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Compile Data Set for Download or QSAR

Found 126 hits Enz. Inhib. hit(s) with Target = 'GST-MKNK1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GST-MKNK1


(Homo sapiens (Human))
BDBM218770
PNG
(US9296757, 92)
Show SMILES COc1cc2[nH]c(=O)sc2cc1Nc1ncnc2sc3CC(CCc3c12)C(=O)N(CCN(C)C)Cc1ccccc1
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n/an/a 0.600n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9296757 (2016)


BindingDB Entry DOI: 10.7270/Q2XK8DD7
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM218771
PNG
(US9296757, 93)
Show SMILES COCCN(CCOC)C(=O)C1CCc2c(C1)sc1ncnc(Nc3cc4sc(=O)[nH]c4cc3OC)c21
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n/an/a 0.700n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9296757 (2016)


BindingDB Entry DOI: 10.7270/Q2XK8DD7
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM218766
PNG
(US9296757, 88)
Show SMILES CCCCN(CC#N)C(=O)C1CCc2c(C1)sc1ncnc(Nc3cc4sc(=O)[nH]c4cc3OC)c21
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n/an/a 1n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9296757 (2016)


BindingDB Entry DOI: 10.7270/Q2XK8DD7
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM218768
PNG
(US9296757, 90)
Show SMILES CCN(CCOC)C(=O)C1CCc2c(C1)sc1ncnc(Nc3cc4sc(=O)[nH]c4cc3OC)c21
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n/an/a 1n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9296757 (2016)


BindingDB Entry DOI: 10.7270/Q2XK8DD7
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM218767
PNG
(US9296757, 89)
Show SMILES CCCCN(C)C(=O)C1CCc2c(C1)sc1ncnc(Nc3cc4sc(=O)[nH]c4cc3OC)c21
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n/an/a 1.90n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9296757 (2016)


BindingDB Entry DOI: 10.7270/Q2XK8DD7
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM218765
PNG
(US9296757, 87)
Show SMILES CCCN(CCOC)C(=O)C1CCc2c(C1)sc1ncnc(Nc3cc4sc(=O)[nH]c4cc3OC)c21
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n/an/a 2n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9296757 (2016)


BindingDB Entry DOI: 10.7270/Q2XK8DD7
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM218764
PNG
(US9296757, 86)
Show SMILES CCN(C(C)C)C(=O)C1CCc2c(C1)sc1ncnc(Nc3cc4sc(=O)[nH]c4cc3OC)c21
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n/an/a 3n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9296757 (2016)


BindingDB Entry DOI: 10.7270/Q2XK8DD7
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM214639
PNG
(US9284319, 7)
Show SMILES OC[C@@H]1CCN(C1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H18N4O2/c24-12-13-7-8-22(11-13)19-6-5-18-20-10-15(23(18)21-19)17-9-14-3-1-2-4-16(14)25-17/h1-6,9-10,13,24H,7-8,11-12H2/t13-/m1/s1
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n/an/a 4n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM218763
PNG
(US9296757, 85)
Show SMILES COc1cc2[nH]c(=O)sc2cc1Nc1ncnc2sc3CC(CCc3c12)C(=O)N(C)C
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n/an/a 4n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9296757 (2016)


BindingDB Entry DOI: 10.7270/Q2XK8DD7
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM218709
PNG
(US9296757, 31)
Show SMILES COc1cc2[nH]c(=O)sc2cc1Nc1ncnc2sc3CC(CCc3c12)C(=O)NC(C)C
PDB
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n/an/a 4n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9296757 (2016)


BindingDB Entry DOI: 10.7270/Q2XK8DD7
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM214635
PNG
(US9284319, 3)
Show SMILES OC1CCN(C1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H16N4O2/c23-13-7-8-21(11-13)18-6-5-17-19-10-14(22(17)20-18)16-9-12-3-1-2-4-15(12)24-16/h1-6,9-10,13,23H,7-8,11H2
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n/an/a 6n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM214633
PNG
(US9284319, 1)
Show SMILES OC[C@@H]1CCCN1c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H18N4O2/c24-12-14-5-3-9-22(14)19-8-7-18-20-11-15(23(18)21-19)17-10-13-4-1-2-6-16(13)25-17/h1-2,4,6-8,10-11,14,24H,3,5,9,12H2/t14-/m0/s1
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n/an/a 7n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM218714
PNG
(US9296757, 36)
Show SMILES CN(C)CCN(Cc1ccccc1)C(=O)C1CCc2c(C1)sc1ncnc(Nc3ccc4[nH]c(=O)sc4c3)c21
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n/an/a 9n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9296757 (2016)


