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Found 494 Enz. Inhib. hit(s) with Target = 'Receptor-type tyrosine-protein phosphatase beta'
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50270587(5-(3-Cyclohexyl-4'-fluoro-2'-trifluoromethyl-biphe...)
Affinity DataKi:  220nMAssay Description:Inhibition of PtpBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50118751(6-(Oxalyl-amino)-1H-indole-7-carboxylic acid | 6-(...)
Affinity DataKi:  3.60E+3nMAssay Description:Inhibition of PTPRBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50118796(6-(OXALYL-AMINO)-1H-INDOLE-5-CARBOXYLIC ACID | 6-(...)
Affinity DataKi:  6.00E+3nMAssay Description:Inhibition of PTPRBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50118744(2-(Oxalyl-amino)-4,7-dihydro-5H-thieno[2,3-c]pyran...)
Affinity DataKi:  1.10E+4nMAssay Description:Inhibition of PTPRBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50299462(2-(3-(dihydroxymethyl)naphthalen-2-ylamino)-2-oxoa...)
Affinity DataKi:  1.40E+4nMAssay Description:Inhibition of PTPRBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50118778(5-iodo-2-(oxaloamino)benzoic acid | CHEMBL336908)
Affinity DataKi:  1.70E+4nMAssay Description:Inhibition of PTPRBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50118749(2-(Oxalyl-amino)-thiophene-3-carboxylic acid | 2-(...)
Affinity DataKi:  1.80E+4nMAssay Description:Inhibition of PTPRBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50118762(2-(Oxalyl-amino)-4,5,6,7-tetrahydro-benzo[b]thioph...)
Affinity DataKi:  1.90E+4nMAssay Description:Inhibition of PTPRBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50299461((S)-7-(1,1-Dioxo-1H-1lambda*6*-benzo[d]isothiazol-...)
Affinity DataKi:  2.10E+4nMAssay Description:Inhibition of PTPRBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50441456(CHEMBL1369374)
Affinity DataKi:  2.60E+4nMAssay Description:Noncompetitive inhibition of human GST-tagged LMW-PTP-B expressed in Escherichia coli JM 109 cells using p-nitrophenyl phosphate as substrate after 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50118789(2-(oxaloamino)benzoic acid | CHEMBL139050)
Affinity DataKi:  3.30E+4nMAssay Description:Inhibition of PTPRBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50441457(CHEMBL1358072)
Affinity DataKi:  7.32E+4nMAssay Description:Noncompetitive inhibition of human GST-tagged LMW-PTP-B expressed in Escherichia coli JM 109 cells using p-nitrophenyl phosphate as substrate after 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50312261((4-(4-bromo-3,5-bis(trifluoromethyl)phenylcarbamoy...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human PtpBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50118779(3-(Oxalyl-amino)-thiophene-2-carboxylic acid | 3-(...)
Affinity DataKi:  1.60E+5nMAssay Description:Inhibition of PTPRBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50118792(2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]P...)
Affinity DataKi:  5.60E+5nMAssay Description:Inhibition of PTPRBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM359101(US10220048, Compound AA11 | US10952992, No. AA11 |...)
Affinity DataIC50:  0.0100nMAssay Description:Non-limiting examples of the HPTP-β IC50(μM) activity for illustrative compounds are listed in TABLE 2.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM359101(US10220048, Compound AA11 | US10952992, No. AA11 |...)
Affinity DataIC50:  0.0100nMAssay Description:Non-limiting examples of the HPTP-β IC50 (μM) activity.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM359101(US10220048, Compound AA11 | US10952992, No. AA11 |...)
Affinity DataIC50:  0.0100nMAssay Description:Non-limiting examples of the HPTPβ IC50 (μM) activity.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM359101(US10220048, Compound AA11 | US10952992, No. AA11 |...)
Affinity DataIC50:  0.0100nMAssay Description:HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM359121(US10220048, Compound AA31 | US10952992, No. AA31 |...)
Affinity DataIC50:  0.0800nMAssay Description:Non-limiting examples of the HPTP-β IC50(μM) activity for illustrative compounds are listed in TABLE 2.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM359121(US10220048, Compound AA31 | US10952992, No. AA31 |...)
Affinity DataIC50:  0.0800nMAssay Description:Non-limiting examples of the HPTPβ IC50 (μM) activity.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM359106(US10220048, Compound AA16 | US10952992, No. AA16 |...)
Affinity DataIC50:  0.0800nMAssay Description:Non-limiting examples of the HPTP-β IC50(μM) activity for illustrative compounds are listed in TABLE 2.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM359106(US10220048, Compound AA16 | US10952992, No. AA16 |...)
Affinity DataIC50:  0.0800nMAssay Description:Non-limiting examples of the HPTP-β IC50 (μM) activity.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM359121(US10220048, Compound AA31 | US10952992, No. AA31 |...)
Affinity DataIC50:  0.0800nMAssay Description:Non-limiting examples of the HPTP-β IC50 (μM) activity.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM359106(US10220048, Compound AA16 | US10952992, No. AA16 |...)
Affinity DataIC50:  0.0800nMAssay Description:Non-limiting examples of the HPTPβ IC50 (μM) activity.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM359106(US10220048, Compound AA16 | US10952992, No. AA16 |...)
