Compile Data Set for Download or QSAR
maximum 50k data
Found 1181 Enz. Inhib. hit(s) with Target = 'Ephrin type-B receptor 4'
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM6219(BMCL182776 Compound 1 | Chlorobenzodioxole deriv. ...)
Affinity DataIC50:  350nMpH: 7.4 T: 2°CAssay Description:This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...More data for this Ligand-Target Pair
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM25202(2-N-(3-chloro-4-methoxyphenyl)-4-N-(3,4,5-trimetho...)
Affinity DataIC50:  1.60E+4nMpH: 7.4 T: 2°CAssay Description:This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...More data for this Ligand-Target Pair
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM21(CHEMBL24828 | N-(4-bromo-2-fluorophenyl)-6-methoxy...)
Affinity DataKd:  520nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKd:  1.70E+3nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataKd:  1.80E+3nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM31093(4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-py...)
Affinity DataKd:  560nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM31090((E)-N-[4-(3-chloro-4-fluoro-anilino)-3-cyano-7-eth...)
Affinity DataKd:  2.80E+3nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataKd:  0.340nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM4779(CHEMBL31965 | CHEMBL545315 | CI-1033 | Canertinib ...)
Affinity DataKd:  1.80E+3nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM25203(2-N-(5-chloro-2H-1,3-benzodioxol-4-yl)-4-N-(3,4,5-...)
Affinity DataIC50:  2.96E+3nMpH: 7.4 T: 2°CAssay Description:This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM25204(4,6-Pyrimidine derivative, 6 | 4-N-(5-chloro-2H-1,...)
Affinity DataIC50:  2.54E+3nMpH: 7.4 T: 2°CAssay Description:This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM25205(2,4-Pyrimidine derivative, 7 | 4-N-(5-chloro-2H-1,...)
Affinity DataIC50:  240nMpH: 7.4 T: 2°CAssay Description:This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...More data for this Ligand-Target Pair
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM25206(2,4-Pyrimidine derivative, 8 | 4-N-(5-chloro-2H-1,...)
Affinity DataIC50:  1.55E+3nMpH: 7.4 T: 2°CAssay Description:This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM25207(2,4-Pyrimidine derivative, 9 | 4-N-(5-chloro-2H-1,...)
Affinity DataIC50:  5.00E+3nMpH: 7.4 T: 2°CAssay Description:This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM25208(2,4-Pyrimidine derivative, 10 | 4-N-(5-chloro-2H-1...)
Affinity DataIC50:  1.15E+3nMpH: 7.4 T: 2°CAssay Description:This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM25209(2,4-Pyrimidine derivative, 11 | 4-N-(5-chloro-2H-1...)
Affinity DataIC50:  2.30E+3nMpH: 7.4 T: 2°CAssay Description:This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM25210(2,4-Pyrimidine derivative, 12 | 4-N-(5-chloro-2H-1...)
Affinity DataIC50:  1.13E+4nMpH: 7.4 T: 2°CAssay Description:This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM25211(2,4-Pyrimidine derivative, 13 | 4-N-(5-chloro-2H-1...)
Affinity DataIC50:  1.33E+3nMpH: 7.4 T: 2°CAssay Description:This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM25212(2,4-Pyrimidine derivative, 14 | 4-N-(5-chloro-2H-1...)
Affinity DataIC50:  6.00E+3nMpH: 7.4 T: 2°CAssay Description:This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM25213(2,4-Pyrimidine derivative, 15 | 4-N-(5-chloro-2H-1...)
Affinity DataIC50:  1.40E+4nMpH: 7.4 T: 2°CAssay Description:This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM25214(2,4-Pyrimidine derivative, 16 | 4-N-(5-chloro-2H-1...)
Affinity DataIC50:  460nMpH: 7.4 T: 2°CAssay Description:This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM25215(2,4-Pyrimidine derivative, 17 | 4-N-(5-chloro-2H-1...)
Affinity DataIC50:  1.60E+3nMpH: 7.4 T: 2°CAssay Description:This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM25216(2,4-Pyrimidine derivative, 18 | 4-N-(5-chloro-2H-1...)
Affinity DataIC50:  3.88E+3nMpH: 7.4 T: 2°CAssay Description:This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM25217(2,4-Pyrimidine derivative, 19 | 4-N-(5-chloro-2H-1...)
