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Compile Data Set for Download or QSAR

Found 7365 hits Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM50392788
PNG
(CHEMBL457614)
Show SMILES CC(C)Oc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cn3)ncc2Cl)[nH]n1
Show InChI InChI=1S/C17H19ClFN7O/c1-9(2)27-15-6-14(25-26-15)23-16-12(18)8-21-17(24-16)22-10(3)13-5-4-11(19)7-20-13/h4-10H,1-3H3,(H3,21,22,23,24,25,26)/t10-/m0/s1
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0.360n/an/an/an/an/an/an/an/a



Zoetis Inc

Curated by ChEMBL


Assay Description
Inhibition of human active TRKA assessed as decrease in substrate phosphorylation incubated for 2 hrs using CSKtide as substrate in presence of ATP m...


Bioorg Med Chem Lett 29: (2019)


Article DOI: 10.1016/j.bmcl.2019.126680
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM50392788
PNG
(CHEMBL457614)
Show SMILES CC(C)Oc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cn3)ncc2Cl)[nH]n1
Show InChI InChI=1S/C17H19ClFN7O/c1-9(2)27-15-6-14(25-26-15)23-16-12(18)8-21-17(24-16)22-10(3)13-5-4-11(19)7-20-13/h4-10H,1-3H3,(H3,21,22,23,24,25,26)/t10-/m0/s1
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3.70n/an/an/an/an/an/an/an/a



Zoetis Inc

Curated by ChEMBL


Assay Description
Inhibition of human inactive TRKA assessed as decrease in substrate phosphorylation incubated for 2 hrs using CSKtide as substrate in presence of ATP...


Bioorg Med Chem Lett 29: (2019)


Article DOI: 10.1016/j.bmcl.2019.126680
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM50502896
PNG
(CHEMBL4458913)
Show SMILES Cc1ccc2nc(CSc3nnc(NC(=O)Nc4cccc(c4)C(F)(F)F)s3)cc(=O)n2c1
Show InChI InChI=1S/C20H15F3N6O2S2/c1-11-5-6-15-24-14(8-16(30)29(15)9-11)10-32-19-28-27-18(33-19)26-17(31)25-13-4-2-3-12(7-13)20(21,22)23/h2-9H,10H2,1H3,(H2,25,26,27,31)
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21n/an/an/an/an/an/an/an/a



Zoetis Inc

Curated by ChEMBL


Assay Description
Inhibition of human inactive TRKA assessed as decrease in substrate phosphorylation incubated for 2 hrs using CSKtide as substrate in presence of ATP...


Bioorg Med Chem Lett 29: (2019)


Article DOI: 10.1016/j.bmcl.2019.126680
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM50502896
PNG
(CHEMBL4458913)
Show SMILES Cc1ccc2nc(CSc3nnc(NC(=O)Nc4cccc(c4)C(F)(F)F)s3)cc(=O)n2c1
Show InChI InChI=1S/C20H15F3N6O2S2/c1-11-5-6-15-24-14(8-16(30)29(15)9-11)10-32-19-28-27-18(33-19)26-17(31)25-13-4-2-3-12(7-13)20(21,22)23/h2-9H,10H2,1H3,(H2,25,26,27,31)
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67n/an/an/an/an/an/an/an/a



Zoetis Inc

Curated by ChEMBL


Assay Description
Inhibition of human active TRKA assessed as decrease in substrate phosphorylation incubated for 2 hrs using CSKtide as substrate in presence of ATP m...


Bioorg Med Chem Lett 29: (2019)


Article DOI: 10.1016/j.bmcl.2019.126680
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM50402020
PNG
(CHEMBL2205426)
Show SMILES CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccncc3)n2)c(=O)c1=O
Show InChI InChI=1S/C23H22N6O2/c1-23(2,3)29-19-18(20(30)21(19)31)27-17-10-13-25-22(28-17)26-16-6-4-14(5-7-16)15-8-11-24-12-9-15/h4-13,29H,1-3H3,(H2,25,26,27,28)
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>2.40E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant TRKA after 1 hr by scintillation counter analysis in presence of gamma-[33P]ATP


Bioorg Med Chem Lett 22: 7615-22 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.009
BindingDB Entry DOI: 10.7270/Q2XK8GQ3
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM50224883
PNG
(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Show SMILES Clc1cc2NC(=O)Nc3cnc(C#N)c(OCCCCOc2cc1NCc1cncs1)n3
Show InChI InChI=1S/C20H18ClN7O3S/c21-13-5-15-17(6-14(13)24-9-12-8-23-11-32-12)30-3-1-2-4-31-19-16(7-22)25-10-18(27-19)28-20(29)26-15/h5-6,8,10-11,24H,1-4,9H2,(H2,26,27,28,29)
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>2.48E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of TRKA


Bioorg Med Chem Lett 17: 6593-601 (2007)


