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Found 176 hits Enz. Inhib. hit(s) with Target = 'Activin receptor-like kinase 1 (ALK1)(aa 166-493)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451789
PNG
(US10710980, Example 21 | US10947218, Example 21)
Show SMILES Nc1ncc(cc1C(=O)N[C@@H]1CC[C@@H](O)[C@@H](F)C1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C1CCOCC1
Show InChI InChI=1S/C28H35FN4O3/c29-24-12-21(5-6-25(24)34)32-27(35)23-11-18(14-31-26(23)30)17-1-3-19(4-2-17)28-13-20(28)15-33(16-28)22-7-9-36-10-8-22/h1-4,11,14,20-22,24-25,34H,5-10,12-13,15-16H2,(H2,30,31)(H,32,35)/t20-,21-,24+,25-,28+/m1/s1
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n/an/a 55n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451789
PNG
(US10710980, Example 21 | US10947218, Example 21)
Show SMILES Nc1ncc(cc1C(=O)N[C@@H]1CC[C@@H](O)[C@@H](F)C1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C1CCOCC1
Show InChI InChI=1S/C28H35FN4O3/c29-24-12-21(5-6-25(24)34)32-27(35)23-11-18(14-31-26(23)30)17-1-3-19(4-2-17)28-13-20(28)15-33(16-28)22-7-9-36-10-8-22/h1-4,11,14,20-22,24-25,34H,5-10,12-13,15-16H2,(H2,30,31)(H,32,35)/t20-,21-,24+,25-,28+/m1/s1
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n/an/a 55n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (1...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451769
PNG
(US10710980, Example 1 | US10947218, Example 1)
Show SMILES CS(=O)(=O)N1CCC(CC1)N1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C29H39N5O4S/c1-39(37,38)34-12-10-24(11-13-34)33-17-22-15-29(22,18-33)21-4-2-19(3-5-21)20-14-26(27(30)31-16-20)28(36)32-23-6-8-25(35)9-7-23/h2-5,14,16,22-25,35H,6-13,15,17-18H2,1H3,(H2,30,31)(H,32,36)/t22-,23-,25-,29+/m1/s1
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n/an/a 75n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (1...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451769
PNG
(US10710980, Example 1 | US10947218, Example 1)
Show SMILES CS(=O)(=O)N1CCC(CC1)N1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C29H39N5O4S/c1-39(37,38)34-12-10-24(11-13-34)33-17-22-15-29(22,18-33)21-4-2-19(3-5-21)20-14-26(27(30)31-16-20)28(36)32-23-6-8-25(35)9-7-23/h2-5,14,16,22-25,35H,6-13,15,17-18H2,1H3,(H2,30,31)(H,32,36)/t22-,23-,25-,29+/m1/s1
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n/an/a 75n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451773
PNG
(US10710980, Example 5 | US10947218, Example 5)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(CCCN1CCOCC1)C2
Show InChI InChI=1S/C30H41N5O3/c31-28-27(29(37)33-25-6-8-26(36)9-7-25)16-22(18-32-28)21-2-4-23(5-3-21)30-17-24(30)19-35(20-30)11-1-10-34-12-14-38-15-13-34/h2-5,16,18,24-26,36H,1,6-15,17,19-20H2,(H2,31,32)(H,33,37)/t24-,25-,26-,30+/m0/s1
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n/an/a 81n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451773
PNG
(US10710980, Example 5 | US10947218, Example 5)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(CCCN1CCOCC1)C2
Show InChI InChI=1S/C30H41N5O3/c31-28-27(29(37)33-25-6-8-26(36)9-7-25)16-22(18-32-28)21-2-4-23(5-3-21)30-17-24(30)19-35(20-30)11-1-10-34-12-14-38-15-13-34/h2-5,16,18,24-26,36H,1,6-15,17,19-20H2,(H2,31,32)(H,33,37)/t24-,25-,26-,30+/m0/s1
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n/an/a 81n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (1...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451778
PNG
(US10710980, Example 10 | US10947218, Example 10)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CCN1CCOCC1)C2
