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Compile Data Set for Download or QSAR

Found 1828 hits Enz. Inhib. hit(s) with Target = 'Eukaryotic translation initiation factor 4E-binding protein 1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545290
PNG
(US11286268, Compound 778)
Show SMILES Cc1cc(ccn1)-c1c(F)cc2nc(C)n(CCOc3ccc(Cl)cc3-c3cc(C)nc4c(csc34)C(O)=O)c(=O)c2c1C#N
Show InChI InChI=1S/C33H23ClFN5O4S/c1-16-10-19(6-7-37-16)28-23(14-36)29-26(13-25(28)35)39-18(3)40(32(29)41)8-9-44-27-5-4-20(34)12-21(27)22-11-17(2)38-30-24(33(42)43)15-45-31(22)30/h4-7,10-13,15H,8-9H2,1-3H3,(H,42,43)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 0.0700n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545157
PNG
(US11286268, Compound 643)
Show SMILES CN1CCN(Cc2c(cc3nc(C)n(CC#Cc4ccc(Cl)cc4-c4ccnc5c(C(O)=O)c(C)sc45)c(=O)c3c2C#N)C(F)(F)F)CC1
Show InChI InChI=1S/C35H28ClF3N6O3S/c1-19-29(34(47)48)31-32(49-19)23(8-9-41-31)24-15-22(36)7-6-21(24)5-4-10-45-20(2)42-28-16-27(35(37,38)39)26(25(17-40)30(28)33(45)46)18-44-13-11-43(3)12-14-44/h6-9,15-16H,10-14,18H2,1-3H3,(H,47,48)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 0.832n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545209
PNG
(US11286268, Compound 695)
Show SMILES Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(Cl)c(O)c(C#N)c3c2=O)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C27H18Cl2N4O5S/c1-12-7-16(25-23(31-12)18(11-39-25)27(36)37)15-8-14(28)3-4-21(15)38-6-5-33-13(2)32-20-9-19(29)24(34)17(10-30)22(20)26(33)35/h3-4,7-9,11,34H,5-6H2,1-2H3,(H,36,37)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 1.05n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM544933
PNG
(US11286268, Compound 419)
Show SMILES Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cnc(C)c(C#N)c3c2=O)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C27H20ClN5O4S/c1-13-8-18(25-24(31-13)20(12-38-25)27(35)36)17-9-16(28)4-5-22(17)37-7-6-33-15(3)32-21-11-30-14(2)19(10-29)23(21)26(33)34/h4-5,8-9,11-12H,6-7H2,1-3H3,(H,35,36)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 1.08n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545525
PNG
(US11286268, Compound 1016)
Show SMILES CCc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cnc(-c4ccccc4)c(C#N)c3c2=O)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C33H24ClN5O4S/c1-3-21-14-23(31-30(38-21)25(17-44-31)33(41)42)22-13-20(34)9-10-27(22)43-12-11-39-18(2)37-26-16-36-29(19-7-5-4-6-8-19)24(15-35)28(26)32(39)40/h4-10,13-14,16-17H,3,11-12H2,1-2H3,(H,41,42)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 1.11n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545738
PNG
(US11286268, Compound 1228)
Show SMILES CN1CCN(CC1)c1c(cc2nc(C)n(CCOc3ccc(Cl)cc3-c3ccnc4c(csc34)-c3nn[nH]n3)c(=O)c2c1C#N)C(F)(F)F
Show InChI InChI=1S/C32H26ClF3N10O2S/c1-17-39-24-14-23(32(34,35)36)28(45-9-7-44(2)8-10-45)21(15-37)26(24)31(47)46(17)11-12-48-25-4-3-18(33)13-20(25)19-5-6-38-27-22(16-49-29(19)27)30-40-42-43-41-30/h3-6,13-14,16H,7-12H2,1-2H3,(H,40,41,42,43)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 1.11n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM544886
PNG
(US11286268, Compound 369)
Show SMILES COc1c(CN(C)C)cc2nc(C)n(CCOc3ccc(Cl)cc3-c3cc(C)nc4c(csc34)C(O)=O)c(=O)c2c1C#N