Article DOI: 10.1016/j.bmcl.2007.09.063
BindingDB Entry DOI: 10.7270/Q2X067WT
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM50093352
PNG
(CHEMBL3586678)
Show SMILES COc1cncc(n1)N1CCc2nc(NC(=O)NCCc3cn(CC(F)F)cn3)sc2C1
Show InChI InChI=1S/C19H22F2N8O2S/c1-31-17-7-22-6-16(26-17)29-5-3-13-14(9-29)32-19(25-13)27-18(30)23-4-2-12-8-28(11-24-12)10-15(20)21/h6-8,11,15H,2-5,9-10H2,1H3,(H2,23,25,27,30)
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3.60E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of TRKA (unknown origin) using ATP and polyE4Y substrate by radiometric assay


J Med Chem 58: 5684-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00498
BindingDB Entry DOI: 10.7270/Q2Z89F53
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM50093351
PNG
(CHEMBL3585362)
Show SMILES COc1cc(cnc1Cl)N1CCc2nc(NC(=O)NCCc3cn(CC(F)F)cn3)sc2C1
Show InChI InChI=1S/C20H22ClF2N7O2S/c1-32-15-6-13(7-25-18(15)21)30-5-3-14-16(9-30)33-20(27-14)28-19(31)24-4-2-12-8-29(11-26-12)10-17(22)23/h6-8,11,17H,2-5,9-10H2,1H3,(H2,24,27,28,31)
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>4.00E+3n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of TRKA (unknown origin) using ATP and polyE4Y substrate by radiometric assay


J Med Chem 58: 5684-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00498
BindingDB Entry DOI: 10.7270/Q2Z89F53
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM356152
PNG
(2-fluoro-5-(1-methyl-1H- pyrazol-3-yl)-N-(5-oxo-2-...)
Show SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2cc3C(=O)NCCc3nc2-c2ccccc2)c(F)cc1C(F)(F)F
Show InChI InChI=1S/C26H19F4N5O2/c1-35-10-8-21(34-35)15-11-16(19(27)13-18(15)26(28,29)30)25(37)33-22-12-17-20(7-9-31-24(17)36)32-23(22)14-5-3-2-4-6-14/h2-6,8,10-13H,7,9H2,1H3,(H,31,36)(H,33,37)
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n/an/a 0.0690n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...


US Patent US9815846 (2017)


BindingDB Entry DOI: 10.7270/Q20P129R
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM356096
PNG
(N-(2-((2,5-dioxoimidazolidin-1- yl)methyl)-4-pheny...)
Show SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2cnc(CN3C(=O)CNC3=O)nc2-c2ccccc2)c(F)cc1C(F)(F)F
Show InChI InChI=1S/C26H19F4N7O3/c1-36-8-7-19(35-36)15-9-16(18(27)10-17(15)26(28,29)30)24(39)33-20-11-31-21(13-37-22(38)12-32-25(37)40)34-23(20)14-5-3-2-4-6-14/h2-11H,12-13H2,1H3,(H,32,40)(H,33,39)
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n/an/a 0.0830n/an/an/an/an/an/a



Merck Sharp & Dohme Corp

US Patent


Assay Description
TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...


US Patent US9815846 (2017)


