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Found 322 Enz. Inhib. hit(s) with Target = 'Ghrelin O-acyltransferase'
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM80086((4aR,6aR,6aS,6bR,8aS,12aS,14bS)-8a-(imidazole-1-ca...)
Affinity DataIC50:  3.80E+4nMpH: 7.0 T: 2°CAssay Description:Assays were performed with ~100 μg of membrane protein, as determined by a Bradford assay. The membrane fraction was preincubated with 1 μM met...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM217379(CDDO-Me, 2)
Affinity DataIC50:  6.00E+3nMpH: 7.0 T: 2°CAssay Description:Assays were performed with ~100 μg of membrane protein, as determined by a Bradford assay. The membrane fraction was preincubated with 1 μM met...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM217391(Cyclohexenone, 18)
Affinity DataIC50: >1.00E+6nMpH: 7.0 T: 2°CAssay Description:Assays were performed with ~100 μg of membrane protein, as determined by a Bradford assay. The membrane fraction was preincubated with 1 μM met...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM217390(2-Bromo-2-cyclohexenone, 17)
Affinity DataIC50:  5.00E+5nMpH: 7.0 T: 2°CAssay Description:Assays were performed with ~100 μg of membrane protein, as determined by a Bradford assay. The membrane fraction was preincubated with 1 μM met...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM217389(2-Cyano-2-cyclohexenone, 16)
Affinity DataIC50:  1.20E+6nMpH: 7.0 T: 2°CAssay Description:Assays were performed with ~100 μg of membrane protein, as determined by a Bradford assay. The membrane fraction was preincubated with 1 μM met...More data for this Ligand-Target Pair
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In DepthDetails ArticlePubMed
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM17289((1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7...)
Affinity DataIC50: >1.00E+6nMpH: 7.0 T: 2°CAssay Description:Assays were performed with ~100 μg of membrane protein, as determined by a Bradford assay. The membrane fraction was preincubated with 1 μM met...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM217380(CDDO-EA, 3)
Affinity DataIC50:  8.00E+3nMpH: 7.0 T: 2°CAssay Description:Assays were performed with ~100 μg of membrane protein, as determined by a Bradford assay. The membrane fraction was preincubated with 1 μM met...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM217381(CDDO-TFEA, 4)
Affinity DataIC50:  4.40E+4nMpH: 7.0 T: 2°CAssay Description:Assays were performed with ~100 μg of membrane protein, as determined by a Bradford assay. The membrane fraction was preincubated with 1 μM met...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM50096348(2-Cyano-3,12-Dioxooleana-1,9(11)-Dien-28-Oic Acid ...)
Affinity DataIC50: >1.00E+5nMpH: 7.0 T: 2°CAssay Description:Assays were performed with ~100 μg of membrane protein, as determined by a Bradford assay. The membrane fraction was preincubated with 1 μM met...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM217382(Ursolic acid, 6)
Affinity DataIC50: >1.00E+5nMpH: 7.0 T: 2°CAssay Description:Assays were performed with ~100 μg of membrane protein, as determined by a Bradford assay. The membrane fraction was preincubated with 1 μM met...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM217383(Oleanic acid, 7)
Affinity DataIC50: >1.00E+5nMpH: 7.0 T: 2°CAssay Description:Assays were performed with ~100 μg of membrane protein, as determined by a Bradford assay. The membrane fraction was preincubated with 1 μM met...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM50242128(CHEMBL511822 | Taraxerol, 8 | taraxerol)
Affinity DataIC50: >1.00E+5nMpH: 7.0 T: 2°CAssay Description:Assays were performed with ~100 μg of membrane protein, as determined by a Bradford assay. The membrane fraction was preincubated with 1 μM met...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM217384(Steroid scaffold, 9)
Affinity DataIC50:  8.00E+3nMpH: 7.0 T: 2°CAssay Description:Assays were performed with ~100 μg of membrane protein, as determined by a Bradford assay. The membrane fraction was preincubated with 1 μM met...More data for this Ligand-Target Pair
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In DepthDetails ArticlePubMed
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM217385(Steroid scaffold, 10)
Affinity DataIC50:  8.30E+4nMpH: 7.0 T: 2°CAssay Description:Assays were performed with ~100 μg of membrane protein, as determined by a Bradford assay. The membrane fraction was preincubated with 1 μM met...More data for this Ligand-Target Pair
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In DepthDetails ArticlePubMed
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM217386(Steroid scaffold, 11)
Affinity DataIC50:  1.70E+5nMpH: 7.0 T: 2°CAssay Description:Assays were performed with ~100 μg of membrane protein, as determined by a Bradford assay. The membrane fraction was preincubated with 1 μM met...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM217387(Steroid scaffold, 12)
Affinity DataIC50: >4.00E+5nMpH: 7.0 T: 2°CAssay Description:Assays were performed with ~100 μg of membrane protein, as determined by a Bradford assay. The membrane fraction was preincubated with 1 μM met...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM217388(Steroid scaffold, 13)
Affinity DataIC50: >4.00E+5nMpH: 7.0 T: 2°CAssay Description:Assays were performed with ~100 μg of membrane protein, as determined by a Bradford assay. The membrane fraction was preincubated with 1 μM met...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM92505(4-Cholesten-3-one | Steroid scaffold, 14)
Affinity DataIC50: >1.00E+6nMpH: 7.0 T: 2°CAssay Description:Assays were performed with ~100 μg of membrane protein, as determined by a Bradford assay. The membrane fraction was preincubated with 1 μM met...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM289089(N-[(1S)-2-[4-[2-[4-Amino- 6-methyl-2- (trifluorome...)