Show InChI InChI=1S/C31H28ClN5O5S/c1-16-10-21(29-27(34-16)23(15-43-29)31(39)40)20-12-19(32)6-7-25(20)42-9-8-37-17(2)35-24-11-18(14-36(3)4)28(41-5)22(13-33)26(24)30(37)38/h6-7,10-12,15H,8-9,14H2,1-5H3,(H,39,40)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 1.32n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM544980
PNG
(US11286268, Compound 465 | US11286268, Compound 93...)
Show SMILES Cc1cc(cc(C)n1)-c1c(cc2nc(C)n(CCOc3ccc(Cl)cc3-c3cc(C)nc4c(csc34)C(O)=O)c(=O)c2c1C#N)C(F)(F)F
Show InChI InChI=1S/C35H25ClF3N5O4S/c1-16-9-20(10-17(2)41-16)29-24(14-40)30-27(13-26(29)35(37,38)39)43-19(4)44(33(30)45)7-8-48-28-6-5-21(36)12-22(28)23-11-18(3)42-31-25(34(46)47)15-49-32(23)31/h5-6,9-13,15H,7-8H2,1-4H3,(H,46,47)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 1.36n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545407
PNG
(US11286268, Compound 897)
Show SMILES COc1ncc2nc(C)n(CCOc3ccc(Cl)cc3-c3cc(C)nc4c(csc34)C(O)=O)c(=O)c2c1C#N
Show InChI InChI=1S/C27H20ClN5O5S/c1-13-8-17(24-23(31-13)19(12-39-24)27(35)36)16-9-15(28)4-5-21(16)38-7-6-33-14(2)32-20-11-30-25(37-3)18(10-29)22(20)26(33)34/h4-5,8-9,11-12H,6-7H2,1-3H3,(H,35,36)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 1.40n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545578
PNG
(US11286268, Compound 1069)
Show SMILES CCc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3c(C)nc(N)c(C#N)c3c2=O)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C28H23ClN6O4S/c1-4-16-10-18(25-24(34-16)20(12-40-25)28(37)38)17-9-15(29)5-6-21(17)39-8-7-35-14(3)33-23-13(2)32-26(31)19(11-30)22(23)27(35)36/h5-6,9-10,12H,4,7-8H2,1-3H3,(H2,31,32)(H,37,38)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 1.52n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545153
PNG
(US11286268, Compound 639 | US11286268, Compound 89...)
Show SMILES CCc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(CN(C)C)c(OC(F)F)c(C#N)c3c2=O)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C32H28ClF2N5O5S/c1-5-19-12-21(29-27(38-19)23(15-46-29)31(42)43)20-11-18(33)6-7-25(20)44-9-8-40-16(2)37-24-10-17(14-39(3)4)28(45-32(34)35)22(13-36)26(24)30(40)41/h6-7,10-12,15,32H,5,8-9,14H2,1-4H3,(H,42,43)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 1.57n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545153
PNG
(US11286268, Compound 639 | US11286268, Compound 89...)
Show SMILES CCc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(CN(C)C)c(OC(F)F)c(C#N)c3c2=O)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C32H28ClF2N5O5S/c1-5-19-12-21(29-27(38-19)23(15-46-29)31(42)43)20-11-18(33)6-7-25(20)44-9-8-40-16(2)37-24-10-17(14-39(3)4)28(45-32(34)35)22(13-36)26(24)30(40)41/h6-7,10-12,15,32H,5,8-9,14H2,1-4H3,(H,42,43)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 1.57n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM544904
PNG
(US11286268, Compound 390)
Show SMILES Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(c(Cc4ccccn4)nc3c2=O)C(F)(F)F)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C32H23ClF3N5O4S/c1-16-11-21(29-27(38-16)22(15-46-29)31(43)44)20-12-18(33)6-7-26(20)45-10-9-41-17(2)39-25-14-23(32(34,35)36)24(40-28(25)30(41)42)13-19-5-3-4-8-37-19/h3-8,11-12,14-15H,9-10,13H2,1-2H3,(H,43,44)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 1.75n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545084
