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Compile Data Set for Download or QSAR

Found 176 hits Enz. Inhib. hit(s) with Target = 'Activin receptor-like kinase 3 (ALK3) (aa 198-525)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451789
PNG
(US10710980, Example 21 | US10947218, Example 21)
Show SMILES Nc1ncc(cc1C(=O)N[C@@H]1CC[C@@H](O)[C@@H](F)C1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C1CCOCC1
Show InChI InChI=1S/C28H35FN4O3/c29-24-12-21(5-6-25(24)34)32-27(35)23-11-18(14-31-26(23)30)17-1-3-19(4-2-17)28-13-20(28)15-33(16-28)22-7-9-36-10-8-22/h1-4,11,14,20-22,24-25,34H,5-10,12-13,15-16H2,(H2,30,31)(H,32,35)/t20-,21-,24+,25-,28+/m1/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 260n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451789
PNG
(US10710980, Example 21 | US10947218, Example 21)
Show SMILES Nc1ncc(cc1C(=O)N[C@@H]1CC[C@@H](O)[C@@H](F)C1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C1CCOCC1
Show InChI InChI=1S/C28H35FN4O3/c29-24-12-21(5-6-25(24)34)32-27(35)23-11-18(14-31-26(23)30)17-1-3-19(4-2-17)28-13-20(28)15-33(16-28)22-7-9-36-10-8-22/h1-4,11,14,20-22,24-25,34H,5-10,12-13,15-16H2,(H2,30,31)(H,32,35)/t20-,21-,24+,25-,28+/m1/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 260n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451769
PNG
(US10710980, Example 1 | US10947218, Example 1)
Show SMILES CS(=O)(=O)N1CCC(CC1)N1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C29H39N5O4S/c1-39(37,38)34-12-10-24(11-13-34)33-17-22-15-29(22,18-33)21-4-2-19(3-5-21)20-14-26(27(30)31-16-20)28(36)32-23-6-8-25(35)9-7-23/h2-5,14,16,22-25,35H,6-13,15,17-18H2,1H3,(H2,30,31)(H,32,36)/t22-,23-,25-,29+/m1/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 310n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451769
PNG
(US10710980, Example 1 | US10947218, Example 1)
Show SMILES CS(=O)(=O)N1CCC(CC1)N1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C29H39N5O4S/c1-39(37,38)34-12-10-24(11-13-34)33-17-22-15-29(22,18-33)21-4-2-19(3-5-21)20-14-26(27(30)31-16-20)28(36)32-23-6-8-25(35)9-7-23/h2-5,14,16,22-25,35H,6-13,15,17-18H2,1H3,(H2,30,31)(H,32,36)/t22-,23-,25-,29+/m1/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 310n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451813
PNG
(US10710980, Example 44 | US10947218, Example 44)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C1CCS(=O)(=O)CC1
Show InChI InChI=1S/C28H36N4O4S/c29-26-25(27(34)31-22-5-7-24(33)8-6-22)13-19(15-30-26)18-1-3-20(4-2-18)28-14-21(28)16-32(17-28)23-9-11-37(35,36)12-10-23/h1-4,13,15,21-24,33H,5-12,14,16-17H2,(H2,29,30)(H,31,34)/t21-,22-,24-,28+/m1/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 430n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451813
PNG
(US10710980, Example 44 | US10947218, Example 44)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C1CCS(=O)(=O)CC1
Show InChI InChI=1S/C28H36N4O4S/c29-26-25(27(34)31-22-5-7-24(33)8-6-22)13-19(15-30-26)18-1-3-20(4-2-18)28-14-21(28)16-32(17-28)23-9-11-37(35,36)12-10-23/h1-4,13,15,21-24,33H,5-12,14,16-17H2,(H2,29,30)(H,31,34)/t21-,22-,24-,28+/m1/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 430n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451798
PNG
(US10710980, Example 30 | US10947218, Example 30)
Show SMILES Nc1ncc(cc1C(=O)NC12CC(CO)(C1)C2)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C1CCOCC1
Show InChI InChI=1S/C28H34N4O3/c29-24-23(25(34)31-27-13-26(14-27,15-27)17-33)9-19(11-30-24)18-1-3-20(4-2-18)28-10-21(28)12-32(16-28)22-5-7-35-8-6-22/h1-4,9,11,21-22,33H,5-8,10,12-17H2,(H2,29,30)(H,31,34)/t21-,26?,27?,28+/m1/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 500n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451798
