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Found 576 Enz. Inhib. hit(s) with Target = 'Polymerase acidic protein'
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50509159(CHEMBL4588964)
Affinity DataIC50: <2nMAssay Description:Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endonuclease using [6-FAM]AATCGCAGGCAGCACTC[TAM] substrate and measured ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50509165(CHEMBL4459575)
Affinity DataIC50: <2nMAssay Description:Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endonuclease using [6-FAM]AATCGCAGGCAGCACTC[TAM] substrate and measured ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50509161(CHEMBL4563716)
Affinity DataIC50: <2nMAssay Description:Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endonuclease using [6-FAM]AATCGCAGGCAGCACTC[TAM] substrate and measured ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50509169(CHEMBL4545631)
Affinity DataIC50: <2nMAssay Description:Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endonuclease using [6-FAM]AATCGCAGGCAGCACTC[TAM] substrate and measured ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50509167(CHEMBL4539596)
Affinity DataIC50: >2nMAssay Description:Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endonuclease using [6-FAM]AATCGCAGGCAGCACTC[TAM] substrate and measured ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50509165(CHEMBL4459575)
Affinity DataIC50: >2nMAssay Description:Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endonuclease using [6-FAM]AATCGCAGGCAGCACTC[TAM] substrate and measured ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50509155(CHEMBL4440123)
Affinity DataIC50: <2nMAssay Description:Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endonuclease using [6-FAM]AATCGCAGGCAGCACTC[TAM] substrate and measured ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50509167(CHEMBL4539596)
Affinity DataIC50: <2nMAssay Description:Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endonuclease using [6-FAM]AATCGCAGGCAGCACTC[TAM] substrate and measured ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50509169(CHEMBL4545631)
Affinity DataIC50: >2nMAssay Description:Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endonuclease using [6-FAM]AATCGCAGGCAGCACTC[TAM] substrate and measured ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50509159(CHEMBL4588964)
Affinity DataIC50: >2nMAssay Description:Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endonuclease using [6-FAM]AATCGCAGGCAGCACTC[TAM] substrate and measured ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50509155(CHEMBL4440123)
Affinity DataIC50: >2nMAssay Description:Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endonuclease using [6-FAM]AATCGCAGGCAGCACTC[TAM] substrate and measured ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50509161(CHEMBL4563716)
Affinity DataIC50: >2nMAssay Description:Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endonuclease using [6-FAM]AATCGCAGGCAGCACTC[TAM] substrate and measured ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50509170(CHEMBL4440338)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endonuclease using [6-FAM]AATCGCAGGCAGCACTC[TAM] substrate and measured ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50509160(CHEMBL4570983)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endonuclease using [6-FAM]AATCGCAGGCAGCACTC[TAM] substrate and measured ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50509170(CHEMBL4440338)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endonuclease using [6-FAM]AATCGCAGGCAGCACTC[TAM] substrate and measured ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50509160(CHEMBL4570983)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endonuclease using [6-FAM]AATCGCAGGCAGCACTC[TAM] substrate and measured ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50509157(CHEMBL4530222)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endonuclease using [6-FAM]AATCGCAGGCAGCACTC[TAM] substrate and measured ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50509166(CHEMBL4550646)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endonuclease using [6-FAM]AATCGCAGGCAGCACTC[TAM] substrate and measured ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50509157(CHEMBL4530222)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endonuclease using [6-FAM]AATCGCAGGCAGCACTC[TAM] substrate and measured ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50509166(CHEMBL4550646)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endonuclease using [6-FAM]AATCGCAGGCAGCACTC[TAM] substrate and measured ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50509172(CHEMBL4553243)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endonuclease using [6-FAM]AATCGCAGGCAGCACTC[TAM] substrate and measured ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50508967(CHEMBL3944613)
Affinity DataIC50:  5nMAssay Description:Inhibition of Influenza A virus CENMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50509172(CHEMBL4553243)
Affinity DataIC50:  5nMAssay Description:Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endonuclease using [6-FAM]AATCGCAGGCAGCACTC[TAM] substrate and measured ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50509173(CHEMBL4469796)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endonuclease using [6-FAM]AATCGCAGGCAGCACTC[TAM] substrate and measured ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50509173(CHEMBL4469796)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endonuclease using [6-FAM]AATCGCAGGCAGCACTC[TAM] substrate and measured ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50509168(CHEMBL4460007)
Affinity DataIC50:  6nMAssay Description:Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endonuclease using [6-FAM]AATCGCAGGCAGCACTC[TAM] substrate and measured ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50509154(CHEMBL4453833)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endonuclease using [6-FAM]AATCGCAGGCAGCACTC[TAM] substrate and measured ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50509154(CHEMBL4453833)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endonuclease using [6-FAM]AATCGCAGGCAGCACTC[TAM] substrate and measured ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50509168(CHEMBL4460007)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endonuclease using [6-FAM]AATCGCAGGCAGCACTC[TAM] substrate and measured ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50509152(CHEMBL4535893)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endonuclease using [6-FAM]AATCGCAGGCAGCACTC[TAM] substrate and measured ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50509152(CHEMBL4535893)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endonuclease using [6-FAM]AATCGCAGGCAGCACTC[TAM] substrate and measured ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolymerase acidic protein()
Novartis