PNG
(US11286268, Compound 569)
Show SMILES Cc1nc2cc(cc(C#N)c2c(=O)n1CCOc1ccc(Cl)cc1-c1ccnc2c(csc12)C(=O)NS(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C28H19ClF3N5O5S2/c1-14-35-21-10-16(28(30,31)32)9-15(12-33)23(21)27(39)37(14)7-8-42-22-4-3-17(29)11-19(22)18-5-6-34-24-20(13-43-25(18)24)26(38)36-44(2,40)41/h3-6,9-11,13H,7-8H2,1-2H3,(H,36,38)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM546104
PNG
(US11286268, Compound 1603)
Show SMILES CN(C1CCN(CC(C)(F)F)CC1)c1ncc2nc(C)n(CC#Cc3ccc(Cl)cc3-c3ccnc4c(csc34)C(=O)NS(=O)(=O)C(F)(F)F)c(=O)c2c1C#N
Show InChI InChI=1S/C36H30ClF5N8O4S2/c1-20-46-28-17-45-32(48(3)23-9-13-49(14-10-23)19-35(2,38)39)26(16-43)29(28)34(52)50(20)12-4-5-21-6-7-22(37)15-25(21)24-8-11-44-30-27(18-55-31(24)30)33(51)47-56(53,54)36(40,41)42/h6-8,11,15,17-18,23H,9-10,12-14,19H2,1-3H3,(H,47,51)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 2.12n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM544984
PNG
(US11286268, Compound 469)
Show SMILES Cc1cc(c(C)cn1)-c1c(cc2nc(C)n(CCOc3ccc(Cl)cc3-c3cc(C)nc4c(csc34)C(O)=O)c(=O)c2c1C#N)C(F)(F)F
Show InChI InChI=1S/C35H25ClF3N5O4S/c1-16-14-41-17(2)9-21(16)29-24(13-40)30-27(12-26(29)35(37,38)39)43-19(4)44(33(30)45)7-8-48-28-6-5-20(36)11-22(28)23-10-18(3)42-31-25(34(46)47)15-49-32(23)31/h5-6,9-12,14-15H,7-8H2,1-4H3,(H,46,47)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 2.25n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545105
PNG
(US11286268, Compound 590)
Show SMILES CC1C=C(c2scc(C(O)=O)c2N1=O)c1cc(Cl)ccc1OCCn1c(C)nc2cc(cc(C#N)c2c1=O)C(F)(F)F
Show InChI InChI=1S/C28H19ClF3N4O5S/c1-13-7-19(25-24(36(13)40)20(12-42-25)27(38)39)18-10-17(29)3-4-22(18)41-6-5-35-14(2)34-21-9-16(28(30,31)32)8-15(11-33)23(21)26(35)37/h3-4,7-10,12-13H,5-6H2,1-2H3,(H,38,39)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 2.26n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545347
PNG
(US11286268, Compound 836)
Show SMILES CN1CCN(CC1)c1c(cc2nc(C)n(CCOc3ccc(Cl)cc3-c3cc(C)nc4ccsc34)c(=O)c2c1C#N)C(F)(F)F
Show InChI InChI=1S/C32H28ClF3N6O2S/c1-18-14-22(30-25(38-18)6-13-45-30)21-15-20(33)4-5-27(21)44-12-11-42-19(2)39-26-16-24(32(34,35)36)29(23(17-37)28(26)31(42)43)41-9-7-40(3)8-10-41/h4-6,13-16H,7-12H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 2.33n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545511
PNG
(US11286268, Compound 1002)
Show SMILES CN(C)c1ncc2cc(C)n(CCOc3ccc(Cl)cc3-c3cc(C)nc4c(csc34)C(O)=O)c(=O)c2c1C#N
Show InChI InChI=1S/C29H24ClN5O4S/c1-15-9-20(26-25(33-15)22(14-40-26)29(37)38)19-11-18(30)5-6-23(19)39-8-7-35-16(2)10-17-13-32-27(34(3)4)21(12-31)24(17)28(35)36/h5-6,9-11,13-14H,7-8H2,1-4H3,(H,37,38)
PDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 2.37n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545447
PNG
(US11286268, Compound 938)
Show SMILES Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(c(nc3c2=O)C(C)(C)O)C(F)(F)F)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C29H24ClF3N4O5S/c1-13-9-17(24-22(34-13)18(12-43-24)27(39)40)16-10-15(30)5-6-21(16)42-8-7-37-14(2)35-20-11-19(29(31,32)33)25(28(3,4)41)36-23(20)26(37)38/h5-6,9-12,41H,7-8H2,1-4H3,(H,39,40)
PDB