PNG
(US10710980, Example 30 | US10947218, Example 30)
Show SMILES Nc1ncc(cc1C(=O)NC12CC(CO)(C1)C2)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C1CCOCC1
Show InChI InChI=1S/C28H34N4O3/c29-24-23(25(34)31-27-13-26(14-27,15-27)17-33)9-19(11-30-24)18-1-3-20(4-2-18)28-10-21(28)12-32(16-28)22-5-7-35-8-6-22/h1-4,9,11,21-22,33H,5-8,10,12-17H2,(H2,29,30)(H,31,34)/t21-,26?,27?,28+/m1/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 500n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451796
PNG
(US10710980, Example 28 | US10947218, Example 28)
Show SMILES Nc1ncc(cc1C(=O)NC12CC(CO)(C1)C2)-c1ccc(cc1)[C@]12C[C@H]1CN(C2)C1CCOCC1
Show InChI InChI=1S/C28H34N4O3/c29-24-23(25(34)31-27-13-26(14-27,15-27)17-33)9-19(11-30-24)18-1-3-20(4-2-18)28-10-21(28)12-32(16-28)22-5-7-35-8-6-22/h1-4,9,11,21-22,33H,5-8,10,12-17H2,(H2,29,30)(H,31,34)/t21-,26?,27?,28+/m0/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 530n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451796
PNG
(US10710980, Example 28 | US10947218, Example 28)
Show SMILES Nc1ncc(cc1C(=O)NC12CC(CO)(C1)C2)-c1ccc(cc1)[C@]12C[C@H]1CN(C2)C1CCOCC1
Show InChI InChI=1S/C28H34N4O3/c29-24-23(25(34)31-27-13-26(14-27,15-27)17-33)9-19(11-30-24)18-1-3-20(4-2-18)28-10-21(28)12-32(16-28)22-5-7-35-8-6-22/h1-4,9,11,21-22,33H,5-8,10,12-17H2,(H2,29,30)(H,31,34)/t21-,26?,27?,28+/m0/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 530n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451822
PNG
(US10710980, Example 51 | US10947218, Example 51)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(CCC#N)C2
Show InChI InChI=1S/C26H31N5O2/c27-10-1-11-31-15-20-13-26(20,16-31)19-4-2-17(3-5-19)18-12-23(24(28)29-14-18)25(33)30-21-6-8-22(32)9-7-21/h2-5,12,14,20-22,32H,1,6-9,11,13,15-16H2,(H2,28,29)(H,30,33)/t20-,21-,22-,26+/m0/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 780n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451822
PNG
(US10710980, Example 51 | US10947218, Example 51)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(CCC#N)C2
Show InChI InChI=1S/C26H31N5O2/c27-10-1-11-31-15-20-13-26(20,16-31)19-4-2-17(3-5-19)18-12-23(24(28)29-14-18)25(33)30-21-6-8-22(32)9-7-21/h2-5,12,14,20-22,32H,1,6-9,11,13,15-16H2,(H2,28,29)(H,30,33)/t20-,21-,22-,26+/m0/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 780n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451772
PNG
(US10710980, Example 4 | US10947218, Example 4)
Show SMILES C[C@H](N1CC2(COC2)C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C25H32N4O3/c1-16(29-12-25(13-29)14-32-15-25)17-2-4-18(5-3-17)19-10-22(23(26)27-11-19)24(31)28-20-6-8-21(30)9-7-20/h2-5,10-11,16,20-21,30H,6-9,12-15H2,1H3,(H2,26,27)(H,28,31)/t16-,20-,21-/m0/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 830n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451807
PNG
(US10710980, Example 39 | US10947218, Example 39)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C1CCN(CC(F)(F)F)CC1
Show InChI InChI=1S/C30H38F3N5O2/c31-30(32,33)18-37-11-9-24(10-12-37)38-16-22-14-29(22,17-38)21-3-1-19(2-4-21)20-13-26(27(34)35-15-20)28(40)36-23-5-7-25(39)8-6-23/h1-4,13,15,22-25,39H,5-12,14,16-18H2,(H2,34,35)(H,36,40)/t22-,23-,25-,29+/m1/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 830n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451772
PNG
(US10710980, Example 4 | US10947218, Example 4)
