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Found 4001 Enz. Inhib. hit(s) with Target = 'Nociceptin receptor'
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM21842((2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2...)
Affinity DataKi:  0.130nM ΔG°:  -55.9kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM239934(US9403767, 117)
Affinity DataKi:  0.130nMpH: 7.4Assay Description:The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM21844(8-[(1R,3aR)-2,3,3a,4,5,6-hexahydro-1H-phenalen-1-y...)
Affinity DataKi:  0.390nM ΔG°:  -53.2kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM239921(US9403767, 99)
Affinity DataKi:  0.540nMpH: 7.4Assay Description:The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM239925(US9403767, 104 | US9403767, 105)
Affinity DataKi:  0.650nMpH: 7.4Assay Description:The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM239911(US9403767, 76 | US9403767, 77)
Affinity DataKi:  0.710nMpH: 7.4Assay Description:The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM239914(US9403767, 85)
Affinity DataKi:  0.810nMpH: 7.4Assay Description:The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM97714(US8476271, 405)
Affinity DataKi:  1.10nM ΔG°:  -51.1kJ/molepH: 7.4 T: 2°CAssay Description:In vitro binding assay using ORL-1m Mu-opioid, kappa-opioid, and delta-opioid receptor. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM239892(US9403767, 50 | US9403767, 51)
Affinity DataKi:  1.28nMpH: 7.4Assay Description:The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM239935(US9403767, 119)
Affinity DataKi:  1.43nMpH: 7.4Assay Description:The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM239890(US9403767, 48 | US9403767, 49)
Affinity DataKi:  1.55nMpH: 7.4Assay Description:The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM239873(US9403767, 29 | US9403767, 30)
Affinity DataKi:  1.60nMpH: 7.4Assay Description:The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...More data for this Ligand-Target Pair
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TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM26906(8-[bis(2-chlorophenyl)methyl]-3-[2-(ethylamino)eth...)
Affinity DataKi:  2.10nM ΔG°:  -49.0kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM26913(8-[bis(2-chlorophenyl)methyl]-3-[2-(butylamino)eth...)
Affinity DataKi:  2.15nM ΔG°:  -49.0kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM26916(8-[bis(2-chlorophenyl)methyl]-1-phenyl-3-[2-(pyrro...)
Affinity DataKi:  2.25nM ΔG°:  -48.9kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM97710(US8476271, 16 | US9145408, 362)
Affinity DataKi:  2.40nM ΔG°:  -49.2kJ/molepH: 7.4 T: 2°CAssay Description:In vitro binding assay using ORL-1m Mu-opioid, kappa-opioid, and delta-opioid receptor. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM239923(US9403767, 101 | US9403767, 102)
Affinity DataKi:  2.45nMpH: 7.4Assay Description:The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...More data for this Ligand-Target Pair
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TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM26907(8-[bis(2-chlorophenyl)methyl]-1-phenyl-3-[2-(propa...)
Affinity DataKi:  2.55nM ΔG°:  -48.6kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM239865(US9403767, 18)
Affinity DataKi:  2.70nMpH: 7.4Assay Description:The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...More data for this Ligand-Target Pair
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TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM26914(8-[bis(2-chlorophenyl)methyl]-3-{2-[(2-methylpropy...)
Affinity DataKi:  2.75nM ΔG°:  -48.4kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM21845(2-methyl-1'-[4-(propan-2-yl)cyclohexyl]-2,3-dihydr...)
Affinity DataKi:  3.10nM ΔG°:  -48.1kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM26917(8-[bis(2-chlorophenyl)methyl]-1-phenyl-3-[3-(pyrro...)
Affinity DataKi:  3.20nM ΔG°:  -48.0kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM26910(8-[bis(2-chlorophenyl)methyl]-3-[2-(dimethylamino)...)
Affinity DataKi:  3.5nM ΔG°:  -47.8kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM26911(8-[bis(2-chlorophenyl)methyl]-3-[2-(cyclopropylami...)
Affinity DataKi:  3.70nM ΔG°:  -47.6kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM26915(8-[bis(2-chlorophenyl)methyl]-3-{2-[(cyclohexylmet...)