BindingDB Entry DOI: 10.7270/Q20P129R
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM483575
PNG
(US10927079, Compound 41)
Show SMILES Cc1nnc(CNC(=O)c2nc(c(NC(=O)NC3C(O)CC(C)(C)c4cc(F)c(F)cc34)cc2C)-c2ccccc2)o1
Show InChI InChI=1S/C30H30F2N6O4/c1-15-10-22(34-29(41)36-27-18-11-20(31)21(32)12-19(18)30(3,4)13-23(27)39)26(17-8-6-5-7-9-17)35-25(15)28(40)33-14-24-38-37-16(2)42-24/h5-12,23,27,39H,13-14H2,1-4H3,(H,33,40)(H2,34,36,41)
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM483574
PNG
(US10927079, Compound 40)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1C(N)=O)-c1ccccc1
Show InChI InChI=1S/C26H26F2N4O3/c1-13-9-19(22(31-21(13)24(29)34)14-7-5-4-6-8-14)30-25(35)32-23-15-10-17(27)18(28)11-16(15)26(2,3)12-20(23)33/h4-11,20,23,33H,12H2,1-3H3,(H2,29,34)(H2,30,32,35)/t20-,23-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM483606
PNG
(US10927079, Compound 41b)
Show SMILES Cc1nnc(CNC(=O)c2nc(c(NC(=O)N[C@H]3[C@@H](O)CC(C)(C)c4cc(F)c(F)cc34)cc2C)-c2ccccc2)o1
Show InChI InChI=1S/C30H30F2N6O4/c1-15-10-22(34-29(41)36-27-18-11-20(31)21(32)12-19(18)30(3,4)13-23(27)39)26(17-8-6-5-7-9-17)35-25(15)28(40)33-14-24-38-37-16(2)42-24/h5-12,23,27,39H,13-14H2,1-4H3,(H,33,40)(H2,34,36,41)/t23-,27+/m0/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412309
PNG
(US10399945, Example 42 | US10669239, Compound 42 |...)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1C(=O)NCC(C)(C)O)-c1ccccc1
Show InChI InChI=1S/C30H34F2N4O4/c1-16-11-22(25(17-9-7-6-8-10-17)35-24(16)27(38)33-15-30(4,5)40)34-28(39)36-26-18-12-20(31)21(32)13-19(18)29(2,3)14-23(26)37/h6-13,23,26,37,40H,14-15H2,1-5H3,(H,33,38)(H2,34,36,39)/t23-,26-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM445314
PNG
(US10669239, Compound 43 | US10927079, Compound 43)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1CO)-c1ccccc1
Show InChI InChI=1S/C26H27F2N3O3/c1-14-9-20(23(29-21(14)13-32)15-7-5-4-6-8-15)30-25(34)31-24-16-10-18(27)19(28)11-17(16)26(2,3)12-22(24)33/h4-11,22,24,32-33H,12-13H2,1-3H3,(H2,30,31,34)/t22-,24-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM483578
PNG
(US10927079, Compound 44)
Show SMILES Cc1ncc(cn1)-c1nc(c(NC(=O)NC2C(O)CC(C)(C)c3cc(F)c(F)cc23)cc1C)-c1ccccc1
Show InChI InChI=1S/C30H29F2N5O2/c1-16-10-24(27(18-8-6-5-7-9-18)36-26(16)19-14-33-17(2)34-15-19)35-29(39)37-28-20-11-22(31)23(32)12-21(20)30(3,4)13-25(28)38/h5-12,14-15,25,28,38H,13H2,1-4H3,(H2,35,37,39)
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412311
PNG
(US10399945, Example 44 | US10399945, Example 44a |...)
Show SMILES Cc1ncc(cn1)-c1nc(c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)cc1C)-c1ccccc1
Show InChI InChI=1S/C30H29F2N5O2/c1-16-10-24(27(18-8-6-5-7-9-18)36-26(16)19-14-33-17(2)34-15-19)35-29(39)37-28-20-11-22(31)23(32)12-21(20)30(3,4)13-25(28)38/h5-12,14-15,25,28,38H,13H2,1-4H3,(H2,35,37,39)/t25-,28-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM483602
PNG
(US10927079, Compound 44b)
Show SMILES Cc1ncc(cn1)-c1nc(c(NC(=O)N[C@H]2[C@@H](O)CC(C)(C)c3cc(F)c(F)cc23)cc1C)-c1ccccc1
Show InChI InChI=1S/C30H29F2N5O2/c1-16-10-24(27(18-8-6-5-7-9-18)36-26(16)19-14-33-17(2)34-15-19)35-29(39)37-28-20-11-22(31)23(32)12-21(20)30(3,4)13-25(28)38/h5-12,14-15,25,28,38H,13H2,1-4H3,(H2,35,37,39)/t25-,28+/m0/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM445318
PNG
(US10669239, Compound 45 | US10927079, Compound 45)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1-c1ccc(CO)cc1)-c1ccccc1
Show InChI InChI=1S/C32H31F2N3O3/c1-18-13-26(29(20-7-5-4-6-8-20)36-28(18)21-11-9-19(17-38)10-12-21)35-31(40)37-30-22-14-24(33)25(34)15-23(22)32(2,3)16-27(30)39/h4-15,27,30,38-39H,16-17H2,1-3H3,(H2,35,37,40)/t27-,30-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM483580
PNG
(US10927079, Compound 46)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1-c1cccc(CO)c1)-c1ccccc1
Show InChI InChI=1S/C32H31F2N3O3/c1-18-12-26(29(20-9-5-4-6-10-20)36-28(18)21-11-7-8-19(13-21)17-38)35-31(40)37-30-22-14-24(33)25(34)15-23(22)32(2,3)16-27(30)39/h4-15,27,30,38-39H,16-17H2,1-3H3,(H2,35,37,40)/t27-,30-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM50524981
PNG
(CHEMBL4562879)
Show SMILES C[C@H](Nc1ccc2ncc(-c3cc(C)n[nH]3)n2n1)c1ccc(F)cc1F
Show InChI InChI=1S/C18H16F2N6/c1-10-7-15(24-23-10)16-9-21-18-6-5-17(25-26(16)18)22-11(2)13-4-3-12(19)8-14(13)20/h3-9,11H,1-2H3,(H,22,25)(H,23,24)/t11-/m0/s1
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n/an/a 0.100n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human TrkA kinase domain (436 to 790 residues) expressed in baculovirus expression system using biotin-poly-GT as...