Affinity DataIC50:  0.0800nMAssay Description:HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM359121(US10220048, Compound AA31 | US10952992, No. AA31 |...)
Affinity DataIC50:  0.0800nMAssay Description:HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM359113(US10220048, Compound AA23 | US10952992, No. AA23 |...)
Affinity DataIC50:  0.0900nMAssay Description:Non-limiting examples of the HPTP-β IC50(μM) activity for illustrative compounds are listed in TABLE 2.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM359113(US10220048, Compound AA23 | US10952992, No. AA23 |...)
Affinity DataIC50:  0.0900nMAssay Description:Non-limiting examples of the HPTP-β IC50 (μM) activity.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM359113(US10220048, Compound AA23 | US10952992, No. AA23 |...)
Affinity DataIC50:  0.0900nMAssay Description:Non-limiting examples of the HPTPβ IC50 (μM) activity.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM359113(US10220048, Compound AA23 | US10952992, No. AA23 |...)
Affinity DataIC50:  0.0900nMAssay Description:HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM359118(US10220048, Compound AA28 | US10952992, No. AA28 |...)
Affinity DataIC50:  0.100nMAssay Description:Non-limiting examples of the HPTP-β IC50(μM) activity for illustrative compounds are listed in TABLE 2.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM359118(US10220048, Compound AA28 | US10952992, No. AA28 |...)
Affinity DataIC50:  0.100nMAssay Description:Non-limiting examples of the HPTPβ IC50 (μM) activity.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM359099(US10220048, Compound AA9 | US10952992, No. AA9 | U...)
Affinity DataIC50:  0.100nMAssay Description:Non-limiting examples of the HPTP-β IC50(μM) activity for illustrative compounds are listed in TABLE 2.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM359104(US10220048, Compound AA14 | US10952992, No. AA14 |...)
Affinity DataIC50:  0.100nMAssay Description:Non-limiting examples of the HPTP-β IC50(μM) activity for illustrative compounds are listed in TABLE 2.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM359099(US10220048, Compound AA9 | US10952992, No. AA9 | U...)
Affinity DataIC50:  0.100nMAssay Description:Non-limiting examples of the HPTP-β IC50 (μM) activity.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM359104(US10220048, Compound AA14 | US10952992, No. AA14 |...)
Affinity DataIC50:  0.100nMAssay Description:Non-limiting examples of the HPTP-β IC50 (μM) activity.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM359118(US10220048, Compound AA28 | US10952992, No. AA28 |...)
Affinity DataIC50:  0.100nMAssay Description:Non-limiting examples of the HPTP-β IC50 (μM) activity.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM359099(US10220048, Compound AA9 | US10952992, No. AA9 | U...)
Affinity DataIC50:  0.100nMAssay Description:Non-limiting examples of the HPTPβ IC50 (μM) activity.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM359104(US10220048, Compound AA14 | US10952992, No. AA14 |...)
Affinity DataIC50:  0.100nMAssay Description:Non-limiting examples of the HPTPβ IC50 (μM) activity.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM359099(US10220048, Compound AA9 | US10952992, No. AA9 | U...)
Affinity DataIC50:  0.100nMAssay Description:HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM359104(US10220048, Compound AA14 | US10952992, No. AA14 |...)
Affinity DataIC50:  0.100nMAssay Description:HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM359118(US10220048, Compound AA28 | US10952992, No. AA28 |...)
Affinity DataIC50:  0.100nMAssay Description:HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM359117(US10220048, Compound AA27 | US10952992, No. AA27 |...)
Affinity DataIC50:  0.140nMAssay Description:Non-limiting examples of the HPTP-β IC50(μM) activity for illustrative compounds are listed in TABLE 2.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM359117(US10220048, Compound AA27 | US10952992, No. AA27 |...)
Affinity DataIC50:  0.140nMAssay Description:Non-limiting examples of the HPTPβ IC50 (μM) activity.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM359117(US10220048, Compound AA27 | US10952992, No. AA27 |...)
Affinity DataIC50:  0.140nMAssay Description:Non-limiting examples of the HPTP-β IC50 (μM) activity.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM359117(US10220048, Compound AA27 | US10952992, No. AA27 |...)
Affinity DataIC50:  0.140nMAssay Description:HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM359091(US10220048, Compound AA1 | US10220048, Compound AA...)
Affinity DataIC50:  0.157nMAssay Description:Non-limiting examples of the HPTP-β IC50(μM) activity for illustrative compounds are listed in TABLE 2.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM359091(US10220048, Compound AA1 | US10220048, Compound AA...)
Affinity DataIC50:  0.157nMAssay Description:Non-limiting examples of the HPTP-β IC50 (μM) activity.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein phosphatase beta(Homo sapiens (Human))
Astex Therapeutics

Curated by ChEMBL
LigandPNGBDBM359091(US10220048, Compound AA1 | US10220048, Compound AA...)
Affinity DataIC50:  0.157nMAssay Description:HPTP-β inhibition can be tested by any method chosen by the formulator, for example, Amarasinge K. K. et al., “Design and Synthesis of Potent, N...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
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