BindingDB Entry DOI: 10.7270/Q2XK8DD7
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM218687
PNG
(US9296757, 9)
Show SMILES O=C(NCc1ccccc1)C1CCc2c(C1)sc1ncnc(Nc3ccc4[nH]c(=O)sc4c3)c21
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n/an/a 9n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9296757 (2016)


BindingDB Entry DOI: 10.7270/Q2XK8DD7
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM218688
PNG
(US9296757, 10)
Show SMILES FC(F)(F)c1cccc(CNC(=O)C2CCc3c(C2)sc2ncnc(Nc4ccc5[nH]c(=O)sc5c4)c32)c1
PDB
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n/an/a 11n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9296757 (2016)


BindingDB Entry DOI: 10.7270/Q2XK8DD7
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM214649
PNG
(US9284319, R7 | US9730929, Example R7 | US9783543,...)
Show SMILES CN(C)CCNc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H19N5O/c1-22(2)10-9-19-17-7-8-18-20-12-14(23(18)21-17)16-11-13-5-3-4-6-15(13)24-16/h3-8,11-12H,9-10H2,1-2H3,(H,19,21)
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n/an/a 11n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM214638
PNG
(US9284319, 6)
Show SMILES OC1CN(C1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C17H14N4O2/c22-12-9-20(10-12)17-6-5-16-18-8-13(21(16)19-17)15-7-11-3-1-2-4-14(11)23-15/h1-8,12,22H,9-10H2
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n/an/a 12n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM214637
PNG
(US9284319, 5)
Show SMILES OCC1CCCN(C1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C20H20N4O2/c25-13-14-4-3-9-23(12-14)20-8-7-19-21-11-16(24(19)22-20)18-10-15-5-1-2-6-17(15)26-18/h1-2,5-8,10-11,14,25H,3-4,9,12-13H2
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n/an/a 13n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM214649
PNG
(US9284319, R7 | US9730929, Example R7 | US9783543,...)
Show SMILES CN(C)CCNc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H19N5O/c1-22(2)10-9-19-17-7-8-18-20-12-14(23(18)21-17)16-11-13-5-3-4-6-15(13)24-16/h3-8,11-12H,9-10H2,1-2H3,(H,19,21)
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n/an/a 13n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM214639
PNG
(US9284319, 7)
Show SMILES OC[C@@H]1CCN(C1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H18N4O2/c24-12-13-7-8-22(11-13)19-6-5-18-20-10-15(23(18)21-19)17-9-14-3-1-2-4-16(14)25-17/h1-6,9-10,13,24H,7-8,11-12H2/t13-/m1/s1
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n/an/a 14n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM214641
PNG
(US9284319, 9)
Show SMILES O[C@@H]1CCN(C1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H16N4O2/c23-13-7-8-21(11-13)18-6-5-17-19-10-14(22(17)20-18)16-9-12-3-1-2-4-15(12)24-16/h1-6,9-10,13,23H,7-8,11H2/t13-/m1/s1
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n/an/a 15n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM214636
PNG
(US9284319, 4)
Show SMILES O[C@@H]1CCCN(C1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H18N4O2/c24-14-5-3-9-22(12-14)19-8-7-18-20-11-15(23(18)21-19)17-10-13-4-1-2-6-16(13)25-17/h1-2,4,6-8,10-11,14,24H,3,5,9,12H2/t14-/m1/s1
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n/an/a 15n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM214640
PNG
(US9284319, 8)
Show SMILES O[C@H]1CCN(C1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H16N4O2/c23-13-7-8-21(11-13)18-6-5-17-19-10-14(22(17)20-18)16-9-12-3-1-2-4-15(12)24-16/h1-6,9-10,13,23H,7-8,11H2/t13-/m0/s1
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n/an/a 15n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM218708
PNG
(US9296757, 30 | US9296757, 33)
Show SMILES CCOC(=O)C1CCc2c(C1)sc1ncnc(Nc3cc4sc(=O)[nH]c4cc3OC)c21
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n/an/a 15n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9296757 (2016)