US Patent
LigandPNGBDBM474361((S)-6-benzhydryl-11-hydroxy-3-(1H-pyrazol- 4-yl)-5...)
Affinity DataIC50:  8nMAssay Description:Compounds were dissolved and serially diluted in 100% DMSO then 0.5 μl was transferred to 384-well plates. 50 nM truncated Influenza A/victoria/...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolymerase acidic protein()
Novartis

US Patent
LigandPNGBDBM474361((S)-6-benzhydryl-11-hydroxy-3-(1H-pyrazol- 4-yl)-5...)
Affinity DataIC50:  8nMAssay Description:Compounds were dissolved and serially diluted in 100% DMSO then 0.5 μl was transferred to 384-well plates. 50 nM truncated Influenza A/victoria/...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolymerase acidic protein()
Novartis

US Patent
LigandPNGBDBM474346((S)-6-benzhydryl-3-bromo-11-hydroxy-5H- imidazo[1,...)
Affinity DataIC50:  9nMAssay Description:Compounds were dissolved and serially diluted in 100% DMSO then 0.5 μl was transferred to 384-well plates. 50 nM truncated Influenza A/victoria/...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolymerase acidic protein()
Novartis

US Patent
LigandPNGBDBM474354((S)-6-((S)-(3-fluorophenyl)(4- fluorophenyl)methyl...)
Affinity DataIC50:  9nMAssay Description:Compounds were dissolved and serially diluted in 100% DMSO then 0.5 μl was transferred to 384-well plates. 50 nM truncated Influenza A/victoria/...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolymerase acidic protein()
Novartis

US Patent
LigandPNGBDBM474346((S)-6-benzhydryl-3-bromo-11-hydroxy-5H- imidazo[1,...)
Affinity DataIC50:  9nMAssay Description:Compounds were dissolved and serially diluted in 100% DMSO then 0.5 μl was transferred to 384-well plates. 50 nM truncated Influenza A/victoria/...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolymerase acidic protein()
Novartis

US Patent
LigandPNGBDBM474354((S)-6-((S)-(3-fluorophenyl)(4- fluorophenyl)methyl...)
Affinity DataIC50:  9nMAssay Description:Compounds were dissolved and serially diluted in 100% DMSO then 0.5 μl was transferred to 384-well plates. 50 nM truncated Influenza A/victoria/...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolymerase acidic protein()
Novartis

US Patent
LigandPNGBDBM474367((S)-6-((S)-(3-bromophenyl)(4- fluorophenyl)methyl)...)
Affinity DataIC50:  10nMAssay Description:Compounds were dissolved and serially diluted in 100% DMSO then 0.5 μl was transferred to 384-well plates. 50 nM truncated Influenza A/victoria/...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolymerase acidic protein()
Novartis