Show SMILES C[C@H](N1CC2(COC2)C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C25H32N4O3/c1-16(29-12-25(13-29)14-32-15-25)17-2-4-18(5-3-17)19-10-22(23(26)27-11-19)24(31)28-20-6-8-21(30)9-7-20/h2-5,10-11,16,20-21,30H,6-9,12-15H2,1H3,(H2,26,27)(H,28,31)/t16-,20-,21-/m0/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 830n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451807
PNG
(US10710980, Example 39 | US10947218, Example 39)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C1CCN(CC(F)(F)F)CC1
Show InChI InChI=1S/C30H38F3N5O2/c31-30(32,33)18-37-11-9-24(10-12-37)38-16-22-14-29(22,17-38)21-3-1-19(2-4-21)20-13-26(27(34)35-15-20)28(40)36-23-5-7-25(39)8-6-23/h1-4,13,15,22-25,39H,5-12,14,16-18H2,(H2,34,35)(H,36,40)/t22-,23-,25-,29+/m1/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 830n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451775
PNG
(US10710980, Example 7 | US10947218, Example 7)
Show SMILES COCCN1C[C@@H]2C[C@@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)NC12CCC(O)(CC1)CC2
Show InChI InChI=1S/C28H36N4O3/c1-35-13-12-32-17-22-15-28(22,18-32)21-4-2-19(3-5-21)20-14-23(24(29)30-16-20)25(33)31-26-6-9-27(34,10-7-26)11-8-26/h2-5,14,16,22,34H,6-13,15,17-18H2,1H3,(H2,29,30)(H,31,33)/t22-,26?,27?,28+/m0/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 875n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451775
PNG
(US10710980, Example 7 | US10947218, Example 7)
Show SMILES COCCN1C[C@@H]2C[C@@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)NC12CCC(O)(CC1)CC2
Show InChI InChI=1S/C28H36N4O3/c1-35-13-12-32-17-22-15-28(22,18-32)21-4-2-19(3-5-21)20-14-23(24(29)30-16-20)25(33)31-26-6-9-27(34,10-7-26)11-8-26/h2-5,14,16,22,34H,6-13,15,17-18H2,1H3,(H2,29,30)(H,31,33)/t22-,26?,27?,28+/m0/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 875n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451803
PNG
(US10710980, Example 35 | US10947218, Example 35)
Show SMILES Nc1ncc(cc1C(=O)NC12CCC(O)(CC1)CC2)-c1ccc(cc1)[C@]12C[C@H]1CN(C2)C1CCC(F)(F)CC1
Show InChI InChI=1S/C31H38F2N4O2/c32-31(33)7-5-24(6-8-31)37-18-23-16-30(23,19-37)22-3-1-20(2-4-22)21-15-25(26(34)35-17-21)27(38)36-28-9-12-29(39,13-10-28)14-11-28/h1-4,15,17,23-24,39H,5-14,16,18-19H2,(H2,34,35)(H,36,38)/t23-,28?,29?,30+/m0/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 903n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451803
PNG
(US10710980, Example 35 | US10947218, Example 35)
Show SMILES Nc1ncc(cc1C(=O)NC12CCC(O)(CC1)CC2)-c1ccc(cc1)[C@]12C[C@H]1CN(C2)C1CCC(F)(F)CC1
Show InChI InChI=1S/C31H38F2N4O2/c32-31(33)7-5-24(6-8-31)37-18-23-16-30(23,19-37)22-3-1-20(2-4-22)21-15-25(26(34)35-17-21)27(38)36-28-9-12-29(39,13-10-28)14-11-28/h1-4,15,17,23-24,39H,5-14,16,18-19H2,(H2,34,35)(H,36,38)/t23-,28?,29?,30+/m0/s1
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n/an/a 903n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451802
PNG
(US10710980, Example 34 | US10947218, Example 34)
Show SMILES Nc1ncc(cc1C(=O)NC12CCC(O)(CC1)CC2)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C1CCOCC1
Show InChI InChI=1S/C30H38N4O3/c31-26-25(27(35)33-28-7-10-29(36,11-8-28)12-9-28)15-21(17-32-26)20-1-3-22(4-2-20)30-16-23(30)18-34(19-30)24-5-13-37-14-6-24/h1-4,15,17,23-24,36H,5-14,16,18-19H2,(H2,31,32)(H,33,35)/t23-,28?,29?,30+/m1/s1
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UniChem
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n/an/a 914n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451802
PNG
(US10710980, Example 34 | US10947218, Example 34)
Show SMILES Nc1ncc(cc1C(=O)NC12CCC(O)(CC1)CC2)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C1CCOCC1
Show InChI InChI=1S/C30H38N4O3/c31-26-25(27(35)33-28-7-10-29(36,11-8-28)12-9-28)15-21(17-32-26)20-1-3-22(4-2-20)30-16-23(30)18-34(19-30)24-5-13-37-14-6-24/h1-4,15,17,23-24,36H,5-14,16,18-19H2,(H2,31,32)(H,33,35)/t23-,28?,29?,30+/m1/s1