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UniProtKB/SwissProt

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n/an/a 2.44n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545305
PNG
(US11286268, Compound 792)
Show SMILES Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cnc(Cl)c(C#N)c3c2=O)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C26H17Cl2N5O4S/c1-12-7-16(23-22(31-12)18(11-38-23)26(35)36)15-8-14(27)3-4-20(15)37-6-5-33-13(2)32-19-10-30-24(28)17(9-29)21(19)25(33)34/h3-4,7-8,10-11H,5-6H2,1-2H3,(H,35,36)
PDB

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UniProtKB/SwissProt

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US Patent
n/an/a 2.44n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545130
PNG
(US11286268, Compound 616)
Show SMILES CN1CCN(Cc2c(cc3nc(C)n(CC#Cc4ccc(Cl)cc4-c4cc(C)nc5c(csc45)C(O)=O)c(=O)c3c2C#N)C(F)(F)F)CC1
Show InChI InChI=1S/C35H28ClF3N6O3S/c1-19-13-24(32-31(41-19)27(18-49-32)34(47)48)23-14-22(36)7-6-21(23)5-4-8-45-20(2)42-29-15-28(35(37,38)39)26(25(16-40)30(29)33(45)46)17-44-11-9-43(3)10-12-44/h6-7,13-15,18H,8-12,17H2,1-3H3,(H,47,48)
PDB

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UniProtKB/SwissProt

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US Patent
n/an/a 2.45n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545733
PNG
(US11286268, Compound 1223)
Show SMILES CCc1cc(cc(n1)C(O)=O)-c1cc(Cl)ccc1OCCn1c(C)nc2cc(c(N3CCN(C)CC3)c(C#N)c2c1=O)C(F)(F)F
Show InChI InChI=1S/C32H30ClF3N6O4/c1-4-21-13-19(14-26(39-21)31(44)45)22-15-20(33)5-6-27(22)46-12-11-42-18(2)38-25-16-24(32(34,35)36)29(23(17-37)28(25)30(42)43)41-9-7-40(3)8-10-41/h5-6,13-16H,4,7-12H2,1-3H3,(H,44,45)
PDB

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UniProtKB/SwissProt

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n/an/a 2.79n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM544884
PNG
(US11286268, Compound 367)
Show SMILES Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(F)c(CN4CCOCC4)c(C#N)c3c2=O)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C32H27ClFN5O5S/c1-17-11-21(30-29(36-17)24(16-45-30)32(41)42)20-12-19(33)3-4-27(20)44-10-7-39-18(2)37-26-13-25(34)23(15-38-5-8-43-9-6-38)22(14-35)28(26)31(39)40/h3-4,11-13,16H,5-10,15H2,1-2H3,(H,41,42)
PDB

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UniProtKB/SwissProt

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n/an/a 2.87n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM544953
PNG
(US11286268, Compound 439a)
Show SMILES CN(C)c1c(cc2nc(C)n(CCOc3ccc(Cl)cc3-c3cc(C)nc4c(csc34)C(O)=O)c(=O)c2c1C#N)C(F)F
Show InChI InChI=1S/C30H24ClF2N5O4S/c1-14-9-18(27-25(35-14)21(13-43-27)30(40)41)17-10-16(31)5-6-23(17)42-8-7-38-15(2)36-22-11-19(28(32)33)26(37(3)4)20(12-34)24(22)29(38)39/h5-6,9-11,13,28H,7-8H2,1-4H3,(H,40,41)
PDB

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US Patent
n/an/a 2.87n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM544834
PNG
(US11286268, Compound 318)
Show SMILES Cc1c(c2cc(cc(C#N)c2c(=O)n1CCOc1ccc(Cl)cc1-c1ccnc2c(csc12)C(O)=O)C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C29H19ClF3N3O6S2/c1-14-26(44(2,40)41)20-10-16(29(31,32)33)9-15(12-34)23(20)27(37)36(14)7-8-42-22-4-3-17(30)11-19(22)18-5-6-35-24-21(28(38)39)13-43-25(18)24/h3-6,9-11,13H,7-8H2,1-2H3,(H,38,39)
PDB

