Affinity DataKd: 3.10nMpH: 5.0 T: 2°CAssay Description:To establish binding constants for the compounds/drugs to PAI-1, an indirect approach using surface plasmon resonance (SPR) was employed. Varying con...More data for this Ligand-Target Pair
Affinity DataKd: 3.10nMpH: 7.8 T: 2°CAssay Description:Enzyme activity assay using human and murine PAI-1.More data for this Ligand-Target Pair
Affinity DataKd: 5.30nMpH: 5.0 T: 2°CAssay Description:To establish binding constants for the compounds/drugs to PAI-1, an indirect approach using surface plasmon resonance (SPR) was employed. Varying con...More data for this Ligand-Target Pair
Affinity DataKd: 5.30nMpH: 7.8 T: 2°CAssay Description:Enzyme activity assay using human and murine PAI-1.More data for this Ligand-Target Pair
Affinity DataKd: 23nMpH: 7.8 T: 2°CAssay Description:Enzyme activity assay using human and murine PAI-1.More data for this Ligand-Target Pair
Affinity DataKd: 23nMpH: 5.0 T: 2°CAssay Description:To establish binding constants for the compounds/drugs to PAI-1, an indirect approach using surface plasmon resonance (SPR) was employed. Varying con...More data for this Ligand-Target Pair
Affinity DataKd: 31nMpH: 7.8 T: 2°CAssay Description:Enzyme activity assay using human and murine PAI-1.More data for this Ligand-Target Pair
Affinity DataKd: 31nMpH: 5.0 T: 2°CAssay Description:To establish binding constants for the compounds/drugs to PAI-1, an indirect approach using surface plasmon resonance (SPR) was employed. Varying con...More data for this Ligand-Target Pair
Affinity DataKd: 51nMpH: 5.0 T: 2°CAssay Description:To establish binding constants for the compounds/drugs to PAI-1, an indirect approach using surface plasmon resonance (SPR) was employed. Varying con...More data for this Ligand-Target Pair
Affinity DataKd: 51nMpH: 7.8 T: 2°CAssay Description:Enzyme activity assay using human and murine PAI-1.More data for this Ligand-Target Pair
Affinity DataKd: 67nMpH: 5.0 T: 2°CAssay Description:To establish binding constants for the compounds/drugs to PAI-1, an indirect approach using surface plasmon resonance (SPR) was employed. Varying con...More data for this Ligand-Target Pair
Affinity DataKd: 67nMpH: 7.8 T: 2°CAssay Description:Enzyme activity assay using human and murine PAI-1.More data for this Ligand-Target Pair
Affinity DataKd: 480nMAssay Description:Binding affinity of the compound to towards NBD-labeled S119C Plasminogen activator inhibitor-1 mutant in ratMore data for this Ligand-Target Pair
Affinity DataKd: 700nMAssay Description:Allosteric inhibition of full length human plasmin by using chromogenic substrate spectrozyme PL preincubated for 5 mins followed by substrate additi...More data for this Ligand-Target Pair
Affinity DataKd: 1.00E+3nMAssay Description:Binding affinity to human plasmin assessed as loss of intrinsic tryptophan fluorescence at 250 uM by spectrofluorometric methodMore data for this Ligand-Target Pair
Affinity DataKd: 1.10E+3nMAssay Description:Binding affinity to human plasma full length Glu-plasminogen K1 domain by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Affinity DataKd: 1.10E+3nMAssay Description:Binding affinity to plasminogen K1 domain (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 1.90E+3nMAssay Description:Binding affinity to human plasmin assessed as loss of intrinsic tryptophan fluorescence at 250 uM by spectrofluorometric methodMore data for this Ligand-Target Pair
Affinity DataKd: 2.20E+3nMAssay Description:Binding affinity to human plasma N-terminal truncated Lys-plasminogen K1 domain by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Affinity DataKd: 3.60E+3nMAssay Description:Binding affinity to human dansyl-EGR-chloromethylketone-plasmin complex assessed as loss of intrinsic tryptophan fluorescence by spectrofluorometric ...More data for this Ligand-Target Pair
Affinity DataKd: 4.40E+3nMAssay Description:Allosteric inhibition of human plasmin using chromogenic substrate spectrozyme PL preincubated for 5 mins followed by substrate addition measured ove...More data for this Ligand-Target Pair
Affinity DataKd: 5.00E+3nMAssay Description:Binding affinity of compound towards latent Plasminogen activator inhibitor-1 expressed as apparent KdMore data for this Ligand-Target Pair
Affinity DataKd: 5.40E+3nMAssay Description:Allosteric inhibition of human plasmin using chromogenic substrate spectrozyme PL preincubated for 5 mins followed by substrate addition measured ove...More data for this Ligand-Target Pair
