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Found 734 Enz. Inhib. hit(s) with Target = 'Dual specificity protein kinase CLK2'
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >8.75E+3nMAssay Description:Inhibition of CLK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50512318(CHEMBL4546504)
Affinity DataIC50:  0.261nMAssay Description:Inhibition of recombinant human GST-tagged CLK2 catalytic domain (137 to 498 residues) expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50:  0.550nMAssay Description:Inhibition of human CLK2 incubated for 2 hrsMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM445772(US10669240, Compound 68 | US10669240, Compound 69)
Affinity DataIC50:  0.822nMAssay Description:Inhibition of CLK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50566490(CHEMBL4848224)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human CLK2 incubated for 2 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50589393(CHEMBL5202010)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of CLK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM317482(4-(4-((1s,4s)-4-hydroxy-4- methylcyclohexyloxy)-5-...)
Affinity DataIC50:  1.43nMAssay Description:The kinase activity is measured using a radioactivity based kinase assay, which measures the incorporation of a radioactively labeled phosphate moiet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50566492(CHEMBL4872225)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human CLK2 incubated for 2 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50566489(CHEMBL4848072)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human CLK2 incubated for 2 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM317465(4-(4-(cyclopentyloxy)-5-(4- (methylcarbamoyl)pheny...)
Affinity DataIC50:  1.91nMAssay Description:The kinase activity is measured using a radioactivity based kinase assay, which measures the incorporation of a radioactively labeled phosphate moiet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM293424(US10106527, Compound 10 | US10106527, Compound 142...)
Affinity DataIC50:  2nMAssay Description:Inhibition of CLK2 (unknown origin) by Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM293424(US10106527, Compound 10 | US10106527, Compound 142...)
Affinity DataIC50:  2nMAssay Description:Inhibition of CLK2 (unknown origin) by Z'-LYTE kinase assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM317483(3-chloro-N-methyl-4-(5-(4- (methylcarbamoyl)phenyl...)
Affinity DataIC50:  2.10nMAssay Description:The kinase activity is measured using a radioactivity based kinase assay, which measures the incorporation of a radioactively labeled phosphate moiet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM317471((S)-3-chloro-N-methyl-4-(5-(2- methylbenzo[d]oxazo...)
Affinity DataIC50:  2.27nMAssay Description:The kinase activity is measured using a radioactivity based kinase assay, which measures the incorporation of a radioactively labeled phosphate moiet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM317469(3-methoxy-4-(4-methoxy-5-(6- methoxypyridin-3-yl)-...)
Affinity DataIC50:  2.29nMAssay Description:The kinase activity is measured using a radioactivity based kinase assay, which measures the incorporation of a radioactively labeled phosphate moiet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM317475(3-cyano-N-methyl-4-(5-(2- methylbenzo[d]oxazol-6-y...)
Affinity DataIC50:  2.32nMAssay Description:The kinase activity is measured using a radioactivity based kinase assay, which measures the incorporation of a radioactively labeled phosphate moiet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50566488(CHEMBL4875513)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of human CLK2 incubated for 2 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50592247(CHEMBL5200367)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of human recombinant GST-tagged Clk2 expressed in Baculovirus expression system using GRSRSRSRSRSRSRSR peptide as substrate preincubated f...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of human CLK2 using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM317485(3-chloro-N-methyl-4-(5-(1- methyl-1H-pyrazol-4-yl)...)
Affinity DataIC50:  3.29nMAssay Description:The kinase activity is measured using a radioactivity based kinase assay, which measures the incorporation of a radioactively labeled phosphate moiet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM317468(4-(4-(cyclopentyloxy)-5-(2- methylbenzo[d]oxazol-6...)
Affinity DataIC50:  3.38nMAssay Description:The kinase activity is measured using a radioactivity based kinase assay, which measures the incorporation of a radioactively labeled phosphate moiet...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM317467(3-methoxy-N-methyl-4-(5-(2- methylbenzo[d]oxazol-6...)