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US Patent
n/an/a 914n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451825
PNG
(US10710980, Example 54 | US10947218, Example 54)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CC#C)C2
Show InChI InChI=1S/C26H30N4O2/c1-2-11-30-15-20-13-26(20,16-30)19-5-3-17(4-6-19)18-12-23(24(27)28-14-18)25(32)29-21-7-9-22(31)10-8-21/h1,3-6,12,14,20-22,31H,7-11,13,15-16H2,(H2,27,28)(H,29,32)/t20-,21-,22-,26+/m1/s1
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US Patent
n/an/a 920n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451825
PNG
(US10710980, Example 54 | US10947218, Example 54)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CC#C)C2
Show InChI InChI=1S/C26H30N4O2/c1-2-11-30-15-20-13-26(20,16-30)19-5-3-17(4-6-19)18-12-23(24(27)28-14-18)25(32)29-21-7-9-22(31)10-8-21/h1,3-6,12,14,20-22,31H,7-11,13,15-16H2,(H2,27,28)(H,29,32)/t20-,21-,22-,26+/m1/s1
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PC sid
UniChem
US Patent
n/an/a 920n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451774
PNG
(US10710980, Example 6 | US10947218, Example 6)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C(CF)CF
Show InChI InChI=1S/C26H32F2N4O2/c27-11-21(12-28)32-14-19-10-26(19,15-32)18-3-1-16(2-4-18)17-9-23(24(29)30-13-17)25(34)31-20-5-7-22(33)8-6-20/h1-4,9,13,19-22,33H,5-8,10-12,14-15H2,(H2,29,30)(H,31,34)/t19-,20-,22-,26+/m1/s1
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n/an/a 940n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451774
PNG
(US10710980, Example 6 | US10947218, Example 6)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C(CF)CF
Show InChI InChI=1S/C26H32F2N4O2/c27-11-21(12-28)32-14-19-10-26(19,15-32)18-3-1-16(2-4-18)17-9-23(24(29)30-13-17)25(34)31-20-5-7-22(33)8-6-20/h1-4,9,13,19-22,33H,5-8,10-12,14-15H2,(H2,29,30)(H,31,34)/t19-,20-,22-,26+/m1/s1
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PC sid
UniChem
US Patent
n/an/a 940n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451805
PNG
(US10710980, Example 37 | US10947218, Example 37)
Show SMILES CC#CCN1C[C@@H]2C[C@@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C27H32N4O2/c1-2-3-12-31-16-21-14-27(21,17-31)20-6-4-18(5-7-20)19-13-24(25(28)29-15-19)26(33)30-22-8-10-23(32)11-9-22/h4-7,13,15,21-23,32H,8-12,14,16-17H2,1H3,(H2,28,29)(H,30,33)/t21-,22-,23-,27+/m0/s1
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n/an/a 960n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451805
PNG
(US10710980, Example 37 | US10947218, Example 37)
Show SMILES CC#CCN1C[C@@H]2C[C@@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C27H32N4O2/c1-2-3-12-31-16-21-14-27(21,17-31)20-6-4-18(5-7-20)19-13-24(25(28)29-15-19)26(33)30-22-8-10-23(32)11-9-22/h4-7,13,15,21-23,32H,8-12,14,16-17H2,1H3,(H2,28,29)(H,30,33)/t21-,22-,23-,27+/m0/s1
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PC sid
UniChem
US Patent
n/an/a 960n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451783
PNG
(US10710980, Example 15 | US10947218, Example 15)
Show SMILES Nc1ncc(cc1C(=O)NC12CCC(O)(CC1)CC2)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CCN1CCOCC1)C2
Show InChI InChI=1S/C31H41N5O3/c32-27-26(28(37)34-29-5-8-30(38,9-6-29)10-7-29)17-23(19-33-27)22-1-3-24(4-2-22)31-18-25(31)20-36(21-31)12-11-35-13-15-39-16-14-35/h1-4,17,19,25,38H,5-16,18,20-21H2,(H2,32,33)(H,34,37)/t25-,29?,30?,31+/m1/s1
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PC sid
UniChem
US Patent
n/an/a 967n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451783
PNG
(US10710980, Example 15 | US10947218, Example 15)