Affinity DataIC50:  640nMpH: 7.4 T: 2°CAssay Description:This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM25218(2,4-Pyrimidine derivative, 20 | 4-N-(5-chloro-2H-1...)
Affinity DataIC50:  1.94E+3nMpH: 7.4 T: 2°CAssay Description:This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM25219(2,4-Pyrimidine derivative, 21 | 2-({4-[(5-chloro-2...)
Affinity DataIC50:  2.05E+4nMpH: 7.4 T: 2°CAssay Description:This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM25220(2,4-Pyrimidine derivative, 22 | 3-({4-[(5-chloro-2...)
Affinity DataIC50:  550nMpH: 7.4 T: 2°CAssay Description:This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM25221(2,4-Pyrimidine derivative, 23 | 4-({4-[(5-chloro-2...)
Affinity DataIC50:  1.25E+3nMpH: 7.4 T: 2°CAssay Description:This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM25222(2,4-Pyrimidine derivative, 24 | 2-({4-[(5-chloro-2...)
Affinity DataIC50:  3.55E+4nMpH: 7.4 T: 2°CAssay Description:This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM25223(2,4-Pyrimidine derivative, 25 | 3-({4-[(5-chloro-2...)
Affinity DataIC50:  40nMpH: 7.4 T: 2°CAssay Description:This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...More data for this Ligand-Target Pair
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM25224(2,4-Pyrimidine derivative, 26 | 4-({4-[(5-chloro-2...)
Affinity DataIC50:  300nMpH: 7.4 T: 2°CAssay Description:This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM25225(2,4-Pyrimidine derivative, 27 | 4-N-(5-chloro-2H-1...)
Affinity DataIC50:  4.10E+4nMpH: 7.4 T: 2°CAssay Description:This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM25226(2,4-Pyrimidine derivative, 28 | 4-N-(5-chloro-2H-1...)
Affinity DataIC50:  90nMpH: 7.4 T: 2°CAssay Description:This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...More data for this Ligand-Target Pair
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM25227(2,4-Pyrimidine derivative, 29 | 4-N-(5-chloro-2H-1...)
Affinity DataIC50:  630nMpH: 7.4 T: 2°CAssay Description:This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM25228(2,4-Pyrimidine derivative, 30 | 4-N-(5-chloro-2H-1...)
Affinity DataIC50:  7.85E+3nMpH: 7.4 T: 2°CAssay Description:This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM25229(2,4-Pyrimidine derivative, 31 | 4-N-(5-chloro-2H-1...)
Affinity DataIC50:  580nMpH: 7.4 T: 2°CAssay Description:This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...More data for this Ligand-Target Pair
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM25230(2,4-Pyrimidine derivative, 32 | 4-N-(5-chloro-2H-1...)
Affinity DataIC50:  1.00E+3nMpH: 7.4 T: 2°CAssay Description:This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM21079(1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...)
Affinity DataKd:  1.40E+3nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM50376901(CHEMBL256101 | TG-100855)
Affinity DataKi:  7.27nMAssay Description:Inhibition of EphB4 by luminescence based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
Affinity DataKi:  37nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM50198782(([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]tri...)
Affinity DataKi:  63.8nMAssay Description:Inhibition of EphB4 by luminescence based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM50198782(([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]tri...)
Affinity DataKi:  63.8nMAssay Description:Inhibition of EphB4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM50463484(CHEMBL4248525)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of EphB4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM50463483(CHEMBL4245242)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of EphB4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM50463479(CHEMBL4249925)
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of EphB4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM50393033(CHEMBL2152699)
Affinity DataIC50:  9.40E+3nMAssay Description:Inhibition of EphB4 by FRET assay in presence of 30 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM50393034(CHEMBL2152704)
Affinity DataIC50:  300nMAssay Description:Inhibition of EphB4 by FRET assay in presence of 30 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM50393035(CHEMBL2152698)
Affinity DataIC50:  8.40E+3nMAssay Description:Inhibition of EphB4 in presence of 1 uM radiolabeled ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM50393033(CHEMBL2152699)
Affinity DataIC50:  5.20E+3nMAssay Description:Inhibition of EphB4 in presence of 1 uM radiolabeled ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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