BindingDB Entry DOI: 10.7270/Q2XK8DD7
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM214648
PNG
(US9284319, R6 | US9730929, Example R6 | US9783543,...)
Show SMILES C(Cc1ccccn1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C21H17N5O/c1-2-7-18-15(5-1)13-19(27-18)17-14-24-21-9-8-20(25-26(17)21)23-12-10-16-6-3-4-11-22-16/h1-9,11,13-14H,10,12H2,(H,23,25)
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n/an/a 17n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM214635
PNG
(US9284319, 3)
Show SMILES OC1CCN(C1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H16N4O2/c23-13-7-8-21(11-13)18-6-5-17-19-10-14(22(17)20-18)16-9-12-3-1-2-4-15(12)24-16/h1-6,9-10,13,23H,7-8,11H2
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n/an/a 17n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM218747
PNG
(US9296757, 69)
Show SMILES CCCN(CCOC)C(=O)C1CCc2c(C1)sc1ncnc(Nc3ccc4[nH]c(=O)sc4c3)c21
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n/an/a 19n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9296757 (2016)


BindingDB Entry DOI: 10.7270/Q2XK8DD7
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM214640
PNG
(US9284319, 8)
Show SMILES O[C@H]1CCN(C1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H16N4O2/c23-13-7-8-21(11-13)18-6-5-17-19-10-14(22(17)20-18)16-9-12-3-1-2-4-15(12)24-16/h1-6,9-10,13,23H,7-8,11H2/t13-/m0/s1
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n/an/a 19n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM214633
PNG
(US9284319, 1)
Show SMILES OC[C@@H]1CCCN1c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H18N4O2/c24-12-14-5-3-9-22(14)19-8-7-18-20-11-15(23(18)21-19)17-10-13-4-1-2-6-16(13)25-17/h1-2,4,6-8,10-11,14,24H,3,5,9,12H2/t14-/m0/s1
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n/an/a 19n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM218712
PNG
(US9296757, 34)
Show SMILES CCCCN(CC#N)C(=O)C1CCc2c(C1)sc1ncnc(Nc3ccc4[nH]c(=O)sc4c3)c21
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n/an/a 20n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9296757 (2016)


BindingDB Entry DOI: 10.7270/Q2XK8DD7
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM214642
PNG
(US9284319, 10)
Show SMILES OC[C@H]1CCN(C1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H18N4O2/c24-12-13-7-8-22(11-13)19-6-5-18-20-10-15(23(18)21-19)17-9-14-3-1-2-4-16(14)25-17/h1-6,9-10,13,24H,7-8,11-12H2/t13-/m0/s1
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n/an/a 20n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM218719
PNG
(US9296757, 41)
Show SMILES CCCCN(C)C(=O)C1CCc2c(C1)sc1ncnc(Nc3ccc4[nH]c(=O)sc4c3)c21
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n/an/a 21n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9296757 (2016)


BindingDB Entry DOI: 10.7270/Q2XK8DD7
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM218707
PNG
(US9296757, 29 | US9296757, 37)
Show SMILES CN1CCN(CC1)C(=O)C1CCc2c(C1)sc1ncnc(Nc3ccc4[nH]c(=O)sc4c3)c21
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n/an/a 22n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9296757 (2016)


BindingDB Entry DOI: 10.7270/Q2XK8DD7
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM214634
PNG
(US9284319, 2)
Show SMILES OC[C@H]1CCCN1c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H18N4O2/c24-12-14-5-3-9-22(14)19-8-7-18-20-11-15(23(18)21-19)17-10-13-4-1-2-6-16(13)25-17/h1-2,4,6-8,10-11,14,24H,3,5,9,12H2/t14-/m1/s1
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n/an/a 22n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM214650
PNG
(US10688093, Compound 229_0237_0073 | US9284319, R8...)
Show SMILES C(Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccncc1
Show InChI InChI=1S/C20H15N5O/c1-2-4-17-15(3-1)11-18(26-17)16-13-23-20-6-5-19(24-25(16)20)22-12-14-7-9-21-10-8-14/h1-11,13H,12H2,(H,22,24)
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n/an/a 23n/an/an/an/a7.522



Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM218748
PNG
(US9296757, 70)
Show SMILES CCN(CCOC)C(=O)C1CCc2c(C1)sc1ncnc(Nc3ccc4[nH]c(=O)sc4c3)c21
PDB
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n/an/a 24n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9296757 (2016)


BindingDB Entry DOI: 10.7270/Q2XK8DD7
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM218692
PNG
(US9296757, 14)
Show SMILES Fc1cccc(CNC(=O)C2CCc3c(C2)sc2ncnc(Nc4ccc5[nH]c(=O)sc5c4)c32)c1
PDB
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n/an/a 25n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9296757 (2016)


BindingDB Entry DOI: 10.7270/Q2XK8DD7
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM218742
PNG
(US9296757, 64)
Show SMILES O=C(C1CCc2c(C1)sc1ncnc(Nc3ccc4[nH]c(=O)sc4c3)c21)N1CCN2CCCCC2C1
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n/an/a 27n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9296757 (2016)