Show InChI InChI=1S/C29H39N5O3/c30-27-26(28(36)32-24-5-7-25(35)8-6-24)15-21(17-31-27)20-1-3-22(4-2-20)29-16-23(29)18-34(19-29)10-9-33-11-13-37-14-12-33/h1-4,15,17,23-25,35H,5-14,16,18-19H2,(H2,30,31)(H,32,36)/t23-,24-,25-,29+/m1/s1
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n/an/a 89n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (1...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451778
PNG
(US10710980, Example 10 | US10947218, Example 10)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CCN1CCOCC1)C2
Show InChI InChI=1S/C29H39N5O3/c30-27-26(28(36)32-24-5-7-25(35)8-6-24)15-21(17-31-27)20-1-3-22(4-2-20)29-16-23(29)18-34(19-29)10-9-33-11-13-37-14-12-33/h1-4,15,17,23-25,35H,5-14,16,18-19H2,(H2,30,31)(H,32,36)/t23-,24-,25-,29+/m1/s1
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n/an/a 89n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451770
PNG
(US10710980, Example 2 | US10947218, Example 2)
Show SMILES CC(C)N1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C26H34N4O2/c1-16(2)30-14-20-12-26(20,15-30)19-5-3-17(4-6-19)18-11-23(24(27)28-13-18)25(32)29-21-7-9-22(31)10-8-21/h3-6,11,13,16,20-22,31H,7-10,12,14-15H2,1-2H3,(H2,27,28)(H,29,32)/t20-,21-,22-,26+/m1/s1
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n/an/a 93n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (1...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451770
PNG
(US10710980, Example 2 | US10947218, Example 2)
Show SMILES CC(C)N1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C26H34N4O2/c1-16(2)30-14-20-12-26(20,15-30)19-5-3-17(4-6-19)18-11-23(24(27)28-13-18)25(32)29-21-7-9-22(31)10-8-21/h3-6,11,13,16,20-22,31H,7-10,12,14-15H2,1-2H3,(H2,27,28)(H,29,32)/t20-,21-,22-,26+/m1/s1
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n/an/a 93n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451805
PNG
(US10710980, Example 37 | US10947218, Example 37)
Show SMILES CC#CCN1C[C@@H]2C[C@@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C27H32N4O2/c1-2-3-12-31-16-21-14-27(21,17-31)20-6-4-18(5-7-20)19-13-24(25(28)29-15-19)26(33)30-22-8-10-23(32)11-9-22/h4-7,13,15,21-23,32H,8-12,14,16-17H2,1H3,(H2,28,29)(H,30,33)/t21-,22-,23-,27+/m0/s1
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n/an/a 100n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (1...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451805
PNG
(US10710980, Example 37 | US10947218, Example 37)
Show SMILES CC#CCN1C[C@@H]2C[C@@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C27H32N4O2/c1-2-3-12-31-16-21-14-27(21,17-31)20-6-4-18(5-7-20)19-13-24(25(28)29-15-19)26(33)30-22-8-10-23(32)11-9-22/h4-7,13,15,21-23,32H,8-12,14,16-17H2,1H3,(H2,28,29)(H,30,33)/t21-,22-,23-,27+/m0/s1
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n/an/a 100n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451787
PNG
(US10710980, Example 19 | US10947218, Example 19)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C1CCOCC1
Show InChI InChI=1S/C28H36N4O3/c29-26-25(27(34)31-22-5-7-24(33)8-6-22)13-19(15-30-26)18-1-3-20(4-2-18)28-14-21(28)16-32(17-28)23-9-11-35-12-10-23/h1-4,13,15,21-24,33H,5-12,14,16-17H2,(H2,29,30)(H,31,34)/t21-,22-,24-,28+/m1/s1
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NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451787
PNG
(US10710980, Example 19 | US10947218, Example 19)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C1CCOCC1
Show InChI InChI=1S/C28H36N4O3/c29-26-25(27(34)31-22-5-7-24(33)8-6-22)13-19(15-30-26)18-1-3-20(4-2-18)28-14-21(28)16-32(17-28)23-9-11-35-12-10-23/h1-4,13,15,21-24,33H,5-12,14,16-17H2,(H2,29,30)(H,31,34)/t21-,22-,24-,28+/m1/s1
