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Found 1241 Enz. Inhib. hit(s) with Target = 'Thromboxane-A synthase'
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50071137((Z)-7-{3-[(R)-4-(4-Cyclohexyl-butylcarbamoyl)-4,5-...)
Affinity DataKd:  452nMAssay Description:In vitro inhibition of thromboxane synthase (TSI) activity was determined by using human serum levels of TXB2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(MOUSE)
Kyoto University

Curated by PDSP Ki Database
LigandPNGBDBM50008780(7-{3-[3-Hydroxy-4-(4-iodo-phenoxy)-but-1-enyl]-7-o...)
Affinity DataKi:  0.560nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(MOUSE)
Kyoto University

Curated by PDSP Ki Database
LigandPNGBDBM50008805(7-(3-Benzenesulfonylamino-bicyclo[2.2.1]hept-2-yl)...)
Affinity DataKi:  0.680nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50188619(1-(2-(p-toluidino)-5-nitrophenylsulfonyl)-3-tert-b...)
Affinity DataKi:  1.10nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50167939(3,4-DNH | 5-Hydroxy Tryptamine | BM 613 | Benzen |...)
Affinity DataKi:  2.10nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(MOUSE)
Kyoto University

Curated by PDSP Ki Database
LigandPNGBDBM50283049((Z)-7-[(1R,2R,3S,5S)-5-(Biphenyl-4-ylmethoxy)-3-hy...)
Affinity DataKi:  12nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(MOUSE)
Kyoto University

Curated by PDSP Ki Database
LigandPNGBDBM50008781(7-(3-(2-ethyl-N-phenylhydrazinecarboxamide)-7-oxa-...)
Affinity DataKi:  13nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(MOUSE)
Kyoto University

Curated by PDSP Ki Database
LigandPNGBDBM81948(CAS_89617-02-7 | ONO 11,113 | ONO-11113 | STA2)
Affinity DataKi:  14nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(MOUSE)
Kyoto University

Curated by PDSP Ki Database
LigandPNGBDBM50018531((Z)-7-[(S)-6-((E)-(S)-3-Hydroxy-oct-1-enyl)-2-oxa-...)
Affinity DataKi:  67nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(MOUSE)
Kyoto University

Curated by PDSP Ki Database
LigandPNGBDBM85177(CAS_80558-61-8 | M&B-28767 | NSC_119139)
Affinity DataKi:  1.30E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM86692(K117)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM86693(K376)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM86691(K604)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(BOVINE)
Columbia University

