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Compile Data Set for Download or QSAR

Found 7 hits Enz. Inhib. hit(s) with Target = 'Formyl peptide receptor 2'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Formyl peptide receptor 2


(Mus musculus)
BDBM50559829
PNG
(CHEMBL4784510)
Show SMILES COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccccc2)c(F)c1
Show InChI InChI=1S/C18H17F2N3O3/c1-26-11-7-13(19)15(14(20)8-11)12-9-21-17(24)16(12)23-18(25)22-10-5-3-2-4-6-10/h2-8,12,16H,9H2,1H3,(H,21,24)(H2,22,23,25)/t12-,16-/m0/s1
KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
PubMed
n/an/an/an/a 0.5n/an/an/an/a



Kyorin Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at mouse FPR2 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay


J Med Chem 63: 9003-9019 (2020)

More data for this
Ligand-Target Pair
Formyl peptide receptor 2


(Mus musculus)
BDBM50559829
PNG
(CHEMBL4784510)
Show SMILES COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccccc2)c(F)c1
Show InChI InChI=1S/C18H17F2N3O3/c1-26-11-7-13(19)15(14(20)8-11)12-9-21-17(24)16(12)23-18(25)22-10-5-3-2-4-6-10/h2-8,12,16H,9H2,1H3,(H,21,24)(H2,22,23,25)/t12-,16-/m0/s1
KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
PubMed
n/an/an/an/a<1n/an/an/an/a



Kyorin Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at FPR2 in mouse peritoneal macrophages assessed as inhibition of stimulated phagocytosis preincubated for 15 mins followed by FITC ...


J Med Chem 63: 9003-9019 (2020)

More data for this
Ligand-Target Pair
Formyl peptide receptor 2


(Mus musculus)
BDBM50559821
PNG
(CHEMBL4781596)
Show SMILES COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1
Show InChI InChI=1S/C18H16F3N3O3/c1-27-11-6-13(20)15(14(21)7-11)12-8-22-17(25)16(12)24-18(26)23-10-4-2-9(19)3-5-10/h2-7,12,16H,8H2,1H3,(H,22,25)(H2,23,24,26)/t12-,16-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/an/an/a 1.5n/an/an/an/a



Kyorin Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanni...


J Med Chem 63: 9003-9019 (2020)

More data for this
Ligand-Target Pair
Formyl peptide receptor 2


(Mus musculus)
BDBM50559840
PNG
(CHEMBL4760897)
Show SMILES COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)s2)c(F)c1
Show InChI InChI=1S/C16H14ClF2N3O3S/c1-25-7-4-9(18)13(10(19)5-7)8-6-20-15(23)14(8)22-16(24)21-12-3-2-11(17)26-12/h2-5,8,14H,6H2,1H3,(H,20,23)(H2,21,22,24)/t8-,14-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/an/an/a 1.40n/an/an/an/a



Kyorin Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanni...


J Med Chem 63: 9003-9019 (2020)

More data for this
Ligand-Target Pair
Formyl peptide receptor 2


(Mus musculus)
BDBM50559835
PNG
(CHEMBL4762030)
Show SMILES COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)c(F)c2)c(F)c1
Show InChI InChI=1S/C18H15F4N3O3/c1-28-9-5-13(21)15(14(22)6-9)10-7-23-17(26)16(10)25-18(27)24-8-2-3-11(19)12(20)4-8/h2-6,10,16H,7H2,1H3,(H,23,26)(H2,24,25,27)/t10-,16-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/an/an/a 8.5n/an/an/an/a



Kyorin Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanni...


J Med Chem 63: 9003-9019 (2020)

More data for this
Ligand-Target Pair
Formyl peptide receptor 2


(Mus musculus)
BDBM50559838
PNG
(CHEMBL4790836)
Show SMILES COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(C)c(O)c2)c(F)c1
Show InChI InChI=1S/C19H19F2N3O4/c1-9-3-4-10(5-15(9)25)23-19(27)24-17-12(8-22-18(17)26)16-13(20)6-11(28-2)7-14(16)21/h3-7,12,17,25H,8H2,1-2H3,(H,22,26)(H2,23,24,27)/t12-,17-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
PubMed
n/an/an/an/a 0.630n/an/an/an/a



Kyorin Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanni...


J Med Chem 63: 9003-9019 (2020)

More data for this
Ligand-Target Pair
Formyl peptide receptor 2


(Mus musculus)
BDBM50559829
PNG
(CHEMBL4784510)
Show SMILES COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccccc2)c(F)c1
Show InChI InChI=1S/C18H17F2N3O3/c1-26-11-7-13(19)15(14(20)8-11)12-9-21-17(24)16(12)23-18(25)22-10-5-3-2-4-6-10/h2-8,12,16H,9H2,1H3,(H,21,24)(H2,22,23,25)/t12-,16-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
Purchase

PC cid
PC sid
UniChem
PubMed
n/an/an/an/a 3.40n/an/an/an/a



Kyorin Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Agonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanni...


J Med Chem 63: 9003-9019 (2020)

More data for this
Ligand-Target Pair