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n/an/a 105n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (1...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451785
PNG
(US10710980, Example 17 | US10947218, Example 17)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(CCC(F)(F)F)C2
Show InChI InChI=1S/C26H31F3N4O2/c27-26(28,29)9-10-33-14-19-12-25(19,15-33)18-3-1-16(2-4-18)17-11-22(23(30)31-13-17)24(35)32-20-5-7-21(34)8-6-20/h1-4,11,13,19-21,34H,5-10,12,14-15H2,(H2,30,31)(H,32,35)/t19-,20-,21-,25+/m0/s1
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n/an/a 110n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451785
PNG
(US10710980, Example 17 | US10947218, Example 17)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(CCC(F)(F)F)C2
Show InChI InChI=1S/C26H31F3N4O2/c27-26(28,29)9-10-33-14-19-12-25(19,15-33)18-3-1-16(2-4-18)17-11-22(23(30)31-13-17)24(35)32-20-5-7-21(34)8-6-20/h1-4,11,13,19-21,34H,5-10,12,14-15H2,(H2,30,31)(H,32,35)/t19-,20-,21-,25+/m0/s1
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n/an/a 110n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (1...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451822
PNG
(US10710980, Example 51 | US10947218, Example 51)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(CCC#N)C2
Show InChI InChI=1S/C26H31N5O2/c27-10-1-11-31-15-20-13-26(20,16-31)19-4-2-17(3-5-19)18-12-23(24(28)29-14-18)25(33)30-21-6-8-22(32)9-7-21/h2-5,12,14,20-22,32H,1,6-9,11,13,15-16H2,(H2,28,29)(H,30,33)/t20-,21-,22-,26+/m0/s1
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n/an/a 120n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451819
PNG
(US10710980, Example 48 | US10947218, Example 48)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CCF)C2
Show InChI InChI=1S/C25H31FN4O2/c26-9-10-30-14-19-12-25(19,15-30)18-3-1-16(2-4-18)17-11-22(23(27)28-13-17)24(32)29-20-5-7-21(31)8-6-20/h1-4,11,13,19-21,31H,5-10,12,14-15H2,(H2,27,28)(H,29,32)/t19-,20-,21-,25+/m1/s1
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NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451822
PNG
(US10710980, Example 51 | US10947218, Example 51)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(CCC#N)C2
Show InChI InChI=1S/C26H31N5O2/c27-10-1-11-31-15-20-13-26(20,16-31)19-4-2-17(3-5-19)18-12-23(24(28)29-14-18)25(33)30-21-6-8-22(32)9-7-21/h2-5,12,14,20-22,32H,1,6-9,11,13,15-16H2,(H2,28,29)(H,30,33)/t20-,21-,22-,26+/m0/s1
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n/an/a 120n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (1...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451819
PNG
(US10710980, Example 48 | US10947218, Example 48)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CCF)C2
Show InChI InChI=1S/C25H31FN4O2/c26-9-10-30-14-19-12-25(19,15-30)18-3-1-16(2-4-18)17-11-22(23(27)28-13-17)24(32)29-20-5-7-21(31)8-6-20/h1-4,11,13,19-21,31H,5-10,12,14-15H2,(H2,27,28)(H,29,32)/t19-,20-,21-,25+/m1/s1
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n/an/a 120n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (1...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451777
PNG
(US10710980, Example 9 | US10947218, Example 9)
Show SMILES CC(C)N1C[C@@H]2C[C@@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C26H34N4O2/c1-16(2)30-14-20-12-26(20,15-30)19-5-3-17(4-6-19)18-11-23(24(27)28-13-18)25(32)29-21-7-9-22(31)10-8-21/h3-6,11,13,16,20-22,31H,7-10,12,14-15H2,1-2H3,(H2,27,28)(H,29,32)/t20-,21-,22-,26+/m0/s1
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n/an/a 127n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451777
PNG
(US10710980, Example 9 | US10947218, Example 9)