Show SMILES Nc1ncc(cc1C(=O)NC12CCC(O)(CC1)CC2)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CCN1CCOCC1)C2
Show InChI InChI=1S/C31H41N5O3/c32-27-26(28(37)34-29-5-8-30(38,9-6-29)10-7-29)17-23(19-33-27)22-1-3-24(4-2-22)31-18-25(31)20-36(21-31)12-11-35-13-15-39-16-14-35/h1-4,17,19,25,38H,5-16,18,20-21H2,(H2,32,33)(H,34,37)/t25-,29?,30?,31+/m1/s1
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PC sid
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US Patent
n/an/a 967n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451819
PNG
(US10710980, Example 48 | US10947218, Example 48)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CCF)C2
Show InChI InChI=1S/C25H31FN4O2/c26-9-10-30-14-19-12-25(19,15-30)18-3-1-16(2-4-18)17-11-22(23(27)28-13-17)24(32)29-20-5-7-21(31)8-6-20/h1-4,11,13,19-21,31H,5-10,12,14-15H2,(H2,27,28)(H,29,32)/t19-,20-,21-,25+/m1/s1
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US Patent
n/an/a 970n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451819
PNG
(US10710980, Example 48 | US10947218, Example 48)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CCF)C2
Show InChI InChI=1S/C25H31FN4O2/c26-9-10-30-14-19-12-25(19,15-30)18-3-1-16(2-4-18)17-11-22(23(27)28-13-17)24(32)29-20-5-7-21(31)8-6-20/h1-4,11,13,19-21,31H,5-10,12,14-15H2,(H2,27,28)(H,29,32)/t19-,20-,21-,25+/m1/s1
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PC sid
UniChem
US Patent
n/an/a 970n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451831
PNG
(US10710980, Example 60 | US10947218, Example 60)
Show SMILES CC#CCN1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C27H32N4O2/c1-2-3-12-31-16-21-14-27(21,17-31)20-6-4-18(5-7-20)19-13-24(25(28)29-15-19)26(33)30-22-8-10-23(32)11-9-22/h4-7,13,15,21-23,32H,8-12,14,16-17H2,1H3,(H2,28,29)(H,30,33)/t21-,22-,23-,27+/m1/s1
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PC sid
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US Patent
n/an/a 990n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451831
PNG
(US10710980, Example 60 | US10947218, Example 60)
Show SMILES CC#CCN1C[C@H]2C[C@]2(C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C27H32N4O2/c1-2-3-12-31-16-21-14-27(21,17-31)20-6-4-18(5-7-20)19-13-24(25(28)29-15-19)26(33)30-22-8-10-23(32)11-9-22/h4-7,13,15,21-23,32H,8-12,14,16-17H2,1H3,(H2,28,29)(H,30,33)/t21-,22-,23-,27+/m1/s1
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PC sid
UniChem
US Patent
n/an/a 990n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451808
PNG
(US10710980, Example 40 | US10947218, Example 40)
Show SMILES Nc1ncc(cc1C(=O)NC12CCC(O)(CC1)CC2)-c1ccc(cc1)[C@]12C[C@H]1CN(CCN1CCOCC1)C2
Show InChI InChI=1S/C31H41N5O3/c32-27-26(28(37)34-29-5-8-30(38,9-6-29)10-7-29)17-23(19-33-27)22-1-3-24(4-2-22)31-18-25(31)20-36(21-31)12-11-35-13-15-39-16-14-35/h1-4,17,19,25,38H,5-16,18,20-21H2,(H2,32,33)(H,34,37)/t25-,29?,30?,31+/m0/s1
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PC sid
UniChem
US Patent
n/an/a 995n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451808
PNG
(US10710980, Example 40 | US10947218, Example 40)
Show SMILES Nc1ncc(cc1C(=O)NC12CCC(O)(CC1)CC2)-c1ccc(cc1)[C@]12C[C@H]1CN(CCN1CCOCC1)C2
Show InChI InChI=1S/C31H41N5O3/c32-27-26(28(37)34-29-5-8-30(38,9-6-29)10-7-29)17-23(19-33-27)22-1-3-24(4-2-22)31-18-25(31)20-36(21-31)12-11-35-13-15-39-16-14-35/h1-4,17,19,25,38H,5-16,18,20-21H2,(H2,32,33)(H,34,37)/t25-,29?,30?,31+/m0/s1
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PC sid
UniChem
US Patent
n/an/a 995n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451771
PNG
(US10710980, Example 3 | US10947218, Example 3)
