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Found 419 Enz. Inhib. hit(s) with Target = 'Alpha-synuclein'
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM170546(US9085549, 57 | US9085549, 64)
Affinity DataKi:  89nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM170553(US9085549, 58)
Affinity DataKi:  105nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM170546(US9085549, 57 | US9085549, 64)
Affinity DataKi:  124nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM170556(US9085549, 66)
Affinity DataKi:  135nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM170564(US9085549, 82)
Affinity DataKi:  177nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM170562(US9085549, 76)
Affinity DataKi:  219nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM170545(US9085549, 86)
Affinity DataKi:  224nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM170561(US9085549, 72)
Affinity DataKi:  270nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM170547(US9085549, 63)
Affinity DataKi:  283nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM170565(US9085549, 83)
Affinity DataKi:  330nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM170563(US9085549, 78)
Affinity DataKi:  330nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM170551(US9085549, 55)
Affinity DataKi:  370nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM170557(US9085549, 67)
Affinity DataKi:  466nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM170555(US9085549, 62)
Affinity DataKi:  506nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM170544(US9085549, 79)
Affinity DataKi:  537nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM170566(US9085549, 84)
Affinity DataKi:  639nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM170560(US9085549, 70)
Affinity DataKi:  659nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM170558(US9085549, 68)
Affinity DataKi:  697nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM170543(US9085549, 59)
Affinity DataKi:  697nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM170559(US9085549, 69)
Affinity DataKi:  765nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM170549(US9085549, 53)
Affinity DataKi:  813nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM170571(US9085549, 95)
Affinity DataKi:  890nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM170568(US9085549, 88)
Affinity DataKi:  970nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM50157562(1,3-bis(3,4-dihydroxyphenyl)prop-2-en-1-one | 3,3'...)
Affinity DataKi:  1.10E+3nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM170569(US9085549, 89)
Affinity DataKi:  1.20E+3nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM170548(US9085549, 52)
Affinity DataKi:  1.26E+3nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM170572(US9085549, 96)
Affinity DataKi:  1.35E+3nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM170550(US9085549, 54)
Affinity DataKi:  1.64E+3nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM170570(US9085549, 90)
Affinity DataKi:  1.70E+3nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM170567(US9085549, 87)
Affinity DataKi:  2.00E+3nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM170554(US9085549, 61)
Affinity DataKi:  3.10E+3nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM50103964(CHEMBL3593932)
Affinity DataKi:  2.10nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM50103961(CHEMBL3593930)
Affinity DataKi:  3.5nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM50103936(CHEMBL3593928)
Affinity DataKi:  3.80nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM50104103(CHEMBL3593911)
Affinity DataKi:  4.20nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM481149(US10906900, Reference 22a)
Affinity DataKi:  4.70nMAssay Description:Table 5: Fresh solutions of the test compounds (2.5 mM in DMSO) are diluted in PBS pH7.4, at concentrations between 0.5 nM and 5 μM in the prese...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM50103979(CHEMBL3593904)
Affinity DataKi:  12nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM50103934(CHEMBL3593926)
Affinity DataKi:  13nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM481153(US10906900, Reference 22f)
Affinity DataKi:  14.8nMAssay Description:Table 5: Fresh solutions of the test compounds (2.5 mM in DMSO) are diluted in PBS pH7.4, at concentrations between 0.5 nM and 5 μM in the prese...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM50104109(CHEMBL3593922)
Affinity DataKi:  15nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM481154(US10906900, Reference 22g)
Affinity DataKi:  19nMAssay Description:Table 5: Fresh solutions of the test compounds (2.5 mM in DMSO) are diluted in PBS pH7.4, at concentrations between 0.5 nM and 5 μM in the prese...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM481155(US10906900, Reference 22h)
Affinity DataKi:  20.7nMAssay Description:Table 5: Fresh solutions of the test compounds (2.5 mM in DMSO) are diluted in PBS pH7.4, at concentrations between 0.5 nM and 5 μM in the prese...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM50103932(CHEMBL3593924)
Affinity DataKi:  25nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM50185987(2-(1-(6-((2-fluoroethyl)(methyl)amino)naphthalen-2...)
Affinity DataKi:  25.1nMAssay Description:Table 5: Fresh solutions of the test compounds (2.5 mM in DMSO) are diluted in PBS pH7.4, at concentrations between 0.5 nM and 5 μM in the prese...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM481151(US10906900, Reference 22c)
Affinity DataKi:  26nMAssay Description:Table 5: Fresh solutions of the test compounds (2.5 mM in DMSO) are diluted in PBS pH7.4, at concentrations between 0.5 nM and 5 μM in the prese...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM481150(US10906900, Reference 22b)
Affinity DataKi:  28.7nMAssay Description:Table 5: Fresh solutions of the test compounds (2.5 mM in DMSO) are diluted in PBS pH7.4, at concentrations between 0.5 nM and 5 μM in the prese...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM50104145(CHEMBL3593915)
Affinity DataKi:  30nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM50389294(CHEMBL2063787)
Affinity DataKi:  32.1nMAssay Description:Binding affinity to human alpha-synuclein expressed in Escherichia coli BL21 (DE3) cells after 1 hr by thioflavin T fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM50103927(CHEMBL3593903)
Affinity DataKi:  41nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Proteotech

US Patent
LigandPNGBDBM50104059(CHEMBL3593909)
Affinity DataKi:  41nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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