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n/an/a 2.92n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545132
PNG
(US11286268, Compound 618)
Show SMILES CN(Cc1cc2nc(C)n(CCOc3ccc(Cl)cc3-c3cc(C)nc4c(csc34)C(O)=O)c(=O)c2c(C#N)c1OC(F)F)C(C)(C)C
Show InChI InChI=1S/C34H32ClF2N5O5S/c1-17-11-22(30-28(39-17)24(16-48-30)32(44)45)21-13-20(35)7-8-26(21)46-10-9-42-18(2)40-25-12-19(15-41(6)34(3,4)5)29(47-33(36)37)23(14-38)27(25)31(42)43/h7-8,11-13,16,33H,9-10,15H2,1-6H3,(H,44,45)
PDB

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UniProtKB/SwissProt

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n/an/a 2.98n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545732
PNG
(US11286268, Compound 1222)
Show SMILES CN1CCN(CC1)c1c(cc2nc(C)n(CCOc3ccc(Cl)cc3-c3cc(C)nc(c3)C(O)=O)c(=O)c2c1C#N)C(F)(F)F
Show InChI InChI=1S/C31H28ClF3N6O4/c1-17-12-19(13-25(37-17)30(43)44)21-14-20(32)4-5-26(21)45-11-10-41-18(2)38-24-15-23(31(33,34)35)28(22(16-36)27(24)29(41)42)40-8-6-39(3)7-9-40/h4-5,12-15H,6-11H2,1-3H3,(H,43,44)
PDB

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UniProtKB/SwissProt

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n/an/a 3.02n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545293
PNG
(US11286268, Compound 781)
Show SMILES CN(C)C(=O)c1nc2c(cc1C(F)(F)F)nc(C)n(CCOc1ccc(Cl)cc1-c1cc(C)nc3c(csc13)C(O)=O)c2=O
Show InChI InChI=1S/C29H23ClF3N5O5S/c1-13-9-17(25-22(34-13)18(12-44-25)28(41)42)16-10-15(30)5-6-21(16)43-8-7-38-14(2)35-20-11-19(29(31,32)33)23(26(39)37(3)4)36-24(20)27(38)40/h5-6,9-12H,7-8H2,1-4H3,(H,41,42)
PDB

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US Patent
n/an/a 3.12n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545735
PNG
(US11286268, Compound 1225)
Show SMILES CN(C)c1cc(cc(n1)C(O)=O)-c1cc(Cl)ccc1OCCn1c(C)nc2cc(c(N3CCN(C)CC3)c(C#N)c2c1=O)C(F)(F)F
Show InChI InChI=1S/C32H31ClF3N7O4/c1-18-38-24-16-23(32(34,35)36)29(42-9-7-41(4)8-10-42)22(17-37)28(24)30(44)43(18)11-12-47-26-6-5-20(33)15-21(26)19-13-25(31(45)46)39-27(14-19)40(2)3/h5-6,13-16H,7-12H2,1-4H3,(H,45,46)
PDB

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US Patent
n/an/a 3.12n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545168
PNG
(US11286268, Compound 654)
Show SMILES Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(cc(C#N)c3c2=O)-c2cccnc2)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C32H22ClN5O4S/c1-17-10-24(30-29(36-17)25(16-43-30)32(40)41)23-13-22(33)5-6-27(23)42-9-8-38-18(2)37-26-12-20(19-4-3-7-35-15-19)11-21(14-34)28(26)31(38)39/h3-7,10-13,15-16H,8-9H2,1-2H3,(H,40,41)
PDB

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US Patent
n/an/a 3.12n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545471
PNG
(US11286268, Compound 962)
Show SMILES Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(Cl)c(Nc4cncc(F)c4)c(C#N)c3c2=O)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C32H21Cl2FN6O4S/c1-15-7-21(30-29(38-15)23(14-46-30)32(43)44)20-8-17(33)3-4-26(20)45-6-5-41-16(2)39-25-10-24(34)28(22(11-36)27(25)31(41)42)40-19-9-18(35)12-37-13-19/h3-4,7-10,12-14,40H,5-6H2,1-2H3,(H,43,44)
PDB