Affinity DataKd: 9.00E+3nMAssay Description:Binding affinity to human plasminogen K1 domain by ultrafiltration techniqueMore data for this Ligand-Target Pair
Affinity DataKd: 1.50E+4nMAssay Description:Binding affinity to human immobilized PAI1 by surface plasmon resonanceMore data for this Ligand-Target Pair
Affinity DataKd: 3.60E+4nMAssay Description:Binding affinity to human plasma N-terminal truncated Lys-plasminogen by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Affinity DataKd: 7.50E+5nMAssay Description:Binding affinity to human plasma full length Glu-plasminogen by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.0410nMAssay Description:Inhibition of human plasmin using Ac-RM(O2)YR-pNA as substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataKi: 0.0510nMAssay Description:Inhibition of human plasmin using Ac-RM(O2)YR-pNA as substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataKi: 0.0700nMAssay Description:Inhibition of human plasmin using Mes-DSer(Bzl)-Phe-Arg-AMC as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.0700nMAssay Description:Inhibition of human plasmin using Mes-DSer(Bzl)-Phe-Arg-AMC as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.130nMAssay Description:Inhibition of human plasmin using Mes-DSer(Bzl)-Phe-Arg-AMC as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.130nMAssay Description:Inhibition of human plasmin using Mes-DSer(Bzl)-Phe-Arg-AMC as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.140nMAssay Description:Inhibition of human plasmin using Ac-RM(O2)YR-pNA as substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataKi: 0.150nMAssay Description:Binding affinity to human plasmin assessed as slow binding constant in presence of Mes-DArg-Phe-Arg-AMC after 20 mins by Dixon plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.150nMAssay Description:Binding affinity to human plasmin assessed as slow binding constant in presence of Mes-DArg-Phe-Arg-AMC after 20 mins by Dixon plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Inhibition of human plasmin protease domain using Tos-Gly-Pro-Lys-pNA as substrate by micro plate reader analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.210nMAssay Description:Inhibition of human plasmin using Ac-RM(O2)YR-pNA as substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataKi: 0.25nMAssay Description:The inhibitory effect for the individual enzymes was determined in analogy to a previously disclosed method (Stürzebecher et al., J. Med. Chem.,...More data for this Ligand-Target Pair
Affinity DataKi: 0.25nMAssay Description:Inhibition of human plasmin using tosyl-Gly-Pro-Lys-pNA as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 0.320nMAssay Description:Inhibition of human plasmin using Mes-DSer(Bzl)-Phe-Arg-AMC as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.320nMAssay Description:Inhibition of human plasmin using Mes-DSer(Bzl)-Phe-Arg-AMC as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:The inhibitory effect for the individual enzymes was determined in analogy to a previously disclosed method (Stürzebecher et al., J. Med. Chem.,...More data for this Ligand-Target Pair
Affinity DataKi: 0.420nMAssay Description:Binding affinity to human plasmin assessed as slow binding constant in presence of Mes-DArg-Phe-Arg-AMC after 20 mins by Dixon plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.420nMAssay Description:Binding affinity to human plasmin assessed as slow binding constant in presence of Mes-DArg-Phe-Arg-AMC after 20 mins by Dixon plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.430nMAssay Description:Binding affinity to human plasmin assessed as slow binding constant in presence of Mes-DArg-Phe-Arg-AMC after 20 mins by Dixon plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.430nMAssay Description:Binding affinity to human plasmin assessed as slow binding constant in presence of Mes-DArg-Phe-Arg-AMC after 20 mins by Dixon plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.450nMAssay Description:Inhibition of human plasmin using Mes-DSer(Bzl)-Phe-Arg-AMC as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.450nMAssay Description:Inhibition of human plasmin using Ac-RM(O2)YR-pNA as substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataKi: 0.450nMAssay Description:Inhibition of human plasmin using Mes-DSer(Bzl)-Phe-Arg-AMC as substrate by Dixon plot analysisMore data for this Ligand-Target Pair