Found 2748 Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase kinase kinase 5' TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 62nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 122nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 19nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 38nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 16nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 528nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 12nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 146nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 18nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 6nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 7nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 1.24E+4nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 10nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 29nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 17nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 214nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 20nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 10nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 16nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 64nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 20nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 237nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 41nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 8nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 9nMpH: 7.5 T: 2°CAssay Description:The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataKd: >1.00E+3nMpH: 7.5Assay Description:In vitro activity assay using various kinases.More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 11nMpH: 7.5 T: 2°CAssay Description:The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 4nMpH: 7.5 T: 2°CAssay Description:The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 19nMpH: 7.5 T: 2°CAssay Description:The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 14nMpH: 7.5 T: 2°CAssay Description:The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 69nMpH: 7.5 T: 2°CAssay Description:The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 7nMpH: 7.5 T: 2°CAssay Description:The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 5nMpH: 7.5 T: 2°CAssay Description:The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 6nMpH: 7.5 T: 2°CAssay Description:The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 55nMpH: 7.5 T: 2°CAssay Description:The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 7nMpH: 7.5 T: 2°CAssay Description:The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 81nMpH: 7.5 T: 2°CAssay Description:The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: >1.00E+4nMpH: 7.5 T: 2°CAssay Description:Fluorescence assay used for determination of catch and release efficiency. More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: >1.00E+4nMpH: 7.5Assay Description:In vitro activity assay using various kinases.More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: >1.00E+4nMpH: 7.5Assay Description:In vitro activity assay using various kinases.More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: 60nMpH: 7.5 T: 2°CAssay Description:The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataKi: <200nMAssay Description:The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataKi: <200nMAssay Description:The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataKi: <200nMAssay Description:The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataKi: <200nMAssay Description:The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataKi: <200nMAssay Description:The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...More data for this Ligand-Target Pair