Curated by PDSP Ki Database
LigandPNGBDBM86757(CAS_0 | NSC_11603174 | [11C]MMP)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM10024(5-(1H-imidazol-1-ylmethyl)-5,6,7,8-tetrahydroquino...)
Affinity DataIC50:  2.00E+3nMAssay Description:Thromboxane A2 synthase activity was assayed by measuring the fragmentation of prostaglandin H2 to form 12-hydroxy-5, 8,10-heptadecatrienoic acid and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM10025(5-(1H-imidazol-1-ylmethyl)-7,8-dihydroquinoline | ...)
Affinity DataIC50:  1.50E+3nMAssay Description:Thromboxane A2 synthase activity was assayed by measuring the fragmentation of prostaglandin H2 to form 12-hydroxy-5, 8,10-heptadecatrienoic acid and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM10026(5-[2-(1H-imidazol-1-yl)ethyl]-5,6,7,8-tetrahydroqu...)
Affinity DataIC50:  630nMAssay Description:Thromboxane A2 synthase activity was assayed by measuring the fragmentation of prostaglandin H2 to form 12-hydroxy-5, 8,10-heptadecatrienoic acid and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM10027(5-[2-(1H-imidazol-1-yl)ethyl]-7,8-dihydroquinoline...)
Affinity DataIC50:  290nMAssay Description:Thromboxane A2 synthase activity was assayed by measuring the fragmentation of prostaglandin H2 to form 12-hydroxy-5, 8,10-heptadecatrienoic acid and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM10028(5-[2-(1H-imidazol-1-yl)ethyl]quinoline | 5-[2-(Imi...)
Affinity DataIC50:  1.20E+3nMAssay Description:Thromboxane A2 synthase activity was assayed by measuring the fragmentation of prostaglandin H2 to form 12-hydroxy-5, 8,10-heptadecatrienoic acid and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM10029(1-[2-(1,2,3,4-tetrahydronaphthalen-1-yl)ethyl]-1H-...)
Affinity DataIC50:  3.40E+3nMAssay Description:Thromboxane A2 synthase activity was assayed by measuring the fragmentation of prostaglandin H2 to form 12-hydroxy-5, 8,10-heptadecatrienoic acid and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM10030(5-[3-(1H-imidazol-1-yl)propyl]-5,6,7,8-tetrahydroq...)
Affinity DataIC50:  2.30E+3nMAssay Description:Thromboxane A2 synthase activity was assayed by measuring the fragmentation of prostaglandin H2 to form 12-hydroxy-5, 8,10-heptadecatrienoic acid and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM10031(5-[3-(1H-imidazol-1-yl)propyl]-7,8-dihydroquinolin...)
Affinity DataIC50:  680nMAssay Description:Thromboxane A2 synthase activity was assayed by measuring the fragmentation of prostaglandin H2 to form 12-hydroxy-5, 8,10-heptadecatrienoic acid and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM10032(1-[2-(4,5,6,7-Tetrahydrobenzo[b]furan-4-yl)ethyl]-...)
Affinity DataIC50:  1.01E+3nMAssay Description:Thromboxane A2 synthase activity was assayed by measuring the fragmentation of prostaglandin H2 to form 12-hydroxy-5, 8,10-heptadecatrienoic acid and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM10033(1-[2-(4,5,6,7-Tetrahydrobenzo[b]thiophen-4-yl)ethy...)
Affinity DataIC50:  1.23E+3nMAssay Description:Thromboxane A2 synthase activity was assayed by measuring the fragmentation of prostaglandin H2 to form 12-hydroxy-5, 8,10-heptadecatrienoic acid and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM10034(1-[(2E)-2-(6,7-dihydro-1-benzofuran-4(5H)-ylidene)...)
Affinity DataIC50:  3.55E+3nMAssay Description:Thromboxane A2 synthase activity was assayed by measuring the fragmentation of prostaglandin H2 to form 12-hydroxy-5, 8,10-heptadecatrienoic acid and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM10035(1-[(2Z)-2-(6,7-dihydro-1-benzofuran-4(5H)-ylidene)...)
Affinity DataIC50:  4.10E+3nMAssay Description:Thromboxane A2 synthase activity was assayed by measuring the fragmentation of prostaglandin H2 to form 12-hydroxy-5, 8,10-heptadecatrienoic acid and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM10036(1-[(2E)-2-(6,7-dihydro-1-benzothien-4(5H)-ylidene)...)
Affinity DataIC50:  1.70E+3nMAssay Description:Thromboxane A2 synthase activity was assayed by measuring the fragmentation of prostaglandin H2 to form 12-hydroxy-5, 8,10-heptadecatrienoic acid and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM10037(1-[(2Z)-2-(6,7-dihydro-1-benzothien-4(5H)-ylidene)...)
Affinity DataIC50:  1.26E+3nMAssay Description:Thromboxane A2 synthase activity was assayed by measuring the fragmentation of prostaglandin H2 to form 12-hydroxy-5, 8,10-heptadecatrienoic acid and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM10038(1-[2-(1-benzothiophen-4-yl)ethyl]-1H-imidazole | 1...)
Affinity DataIC50:  5.30E+3nMAssay Description:Thromboxane A2 synthase activity was assayed by measuring the fragmentation of prostaglandin H2 to form 12-hydroxy-5, 8,10-heptadecatrienoic acid and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM10023(5-(1H-imidazol-1-yl)-5,6,7,8-tetrahydroquinoline |...)
Affinity DataAssay Description:Thromboxane A2 synthase activity was assayed by measuring the fragmentation of prostaglandin H2 to form 12-hydroxy-5, 8,10-heptadecatrienoic acid and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM10039(8-(1H-imidazol-1-yl)-5,6,7,8-tetrahydroquinoline |...)
Affinity DataAssay Description:Thromboxane A2 synthase activity was assayed by measuring the fragmentation of prostaglandin H2 to form 12-hydroxy-5, 8,10-heptadecatrienoic acid and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM10040(6-(1H-imidazol-1-yl)isoquinoline | 6-(Imidazol-1-y...)
