Compile Data Set for Download or QSAR
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Found 511 Enz. Inhib. hit(s) with Target = 'Tryptase'
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM14307((2R)-N-[(1S)-1-{[6-amino-1-(1,3-benzothiazol-2-yl)...)
Affinity DataKi:  23nM ΔG°:  -43.2kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM14169(4-Iodobenzo[b]thiophene-2-carboxamidine | APC-6860...)
Affinity DataKi:  1.50E+3nM ΔG°:  -32.9kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM14297(US10676470, Compound 23 | US11332464, Compound 23 ...)
Affinity DataKi:  7.30E+3nM ΔG°:  -29.0kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM14170(APC-7377 | Benzo[b]thiophene-2-carboxamidine | [am...)
Affinity DataKi:  9.90E+3nM ΔG°:  -28.3kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM14299(benzthiazole analog 2 | benzyl N-[(2S)-1-(1,3-benz...)
Affinity DataKi:  1.20E+4nM ΔG°:  -27.8kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM14308((2S)-N-[3-(2-amino-1H-1,3-benzodiazol-5-yl)-1-(1,3...)
Affinity DataKi:  1.80E+4nM ΔG°:  -26.8kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM772(Benzamidine | CHEMBL79897 | [amino(phenyl)methylid...)
Affinity DataKi:  2.00E+4nM ΔG°:  -26.6kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM14300(benzthiazole analog 3 | benzyl N-[(2S,4E)-6-amino-...)
Affinity DataKi:  2.50E+4nM ΔG°:  -26.0kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM14309(2-Aminobenzimidazole Compound 13 | N-[3-(2-amino-1...)
Affinity DataKi:  3.10E+4nM ΔG°:  -25.5kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM14171(APC-7538 | Thieno[2,3-b]pyridine-2-carboxamidine |...)
Affinity DataKi:  3.40E+4nM ΔG°:  -25.2kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM14301(benzthiazole analog 4 | benzyl N-[(2S)-1-(1,3-benz...)
Affinity DataKi:  4.50E+4nM ΔG°:  -24.6kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM14310(2-Aminobenzimidazole Compound 14 | 3-(2-amino-1H-1...)
Affinity DataKi:  9.40E+4nM ΔG°:  -22.8kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM7960(1H-1,3-benzodiazol-2-amine | 2-Aminobenzimidazole ...)
Affinity DataKi:  1.10E+5nM ΔG°:  -22.4kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM14305(benzthiazole analog 8 | benzyl N-[(2S)-1-(1,3-benz...)
Affinity DataKi: >1.50E+5nM ΔG°: >-21.6kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM14304(benzthiazole analog 7 | benzyl N-[(2S)-3-(3-amino-...)
Affinity DataKi: >1.50E+5nM ΔG°: >-21.6kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM14303(benzthiazole analog 6 | benzyl N-[(2S)-3-[(3R)-3-a...)
Affinity DataKi: >1.50E+5nM ΔG°: >-21.6kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM14302(benzthiazole analog 5 | benzyl N-[(2S)-3-(6-aminop...)
Affinity DataKi: >1.50E+5nM ΔG°: >-21.6kJ/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM16127(2,2 -methanediylbis(1H-benzimidazole-6-carboximida...)
Affinity DataKi:  5nM ΔG°:  -46.9kJ/molepH: 8.2 T: 2°CAssay Description:Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM16304(2-(1H-1,3-benzodiazol-2-ylcarbonyl)-1H-1,3-benzodi...)
Affinity DataKi:  50nM ΔG°:  -41.3kJ/molepH: 8.2 T: 2°CAssay Description:Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM16303(2-(1H-1,3-benzodiazol-2-ylmethyl)-1H-1,3-benzodiaz...)
Affinity DataKi:  69.5nM ΔG°:  -40.4kJ/molepH: 8.2 T: 2°CAssay Description:Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM16307(2-(pyridin-2-ylmethyl)-1H-1,3-benzodiazole-6-carbo...)
Affinity DataKi:  310nM ΔG°:  -36.8kJ/molepH: 8.2 T: 2°CAssay Description:Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM16306(2-(pyridin-2-yl)-1H-1,3-benzodiazole-6-carboximida...)
Affinity DataKi:  1.60E+3nM ΔG°:  -32.7kJ/molepH: 8.2 T: 2°CAssay Description:Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM16305(2-(1H-imidazol-2-ylmethyl)-1H-1,3-benzodiazole-6-c...)
Affinity DataKi:  1.65E+3nM ΔG°:  -32.7kJ/molepH: 8.2 T: 2°CAssay Description:Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM16309(2-(quinolin-8-yl)-1H-1,3-benzodiazole-6-carboximid...)
Affinity DataKi:  1.10E+4nM ΔG°:  -28.0kJ/molepH: 8.2 T: 2°CAssay Description:Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM16308(2-(isoquinolin-1-yl)-1H-1,3-benzodiazole-6-carboxi...)
