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Found 682 Enz. Inhib. hit(s) with Target = 'Transthyretin'
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM25406(4-(2,4-dichlorophenoxy)-3-hydroxybenzoic acid | CH...)
Affinity DataKd:  27nMpH: 4.4Assay Description:Binding affinity to transthyretin at pH 4.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM17636(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
Affinity DataIC50:  2.90E+3nMpH: 4.4Assay Description:Inhibition of human transthyretin fibril formation at pH 4.4 after 72 hrsMore data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM50225218(4-(chloromethyl)-2-methoxy-1-phenoxybenzene | CHEM...)
Affinity DataIC50:  1.94E+3nMpH: 4.4Assay Description:Inhibition of transthyretin fibril formation at pH 4.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM50225216(2-(2,4-dichlorophenoxy)-5-(hydroxymethyl)phenol | ...)
Affinity DataIC50:  1.36E+3nMpH: 4.4Assay Description:Inhibition of transthyretin fibril formation at pH 4.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM50225217(5-(chloromethyl)-2-(2,4-dichlorophenoxy)phenol | C...)
Affinity DataIC50:  850nMpH: 4.4Assay Description:Inhibition of transthyretin fibril formation at pH 4.4More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM50225219(3-methoxy-4-phenoxybenzaldehyde | CHEMBL241453)
Affinity DataKd:  88nMpH: 4.4Assay Description:Binding affinity to transthyretin at pH 4.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM8726(5-chloro-2-(2,4-dichlorophenoxy)phenol | CHEMBL849...)
Affinity DataIC50:  5.35E+4nMpH: 4.4Assay Description:Inhibition of transthyretin fibril formation at pH 4.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM50225220(CHEMBL559 | D-thyroxine | O-(4-hydroxy-3,5-diiodop...)
Affinity DataIC50:  7.17E+3nMpH: 4.4Assay Description:Inhibition of transthyretin fibril formation at pH 4.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM50225221(2,3,6-trichloro-N-(4H-1,2,4-triazol-3-yl)benzamide...)
Affinity DataIC50:  1.06E+3nMpH: 4.4Assay Description:Inhibition of transthyretin fibril formation at pH 4.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM8726(5-chloro-2-(2,4-dichlorophenoxy)phenol | CHEMBL849...)
Affinity DataKd:  1.44E+5nMpH: 4.4Assay Description:Binding affinity to transthyretin at pH 4.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM50225224(4-(2,4-dichlorophenoxy)-3-hydroxybenzaldehyde | CH...)
Affinity DataKd:  13.9nMpH: 4.4Assay Description:Binding affinity to transthyretin at pH 4.4More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM50225222((4-(2,4-dinitrophenoxy)-3-methoxyphenyl)methanol |...)
Affinity DataIC50:  2.00E+4nMpH: 4.4Assay Description:Inhibition of transthyretin fibril formation at pH 4.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM50225223(4-(2,4-dinitrophenoxy)-3-hydroxybenzaldehyde | CHE...)
Affinity DataIC50:  5.50E+4nMpH: 4.4Assay Description:Inhibition of transthyretin fibril formation at pH 4.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM50225225(5-(hydroxymethyl)-2-phenoxyphenol | CHEMBL238590)
Affinity DataIC50:  4.50E+4nMpH: 4.4Assay Description:Inhibition of transthyretin fibril formation at pH 4.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM50225226(4-(2,4-dichlorophenoxy)-3-methoxybenzoic acid | CH...)
Affinity DataIC50:  475nMpH: 4.4Assay Description:Inhibition of transthyretin fibril formation at pH 4.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM50225227(2,4-dichloro-1-(4-(chloromethyl)-2-methoxyphenoxy)...)
Affinity DataIC50:  3.16E+3nMpH: 4.4Assay Description:Inhibition of transthyretin fibril formation at pH 4.4More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM50225226(4-(2,4-dichlorophenoxy)-3-methoxybenzoic acid | CH...)
Affinity DataKd:  0.200nMpH: 4.4Assay Description:Binding affinity to transthyretin at pH 4.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM50225229(2-(5-mercapto-1,3,4-oxadiazol-2-yl)phenol | CHEMBL...)
Affinity DataIC50:  3.10E+3nMpH: 4.4Assay Description:Inhibition of transthyretin fibril formation at pH 4.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM50225230(4-(2,4-dinitrophenoxy)-3-methoxybenzoic acid | CHE...)
Affinity DataIC50:  2.00E+4nMpH: 4.4Assay Description:Inhibition of transthyretin fibril formation at pH 4.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM50225228(3-hydroxy-4-phenoxybenzoic acid | CHEMBL241454)
Affinity DataIC50:  3.18E+3nMpH: 4.4Assay Description:Inhibition of transthyretin fibril formation at pH 4.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM50225219(3-methoxy-4-phenoxybenzaldehyde | CHEMBL241453)
Affinity DataIC50:  1.31E+3nMpH: 4.4Assay Description:Inhibition of transthyretin fibril formation at pH 4.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM50225224(4-(2,4-dichlorophenoxy)-3-hydroxybenzaldehyde | CH...)
Affinity DataIC50:  520nMpH: 4.4Assay Description:Inhibition of transthyretin fibril formation at pH 4.4More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM25406(4-(2,4-dichlorophenoxy)-3-hydroxybenzoic acid | CH...)