Affinity DataIC50:  3.5nMAssay Description:The kinase activity is measured using a radioactivity based kinase assay, which measures the incorporation of a radioactively labeled phosphate moiet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of CLK2 (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of N-terminal GST-tagged human CLK2 (138 to end residues) using SR-rich substrate and [gamma-33P]ATP incubated for 40 mins by scintillatio...More data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of N-terminal GST-tagged human CLK2 (138 to end residues) using SR-rich substrate and [gamma-33P]ATP incubated for 40 mins by scintillatio...More data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant human CLK2 in presence of ATP by radiometric filter-binding assayMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant human CLK2 in presence of ATP by radiometric filter-binding assayMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM317460(4-(5-(4-hydroxyphenyl)-4- (tetrahydro-2H-pyran-4-y...)
Affinity DataIC50:  4.33nMAssay Description:The kinase activity is measured using a radioactivity based kinase assay, which measures the incorporation of a radioactively labeled phosphate moiet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM317466(4-(4-methoxy-5-(pyridin-4-yl)- 7H-pyrrolo[2,3-d]py...)
Affinity DataIC50:  4.56nMAssay Description:The kinase activity is measured using a radioactivity based kinase assay, which measures the incorporation of a radioactively labeled phosphate moiet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50246769(CHEMBL4064608)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human CLK2 (138 end residues) expressed in baculovirus infected Sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50237672(CHEMBL4089159)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of CLK2 (unknown origin) pretreated for 30 mins followed by substrate addition measured after 5 hrs in presence of 1 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of human CLK2 using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of CLK2 (unknown origin) assessed as transfer of radiolabelled phosphate group from ATP by reaction biology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM317481(4-(4-cyclobutoxy-5-(2- methylbenzo[d]oxazol-6-yl)-...)
Affinity DataIC50:  5.92nMAssay Description:The kinase activity is measured using a radioactivity based kinase assay, which measures the incorporation of a radioactively labeled phosphate moiet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50235022(CHEMBL4078898)
Affinity DataIC50:  6nMAssay Description:Inhibition of human CLK2 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50235022(CHEMBL4078898)
Affinity DataIC50:  6nMAssay Description:Inhibition of human CLK2 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM317462(4-(4-(cyclopentyloxy)-5-(2- methylbenzo[d]oxazol-6...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human GST-tagged CLK2 expressed in baculovirus by Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM317462(4-(4-(cyclopentyloxy)-5-(2- methylbenzo[d]oxazol-6...)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of CLK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50235020(CHEMBL4094492)
Affinity DataIC50:  7nMAssay Description:Inhibition of human CLK2 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human CLK2 Long (130 to 496 residues) expressed in Escherichia coli BL21 (DE3) Turner using GSK3 as substrate incubated for 60 mins in ...More data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50235020(CHEMBL4094492)
Affinity DataIC50:  7nMAssay Description:Inhibition of human CLK2 using YRRAAVPPSPSLSRHSSPHQS(p)EDEEE as substrate in presence of [gamma-33P]ATP after 40 mins by scintillation counter methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50589392(Adavivint | LORECIVIVINT | Lorecivivint | SM-04690...)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of CLK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50589392(Adavivint | LORECIVIVINT | Lorecivivint | SM-04690...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human CLK2More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50590222(CHEMBL5193374)
Affinity DataIC50:  8nMAssay Description:Inhibition of CLK2 (unknown origin) assessed as substrate phosphorylation using coumarin and fluorescein-labeled peptide as substrate incubated for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM317462(4-(4-(cyclopentyloxy)-5-(2- methylbenzo[d]oxazol-6...)
Affinity DataIC50:  8.17nMAssay Description:The kinase activity is measured using a radioactivity based kinase assay, which measures the incorporation of a radioactively labeled phosphate moiet...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM317476(N-methyl-4-(5-(2- methylbenzo[d]oxazol-6-yl)-4- (t...)
Affinity DataIC50:  9.41nMAssay Description:The kinase activity is measured using a radioactivity based kinase assay, which measures the incorporation of a radioactively labeled phosphate moiet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50590220(CHEMBL5202285)
Affinity DataIC50:  9.60nMAssay Description:Inhibition of CLK2 (unknown origin) assessed as substrate phosphorylation using coumarin and fluorescein-labeled peptide as substrate incubated for 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50566479(CHEMBL4875815)
Affinity DataIC50:  9.70nMAssay Description:Inhibition of human CLK2 incubated for 2 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50: <10nMAssay Description:Inhibition of recombinant human GST-tagged CLK2 catalytic domain expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50536678(CHEMBL4550702)
Affinity DataIC50: <10nMAssay Description:Inhibition of recombinant human GST-tagged CLK2 catalytic domain expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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