Bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyosin light chain kinase family member 4(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM597761(US11608319, Compound 8)
Affinity DataIC50:  55nMAssay Description:Table 4: Assay for Inhibitory Effect on Myosin Light Chain Kinase 4 (MYLK-4). The experimental procedure referred to the LanthaScreen Eu Kinase Bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyosin light chain kinase family member 4(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM597760(US11608319, Compound 7)
Affinity DataIC50:  55nMAssay Description:Table 4: Assay for Inhibitory Effect on Myosin Light Chain Kinase 4 (MYLK-4). The experimental procedure referred to the LanthaScreen Eu Kinase Bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50280875(3-(5-oxo-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrr...)
Affinity DataIC50:  82nMAssay Description:In vitro for inhibitory activity against myosin light-chain kinase from chicken gizzard (M-kinase)More data for this Ligand-Target Pair
In DepthDetails Article
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50074648(CHEMBL268790 | R-K-K-Y-(Ach)-(Ach)-R-R-K-NH2)
Affinity DataIC50:  110nMAssay Description:Inhibitory activity against MLCK (smooth muscle myosin light chain kinase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Tumor Biology Center

LigandPNGBDBM3048(23-[3-(dimethylamino)-2-hydroxypropyl]-3-methyl-3,...)
Affinity DataIC50:  120nMAssay Description:Tested for inhibition of Myosin light chain kinase from chicken gizzardMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50074635(CHEMBL425624 | R-K-K-Y-K-P-R-R-K-NH2)
Affinity DataIC50:  120nMAssay Description:Inhibitory activity against MLCK (smooth muscle myosin light chain kinase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM3049(23-[3-(dimethylamino)-2-hydroxypropyl]-7-methoxy-3...)
Affinity DataIC50:  120nMpH: 7.2 T: 2°CAssay Description:The activity of MLCK is measured by its ability to transfer 32P from [gamma-32P]ATP to myosin light-chain.More data for this Ligand-Target Pair
In DepthDetails Article
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM3048(23-[3-(dimethylamino)-2-hydroxypropyl]-3-methyl-3,...)
Affinity DataIC50:  120nMpH: 7.2 T: 2°CAssay Description:The activity of MLCK is measured by its ability to transfer 32P from [gamma-32P]ATP to myosin light-chain.More data for this Ligand-Target Pair
In DepthDetails Article
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Tumor Biology Center

LigandPNGBDBM50284318(13-(3-dimethylamino-2-hydroxypropyl)-3-methoxy-12-...)
Affinity DataIC50:  120nMAssay Description:Tested for inhibition of Myosin light chain kinase from chicken gizzardMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMyosin light chain kinase 3(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  129nMAssay Description:Inhibition of human MYLK3 using KKRPQRRYSNVF as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50074644(CHEMBL409544 | R-K-K-Y-K-F-R-R-K-NH2)
Affinity DataIC50:  150nMAssay Description:Inhibitory activity against MLCK (smooth muscle myosin light chain kinase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50074657(CHEMBL267348 | R-K-K-Y-K-S-R-R-K-NH2)
Affinity DataIC50:  150nMAssay Description:Inhibitory activity against MLCK (smooth muscle myosin light chain kinase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase 2, skeletal/cardiac muscle(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50154342(CHEMBL3774448)
Affinity DataIC50:  157nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged MLCK expressed in baculovirus expression system by lantha screen kinase binding ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50074642(CHEMBL262895 | R-K-K-Y-K-I-R-R-K-NH2)
Affinity DataIC50:  160nMAssay Description:Inhibitory activity against MLCK (smooth muscle myosin light chain kinase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50074637(CHEMBL265891 | R-K-K-Y-K-M-R-R-K-NH2)
Affinity DataIC50:  160nMAssay Description:Inhibitory activity against MLCK (smooth muscle myosin light chain kinase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Tumor Biology Center

LigandPNGBDBM15234((1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-...)
Affinity DataIC50:  170nMAssay Description:Inhibition of MLCK by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM3046(3-{7,19-dimethoxy-23-methyl-12,14-dioxo-3,13,23-tr...)
Affinity DataIC50:  180nMpH: 7.2 T: 2°CAssay Description:The activity of MLCK is measured by its ability to transfer 32P from [gamma-32P]ATP to myosin light-chain.More data for this Ligand-Target Pair
In DepthDetails Article
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Tumor Biology Center

LigandPNGBDBM3046(3-{7,19-dimethoxy-23-methyl-12,14-dioxo-3,13,23-tr...)
Affinity DataIC50:  180nMAssay Description:Tested for inhibition of Myosin light chain kinase from chicken gizzardMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMyosin light chain kinase 3(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  188nMAssay Description:Inhibition of human MYLK3 using KKRPQRRYSNVF as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM3045(3-{19-methoxy-23-methyl-12,14-dioxo-3,13,23-triaza...)
Affinity DataIC50:  200nMpH: 7.2 T: 2°CAssay Description:The activity of MLCK is measured by its ability to transfer 32P from [gamma-32P]ATP to myosin light-chain.More data for this Ligand-Target Pair
In DepthDetails Article
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Tumor Biology Center

LigandPNGBDBM3044(3-{7-methoxy-23-methyl-12,14-dioxo-3,13,23-triazah...)
Affinity DataIC50:  200nMAssay Description:Tested for inhibition of Myosin light chain kinase from chicken gizzardMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50074639(CHEMBL404932 | R-K-K-Y-K-W-R-R-K-NH2)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against MLCK (smooth muscle myosin light chain kinase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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