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Found 19 Enz. Inhib. hit(s) with Target = 'Potassium-transporting ATPase alpha chain 2'
TargetPotassium-transporting ATPase alpha chain 2(Homo sapiens (Human))
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50408438(CHEMBL2068911)
Affinity DataIC50:  30nMAssay Description:Compound was evaluated for its ability to inhibit the specific [3H]-ouabain binding to dog kidney Na+/K+ ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 2(Homo sapiens (Human))
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50408439(CHEMBL2068890)
Affinity DataIC50:  60nMAssay Description:Compound was evaluated for its ability to inhibit the specific [3H]-ouabain binding to dog kidney Na+/K+ ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 2(Homo sapiens (Human))
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM66977(3-[(3S,5R,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3,...)
Affinity DataIC50:  80nMAssay Description:Compound was evaluated for its ability to inhibit the specific [3H]-ouabain binding to dog kidney Na+/K+ ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 2(Homo sapiens (Human))
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50066032(CHEMBL323301 | [(1R,4bR,7S,8aR)-7-Hydroxy-1,4b,8,8...)
Affinity DataIC50:  100nMAssay Description:Compound was evaluated for its ability to inhibit the specific [3H]-ouabain binding to dog kidney Na+/K+ ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 2(Homo sapiens (Human))
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50066031((E)-(S)-4-((2S,4bS,7S,8aR)-7-Hydroxy-2,4b-dimethyl...)
Affinity DataIC50:  120nMAssay Description:Compound was evaluated for its ability to inhibit the specific [3H]-ouabain binding to dog kidney Na+/K+ ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 2(Homo sapiens (Human))
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50066029(4-[(S)-1-((2S,4bS,7S,8aR)-7-Hydroxy-2,4b-dimethyl-...)
Affinity DataIC50:  130nMAssay Description:Compound was evaluated for its ability to inhibit the specific [3H]-ouabain binding to dog kidney Na+/K+ ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 2(Homo sapiens (Human))
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50066036(4-[(R)-1-((2R,4bS,7S,8aR)-7-Hydroxy-2,4b-dimethyl-...)
Affinity DataIC50:  200nMAssay Description:Compound was evaluated for its ability to inhibit the specific [3H]-ouabain binding to dog kidney Na+/K+ ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 2(Homo sapiens (Human))
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50131828((E,Z)10,13-Dimethyl-tetradecahydro-cyclopenta[a]ph...)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against Na+/K+ ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 2(Homo sapiens (Human))
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50066034((E)-(R)-4-((2R,4bS,7S,8aR)-7-Hydroxy-2,4b-dimethyl...)
Affinity DataIC50:  250nMAssay Description:Compound was evaluated for its ability to inhibit the specific [3H]-ouabain binding to dog kidney Na+/K+ ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 2(Homo sapiens (Human))
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50408437(CHEMBL2068917)
Affinity DataIC50:  350nMAssay Description:Compound was evaluated for its ability to inhibit the specific [3H]-ouabain binding to dog kidney Na+/K+ ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 2(Homo sapiens (Human))
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50408440(CHEMBL2068987)
Affinity DataIC50:  5.89E+3nMAssay Description:Compound was evaluated for its ability to inhibit the specific [3H]-ouabain binding to dog kidney Na+/K+ ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 2(Homo sapiens (Human))
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50131829((E)4,10,13-Trimethyl-tetradecahydro-cyclopenta[a]p...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibitory activity against Na+/K+ ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 2(Homo sapiens (Human))
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50131821((E,Z)10,13-Dimethyl-tetradecahydro-cyclopenta[a]ph...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibitory activity against Na+/K+ ATPase measured by 32P-ATP hydrolysis methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 2(Homo sapiens (Human))
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50286741(CHEMBL168713 | methyl 18-[6-(2-{2-[4,5-dihydroxy-3...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibitory activity of the compound against rat kidney Na+/K+ ATPase was determined by fiske subbarow methodMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPotassium-transporting ATPase alpha chain 2(Homo sapiens (Human))
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50131832((E)2,10,13-Trimethyl-tetradecahydro-cyclopenta[a]p...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibitory activity against Na+/K+ ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 2(Homo sapiens (Human))
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50013297(CHEMBL149689 | N-[4-(5-Methyl-1H-pyrrol-3-yl)-thia...)
Affinity DataIC50: >1.00E+5nMAssay Description:Tested against canine renal Na+/K+ ATPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 2(Homo sapiens (Human))
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50131823((E,Z)6,17-Dihydroxy-10,13-dimethyl-hexadecahydro-c...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory activity against Na+/K+ ATPase was determined in guinea pigMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium-transporting ATPase alpha chain 2(Homo sapiens (Human))
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50286739(4-((1R,3S,5S,8R,10R,11R,13R,14S,17R)-1,5,11,14-tet...)
Affinity DataIC50:  2.00E+5nMAssay Description:Inhibitory activity of the compound against rat kidney Na+/K+ ATPase was determined by fiske subbarow methodMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPotassium-transporting ATPase alpha chain 2(Homo sapiens (Human))
Prassis Istituto Di Ricerche Sigma-Tau

Curated by ChEMBL
LigandPNGBDBM50286740(CHEMBL406262 | Saponin derivative)
Affinity DataIC50:  4.00E+5nMAssay Description:Inhibitory activity of the compound against rat kidney Na+/K+ ATPase was determined by fiske subbarow methodMore data for this Ligand-Target Pair
In DepthDetails Article