Show SMILES CC(C)N1C[C@@H]2C[C@@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C26H34N4O2/c1-16(2)30-14-20-12-26(20,15-30)19-5-3-17(4-6-19)18-11-23(24(27)28-13-18)25(32)29-21-7-9-22(31)10-8-21/h3-6,11,13,16,20-22,31H,7-10,12,14-15H2,1-2H3,(H2,27,28)(H,29,32)/t20-,21-,22-,26+/m0/s1
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n/an/a 127n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (1...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451793
PNG
(US10710980, Example 25 | US10947218, Example 25)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C1CCC(F)(F)CC1
Show InChI InChI=1S/C29H36F2N4O2/c30-29(31)11-9-23(10-12-29)35-16-21-14-28(21,17-35)20-3-1-18(2-4-20)19-13-25(26(32)33-15-19)27(37)34-22-5-7-24(36)8-6-22/h1-4,13,15,21-24,36H,5-12,14,16-17H2,(H2,32,33)(H,34,37)/t21-,22-,24-,28+/m1/s1
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n/an/a 130n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451788
PNG
(US10710980, Example 20 | US10947218, Example 20)
Show SMILES COCCN1C[C@@H]2C[C@@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C26H34N4O3/c1-33-11-10-30-15-20-13-26(20,16-30)19-4-2-17(3-5-19)18-12-23(24(27)28-14-18)25(32)29-21-6-8-22(31)9-7-21/h2-5,12,14,20-22,31H,6-11,13,15-16H2,1H3,(H2,27,28)(H,29,32)/t20-,21-,22-,26+/m0/s1
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n/an/a 130n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (1...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451793
PNG
(US10710980, Example 25 | US10947218, Example 25)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C1CCC(F)(F)CC1
Show InChI InChI=1S/C29H36F2N4O2/c30-29(31)11-9-23(10-12-29)35-16-21-14-28(21,17-35)20-3-1-18(2-4-20)19-13-25(26(32)33-15-19)27(37)34-22-5-7-24(36)8-6-22/h1-4,13,15,21-24,36H,5-12,14,16-17H2,(H2,32,33)(H,34,37)/t21-,22-,24-,28+/m1/s1
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n/an/a 130n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (1...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451788
PNG
(US10710980, Example 20 | US10947218, Example 20)
Show SMILES COCCN1C[C@@H]2C[C@@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C26H34N4O3/c1-33-11-10-30-15-20-13-26(20,16-30)19-4-2-17(3-5-19)18-12-23(24(27)28-14-18)25(32)29-21-6-8-22(31)9-7-21/h2-5,12,14,20-22,31H,6-11,13,15-16H2,1H3,(H2,27,28)(H,29,32)/t20-,21-,22-,26+/m0/s1
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n/an/a 130n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451795
PNG
(US10710980, Example 27 | US10947218, Example 27)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(C2)C1CCC(F)(F)CC1
Show InChI InChI=1S/C29H36F2N4O2/c30-29(31)11-9-23(10-12-29)35-16-21-14-28(21,17-35)20-3-1-18(2-4-20)19-13-25(26(32)33-15-19)27(37)34-22-5-7-24(36)8-6-22/h1-4,13,15,21-24,36H,5-12,14,16-17H2,(H2,32,33)(H,34,37)/t21-,22-,24-,28+/m0/s1
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n/an/a 135n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451795
PNG
(US10710980, Example 27 | US10947218, Example 27)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(C2)C1CCC(F)(F)CC1
Show InChI InChI=1S/C29H36F2N4O2/c30-29(31)11-9-23(10-12-29)35-16-21-14-28(21,17-35)20-3-1-18(2-4-20)19-13-25(26(32)33-15-19)27(37)34-22-5-7-24(36)8-6-22/h1-4,13,15,21-24,36H,5-12,14,16-17H2,(H2,32,33)(H,34,37)/t21-,22-,24-,28+/m0/s1
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n/an/a 135n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (1...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451771
PNG
(US10710980, Example 3 | US10947218, Example 3)
Show SMILES C[C@@H](N1CC2(COC2)C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C25H32N4O3/c1-16(29-12-25(13-29)14-32-15-25)17-2-4-18(5-3-17)19-10-22(23(26)27-11-19)24(31)28-20-6-8-21(30)9-7-20/h2-5,10-11,16,20-21,30H,6-9,12-15H2,1H3,(H2,26,27)(H,28,31)/t16-,20-,21-/m1/s1