Affinity DataKi:  5.45E+4nM ΔG°:  -24.1kJ/molepH: 8.2 T: 2°CAssay Description:Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM16310(2-(isoquinolin-3-yl)-1H-1,3-benzodiazole-6-carboxi...)
Affinity DataKi:  6.33E+4nM ΔG°:  -23.7kJ/molepH: 8.2 T: 2°CAssay Description:Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50083552(1,9-di{4-[5-amino(imino)methylbenzo[b]furan-2-ylca...)
Affinity DataKi:  0.0190nMAssay Description:Inhibition of tryptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50083561(1-{4-[5-amino(imino)methylbenzo[b]thiophen-2-ylcar...)
Affinity DataKi:  0.0280nMAssay Description:Inhibition of tryptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50083556(1-{4-[5-amino(imino)methylbenzo[b]furan-2-ylcarbon...)
Affinity DataKi:  0.0290nMAssay Description:Inhibition of tryptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50083541(1-{4-[5-amino(imino)methyl-4,5,6,7-tetrahydrothien...)
Affinity DataKi:  0.0460nMAssay Description:Inhibition of tryptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50083548(1-{4-[5-amino(imino)methylbenzo[b]furan-2-ylcarbon...)
Affinity DataKi:  0.0570nMAssay Description:Inhibition of tryptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM50093142(1,5-di{4-[4-amino(imino)methylaminobenzylcarbamoyl...)
Affinity DataKi:  0.0700nMAssay Description:Inhibitory activity against human tryptase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50218667(APC-1390 | CHEMBL46809)
Affinity DataKi:  0.0700nMAssay Description:Binding affinity to 5-HT3 serotonin receptor in NG 108-15 neuroblastoma glioma cells using [3H]-GR-65,630 radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50093175(CHEMBL311655 | Derivative of APC-2059)
Affinity DataKi:  0.100nMAssay Description:Evaluated for its inhibitory potency against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50093157(CHEMBL431969 | Derivative of piperazine-1-carboxyl...)
Affinity DataKi:  0.100nMAssay Description:Evaluated for its inhibitory potency against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50217306(CHEMBL112049)
Affinity DataKi:  0.120nMAssay Description:Inhibition of tryptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50093192(CHEMBL311482 | Derivative of piperazine-1-carboxyl...)
Affinity DataKi:  0.200nMAssay Description:Evaluated for its inhibitory potency against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM50101018(1,4-di{4-[4-amino(imino)methylphenylcarboxamidomet...)
Affinity DataKi:  0.400nMAssay Description:Inhibitory activity against human tryptase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50093167(CHEMBL75750 | Derivative of APC-2059)
Affinity DataKi:  0.400nMAssay Description:Evaluated for its inhibitory potency against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50101018(1,4-di{4-[4-amino(imino)methylphenylcarboxamidomet...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to 5-HT3 serotonin receptor in NG 108-15 neuroblastoma glioma cells using [3H]-GR-65,630 radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50093156(CHEMBL432172 | Derivative of APC-2059)
Affinity DataKi:  0.400nMAssay Description:Evaluated for its inhibitory potency against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50093154(CHEMBL448786 | Derivative of piperazine-1-carboxyl...)
Affinity DataKi:  0.400nMAssay Description:Evaluated for its inhibitory potency against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50218668(CHEMBL42900)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to 5-HT3 serotonin receptor in NG 108-15 neuroblastoma glioma cells using [3H]-GR-65,630 radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50093199(CHEMBL75972 | Derivative of APC-2059)
Affinity DataKi:  0.5nMAssay Description:Evaluated for its inhibitory potency against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50093158(1-{4-[4-amino(imino)methylaminobenzylcarbamoyl]hex...)
Affinity DataKi:  0.5nMAssay Description:Evaluated for its inhibitory potency against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50093173(CHEMBL309830 | Derivative of piperazine-1-carboxyl...)
Affinity DataKi:  0.5nMAssay Description:Evaluated for its inhibitory potency against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM50084616(CHEMBL310290 | [(4-Aminomethyl-benzylcarbamoyl)-me...)
Affinity DataKi:  0.600nMAssay Description:Inhibitory potency against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50093178(CHEMBL76883 | Derivative of APC-2059)
Affinity DataKi:  0.700nMAssay Description:Evaluated for its inhibitory potency against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50101011(1,5-di{4-[4-amino(imino)methylphenylcarboxamidomet...)
Affinity DataKi:  0.850nMAssay Description:Inhibition of trypsin in human mast cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2/delta/gamma(Homo sapiens (Human))
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50101019(1-{4-[4-amino(imino)methylbenzylcarbamoyl]hexahydr...)
Affinity DataKi:  0.910nMAssay Description:Inhibition of trypsin in human mast cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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