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Found 310 Enz. Inhib. hit(s) with Target = 'Lactoylglutathione lyase'
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50126960(CHEMBL3629116)
Affinity DataKi:  0.300nMAssay Description:Inhibition of 6-His tagged recombinant human glyoxalase 1 transfected in Escherichia coli BL21 (DE3) assessed as S-D-lactoylglutathione formation by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50526945(CHEMBL4473806)
Affinity DataKi:  0.960nMAssay Description:Competitive inhibition of human Glyoxalase-1 using GSH and MGO as substrate by Michaelis-Menten analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50126961(CHEMBL3629115)
Affinity DataKi:  1nMAssay Description:Inhibition of 6-His tagged recombinant human glyoxalase 1 transfected in Escherichia coli BL21 (DE3) assessed as S-D-lactoylglutathione formation by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50526943(CHEMBL4436073)
Affinity DataKi:  1nMAssay Description:Competitive inhibition of human Glyoxalase-1 using GSH and MGO as substrateMore data for this Ligand-Target Pair
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human Glyoxalase-1 using GSH and MGO as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...)
Affinity DataKi:  5nMAssay Description:Inhibition of human erythrocyte Glyoxalase-1 using GSH and MGO as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50526944(CHEMBL4450158)
Affinity DataKi:  7nMAssay Description:Competitive inhibition of human Glyoxalase-1 using GSH and MGO as substrateMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50526942(CHEMBL4438930)
Affinity DataKi:  10nMAssay Description:Inhibition of human Glyoxalase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50402202(CHEMBL2203964)
Affinity DataKi:  11nMAssay Description:Inhibition of human GLO1More data for this Ligand-Target Pair
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50092825(CHEMBL128935 | S-(N-phenyl-N-hydroxycarbamoyl)glut...)
Affinity DataKi:  14nMAssay Description:Inhibition of human GLO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50092826((2S)-2-amino-5-{[(1R)-1-[({[(4-bromophenyl)(hydrox...)
Affinity DataKi:  14nMAssay Description:Inhibition of human glyoxalase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50039111(S-(N-Hydroxy-N-(4-bromophenyl)carbamoyl)glutathion...)
Affinity DataKi:  14nMAssay Description:Tested for inhibitory activity against human erythrocyte glyoxalase IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50092826((2S)-2-amino-5-{[(1R)-1-[({[(4-bromophenyl)(hydrox...)
Affinity DataKi:  14nMAssay Description:Binding affinity for Glyoxalase IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50092826((2S)-2-amino-5-{[(1R)-1-[({[(4-bromophenyl)(hydrox...)
Affinity DataKi:  14nMAssay Description:Inhibition of human erythrocyte Glyoxalase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50092827(CHEMBL127840 | S-(N-hexyl-N-hydroxycarbamoyl)gluta...)
Affinity DataKi:  16nMAssay Description:Binding affinity for Glyoxalase IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50092831(CHEMBL128836 | S-(N-heptyl-N-hydroxycarbamoyl)glut...)
Affinity DataKi:  18nMAssay Description:Binding affinity for Glyoxalase IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50526948(CHEMBL4559486)
Affinity DataKi:  19nMAssay Description:Competitive inhibition of human Glyoxalase-1 using GSH and MGO as substrateMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50126957(CHEMBL3629119)
Affinity DataKi:  46nMAssay Description:Inhibition of human glyoxalase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50092824(CHEMBL131578 | S-(N-4chlorophenyl-N-hydroxycarbamo...)
Affinity DataKi:  46nMAssay Description:Competitive inhibition of GLO1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50039108(S-(N-Hydroxy-N-(4-chlorophenyl)carbamoyl)glutathio...)
Affinity DataKi:  46nMAssay Description:Tested for inhibitory activity against human erythrocyte glyoxalase IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50092824(CHEMBL131578 | S-(N-4chlorophenyl-N-hydroxycarbamo...)
Affinity DataKi:  46nMAssay Description:Inhibition of human erythrocyte Glyoxalase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50092824(CHEMBL131578 | S-(N-4chlorophenyl-N-hydroxycarbamo...)
Affinity DataKi:  46nMAssay Description:Inhibition of human glyoxalase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50092824(CHEMBL131578 | S-(N-4chlorophenyl-N-hydroxycarbamo...)
Affinity DataKi:  46nMAssay Description:Binding affinity for Glyoxalase IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50241121((S)-5-((R)-3-(4-bromobenzylthio)-1-(carboxymethyla...)
Affinity DataKi:  80nMAssay Description:Inhibition of GLO1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50126958(CHEMBL3629118)
Affinity DataKi:  130nMAssay Description:Inhibition of human glyoxalase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Mus musculus)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50526947(CHEMBL4584432)
Affinity DataKi:  150nMAssay Description:Competitive inhibition of recombinant mouse His-tagged Glyoxalase-1 using GSH and MGO as substrate by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50039113(S-(N-Hydroxy-N-phenylcarbamoyl)glutathione)
Affinity DataKi:  160nMAssay Description:Tested for inhibitory activity against human erythrocyte glyoxalase IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50092825(CHEMBL128935 | S-(N-phenyl-N-hydroxycarbamoyl)glut...)