Show SMILES C[C@@H](N1CC2(COC2)C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C25H32N4O3/c1-16(29-12-25(13-29)14-32-15-25)17-2-4-18(5-3-17)19-10-22(23(26)27-11-19)24(31)28-20-6-8-21(30)9-7-20/h2-5,10-11,16,20-21,30H,6-9,12-15H2,1H3,(H2,26,27)(H,28,31)/t16-,20-,21-/m1/s1
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n/an/a 1.05E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451771
PNG
(US10710980, Example 3 | US10947218, Example 3)
Show SMILES C[C@@H](N1CC2(COC2)C1)c1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C25H32N4O3/c1-16(29-12-25(13-29)14-32-15-25)17-2-4-18(5-3-17)19-10-22(23(26)27-11-19)24(31)28-20-6-8-21(30)9-7-20/h2-5,10-11,16,20-21,30H,6-9,12-15H2,1H3,(H2,26,27)(H,28,31)/t16-,20-,21-/m1/s1
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US Patent
n/an/a 1.05E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451773
PNG
(US10710980, Example 5 | US10947218, Example 5)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(CCCN1CCOCC1)C2
Show InChI InChI=1S/C30H41N5O3/c31-28-27(29(37)33-25-6-8-26(36)9-7-25)16-22(18-32-28)21-2-4-23(5-3-21)30-17-24(30)19-35(20-30)11-1-10-34-12-14-38-15-13-34/h2-5,16,18,24-26,36H,1,6-15,17,19-20H2,(H2,31,32)(H,33,37)/t24-,25-,26-,30+/m0/s1
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UniChem
US Patent
n/an/a 1.10E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451773
PNG
(US10710980, Example 5 | US10947218, Example 5)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(CCCN1CCOCC1)C2
Show InChI InChI=1S/C30H41N5O3/c31-28-27(29(37)33-25-6-8-26(36)9-7-25)16-22(18-32-28)21-2-4-23(5-3-21)30-17-24(30)19-35(20-30)11-1-10-34-12-14-38-15-13-34/h2-5,16,18,24-26,36H,1,6-15,17,19-20H2,(H2,31,32)(H,33,37)/t24-,25-,26-,30+/m0/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451779
PNG
(US10710980, Example 11 | US10947218, Example 11)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(CCF)C2
Show InChI InChI=1S/C25H31FN4O2/c26-9-10-30-14-19-12-25(19,15-30)18-3-1-16(2-4-18)17-11-22(23(27)28-13-17)24(32)29-20-5-7-21(31)8-6-20/h1-4,11,13,19-21,31H,5-10,12,14-15H2,(H2,27,28)(H,29,32)/t19-,20-,21-,25+/m0/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451779
PNG
(US10710980, Example 11 | US10947218, Example 11)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(CCF)C2
Show InChI InChI=1S/C25H31FN4O2/c26-9-10-30-14-19-12-25(19,15-30)18-3-1-16(2-4-18)17-11-22(23(27)28-13-17)24(32)29-20-5-7-21(31)8-6-20/h1-4,11,13,19-21,31H,5-10,12,14-15H2,(H2,27,28)(H,29,32)/t19-,20-,21-,25+/m0/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.10E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451828
PNG
(US10710980, Example 57 | US10947218, Example 57)
Show SMILES Nc1ncc(cc1C(=O)NC12CCC(O)(CC1)CC2)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CCF)C2
Show InChI InChI=1S/C27H33FN4O2/c28-11-12-32-16-21-14-27(21,17-32)20-3-1-18(2-4-20)19-13-22(23(29)30-15-19)24(33)31-25-5-8-26(34,9-6-25)10-7-25/h1-4,13,15,21,34H,5-12,14,16-17H2,(H2,29,30)(H,31,33)/t21-,25?,26?,27+/m1/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.19E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451828
PNG
(US10710980, Example 57 | US10947218, Example 57)
Show SMILES Nc1ncc(cc1C(=O)NC12CCC(O)(CC1)CC2)-c1ccc(cc1)[C@@]12C[C@@H]1CN(CCF)C2
Show InChI InChI=1S/C27H33FN4O2/c28-11-12-32-16-21-14-27(21,17-32)20-3-1-18(2-4-20)19-13-22(23(29)30-15-19)24(33)31-25-5-8-26(34,9-6-25)10-7-25/h1-4,13,15,21,34H,5-12,14,16-17H2,(H2,29,30)(H,31,33)/t21-,25?,26?,27+/m1/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.19E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451799
PNG
(2-amino-N-((1r,4R)-4-hydroxycyclohexyl)-5-(4-(((R)...)
