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Found 606 Enz. Inhib. hit(s) with Target = 'Ubiquitin carboxyl-terminal hydrolase 2'
TargetUbiquitin carboxyl-terminal hydrolase 2(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50458416(CHEMBL1230155)
Affinity DataKd:  9.00E+5nMAssay Description:Binding affinity to 15N-Gly/Cys/Ser/Trp-labeled human USP2a expressed in Escherichia coli BL21(DE3) assessed as change in chemical shift by NMR metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2 [258-605](Homo sapiens (Human))
Jagiellonian University

LigandPNGBDBM50236238((3alpha,5beta)-3-hydroxycholan-24-oic acid | 3alph...)
Affinity DataIC50:  3.11E+4nMAssay Description:The assays were performed using Infinite 200 PRO - Tecan plate reader and 96-well, black Greiner microplates in a 100 ml reaction volume. The assays ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2 [258-605](Homo sapiens (Human))
Jagiellonian University

LigandPNGBDBM223972(LCACN)
Affinity DataIC50:  7.40E+3nMAssay Description:The assays were performed using Infinite 200 PRO - Tecan plate reader and 96-well, black Greiner microplates in a 100 ml reaction volume. The assays ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2 [258-605](Homo sapiens (Human))
Jagiellonian University

LigandPNGBDBM223973(LCAE)
Affinity DataIC50:  5.80E+3nMAssay Description:The assays were performed using Infinite 200 PRO - Tecan plate reader and 96-well, black Greiner microplates in a 100 ml reaction volume. The assays ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2 [258-605](Homo sapiens (Human))
Jagiellonian University

LigandPNGBDBM50375588(CHEMBL258818 | LCAGLY)
Affinity DataIC50: >5.00E+4nMAssay Description:The assays were performed using Infinite 200 PRO - Tecan plate reader and 96-well, black Greiner microplates in a 100 ml reaction volume. The assays ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2 [258-605](Homo sapiens (Human))
Jagiellonian University

LigandPNGBDBM50375581(CHEMBL410893 | LCAK)
Affinity DataIC50:  3.20E+4nMAssay Description:The assays were performed using Infinite 200 PRO - Tecan plate reader and 96-well, black Greiner microplates in a 100 ml reaction volume. The assays ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2 [258-605](Homo sapiens (Human))
Jagiellonian University

LigandPNGBDBM50375564(CHEMBL260735 | LCAME)
Affinity DataIC50: >5.00E+4nMAssay Description:The assays were performed using Infinite 200 PRO - Tecan plate reader and 96-well, black Greiner microplates in a 100 ml reaction volume. The assays ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2 [258-605](Homo sapiens (Human))
Jagiellonian University

LigandPNGBDBM223974(LCAMR)
Affinity DataIC50: >1.00E+5nMAssay Description:The assays were performed using Infinite 200 PRO - Tecan plate reader and 96-well, black Greiner microplates in a 100 ml reaction volume. The assays ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2 [258-605](Homo sapiens (Human))
Jagiellonian University

LigandPNGBDBM223975(LCANH2)
Affinity DataIC50:  2.79E+4nMAssay Description:The assays were performed using Infinite 200 PRO - Tecan plate reader and 96-well, black Greiner microplates in a 100 ml reaction volume. The assays ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2 [258-605](Homo sapiens (Human))
Jagiellonian University

LigandPNGBDBM223976(LCAHA)
Affinity DataIC50:  9.70E+3nMAssay Description:The assays were performed using Infinite 200 PRO - Tecan plate reader and 96-well, black Greiner microplates in a 100 ml reaction volume. The assays ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2 [258-605](Homo sapiens (Human))
Jagiellonian University

LigandPNGBDBM223978(NSC 632839)
Affinity DataIC50:  3.91E+4nMAssay Description:The assays were performed using Infinite 200 PRO - Tecan plate reader and 96-well, black Greiner microplates in a 100 ml reaction volume. The assays ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2 [258-605](Homo sapiens (Human))
Jagiellonian University

LigandPNGBDBM50236238((3alpha,5beta)-3-hydroxycholan-24-oic acid | 3alph...)
Affinity DataIC50:  3.20E+4nMAssay Description:The assays were performed using Infinite 200 PRO - Tecan plate reader and 96-well, black Greiner microplates in a 100 ml reaction volume. The assays ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2 [258-605](Homo sapiens (Human))
Jagiellonian University