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US Patent
n/an/a 3.15n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545217
PNG
(US11286268, Compound 703)
Show SMILES Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(Cl)c(N4CC(C)(CO)C4)c(C#N)c3c2=O)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C32H27Cl2N5O5S/c1-16-8-20(29-27(36-16)22(12-45-29)31(42)43)19-9-18(33)4-5-25(19)44-7-6-39-17(2)37-24-10-23(34)28(21(11-35)26(24)30(39)41)38-13-32(3,14-38)15-40/h4-5,8-10,12,40H,6-7,13-15H2,1-3H3,(H,42,43)
PDB

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UniProtKB/SwissProt

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US Patent
n/an/a 3.18n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545418
PNG
(US11286268, Compound 908)
Show SMILES Cc1cc(-c2cc(Cl)ccc2C#CCn2c(C)nc3cc(c(-c4ccncn4)c(C#N)c3c2=O)C(F)(F)F)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C33H18ClF3N6O3S/c1-16-10-21(30-29(41-16)23(14-47-30)32(45)46)20-11-19(34)6-5-18(20)4-3-9-43-17(2)42-26-12-24(33(35,36)37)27(25-7-8-39-15-40-25)22(13-38)28(26)31(43)44/h5-8,10-12,14-15H,9H2,1-2H3,(H,45,46)
PDB

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n/an/a 3.26n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545309
PNG
(US11286268, Compound 796)
Show SMILES Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(c(nc3c2=O)N2CC(=O)C2)C(F)(F)F)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C29H21ClF3N5O5S/c1-13-7-18(25-23(34-13)19(12-44-25)28(41)42)17-8-15(30)3-4-22(17)43-6-5-38-14(2)35-21-9-20(29(31,32)33)26(36-24(21)27(38)40)37-10-16(39)11-37/h3-4,7-9,12H,5-6,10-11H2,1-2H3,(H,41,42)
PDB

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UniProtKB/SwissProt

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US Patent
n/an/a 3.27n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545327
PNG
(US11286268, Compound 815)
Show SMILES CN1CCN(CC1(C)C)c1ncc2nc(C)n(CCOc3ccc(Cl)cc3-c3ccnc4c(csc34)C(O)=O)c(=O)c2c1C#N
Show InChI InChI=1S/C32H30ClN7O4S/c1-18-37-24-15-36-29(39-10-9-38(4)32(2,3)17-39)22(14-34)26(24)30(41)40(18)11-12-44-25-6-5-19(33)13-21(25)20-7-8-35-27-23(31(42)43)16-45-28(20)27/h5-8,13,15-16H,9-12,17H2,1-4H3,(H,42,43)
PDB

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UniProtKB/SwissProt

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US Patent
n/an/a 3.31n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545473
PNG
(US11286268, Compound 964)
Show SMILES Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(c(-c4nc(C)ncc4F)c(C#N)c3c2=O)C(F)(F)F)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C33H21ClF4N6O4S/c1-14-8-19(30-28(41-14)21(13-49-30)32(46)47)18-9-17(34)4-5-25(18)48-7-6-44-16(3)43-24-10-22(33(36,37)38)26(20(11-39)27(24)31(44)45)29-23(35)12-40-15(2)42-29/h4-5,8-10,12-13H,6-7H2,1-3H3,(H,46,47)
PDB