BindingDB Entry DOI: 10.7270/Q2XK8DD7
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM218734
PNG
(US9296757, 56)
Show SMILES CN(CC1CCCO1)C(=O)C1CCc2c(C1)sc1ncnc(Nc3ccc4[nH]c(=O)sc4c3)c21
PDB
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n/an/a 27n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9296757 (2016)


BindingDB Entry DOI: 10.7270/Q2XK8DD7
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM218732
PNG
(US9296757, 54)
Show SMILES CC(C)N(CCO)C(=O)C1CCc2c(C1)sc1ncnc(Nc3ccc4[nH]c(=O)sc4c3)c21
PDB
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n/an/a 28n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9296757 (2016)


BindingDB Entry DOI: 10.7270/Q2XK8DD7
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM218730
PNG
(US9296757, 52)
Show SMILES COCCN(CCOC)C(=O)C1CCc2c(C1)sc1ncnc(Nc3ccc4[nH]c(=O)sc4c3)c21
PDB
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n/an/a 30n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9296757 (2016)


BindingDB Entry DOI: 10.7270/Q2XK8DD7
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM218762
PNG
(US9296757, 84)
Show SMILES COC1CCCN(C1)C(=O)C1CCc2c(C1)sc1ncnc(Nc3ccc4[nH]c(=O)sc4c3)c21
PDB
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n/an/a 30n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9296757 (2016)


BindingDB Entry DOI: 10.7270/Q2XK8DD7
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM218753
PNG
(US9296757, 75)
Show SMILES O=C(C1CCc2c(C1)sc1ncnc(Nc3ccc4[nH]c(=O)sc4c3)c21)N1CCCC(C1)C#N
PDB
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n/an/a 32n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9296757 (2016)


BindingDB Entry DOI: 10.7270/Q2XK8DD7
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM218739
PNG
(US9296757, 61)
Show SMILES CN(C1CCN(C1)C(=O)C1CCc2c(C1)sc1ncnc(Nc3ccc4[nH]c(=O)sc4c3)c21)C(C)=O
PDB
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n/an/a 32n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9296757 (2016)


BindingDB Entry DOI: 10.7270/Q2XK8DD7
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM218746
PNG
(US9296757, 68)
Show SMILES CC1CN(CC(C)O1)C(=O)C1CCc2c(C1)sc1ncnc(Nc3ccc4[nH]c(=O)sc4c3)c21
PDB
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n/an/a 32n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9296757 (2016)


BindingDB Entry DOI: 10.7270/Q2XK8DD7
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM218686
PNG
(US9296757, 8)
Show SMILES O=C(Nc1ccccc1)C1CCc2c(C1)sc1ncnc(Nc3ccc4[nH]c(=O)sc4c3)c21
PDB
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n/an/a 33n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9296757 (2016)


BindingDB Entry DOI: 10.7270/Q2XK8DD7
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM214638
PNG
(US9284319, 6)
Show SMILES OC1CN(C1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C17H14N4O2/c22-12-9-20(10-12)17-6-5-16-18-8-13(21(16)19-17)15-7-11-3-1-2-4-14(11)23-15/h1-8,12,22H,9-10H2
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Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM214650
PNG
(US10688093, Compound 229_0237_0073 | US9284319, R8...)
Show SMILES C(Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccncc1
Show InChI InChI=1S/C20H15N5O/c1-2-4-17-15(3-1)11-18(26-17)16-13-23-20-6-5-19(24-25(16)20)22-12-14-7-9-21-10-8-14/h1-11,13H,12H2,(H,22,24)
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Bayer Intellectual Property GmbH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM218759
PNG
(US9296757, 81)
Show SMILES CN1CCN(CC1CCO)C(=O)C1CCc2c(C1)sc1ncnc(Nc3ccc4[nH]c(=O)sc4c3)c21
PDB
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Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9296757 (2016)


BindingDB Entry DOI: 10.7270/Q2XK8DD7
More data for this
Ligand-Target Pair
GST-MKNK1


(Homo sapiens (Human))
BDBM218756
PNG
(US9296757, 78)
Show SMILES O=C(C1CCc2c(C1)sc1ncnc(Nc3ccc4[nH]c(=O)sc4c3)c21)N1CCN(CC2CC2)CC1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 34n/an/an/an/a7.522



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9296757 (2016)


BindingDB Entry DOI: 10.7270/Q2XK8DD7
More data for this
Ligand-Target Pair
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