LigandPNGBDBM21680((4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R,16S)-5,9,1...)
Affinity DataIC50: >1.00E+5nMAssay Description:The assays were performed using Infinite 200 PRO - Tecan plate reader and 96-well, black Greiner microplates in a 100 ml reaction volume. The assays ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2 [258-605](Homo sapiens (Human))
Jagiellonian University

LigandPNGBDBM223972(LCACN)
Affinity DataIC50:  1.39E+4nMAssay Description:The assays were performed using Infinite 200 PRO - Tecan plate reader and 96-well, black Greiner microplates in a 100 ml reaction volume. The assays ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2 [258-605](Homo sapiens (Human))
Jagiellonian University

LigandPNGBDBM223973(LCAE)
Affinity DataIC50:  3.30E+3nMAssay Description:The assays were performed using Infinite 200 PRO - Tecan plate reader and 96-well, black Greiner microplates in a 100 ml reaction volume. The assays ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2 [258-605](Homo sapiens (Human))
Jagiellonian University

LigandPNGBDBM50375588(CHEMBL258818 | LCAGLY)
Affinity DataIC50: >5.00E+4nMAssay Description:The assays were performed using Infinite 200 PRO - Tecan plate reader and 96-well, black Greiner microplates in a 100 ml reaction volume. The assays ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2 [258-605](Homo sapiens (Human))
Jagiellonian University

LigandPNGBDBM50375581(CHEMBL410893 | LCAK)
Affinity DataIC50:  3.31E+4nMAssay Description:The assays were performed using Infinite 200 PRO - Tecan plate reader and 96-well, black Greiner microplates in a 100 ml reaction volume. The assays ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2 [258-605](Homo sapiens (Human))
Jagiellonian University

LigandPNGBDBM50375564(CHEMBL260735 | LCAME)
Affinity DataIC50: >5.00E+4nMAssay Description:The assays were performed using Infinite 200 PRO - Tecan plate reader and 96-well, black Greiner microplates in a 100 ml reaction volume. The assays ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2 [258-605](Homo sapiens (Human))
Jagiellonian University

LigandPNGBDBM223974(LCAMR)
Affinity DataIC50: >1.00E+5nMAssay Description:The assays were performed using Infinite 200 PRO - Tecan plate reader and 96-well, black Greiner microplates in a 100 ml reaction volume. The assays ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2 [258-605](Homo sapiens (Human))
Jagiellonian University

LigandPNGBDBM223975(LCANH2)
Affinity DataIC50:  1.67E+4nMAssay Description:The assays were performed using Infinite 200 PRO - Tecan plate reader and 96-well, black Greiner microplates in a 100 ml reaction volume. The assays ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2 [258-605](Homo sapiens (Human))
Jagiellonian University

LigandPNGBDBM223976(LCAHA)
Affinity DataIC50:  3.70E+3nMAssay Description:The assays were performed using Infinite 200 PRO - Tecan plate reader and 96-well, black Greiner microplates in a 100 ml reaction volume. The assays ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2 [258-605](Homo sapiens (Human))
Jagiellonian University

LigandPNGBDBM223977(TCAS)
Affinity DataIC50: >1.00E+5nMAssay Description:The assays were performed using Infinite 200 PRO - Tecan plate reader and 96-well, black Greiner microplates in a 100 ml reaction volume. The assays ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2 [258-605](Homo sapiens (Human))
Jagiellonian University

LigandPNGBDBM53721((4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-10,13-dim...)
Affinity DataIC50: >1.00E+5nMAssay Description:The assays were performed using Infinite 200 PRO - Tecan plate reader and 96-well, black Greiner microplates in a 100 ml reaction volume. The assays ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2 [258-605](Homo sapiens (Human))
Jagiellonian University