Affinity DataKi:  160nMAssay Description:Inhibition of human erythrocyte Glyoxalase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50092825(CHEMBL128935 | S-(N-phenyl-N-hydroxycarbamoyl)glut...)
Affinity DataKi:  160nMAssay Description:Binding affinity for Glyoxalase IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50092830(CHEMBL129965 | S-(N-pentyl-N-hydroxycarbamoyl)glut...)
Affinity DataKi:  170nMAssay Description:Binding affinity for Glyoxalase IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50241121((S)-5-((R)-3-(4-bromobenzylthio)-1-(carboxymethyla...)
Affinity DataKi:  170nMAssay Description:Inhibition of Glyoxalase-1 (unknown origin) using GSH and MGO as substrates preincubated with substrates for 6 mins followed by enzyme addition by sp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50092822(CHEMBL128447 | S-(N-butyl-N-hydroxycarbamoyl)gluta...)
Affinity DataKi:  180nMAssay Description:Binding affinity for Glyoxalase IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Mus musculus)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50517464(CHEMBL1234300)
Affinity DataKi:  230nMAssay Description:Competitive inhibition of recombinant mouse His-tagged Glyoxalase-1 using GSH and MGO as substrate by spectrophotometric methodMore data for this Ligand-Target Pair
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50517464(CHEMBL1234300)
Affinity DataKi:  230nMAssay Description:Inhibition of human GLO1More data for this Ligand-Target Pair
TargetLactoylglutathione lyase(Mus musculus)
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50233538(18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoole...)
Affinity DataKi:  290nMAssay Description:Inhibition of recombinant mouse Glyoxalase-1 expressed in Escherichia coli BL21 (DE3) pLysS cells using GSH and MGO as substrate by Dixon plotMore data for this Ligand-Target Pair
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50126959(CHEMBL3629117)
Affinity DataKi:  330nMAssay Description:Inhibition of human glyoxalase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50092829(CHEMBL129597 | S-(N-propyl-N-hydroxycarbamoyl)glut...)
Affinity DataKi:  800nMAssay Description:Binding affinity for Glyoxalase IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50092832(CHEMBL128867 | S-(N-ethyl-N-hydroxycarbamoyl)gluta...)
Affinity DataKi:  1.18E+3nMAssay Description:Binding affinity for Glyoxalase IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50039111(S-(N-Hydroxy-N-(4-bromophenyl)carbamoyl)glutathion...)
Affinity DataKi:  1.20E+3nMAssay Description:Tested for inhibitory activity against yeast glyoxalase IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50092826((2S)-2-amino-5-{[(1R)-1-[({[(4-bromophenyl)(hydrox...)
Affinity DataKi:  1.20E+3nMAssay Description:Binding affinity of the compound on yeast glyoxalase I (GlxI) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50092823(CHEMBL129435 | S-(N-methyl-N-hydroxycarbamoyl)glut...)
Affinity DataKi:  1.70E+3nMAssay Description:Binding affinity for Glyoxalase IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50039110(S-(N-Methyl-N-hydroxycarbomyl)ethylglutathione)
Affinity DataKi:  1.70E+3nMAssay Description:Tested for inhibitory activity against human erythrocyte glyoxalase IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50069024(2-Amino-4-[1-(carboxymethyl-carbamoyl)-3-(hydroxy-...)
Affinity DataKi:  1.90E+3nMAssay Description:Compound was evaluated for inhibition of S. cerevisiae glyoxalase-I by using enzymatic assay at each of 6 substrate concentrations between 0.1 mM and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50336257(4-(3-fluorobenzylidene)-1,7-bis(4-hydroxy-3-methox...)
Affinity DataKi:  2.60E+3nMAssay Description:Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50336258(4-(4-fluorobenzylidene)-1,7-bis(4-hydroxy-3-methox...)
Affinity DataKi:  3.20E+3nMAssay Description:Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50039108(S-(N-Hydroxy-N-(4-chlorophenyl)carbamoyl)glutathio...)
Affinity DataKi:  3.60E+3nMAssay Description:Tested for inhibitory activity against yeast glyoxalase IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50092824(CHEMBL131578 | S-(N-4chlorophenyl-N-hydroxycarbamo...)
Affinity DataKi:  3.60E+3nMAssay Description:Binding affinity of the compound on yeast glyoxalase I (GlxI) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50336261(4-(4-hydroxy-3-methoxybenzylidene)-1,7-bis(4-hydro...)
Affinity DataKi:  3.60E+3nMAssay Description:Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50336259(4-(5-(3,4-dimethoxyphenyl)-2-(-3-(3,4-dimethoxyphe...)
Affinity DataKi:  3.60E+3nMAssay Description:Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLactoylglutathione lyase(Homo sapiens (Human))
Chengdu University

Curated by ChEMBL
LigandPNGBDBM50241121((S)-5-((R)-3-(4-bromobenzylthio)-1-(carboxymethyla...)
Affinity DataKi:  4.30E+3nMAssay Description:Compound was evaluated for inhibition of S. cerevisiae glyoxalase-I by using enzymatic assay at each of 6 substrate concentrations between 0.1 mM and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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