US Patent
LigandPNGBDBM474367((S)-6-((S)-(3-bromophenyl)(4- fluorophenyl)methyl)...)
Affinity DataIC50:  10nMAssay Description:Compounds were dissolved and serially diluted in 100% DMSO then 0.5 μl was transferred to 384-well plates. 50 nM truncated Influenza A/victoria/...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolymerase acidic protein()
Novartis

US Patent
LigandPNGBDBM474357((S)-6-((R)-(2-bromo-4-fluorophenyl)(4- fluoropheny...)
Affinity DataIC50:  10nMAssay Description:Compounds were dissolved and serially diluted in 100% DMSO then 0.5 μl was transferred to 384-well plates. 50 nM truncated Influenza A/victoria/...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolymerase acidic protein()
Novartis

US Patent
LigandPNGBDBM474343((S)-6-Benzhydryl-11-hydroxy-5H- imidazo[1,2-a]pyri...)
Affinity DataIC50:  10nMAssay Description:Compounds were dissolved and serially diluted in 100% DMSO then 0.5 μl was transferred to 384-well plates. 50 nM truncated Influenza A/victoria/...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolymerase acidic protein()
Novartis

US Patent
LigandPNGBDBM474343((S)-6-Benzhydryl-11-hydroxy-5H- imidazo[1,2-a]pyri...)
Affinity DataIC50:  10nMAssay Description:Compounds were dissolved and serially diluted in 100% DMSO then 0.5 μl was transferred to 384-well plates. 50 nM truncated Influenza A/victoria/...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolymerase acidic protein()
Novartis

US Patent
LigandPNGBDBM474357((S)-6-((R)-(2-bromo-4-fluorophenyl)(4- fluoropheny...)
Affinity DataIC50:  10nMAssay Description:Compounds were dissolved and serially diluted in 100% DMSO then 0.5 μl was transferred to 384-well plates. 50 nM truncated Influenza A/victoria/...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM105203(6-(4-Fluorophenyl)-3-hydroxy-5-[4-(1H-1, 2, 3, 4-t...)
Affinity DataIC50:  11nMAssay Description:Inhibition of Influenza A virus CENMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolymerase acidic protein [1-204,T86I,G186S](2009 H1N1 Influenza)
Rutgers University

LigandPNGBDBM105203(6-(4-Fluorophenyl)-3-hydroxy-5-[4-(1H-1, 2, 3, 4-t...)
Affinity DataIC50:  11nMAssay Description:Cocktails of 4-8 compounds were used for the initial screening with single compound soaks to verify the bound fragment identity and to rule out coope...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM105203(6-(4-Fluorophenyl)-3-hydroxy-5-[4-(1H-1, 2, 3, 4-t...)
Affinity DataIC50:  11nMAssay Description:Inhibition of Influenza A/Puerto Rico/8/34 (H1N1) PA N-terminal domain endonuclease activity expressed in Escherichia coli BL21 (RIL) cells using (6-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50409783(CHEMBL1626982 | CHEMBL2068710 | CHEMBL2068711 | CH...)
Affinity DataIC50:  12nMAssay Description:Inhibitory concentration against cap-dependent endonuclease activity of influenza A/PR/8/34 RNPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50509158(CHEMBL4438546)
Affinity DataIC50:  13nMAssay Description:Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endonuclease using [6-FAM]AATCGCAGGCAGCACTC[TAM] substrate and measured ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50508966(CHEMBL4452342)
Affinity DataIC50:  13nMAssay Description:Inhibition of 8-histidine tagged influenza virus H1N1 N-terminal PA endonuclease expressed in Escherichia coli BL21 cells using single-stranded 5'-FA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolymerase acidic protein(Hepatitis C virus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50509158(CHEMBL4438546)
Affinity DataIC50:  14nMAssay Description:Inhibition of Influenza A virus RNA-dependent RNA polymerase PA N-terminal endonuclease using [6-FAM]AATCGCAGGCAGCACTC[TAM] substrate and measured ov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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