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n/an/a 136n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (1...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451771
PNG
(US10710980, Example 3 | US10947218, Example 3)
Show SMILES C[C@@H](N1CC2(COC2)C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C25H32N4O3/c1-16(29-12-25(13-29)14-32-15-25)17-2-4-18(5-3-17)19-10-22(23(26)27-11-19)24(31)28-20-6-8-21(30)9-7-20/h2-5,10-11,16,20-21,30H,6-9,12-15H2,1H3,(H2,26,27)(H,28,31)/t16-,20-,21-/m1/s1
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n/an/a 136n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451825
PNG
(US10710980, Example 54 | US10947218, Example 54)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CC#C)C2
Show InChI InChI=1S/C26H30N4O2/c1-2-11-30-15-20-13-26(20,16-30)19-5-3-17(4-6-19)18-12-23(24(27)28-14-18)25(32)29-21-7-9-22(31)10-8-21/h1,3-6,12,14,20-22,31H,7-11,13,15-16H2,(H2,27,28)(H,29,32)/t20-,21-,22-,26+/m1/s1
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n/an/a 140n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451825
PNG
(US10710980, Example 54 | US10947218, Example 54)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CC#C)C2
Show InChI InChI=1S/C26H30N4O2/c1-2-11-30-15-20-13-26(20,16-30)19-5-3-17(4-6-19)18-12-23(24(27)28-14-18)25(32)29-21-7-9-22(31)10-8-21/h1,3-6,12,14,20-22,31H,7-11,13,15-16H2,(H2,27,28)(H,29,32)/t20-,21-,22-,26+/m1/s1
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n/an/a 140n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (1...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451781
PNG
(US10710980, Example 13 | US10947218, Example 13)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(CCN1CCOCC1)C2
Show InChI InChI=1S/C29H39N5O3/c30-27-26(28(36)32-24-5-7-25(35)8-6-24)15-21(17-31-27)20-1-3-22(4-2-20)29-16-23(29)18-34(19-29)10-9-33-11-13-37-14-12-33/h1-4,15,17,23-25,35H,5-14,16,18-19H2,(H2,30,31)(H,32,36)/t23-,24-,25-,29+/m0/s1
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n/an/a 140n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (1...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451781
PNG
(US10710980, Example 13 | US10947218, Example 13)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(CCN1CCOCC1)C2
Show InChI InChI=1S/C29H39N5O3/c30-27-26(28(36)32-24-5-7-25(35)8-6-24)15-21(17-31-27)20-1-3-22(4-2-20)29-16-23(29)18-34(19-29)10-9-33-11-13-37-14-12-33/h1-4,15,17,23-25,35H,5-14,16,18-19H2,(H2,30,31)(H,32,36)/t23-,24-,25-,29+/m0/s1
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n/an/a 140n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451779
PNG
(US10710980, Example 11 | US10947218, Example 11)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(CCF)C2
Show InChI InChI=1S/C25H31FN4O2/c26-9-10-30-14-19-12-25(19,15-30)18-3-1-16(2-4-18)17-11-22(23(27)28-13-17)24(32)29-20-5-7-21(31)8-6-20/h1-4,11,13,19-21,31H,5-10,12,14-15H2,(H2,27,28)(H,29,32)/t19-,20-,21-,25+/m0/s1
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n/an/a 150n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451779
PNG
(US10710980, Example 11 | US10947218, Example 11)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(CCF)C2
Show InChI InChI=1S/C25H31FN4O2/c26-9-10-30-14-19-12-25(19,15-30)18-3-1-16(2-4-18)17-11-22(23(27)28-13-17)24(32)29-20-5-7-21(31)8-6-20/h1-4,11,13,19-21,31H,5-10,12,14-15H2,(H2,27,28)(H,29,32)/t19-,20-,21-,25+/m0/s1