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US Patent
n/an/a 3.32n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545212
PNG
(US11286268, Compound 698)
Show SMILES Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(Cl)c(N4CC(O)C4)c(C#N)c3c2=O)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C30H23Cl2N5O5S/c1-14-7-19(28-26(34-14)21(13-43-28)30(40)41)18-8-16(31)3-4-24(18)42-6-5-37-15(2)35-23-9-22(32)27(36-11-17(38)12-36)20(10-33)25(23)29(37)39/h3-4,7-9,13,17,38H,5-6,11-12H2,1-2H3,(H,40,41)
PDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 3.40n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545307
PNG
(US11286268, Compound 794)
Show SMILES Cc1ccc(-c2cc(Cl)ccc2OCCn2c(C)nc3cnc(C4CC4)c(C#N)c3c2=O)c2scc(C(O)=O)c12
Show InChI InChI=1S/C30H23ClN4O4S/c1-15-3-7-19(28-25(15)22(14-40-28)30(37)38)20-11-18(31)6-8-24(20)39-10-9-35-16(2)34-23-13-33-27(17-4-5-17)21(12-32)26(23)29(35)36/h3,6-8,11,13-14,17H,4-5,9-10H2,1-2H3,(H,37,38)
PDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 3.41n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545145
PNG
(US11286268, Compound 631)
Show SMILES Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(c(-c4ccccn4)c(C#N)c3c2=O)C(F)(F)F)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C33H21ClF3N5O4S/c1-16-11-20(30-29(40-16)22(15-47-30)32(44)45)19-12-18(34)6-7-26(19)46-10-9-42-17(2)41-25-13-23(33(35,36)37)27(24-5-3-4-8-39-24)21(14-38)28(25)31(42)43/h3-8,11-13,15H,9-10H2,1-2H3,(H,44,45)
PDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 3.41n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545545
PNG
(US11286268, Compound 1036)
Show SMILES COc1c(cc2nc(C)n(CCOc3ccc(Cl)cc3-c3cc(C)nc4c(csc34)C(O)=O)c(=O)c2c1C#N)C(F)(F)F
Show InChI InChI=1S/C29H20ClF3N4O5S/c1-13-8-17(26-24(35-13)19(12-43-26)28(39)40)16-9-15(30)4-5-22(16)42-7-6-37-14(2)36-21-10-20(29(31,32)33)25(41-3)18(11-34)23(21)27(37)38/h4-5,8-10,12H,6-7H2,1-3H3,(H,39,40)
PDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 3.51n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM544905
PNG
(US11286268, Compound 391)
Show SMILES CCCCc1nc2c(cc1C(F)(F)F)nc(C)n(CCOc1ccc(Cl)cc1-c1cc(C)nc3c(csc13)C(O)=O)c2=O
Show InChI InChI=1S/C30H26ClF3N4O4S/c1-4-5-6-22-21(30(32,33)34)13-23-26(37-22)28(39)38(16(3)36-23)9-10-42-24-8-7-17(31)12-18(24)19-11-15(2)35-25-20(29(40)41)14-43-27(19)25/h7-8,11-14H,4-6,9-10H2,1-3H3,(H,40,41)
PDB

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UniProtKB/SwissProt

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n/an/a 3.52n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545475
PNG
(US11286268, Compound 966)
Show SMILES Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(c(-c4ncc(F)cn4)c(C#N)c3c2=O)C(F)(F)F)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C32H19ClF4N6O4S/c1-14-7-19(28-27(41-14)21(13-48-28)31(45)46)18-8-16(33)3-4-24(18)47-6-5-43-15(2)42-23-9-22(32(35,36)37)25(20(10-38)26(23)30(43)44)29-39-11-17(34)12-40-29/h3-4,7-9,11-13H,5-6H2,1-2H3,(H,45,46)
PDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 3.58n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545319
PNG
(US11286268, Compound 806)
Show SMILES CN(C)Cc1cc2nc(C)n(CCOc3ccc(Cl)cc3-c3cccc(c3)C(O)=O)c(=O)c2c(C#N)c1OC(F)F
Show InChI InChI=1S/C29H25ClF2N4O5/c1-16-34-23-12-19(15-35(2)3)26(41-29(31)32)22(14-33)25(23)27(37)36(16)9-10-40-24-8-7-20(30)13-21(24)17-5-4-6-18(11-17)28(38)39/h4-8,11-13,29H,9-10,15H2,1-3H3,(H,38,39)
PDB

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UniProtKB/SwissProt

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US Patent
n/an/a 3.58n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545304
PNG
(US11286268, Compound 791)
Show SMILES CN(C)c1ncc2nc(C)n(CCOc3ccc(Cl)cc3-c3cc(C)nc4c(csc34)C(O)=O)c(=O)c2c1C#N
Show InChI InChI=1S/C28H23ClN6O4S/c1-14-9-18(25-24(32-14)20(13-40-25)28(37)38)17-10-16(29)5-6-22(17)39-8-7-35-15(2)33-21-12-31-26(34(3)4)19(11-30)23(21)27(35)36/h5-6,9-10,12-13H,7-8H2,1-4H3,(H,37,38)
PDB