LigandPNGBDBM223978(NSC 632839)
Affinity DataIC50: >5.00E+4nMAssay Description:The assays were performed using Infinite 200 PRO - Tecan plate reader and 96-well, black Greiner microplates in a 100 ml reaction volume. The assays ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM205457((2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9...)
Affinity DataIC50:  2.87E+4nMpH: 7.5 T: 2°CAssay Description:Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50242207(CHEMBL455364 | Mangiferin)
Affinity DataIC50:  6.78E+4nMpH: 7.5 T: 2°CAssay Description:Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50442907(Acetyl Isogambogic Acid | CHEMBL3039433)
Affinity DataIC50:  1.82E+4nMpH: 7.5 T: 2°CAssay Description:Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM200235(Rifampicin | cid_5381226)
Affinity DataIC50:  2.12E+4nMpH: 7.5 T: 2°CAssay Description:Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM65524((-)-Aricine | Heterophylline (VAN) | Quinovatine)
Affinity DataIC50: >1.14E+5nMpH: 7.5 T: 2°CAssay Description:Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50069762(CHEMBL3182437 | ML323 | US9802904, 87)
Affinity DataIC50: >1.14E+5nMpH: 7.5 T: 2°CAssay Description:Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50007788(CHEMBL3233809 | med.21724, Compound 167)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human USP2 using Ub-rhodamine 110 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 20(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50007788(CHEMBL3233809 | med.21724, Compound 167)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human USP20 using Ub-rhodamine 110 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 20(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50007790(CHEMBL3233814 | med.21724, Compound 169)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human USP20 using Ub-rhodamine 110 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 20(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50007791(CHEMBL3233815 | med.21724, Compound 168)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human USP20 using Ub-rhodamine 110 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 21(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50007789(CHEMBL1173044 | GRL-0667 | N-(2H-1,3-benzodioxol-5...)
Affinity DataIC50: >3.10E+4nMAssay Description:Inhibition of human USP21 using Ub-rhodamine 110 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 21(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50007788(CHEMBL3233809 | med.21724, Compound 167)
Affinity DataIC50: >3.10E+4nMAssay Description:Inhibition of human USP21 using Ub-rhodamine 110 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 21(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50007790(CHEMBL3233814 | med.21724, Compound 169)
Affinity DataIC50: >3.10E+4nMAssay Description:Inhibition of human USP21 using Ub-rhodamine 110 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 21(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50007791(CHEMBL3233815 | med.21724, Compound 168)
Affinity DataIC50: >3.10E+4nMAssay Description:Inhibition of human USP21 using Ub-rhodamine 110 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50072959(CHEMBL3410535)
Affinity DataIC50:  3.26E+4nMAssay Description:Inhibition of USP2 catalytic domain (unknown origin) expressed in bacteria using Ub-AMC as substrate preincubated for 30 mins before substrate additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 21(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50436152(SPONGIACIDIN C)
Affinity DataIC50:  1.66E+4nMAssay Description:Inhibition of core catalytic domain of USP21 (unknown origin) using ubiquitin-Rh110 as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50436152(SPONGIACIDIN C)
Affinity DataIC50: >3.16E+4nMAssay Description:Inhibition of core catalytic domain of USP2 (unknown origin) using diubiquitin IQF K4804 as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM217379(CDDO-Me, 2)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition of USP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50269827(CHEMBL4089822)
Affinity DataIC50:  6.61E+4nMAssay Description:Inhibition of recombinant human N-terminal His-tagged USP2 catalytic domain (258 to 605 residues) expressed in Escherichia coli BL21(DE3) using human...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 25(Homo sapiens)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50279687(CHEMBL4174196)
Affinity DataIC50:  200nMAssay Description:Compound was evaluated for the inhibition of dihydrofolate reductase (DHFR) derived from Chicken liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 25(Homo sapiens)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM478031(BDBM50279688 | US10889592, Compound I-12 | US11325...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of recombinant human His6-tagged USP25 expressed in baculovirus infected Sf21 insect cells using Ub-Rh110 as substrate pretreated for 30 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 25(Homo sapiens)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50279691(CHEMBL4160957 | US10889592, Compound I-13 | US1132...)
Affinity DataIC50:  2.00E+3nMAssay Description:Compound was evaluated for the inhibition of dihydrofolate reductase (DHFR) derived from Lactobacillus casei ATCC 7469More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 25(Homo sapiens)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50279692(CHEMBL4159041 | US10889592, Compound I-4 | US11325...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of recombinant human His6-tagged USP25 expressed in baculovirus infected Sf21 insect cells using Ub-Rh110 as substrate pretreated for 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 25(Homo sapiens)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50279693(CHEMBL4169696)
Affinity DataIC50: <200nMAssay Description:Compound was evaluated for the inhibition of dihydrofolate reductase (DHFR) derived from Chicken liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50458415(CHEMBL567508 | EN300-02284)
Affinity DataIC50:  8.70E+3nMAssay Description:Inhibition of human USP2a (258 to 605 residues) expressed in Escherichia coli BL21(DE3) using Ub-AMC as substrate incubated for 30 mins measured at 3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 2(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50458417(CHEMBL4203489)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human USP2a (258 to 605 residues) expressed in Escherichia coli BL21(DE3) using Ub-AMC as substrate incubated for 30 mins measured at 3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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