Compile Data Set for Download or QSAR
maximum 50k data
Found 4248 Enz. Inhib. hit(s) with Target = 'Substance-P receptor'
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50413891(VESTIPITANT)
Affinity DataKd:  0.0302nMAssay Description:Binding affinity to human recombinant NK1 receptor expressed in CHO cells assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Rattus norvegicus (rat))
Rochester

Curated by ChEMBL
LigandPNGBDBM50002462(1,3-Diethyl-2-[3-(1,3,3-trimethyl-1,3-dihydro-indo...)
Affinity DataKd:  0.180nMAssay Description:Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(GUINEA PIG)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50000041((+) (2-Methoxy-benzyl)-(2-phenyl-piperidin-3-yl)-a...)
Affinity DataKd:  0.320nMAssay Description:Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigMore data for this Ligand-Target Pair
TargetSubstance-P receptor(Rattus norvegicus (rat))
Rochester

Curated by ChEMBL
LigandPNGBDBM50002462(1,3-Diethyl-2-[3-(1,3,3-trimethyl-1,3-dihydro-indo...)
Affinity DataKd:  0.970nMAssay Description:Scatchard analysis at concentration of the 1 uM :Apparent affinity constant (Kd) against tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Rattus norvegicus (rat))
Rochester

Curated by ChEMBL
LigandPNGBDBM50002462(1,3-Diethyl-2-[3-(1,3,3-trimethyl-1,3-dihydro-indo...)
Affinity DataKd:  1.5nMAssay Description:Scatchard analysis at concentration of the 10 uM :Apparent affinity constant (Kd) against tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50346328((S)-2-(4-acetamido-3-oxo-4,5-dihydro-1H-benzo[c]az...)
Affinity DataKd:  3.98nMAssay Description:Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine lumines...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50000040(((2S,3S)-2-Benzhydryl-1-aza-bicyclo[2.2.2]oct-3-yl...)
Affinity DataKd:  5.37nMAssay Description:Competitive inhibition of wild type human NK1 receptor expressed in HEK293 cells assessed as decrease in SP1-induced [3H]IP accumulation after 20 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50346329((R)-2-((S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl...)
Affinity DataKd:  15.8nMAssay Description:Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine lumines...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50346326((S)-2-acetyl-N-(3,5-bis(trifluoromethyl)benzyl)-N-...)
Affinity DataKd:  31.6nMAssay Description:Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine lumines...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(GUINEA PIG)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50403168(CHEMBL367312)
Affinity DataKd:  39.8nMAssay Description:The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle str...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(GUINEA PIG)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50406736(CHEMBL406142)
Affinity DataKd:  100nMAssay Description:Tested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(GUINEA PIG)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50403167(CHEMBL172794)
Affinity DataKd:  126nMAssay Description:The compound was evaluated in vitro for the antagonistic activity against Tachykinin receptor 1 in guinea pig myenteric plexus longitudinal muscle st...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(GUINEA PIG)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50403165(CHEMBL424567)
Affinity DataKd:  200nMAssay Description:The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle str...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(GUINEA PIG)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50406739(CHEMBL266884)
Affinity DataKd:  251nMAssay Description:Tested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50289765(CHEMBL292816 | Tributyl-{4-[(R)-2-(N',N''-dicycloh...)
Affinity DataKd:  290nMAssay Description:Binding affinity towards Tachykinin receptor 1, activity expressed as KdMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50289769(CHEMBL555236 | Tributyl-{4-[(R)-2-(N',N''-dicycloh...)
Affinity DataKd:  370nMAssay Description:Binding affinity towards Tachykinin receptor 1, activity expressed as KdMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(GUINEA PIG)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50403166(CHEMBL170299)
Affinity DataKd:  398nMAssay Description:The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle str...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(GUINEA PIG)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50403170(CHEMBL435717)
Affinity DataKd:  501nMAssay Description:The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle str...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50289768(CHEMBL294452 | Tributyl-{4-[(S)-2-(N',N''-dicycloh...)
Affinity DataKd:  540nMAssay Description:Binding affinity towards Tachykinin receptor 1, activity expressed as KdMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50346327((S)-2-(4-acetamido-3-oxo-4,5-dihydro-1H-benzo[c]az...)
Affinity DataKd:  631nMAssay Description:Antagonist activity at human NK1 receptor expressed in CHO-K1 cells assessed as inhibition of substance P-induced calcium-dependent aequorine lumines...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50289776(CHEMBL539631 | Tributyl-{4-[(S)-2-(N',N''-dicycloh...)
Affinity DataKd:  670nMAssay Description:Binding affinity towards Tachykinin receptor 1, activity expressed as KdMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50289775((R)-2-(N',N''-Dicyclohexyl-guanidino)-N-(4-guanidi...)