Affinity DataIC50:  2.59E+3nMpH: 4.4Assay Description:Inhibition of transthyretin fibril formation at pH 4.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM50225228(3-hydroxy-4-phenoxybenzoic acid | CHEMBL241454)
Affinity DataKd:  27nMpH: 4.4Assay Description:Binding affinity to transthyretin at pH 4.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM50225217(5-(chloromethyl)-2-(2,4-dichlorophenoxy)phenol | C...)
Affinity DataKd:  5.70nMpH: 4.4Assay Description:Binding affinity to transthyretin at pH 4.4More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM50225221(2,3,6-trichloro-N-(4H-1,2,4-triazol-3-yl)benzamide...)
Affinity DataKd:  120nMpH: 4.4Assay Description:Binding affinity to transthyretin at pH 4.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM50225231(3-methoxy-4-phenoxybenzoic acid | CHEMBL392872)
Affinity DataIC50:  4.10E+4nMpH: 4.4Assay Description:Inhibition of transthyretin fibril formation at pH 4.4More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM50225229(2-(5-mercapto-1,3,4-oxadiazol-2-yl)phenol | CHEMBL...)
Affinity DataKd:  42nMpH: 4.4Assay Description:Binding affinity to transthyretin at pH 4.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM50323722(4-fluorophenyl 3-(4-hydroxy-3,5-dimethylstyryl)ben...)
Affinity DataIC50:  1.96E+3nMpH: 4.4Assay Description:Inhibition of wild type TTR amyloidogenesis assessed as inhibition of fibril formation after 72 hrs at pH 4.4 by spectrophotometry relative to untrea...More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM50323723(2-nitrophenyl 3-(4-hydroxy-3,5-dimethylstyryl)benz...)
Affinity DataIC50:  2.26E+3nMpH: 4.4Assay Description:Inhibition of wild type TTR amyloidogenesis assessed as inhibition of fibril formation after 72 hrs at pH 4.4 by spectrophotometry relative to untrea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM50323724(CHEMBL1213660 | S-phenyl 3-(4-hydroxy-3,5-dimethyl...)
Affinity DataIC50:  2.00E+3nMpH: 4.4Assay Description:Inhibition of wild type TTR amyloidogenesis assessed as inhibition of fibril formation after 72 hrs at pH 4.4 by spectrophotometry relative to untrea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM50323725(CHEMBL1213659 | S-phenyl 3-(3,5-dibromo-4-hydroxys...)
Affinity DataIC50:  2.00E+3nMpH: 4.4Assay Description:Inhibition of wild type TTR amyloidogenesis assessed as inhibition of fibril formation after 72 hrs at pH 4.4 by spectrophotometry relative to untrea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM50012781(3-(4-hydroxy-3,5-dimethylstyryl)benzoic acid | 3-[...)
Affinity DataIC50:  3.07E+3nMpH: 4.4Assay Description:Inhibition of wild type TTR amyloidogenesis assessed as inhibition of fibril formation after 72 hrs at pH 4.4 by spectrophotometry relative to untrea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM50012798((E)-2,6-dimethyl-4-styrylphenol | 2,6-Dimethyl-4-s...)
Affinity DataIC50:  3.08E+3nMpH: 4.4Assay Description:Inhibition of wild type TTR amyloidogenesis assessed as inhibition of fibril formation after 72 hrs at pH 4.4 by spectrophotometry relative to untrea...More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM50225216(2-(2,4-dichlorophenoxy)-5-(hydroxymethyl)phenol | ...)
Affinity DataKd:  0.300nMpH: 4.4Assay Description:Binding affinity to transthyretin at pH 4.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM249543(US10072016, Compound 141 | US10407433, Compound 14...)
Affinity DataIC50:  20.8nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM249544(US10072016, Compound 142 | US10407433, Compound 14...)
Affinity DataIC50:  23.2nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM249545(US10072016, Compound 143 | US10407433, Compound 14...)
Affinity DataIC50:  52.3nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM249546(US10072016, Compound 144 | US10407433, Compound 14...)
Affinity DataIC50:  70.3nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM249547(US10072016, Compound 145 | US10407433, Compound 14...)
Affinity DataIC50:  67nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM249548(US10072016, Compound 146 | US10407433, Compound 14...)
Affinity DataIC50:  36.5nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM249549(US10072016, Compound 147 | US10407433, Compound 14...)
Affinity DataIC50:  25.5nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM249550(US10072016, Compound 148 | US10407433, Compound 14...)
Affinity DataIC50:  7.41nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM249550(US10072016, Compound 148 | US10407433, Compound 14...)
Affinity DataIC50: <0.169nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM249551(US10072016, Compound 149 | US10407433, Compound 14...)
Affinity DataIC50:  23.4nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM249552(US10072016, Compound 150 | US10407433, Compound 15...)
Affinity DataIC50:  23.7nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM249553(US10072016, Compound 151 | US10407433, Compound 15...)
Affinity DataIC50:  67.7nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM249554(US10072016, Compound 152 | US10407433, Compound 15...)
Affinity DataIC50:  27.8nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM249555(US10072016, Compound 153 | US10407433, Compound 15...)
Affinity DataIC50:  833nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransthyretin(Homo sapiens (Human))
Institute Of Sciences

Curated by ChEMBL
LigandPNGBDBM249556(US10072016, Compound 154 | US10407433, Compound 15...)
Affinity DataIC50:  385nMpH: 7.4 T: 2°CAssay Description:Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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