Affinity DataIC50:  276nMpH: 7.5Assay Description:Prepare test compounds in DMSO to make up a 0.2 mM stock solution. Serially dilute the stock solution in DMSO to obtain a ten-point dilution curve wi...More data for this Ligand-Target Pair
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TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM289088(N-[(1S)-2-[4-[2-[4-Amino- 6-methyl-2- (trifluorome...)
Affinity DataIC50:  420nMpH: 7.5Assay Description:Prepare test compounds in DMSO to make up a 0.2 mM stock solution. Serially dilute the stock solution in DMSO to obtain a ten-point dilution curve wi...More data for this Ligand-Target Pair
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TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM289087(N-[(1S)-2-[4-[2-[4-Amino- 6-methyl-2- (trifluorome...)
Affinity DataIC50:  55.7nMpH: 7.5Assay Description:Prepare test compounds in DMSO to make up a 0.2 mM stock solution. Serially dilute the stock solution in DMSO to obtain a ten-point dilution curve wi...More data for this Ligand-Target Pair
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TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM289086(N-[(1 S)-2-[4-[2-[4-Amino-6-methyl-2-(trifluoromet...)
Affinity DataIC50:  69.5nMpH: 7.5Assay Description:Prepare test compounds in DMSO to make up a 0.2 mM stock solution. Serially dilute the stock solution in DMSO to obtain a ten-point dilution curve wi...More data for this Ligand-Target Pair
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TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM289090(Methyl-[(1S)-2-[4-[2-[4-amino-6-methyl-2-(trifluor...)
Affinity DataIC50:  615nMpH: 7.5Assay Description:Prepare test compounds in DMSO to make up a 0.2 mM stock solution. Serially dilute the stock solution in DMSO to obtain a ten-point dilution curve wi...More data for this Ligand-Target Pair
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TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM50094874(CHEMBL3589131)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of human GOAT octanoylation activity expressed in insect Sf9 cell membranes using GSSFLCAcDan as substrate after 1 hr by reverse phase HPL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM50094875(CHEMBL3589130)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human GOAT octanoylation activity expressed in insect Sf9 cell membranes using GSSFLCAcDan as substrate after 1 hr by reverse phase HPL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM50094876(CHEMBL3589129)
Affinity DataIC50:  700nMAssay Description:Inhibition of human GOAT octanoylation activity expressed in insect Sf9 cell membranes using GSSFLCAcDan as substrate after 1 hr by reverse phase HPL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM50094877(CHEMBL3589128)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of human GOAT octanoylation activity expressed in insect Sf9 cell membranes using GSSFLCAcDan as substrate after 1 hr by reverse phase HPL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM367610(N-[(1S)-2-[4-[2- (4-Amino-2- chloro-6-methyl- pyri...)
Affinity DataIC50:  54.4nMAssay Description:Prepare test compounds in DMSO to make up a 0.2 mM stock solution. Serially dilute the stock solution in DMSO for ten concentrations with final compo...More data for this Ligand-Target Pair
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TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM367611(N-[(1S)-2-[(4R,S)- 4-[2-(4-Amino-6- chloro-2-methy...)
Affinity DataIC50:  574nMAssay Description:Prepare test compounds in DMSO to make up a 0.2 mM stock solution. Serially dilute the stock solution in DMSO for ten concentrations with final compo...More data for this Ligand-Target Pair
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TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM367612(N-[(1S)-2-[4-[2-(4-Amino-6-chloro-2-methyl-pyrimid...)
Affinity DataIC50:  96.4nMAssay Description:Prepare test compounds in DMSO to make up a 0.2 mM stock solution. Serially dilute the stock solution in DMSO for ten concentrations with final compo...More data for this Ligand-Target Pair
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TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM367613(N-[(1S)-2-[4-[2-(4-Amino-6-chloro-2-methyl-pyrimid...)
Affinity DataIC50:  68.9nMAssay Description:Prepare test compounds in DMSO to make up a 0.2 mM stock solution. Serially dilute the stock solution in DMSO for ten concentrations with final compo...More data for this Ligand-Target Pair
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TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM367614(N-[(1S)-2-[4-[2-(4-Amino-6-chloro-2-methyl-pyrimid...)