Show SMILES C[C@@H]1CCCN1Cc1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C24H32N4O2/c1-16-3-2-12-28(16)15-17-4-6-18(7-5-17)19-13-22(23(25)26-14-19)24(30)27-20-8-10-21(29)11-9-20/h4-7,13-14,16,20-21,29H,2-3,8-12,15H2,1H3,(H2,25,26)(H,27,30)/t16-,20-,21-/m1/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451824
PNG
(US10710980, Example 53 | US10947218, Example 53)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(CC#C)C2
Show InChI InChI=1S/C26H30N4O2/c1-2-11-30-15-20-13-26(20,16-30)19-5-3-17(4-6-19)18-12-23(24(27)28-14-18)25(32)29-21-7-9-22(31)10-8-21/h1,3-6,12,14,20-22,31H,7-11,13,15-16H2,(H2,27,28)(H,29,32)/t20-,21-,22-,26+/m0/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451837
PNG
(US10710980, Example 66 | US10947218, Example 66)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(C2)C(CF)CF
Show InChI InChI=1S/C26H32F2N4O2/c27-11-21(12-28)32-14-19-10-26(19,15-32)18-3-1-16(2-4-18)17-9-23(24(29)30-13-17)25(34)31-20-5-7-22(33)8-6-20/h1-4,9,13,19-22,33H,5-8,10-12,14-15H2,(H2,29,30)(H,31,34)/t19-,20-,22-,26+/m0/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...


US Patent US10710980 (2020)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451799
PNG
(2-amino-N-((1r,4R)-4-hydroxycyclohexyl)-5-(4-(((R)...)
Show SMILES C[C@@H]1CCCN1Cc1ccc(cc1)-c1cnc(N)c(c1)C(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C24H32N4O2/c1-16-3-2-12-28(16)15-17-4-6-18(7-5-17)19-13-22(23(25)26-14-19)24(30)27-20-8-10-21(29)11-9-20/h4-7,13-14,16,20-21,29H,2-3,8-12,15H2,1H3,(H2,25,26)(H,27,30)/t16-,20-,21-/m1/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451824
PNG
(US10710980, Example 53 | US10947218, Example 53)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(CC#C)C2
Show InChI InChI=1S/C26H30N4O2/c1-2-11-30-15-20-13-26(20,16-30)19-5-3-17(4-6-19)18-12-23(24(27)28-14-18)25(32)29-21-7-9-22(31)10-8-21/h1,3-6,12,14,20-22,31H,7-11,13,15-16H2,(H2,27,28)(H,29,32)/t20-,21-,22-,26+/m0/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
Activin receptor-like kinase 3 (ALK3) (aa 198-525)


(Homo sapiens (Human))
BDBM451837
PNG
(US10710980, Example 66 | US10947218, Example 66)
Show SMILES Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(C2)C(CF)CF
Show InChI InChI=1S/C26H32F2N4O2/c27-11-21(12-28)32-14-19-10-26(19,15-32)18-3-1-16(2-4-18)17-9-23(24(29)30-13-17)25(34)31-20-5-7-22(33)8-6-20/h1-4,9,13,19-22,33H,5-8,10-12,14-15H2,(H2,29,30)(H,31,34)/t19-,20-,22-,26+/m0/s1
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20E+3n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...


US Patent US10947218 (2021)

More data for this
Ligand-Target Pair
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