Affinity DataAssay Description:Thromboxane A2 synthase activity was assayed by measuring the fragmentation of prostaglandin H2 to form 12-hydroxy-5, 8,10-heptadecatrienoic acid and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM10041(7-(1H-imidazol-1-ylmethyl)isoquinoline | 7-[(Imida...)
Affinity DataIC50:  5.40E+3nMAssay Description:Thromboxane A2 synthase activity was assayed by measuring the fragmentation of prostaglandin H2 to form 12-hydroxy-5, 8,10-heptadecatrienoic acid and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM7962(4-(2-Imidazol-1-yl-ethoxy)-benzoic acid; hydrochlo...)
Affinity DataIC50:  1.10E+3nMAssay Description:Thromboxane A2 synthase activity was assayed by measuring the fragmentation of prostaglandin H2 to form 12-hydroxy-5, 8,10-heptadecatrienoic acid and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50000308(6-(Imidazol-1-yl-phenyl-methyl)-3,4-dihydro-1H-qui...)
Affinity DataIC50:  350nMAssay Description:Compound was evaluated for the inhibition of human blood platelet,thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50000309(6-Imidazol-1-yl-3,4-dihydro-1H-quinolin-2-one | CH...)
Affinity DataIC50:  2.00E+3nMAssay Description:Compound was evaluated for the inhibition of human blood platelet,thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50000310(6-(2-Imidazol-1-yl-vinyl)-3,4-dihydro-1H-quinolin-...)
Affinity DataIC50:  1.20E+3nMAssay Description:Compound was evaluated for the inhibition of human blood platelet thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50000318(6-(2-Imidazol-1-yl-vinyl)-1H-quinolin-2-one | CHEM...)
Affinity DataIC50:  380nMAssay Description:Compound was evaluated for the inhibition of human blood platelet,thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50000306(6-Pyridin-3-yl-3,4-dihydro-1H-quinolin-2-one | 6-P...)
Affinity DataIC50:  540nMAssay Description:Compound was evaluated for the inhibition of human blood platelet,thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50000328(6-(1-Imidazol-1-ylmethyl-hexyl)-3,4-dihydro-1H-qui...)
Affinity DataIC50:  2.50E+4nMAssay Description:Compound was evaluated for the inhibition of human blood platelet thromboxane A2 synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Rattus norvegicus)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50002753(11-[2-(2,6-Dimethoxy-benzoylamino)-ethylsulfanyl]-...)
Affinity DataIC50:  850nMAssay Description:Inhibitory effect of the compound against thromboxane A2 synthase binding to bovine plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Rattus norvegicus)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50002754(11-[2-(Pyridine-3-sulfonylamino)-ethylsulfanyl]-6,...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibitory effect of the compound against thromboxane A2 synthase binding to bovine plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50002755(11-[2-(Benzenesulfonyl-methyl-amino)-ethylsulfanyl...)
Affinity DataIC50:  2.20E+3nMAssay Description:Compound was tested for its inhibitory activity against TXA2 synthase obtained from bovine platelet microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Rattus norvegicus)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50002762(11-(2-Benzenesulfonylamino-ethylsulfanyl)-6,11-dih...)
Affinity DataIC50:  370nMAssay Description:Inhibitory effect of the compound against thromboxane A2 synthase binding to bovine plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50002754(11-[2-(Pyridine-3-sulfonylamino)-ethylsulfanyl]-6,...)
Affinity DataIC50:  1.40E+3nMAssay Description:Compound was tested for its inhibitory activity against TXA2 synthase obtained from bovine platelet microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Rattus norvegicus)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50002767(11-[2-(3-Phenyl-ureido)-ethylsulfanyl]-6,11-dihydr...)
Affinity DataIC50:  830nMAssay Description:Inhibitory effect of the compound against thromboxane A2 synthase binding to bovine plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Rattus norvegicus)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50002755(11-[2-(Benzenesulfonyl-methyl-amino)-ethylsulfanyl...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibitory effect of the compound against thromboxane A2 synthase binding to bovine plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50002762(11-(2-Benzenesulfonylamino-ethylsulfanyl)-6,11-dih...)
Affinity DataIC50:  370nMAssay Description:Compound was tested for its inhibitory activity against TXA2 synthase obtained from bovine platelet microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50008791(7-(3-Pyridin-3-yl-7-oxa-bicyclo[2.2.1]hept-2-yl)-h...)
Affinity DataIC50: >2.00E+3nMAssay Description:In vitro inhibition of thromboxane synthase using [14C]-arachidonic acidMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50008794(6-(3-Pyridin-3-yl-bicyclo[2.2.1]hept-2-yl)-hex-4-e...)
Affinity DataIC50:  29nMAssay Description:In vitro inhibition of thromboxane synthase using [14C]-arachidonic acidMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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