Affinity DataKd:  860nMAssay Description:Binding affinity towards Tachykinin receptor 1, activity expressed as KdMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50289778((S)-2-(N',N''-Dicyclohexyl-guanidino)-N-(4-guanidi...)
Affinity DataKd:  1.10E+3nMAssay Description:Binding affinity towards Tachykinin receptor 1, activity expressed as KdMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(GUINEA PIG)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50403169(CHEMBL405167)
Affinity DataKd:  1.26E+3nMAssay Description:The compound was evaluated in vitro for the antagonistic activity against substance P receptor in guinea pig myenteric plexus longitudinal muscle str...More data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50289770((S)-N-(4-Aminomethyl-phenyl)-2-(N',N''-dicyclohexy...)
Affinity DataKd:  1.30E+3nMAssay Description:Binding affinity towards Tachykinin receptor 1, activity expressed as KdMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50289766(CHEMBL555235 | Tributyl-{4-[(S)-2-(3-cyclohexyl-ur...)
Affinity DataKd:  1.30E+3nMAssay Description:Binding affinity towards Tachykinin receptor 1, activity expressed as KdMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50289763(1N-{4-[1-cyclohexylamino(cyclohexylimino)methylami...)
Affinity DataKd:  1.50E+3nMAssay Description:Binding affinity towards Tachykinin receptor 1, activity expressed as KdMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50289777((S)-2-(N',N''-Dicyclohexyl-guanidino)-N-[4-(N',N''...)
Affinity DataKd:  1.80E+3nMAssay Description:Binding affinity towards Tachykinin receptor 1, activity expressed as KdMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(GUINEA PIG)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50406733(CHEMBL2370702)
Affinity DataKd:  2.00E+3nMAssay Description:Tested for antagonist activity toward NK-1 receptor in guinea pig ileum against the agonist eledoisin (mean +/-, n=4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50289772(5-Aminomethyl-2-[(S)-2-(N',N''-dicyclohexyl-guanid...)
Affinity DataKd:  3.80E+3nMAssay Description:Binding affinity towards Tachykinin receptor 1, activity expressed as KdMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50295070((S)-1-((2S,5S,11R,14S)-14-amino-5-benzyl-15-(4-hyd...)
Affinity DataKi:  0.00110nMAssay Description:Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50295070((S)-1-((2S,5S,11R,14S)-14-amino-5-benzyl-15-(4-hyd...)
Affinity DataKi:  0.00110nMAssay Description:Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50295069((S)-1-((2S,5S,11R,14S)-14-amino-5-benzyl-2-butyl-1...)
Affinity DataKi:  0.00280nMAssay Description:Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50295069((S)-1-((2S,5S,11R,14S)-14-amino-5-benzyl-2-butyl-1...)
Affinity DataKi:  0.00280nMAssay Description:Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50498577(CHEMBL3609619)
Affinity DataKi:  0.00400nMAssay Description:Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50498575(CHEMBL3608939)
Affinity DataKi:  0.00400nMAssay Description:Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM86055(SSR240600)
Affinity DataKi:  0.00430nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50323869((S)-1-((4S,7S,13R)-13-((S)-2-amino-3-(4-hydroxyphe...)
Affinity DataKi:  0.00530nMAssay Description:Displacement of [3H]substance P frome human NK1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50323869((S)-1-((4S,7S,13R)-13-((S)-2-amino-3-(4-hydroxyphe...)
Affinity DataKi:  0.00530nMAssay Description:Displacement of [3H]substance P frome human NK1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50439327(CHEMBL2419544)
Affinity DataKi:  0.00570nMAssay Description:Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM86055(SSR240600)
Affinity DataKi:  0.00610nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264406((S)-1-((2S,5S,11R,14S)-14-amino-5-benzyl-15-(4-hyd...)
Affinity DataKi:  0.00650nMAssay Description:Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264406((S)-1-((2S,5S,11R,14S)-14-amino-5-benzyl-15-(4-hyd...)
Affinity DataKi:  0.00650nMAssay Description:Displacement of [3H]substance P frome human NK1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264406((S)-1-((2S,5S,11R,14S)-14-amino-5-benzyl-15-(4-hyd...)
Affinity DataKi:  0.00700nMAssay Description:Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264406((S)-1-((2S,5S,11R,14S)-14-amino-5-benzyl-15-(4-hyd...)
Affinity DataKi:  0.00700nMAssay Description:Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50341318((S)-1-((2S,5S,11R,14S)-14-amino-5-benzyl-15-(4-hyd...)
Affinity DataKi:  0.00790nMAssay Description:Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50341318((S)-1-((2S,5S,11R,14S)-14-amino-5-benzyl-15-(4-hyd...)
Affinity DataKi:  0.00790nMAssay Description:Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50439329(CHEMBL2419542)
Affinity DataKi:  0.00900nMAssay Description:Displacement of [3H]substance P from human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50498573(CHEMBL3609620)
Affinity DataKi:  0.0160nMAssay Description:Displacement of [3H]-substance P from human NK1 receptor transfected in CHO cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50186527((R)-3-((1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)m...)
Affinity DataKi:  0.0200nMAssay Description:Displacement of [3H]Sar-Met substance P from human recombinant NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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