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n/an/a 150n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (1...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451806
PNG
(US10710980, Example 38 | US10947218, Example 38)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(CC1COC1)C2
Show InChI InChI=1S/C27H34N4O3/c28-25-24(26(33)30-22-5-7-23(32)8-6-22)9-19(11-29-25)18-1-3-20(4-2-18)27-10-21(27)13-31(16-27)12-17-14-34-15-17/h1-4,9,11,17,21-23,32H,5-8,10,12-16H2,(H2,28,29)(H,30,33)/t21-,22-,23-,27+/m0/s1
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n/an/a 160n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451806
PNG
(US10710980, Example 38 | US10947218, Example 38)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(CC1COC1)C2
Show InChI InChI=1S/C27H34N4O3/c28-25-24(26(33)30-22-5-7-23(32)8-6-22)9-19(11-29-25)18-1-3-20(4-2-18)27-10-21(27)13-31(16-27)12-17-14-34-15-17/h1-4,9,11,17,21-23,32H,5-8,10,12-16H2,(H2,28,29)(H,30,33)/t21-,22-,23-,27+/m0/s1
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Novartis AG

US Patent


Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (1...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451780
PNG
(US10710980, Example 12 | US10947218, Example 12)
Show SMILES CC(C)N1CCC(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C25H34N4O2/c1-16(2)29-12-11-19(15-29)17-3-5-18(6-4-17)20-13-23(24(26)27-14-20)25(31)28-21-7-9-22(30)10-8-21/h3-6,13-14,16,19,21-22,30H,7-12,15H2,1-2H3,(H2,26,27)(H,28,31)/t19?,21-,22-
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Novartis AG

US Patent


Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (1...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451780
PNG
(US10710980, Example 12 | US10947218, Example 12)
Show SMILES CC(C)N1CCC(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C25H34N4O2/c1-16(2)29-12-11-19(15-29)17-3-5-18(6-4-17)20-13-23(24(26)27-14-20)25(31)28-21-7-9-22(30)10-8-21/h3-6,13-14,16,19,21-22,30H,7-12,15H2,1-2H3,(H2,26,27)(H,28,31)/t19?,21-,22-
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NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451831
PNG
(US10710980, Example 60 | US10947218, Example 60)
Show SMILES CC#CCN1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C27H32N4O2/c1-2-3-12-31-16-21-14-27(21,17-31)20-6-4-18(5-7-20)19-13-24(25(28)29-15-19)26(33)30-22-8-10-23(32)11-9-22/h4-7,13,15,21-23,32H,8-12,14,16-17H2,1H3,(H2,28,29)(H,30,33)/t21-,22-,23-,27+/m1/s1
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n/an/a 170n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451813
PNG
(US10710980, Example 44 | US10947218, Example 44)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C1CCS(=O)(=O)CC1
Show InChI InChI=1S/C28H36N4O4S/c29-26-25(27(34)31-22-5-7-24(33)8-6-22)13-19(15-30-26)18-1-3-20(4-2-18)28-14-21(28)16-32(17-28)23-9-11-37(35,36)12-10-23/h1-4,13,15,21-24,33H,5-12,14,16-17H2,(H2,29,30)(H,31,34)/t21-,22-,24-,28+/m1/s1
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n/an/a 170n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451813
PNG
(US10710980, Example 44 | US10947218, Example 44)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C1CCS(=O)(=O)CC1
Show InChI InChI=1S/C28H36N4O4S/c29-26-25(27(34)31-22-5-7-24(33)8-6-22)13-19(15-30-26)18-1-3-20(4-2-18)28-14-21(28)16-32(17-28)23-9-11-37(35,36)12-10-23/h1-4,13,15,21-24,33H,5-12,14,16-17H2,(H2,29,30)(H,31,34)/t21-,22-,24-,28+/m1/s1
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n/an/a 170n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (1...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451831
PNG
(US10710980, Example 60 | US10947218, Example 60)