Affinity DataIC50:  170nMAssay Description:Prepare test compounds in DMSO to make up a 0.2 mM stock solution. Serially dilute the stock solution in DMSO for ten concentrations with final compo...More data for this Ligand-Target Pair
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TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM367615(Methyl N-[(1S)-2-[4-[2-(4-amino-6-chloro-2-methyl-...)
Affinity DataIC50:  149nMAssay Description:Prepare test compounds in DMSO to make up a 0.2 mM stock solution. Serially dilute the stock solution in DMSO for ten concentrations with final compo...More data for this Ligand-Target Pair
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TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM396096(6-(5-Methoxy-pyridin-2-ylmethyl)-5-methyl-[1,2,5]o...)
Affinity DataIC50:  1.40nMAssay Description:Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37° C., 5% CO2 in DMEM medium, 10% FCS,...More data for this Ligand-Target Pair
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TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM396099(2-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Affinity DataIC50:  3.60nMAssay Description:Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37° C., 5% CO2 in DMEM medium, 10% FCS,...More data for this Ligand-Target Pair
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TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM396100(6-(6-Chloro-pyridin-2-ylmethyl)-5-methyl-[1,2,5]ox...)
Affinity DataIC50:  0.460nMAssay Description:Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37° C., 5% CO2 in DMEM medium, 10% FCS,...More data for this Ligand-Target Pair
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TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM396101(6-(7-Amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridi...)
Affinity DataIC50:  1.70nMAssay Description:Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37° C., 5% CO2 in DMEM medium, 10% FCS,...More data for this Ligand-Target Pair
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TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM396102(6-(5-Bromo-pyridin-2-ylmethyl)-5-methyl-[1,2,5]oxa...)
Affinity DataIC50:  0.240nMAssay Description:Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37° C., 5% CO2 in DMEM medium, 10% FCS,...More data for this Ligand-Target Pair
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TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM396103(5-Methyl-6-(5-trifluoromethyl-pyridin-2-ylmethyl)-...)
Affinity DataIC50:  0.610nMAssay Description:Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37° C., 5% CO2 in DMEM medium, 10% FCS,...More data for this Ligand-Target Pair
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TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM396104(6-(6-Bromo-pyridin-2-ylmethyl)-5-methyl-[1,2,5]oxa...)
Affinity DataIC50:  0.950nMAssay Description:Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37° C., 5% CO2 in DMEM medium, 10% FCS,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM396105(6-(5-Chloro-pyridin-2-ylmethyl)-5-methyl-[1,2,5]ox...)
Affinity DataIC50:  0.420nMAssay Description:Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37° C., 5% CO2 in DMEM medium, 10% FCS,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM396106(6-(5-Difluoromethyl-pyridin-2-ylmethyl)-5-methyl-[...)
Affinity DataIC50:  0.440nMAssay Description:Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37° C., 5% CO2 in DMEM medium, 10% FCS,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM396107(US10308667, Example 10 | [6-(7-Amino-5-methyl-[1,2...)
Affinity DataIC50:  13nMAssay Description:Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37° C., 5% CO2 in DMEM medium, 10% FCS,...More data for this Ligand-Target Pair
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TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM396108(6-[5-(1,1-Difluoro-ethyl)-pyridin-2-ylmethyl]-5-me...)
Affinity DataIC50:  0.130nMAssay Description:Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37° C., 5% CO2 in DMEM medium, 10% FCS,...More data for this Ligand-Target Pair
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TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM396109(6-(5-Fluoro-pyridin-2-ylmethyl)-5-methyl-[1,2,5]ox...)
Affinity DataIC50:  6.5nMAssay Description:Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37° C., 5% CO2 in DMEM medium, 10% FCS,...More data for this Ligand-Target Pair
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TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM396110(6-(6-Fluoro-pyridin-2-ylmethyl)-5-methyl-[1,2,5]ox...)
Affinity DataIC50:  4.40nMAssay Description:Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37° C., 5% CO2 in DMEM medium, 10% FCS,...More data for this Ligand-Target Pair
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TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM396111(6-(5-Difluoromethoxy-pyridin-2-ylmethyl)-5-methyl-...)
Affinity DataIC50:  0.670nMAssay Description:Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37° C., 5% CO2 in DMEM medium, 10% FCS,...More data for this Ligand-Target Pair
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TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM396112(6-(6-Bromo-5-difluoromethoxy-pyridin-2-ylmethyl)-5...)
Affinity DataIC50:  0.0380nMAssay Description:Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37° C., 5% CO2 in DMEM medium, 10% FCS,...More data for this Ligand-Target Pair
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TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM396113(5-Methyl-6-(6-methylsulfanyl-pyridin-2-ylmethyl)-[...)
Affinity DataIC50:  0.280nMAssay Description:Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37° C., 5% CO2 in DMEM medium, 10% FCS,...More data for this Ligand-Target Pair
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TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Syracuse University

LigandPNGBDBM396114(5-Methyl-6-(5-trifluoromethoxy-pyridin-2-ylmethyl)...)
Affinity DataIC50:  0.220nMAssay Description:Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37° C., 5% CO2 in DMEM medium, 10% FCS,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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