Affinity DataKi:  3.80nM ΔG°:  -47.6kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM116216(US8637502, 56)
Affinity DataKi:  4nM ΔG°:  -44.6kJ/molepH: 7.4 T: 2°CAssay Description:ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM26905(8-[bis(2-chlorophenyl)methyl]-3-[2-(methylamino)et...)
Affinity DataKi:  4.05nM ΔG°:  -47.4kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM21857(1'-[4-(propan-2-yl)cyclohexyl]-2,3-dihydro-1H-spir...)
Affinity DataKi:  4.70nM ΔG°:  -47.1kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM239869(US9403767, 24 | US9403767, 27)
Affinity DataKi:  4.90nMpH: 7.4Assay Description:The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM26909(8-[bis(2-chlorophenyl)methyl]-3-[2-(cyclohexylamin...)
Affinity DataKi:  5nM ΔG°:  -46.9kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM239917(US9403767, 91)
Affinity DataKi:  5.35nMpH: 7.4Assay Description:The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM116220(US8637502, 60)
Affinity DataKi:  5.60nM ΔG°:  -43.8kJ/molepH: 7.4 T: 2°CAssay Description:ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM97711(US8476271, 17 | US8846929, 360 | US8846929, 361 | ...)
Affinity DataKi:  5.70nM ΔG°:  -47.1kJ/molepH: 7.4 T: 2°CAssay Description:In vitro binding assay using ORL-1m Mu-opioid, kappa-opioid, and delta-opioid receptor. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM239861(US9403767, 11)
Affinity DataKi:  6nMpH: 7.4Assay Description:The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM21851(2-benzyl-1'-[4-(propan-2-yl)cyclohexyl]-2,3-dihydr...)
Affinity DataKi:  6.60nM ΔG°:  -46.2kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM239938(US9403767, 122)
Affinity DataKi:  7.40nMpH: 7.4Assay Description:The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM26908(8-[bis(2-chlorophenyl)methyl]-3-[2-(cyclopentylami...)
Affinity DataKi:  8.65nM ΔG°:  -45.6kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM21847(7-fluoro-2-methyl-1'-[4-(propan-2-yl)cyclohexyl]-2...)
Affinity DataKi:  8.90nM ΔG°:  -45.5kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM116200(US8637502, 12)
Affinity DataKi:  8.90nM ΔG°:  -42.7kJ/molepH: 7.4 T: 2°CAssay Description:ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM97712(US8476271, 18 | US8846929, 358 | US9145408, 358)
Affinity DataKi:  9nM ΔG°:  -45.9kJ/molepH: 7.4 T: 2°CAssay Description:In vitro binding assay using ORL-1m Mu-opioid, kappa-opioid, and delta-opioid receptor. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM239894(US9403767, 52)
Affinity DataKi:  10nMpH: 7.4Assay Description:The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM239867(US9403767, 20 | US9403767, 21)
Affinity DataKi:  11nMpH: 7.4Assay Description:The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM116198(US8637502, 17)
Affinity DataKi:  11.5nM ΔG°:  -42.1kJ/molepH: 7.4 T: 2°CAssay Description:ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM21852(2-benzyl-5-fluoro-1'-[4-(propan-2-yl)cyclohexyl]-2...)
Affinity DataKi:  12nM ΔG°:  -44.8kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM26912(8-[bis(2-chlorophenyl)methyl]-3-{2-[bis(propan-2-y...)
Affinity DataKi:  12.1nM ΔG°:  -44.7kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values were obtained by fitting the competition binding curves according to a 4-parameter logistic model. Inhibition constants Ki were derived f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM116217(US8637502, 57)
Affinity DataKi:  13nM ΔG°:  -41.8kJ/molepH: 7.4 T: 2°CAssay Description:ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM239931(US9403767, 114)
Affinity DataKi:  13.8nMpH: 7.4Assay Description:The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM239918(US9403767, 92 | US9403767, 93)
Affinity DataKi:  15nMpH: 7.4Assay Description:The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM239866(US9403767, 19)
Affinity DataKi:  17nMpH: 7.4Assay Description:The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Istituto Superiore Di Sanita

LigandPNGBDBM239860(US9403767, 9)
Affinity DataKi:  17.8nMpH: 7.4Assay Description:The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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