Show SMILES CC#CCN1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C27H32N4O2/c1-2-3-12-31-16-21-14-27(21,17-31)20-6-4-18(5-7-20)19-13-24(25(28)29-15-19)26(33)30-22-8-10-23(32)11-9-22/h4-7,13,15,21-23,32H,8-12,14,16-17H2,1H3,(H2,28,29)(H,30,33)/t21-,22-,23-,27+/m1/s1
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n/an/a 170n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (1...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451772
PNG
(US10710980, Example 4 | US10947218, Example 4)
Show SMILES C[C@H](N1CC2(COC2)C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C25H32N4O3/c1-16(29-12-25(13-29)14-32-15-25)17-2-4-18(5-3-17)19-10-22(23(26)27-11-19)24(31)28-20-6-8-21(30)9-7-20/h2-5,10-11,16,20-21,30H,6-9,12-15H2,1H3,(H2,26,27)(H,28,31)/t16-,20-,21-/m0/s1
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NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451772
PNG
(US10710980, Example 4 | US10947218, Example 4)
Show SMILES C[C@H](N1CC2(COC2)C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C25H32N4O3/c1-16(29-12-25(13-29)14-32-15-25)17-2-4-18(5-3-17)19-10-22(23(26)27-11-19)24(31)28-20-6-8-21(30)9-7-20/h2-5,10-11,16,20-21,30H,6-9,12-15H2,1H3,(H2,26,27)(H,28,31)/t16-,20-,21-/m0/s1
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Novartis AG

US Patent


Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (1...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451838
PNG
(US10710980, Example 67 | US10947218, Example 67)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(CC(F)(F)F)C2
Show InChI InChI=1S/C25H29F3N4O2/c26-25(27,28)14-32-12-18-10-24(18,13-32)17-3-1-15(2-4-17)16-9-21(22(29)30-11-16)23(34)31-19-5-7-20(33)8-6-19/h1-4,9,11,18-20,33H,5-8,10,12-14H2,(H2,29,30)(H,31,34)/t18-,19-,20-,24+/m0/s1
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n/an/a 180n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (1...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451838
PNG
(US10710980, Example 67 | US10947218, Example 67)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(CC(F)(F)F)C2
Show InChI InChI=1S/C25H29F3N4O2/c26-25(27,28)14-32-12-18-10-24(18,13-32)17-3-1-15(2-4-17)16-9-21(22(29)30-11-16)23(34)31-19-5-7-20(33)8-6-19/h1-4,9,11,18-20,33H,5-8,10,12-14H2,(H2,29,30)(H,31,34)/t18-,19-,20-,24+/m0/s1
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NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451824
PNG
(US10710980, Example 53 | US10947218, Example 53)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(CC#C)C2
Show InChI InChI=1S/C26H30N4O2/c1-2-11-30-15-20-13-26(20,16-30)19-5-3-17(4-6-19)18-12-23(24(27)28-14-18)25(32)29-21-7-9-22(31)10-8-21/h1,3-6,12,14,20-22,31H,7-11,13,15-16H2,(H2,27,28)(H,29,32)/t20-,21-,22-,26+/m0/s1
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Novartis AG

US Patent


Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (1...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 1 (ALK1)(aa 166-493)


(Homo sapiens (Human))
BDBM451837
PNG
(US10710980, Example 66 | US10947218, Example 66)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(C2)C(CF)CF
Show InChI InChI=1S/C26H32F2N4O2/c27-11-21(12-28)32-14-19-10-26(19,15-32)18-3-1-16(2-4-18)17-9-23(24(29)30-13-17)25(34)31-20-5-7-22(33)8-6-20/h1-4,9,13,19-22,33H,5-8,10-12,14-15H2,(H2,29,30)(H,31,34)/t19-,20-,22-,26+/m0/s1
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Novartis AG

US Patent


Assay Description
In the applied method, this separation takes place inside a chip that contains a complex capillary system for simultaneous analysis of 12 samples (1...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
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