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UniProtKB/SwissProt

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US Patent
n/an/a 3.59n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545156
PNG
(US11286268, Compound 642)
Show SMILES C[C@H]1CN(Cc2c(cc3nc(C)n(CCOc4ccc(Cl)cc4-c4cc(C)nc5c(csc45)C(O)=O)c(=O)c3c2C#N)C(F)(F)F)C[C@@H](C)O1
Show InChI InChI=1S/C35H31ClF3N5O5S/c1-17-9-23(32-31(41-17)26(16-50-32)34(46)47)22-10-21(36)5-6-29(22)48-8-7-44-20(4)42-28-11-27(35(37,38)39)25(24(12-40)30(28)33(44)45)15-43-13-18(2)49-19(3)14-43/h5-6,9-11,16,18-19H,7-8,13-15H2,1-4H3,(H,46,47)/t18-,19+
PDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 3.63n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM546215
PNG
(US11286268, Compound 1776)
Show SMILES CCN(C1CCN(CC1)[C@@H]1C[C@@H](C1)OC(F)(F)F)c1ncc2nc(C)n(CC#Cc3ccc(Cl)cc3-c3ccnc4c(csc34)C(=O)NS(C)(=O)=O)c(=O)c2c1C#N
Show InChI InChI=1S/C39H36ClF3N8O5S2/c1-4-50(25-10-14-49(15-11-25)26-17-27(18-26)56-39(41,42)43)36-30(19-44)33-32(20-46-36)47-22(2)51(38(33)53)13-5-6-23-7-8-24(40)16-29(23)28-9-12-45-34-31(21-57-35(28)34)37(52)48-58(3,54)55/h7-9,12,16,20-21,25-27H,4,10-11,13-15,17-18H2,1-3H3,(H,48,52)/t26-,27+
PDB

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UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 3.65n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545433
PNG
(US11286268, Compound 923)
Show SMILES CCc1ncc2nc(C)n(CCOc3ccc(Cl)cc3-c3cc(C)nc4c(csc34)C(O)=O)c(=O)c2c1C#N
Show InChI InChI=1S/C28H22ClN5O4S/c1-4-21-19(11-30)24-22(12-31-21)33-15(3)34(27(24)35)7-8-38-23-6-5-16(29)10-17(23)18-9-14(2)32-25-20(28(36)37)13-39-26(18)25/h5-6,9-10,12-13H,4,7-8H2,1-3H3,(H,36,37)
PDB

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UniProtKB/SwissProt

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US Patent
n/an/a 3.71n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM546106
PNG
(US11286268, Compound 1605)
Show SMILES CN(C1CCN(CC(C)(F)F)CC1)c1ncc2nc(C)n(CC#Cc3ccc(Cl)cc3-c3ccnc4c(csc34)C(=O)NS(=O)(=O)C(C)(C)C)c(=O)c2c1C#N
Show InChI InChI=1S/C39H39ClF2N8O4S2/c1-23-46-31-20-45-35(48(6)26-12-16-49(17-13-26)22-39(5,41)42)29(19-43)32(31)37(52)50(23)15-7-8-24-9-10-25(40)18-28(24)27-11-14-44-33-30(21-55-34(27)33)36(51)47-56(53,54)38(2,3)4/h9-11,14,18,20-21,26H,12-13,15-17,22H2,1-6H3,(H,47,51)
PDB

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UniProtKB/SwissProt

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n/an/a 3.78n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545661
PNG
(US11286268, Compound 1152)
Show SMILES CO[C@H]1C[C@H](C1)c1ncc2nc(C)n(CCOc3ccc(Cl)cc3-c3cc(C)nc4c(csc34)C(O)=O)c(=O)c2c1C#N
Show InChI InChI=1S/C31H26ClN5O5S/c1-15-8-21(29-28(35-15)23(14-43-29)31(39)40)20-11-18(32)4-5-25(20)42-7-6-37-16(2)36-24-13-34-27(17-9-19(10-17)41-3)22(12-33)26(24)30(37)38/h4-5,8,11,13-14,17,19H,6-7,9-10H2,1-3H3,(H,39,40)/t17-,19+
PDB

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UniProtKB/SwissProt

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n/an/a 3.80n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair
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