J Med Chem 62: 4915-4935 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01630
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM483581
PNG
(US10927079, Compound 47)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1-c1cccc(c1)C#N)-c1ccccc1
Show InChI InChI=1S/C32H28F2N4O2/c1-18-12-26(29(20-9-5-4-6-10-20)37-28(18)21-11-7-8-19(13-21)17-35)36-31(40)38-30-22-14-24(33)25(34)15-23(22)32(2,3)16-27(30)39/h4-15,27,30,39H,16H2,1-3H3,(H2,36,38,40)/t27-,30-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM483582
PNG
(US10927079, Compound 48)
Show SMILES Cc1cc(NC(=O)NC2C(O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1-c1ccn(C)n1)-c1ccccc1
Show InChI InChI=1S/C29H29F2N5O2/c1-16-12-23(26(17-8-6-5-7-9-17)33-25(16)22-10-11-36(4)35-22)32-28(38)34-27-18-13-20(30)21(31)14-19(18)29(2,3)15-24(27)37/h5-14,24,27,37H,15H2,1-4H3,(H2,32,34,38)
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412318
PNG
(US10399945, Example 48a | US10669239, Compound 48a...)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1-c1ccn(C)n1)-c1ccccc1
Show InChI InChI=1S/C29H29F2N5O2/c1-16-12-23(26(17-8-6-5-7-9-17)33-25(16)22-10-11-36(4)35-22)32-28(38)34-27-18-13-20(30)21(31)14-19(18)29(2,3)15-24(27)37/h5-14,24,27,37H,15H2,1-4H3,(H2,32,34,38)/t24-,27-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM483604
PNG
(US10927079, Compound 48b)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1-c1ccn(C)n1)-c1ccccc1
Show InChI InChI=1S/C29H29F2N5O2/c1-16-12-23(26(17-8-6-5-7-9-17)33-25(16)22-10-11-36(4)35-22)32-28(38)34-27-18-13-20(30)21(31)14-19(18)29(2,3)15-24(27)37/h5-14,24,27,37H,15H2,1-4H3,(H2,32,34,38)/t24-,27+/m0/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412320
PNG
(US10399945, Example 49 | US10927079, Compound 49)
Show SMILES Cc1cc(cnn1)-c1nc(c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)cc1C)-c1ccccc1
Show InChI InChI=1S/C30H29F2N5O2/c1-16-10-24(27(18-8-6-5-7-9-18)35-26(16)19-11-17(2)37-33-15-19)34-29(39)36-28-20-12-22(31)23(32)13-21(20)30(3,4)14-25(28)38/h5-13,15,25,28,38H,14H2,1-4H3,(H2,34,36,39)/t25-,28-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412322
PNG
(US10399945, Example 51 | US10669239, Compound 51 |...)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C29H29F2N5O2/c1-16-10-23(26(17-8-6-5-7-9-17)34-25(16)18-14-32-36(4)15-18)33-28(38)35-27-19-11-21(30)22(31)12-20(19)29(2,3)13-24(27)37/h5-12,14-15,24,27,37H,13H2,1-4H3,(H2,33,35,38)/t24-,27-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412323
PNG
(US10399945, Example 52 | US10669239, Compound 52 |...)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1-c1ccc(cc1)C#N)-c1ccccc1
Show InChI InChI=1S/C32H28F2N4O2/c1-18-13-26(29(20-7-5-4-6-8-20)37-28(18)21-11-9-19(17-35)10-12-21)36-31(40)38-30-22-14-24(33)25(34)15-23(22)32(2,3)16-27(30)39/h4-15,27,30,39H,16H2,1-3H3,(H2,36,38,40)/t27-,30-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412324
PNG
(US10399945, Example 53 | US10669239, Compound 53 |...)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1-c1cn[nH]c1)-c1ccccc1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412325
PNG
(US10399945, Example 54 | US10927079, Compound 54)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1-c1cnc(nc1)C(C)(C)O)-c1ccccc1
Show InChI InChI=1S/C32H33F2N5O3/c1-17-11-24(37-30(41)39-28-20-12-22(33)23(34)13-21(20)31(2,3)14-25(28)40)27(18-9-7-6-8-10-18)38-26(17)19-15-35-29(36-16-19)32(4,5)42/h6-13,15-16,25,28,40,42H,14H2,1-5H3,(H2,37,39,41)/t25-,28-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM445330
PNG
(US10669239, Compound 55 | US10927079, Compound 55)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1-c1ccc(CO)nc1)-c1ccccc1
Show InChI InChI=1S/C31H30F2N4O3/c1-17-11-25(28(18-7-5-4-6-8-18)36-27(17)19-9-10-20(16-38)34-15-19)35-30(40)37-29-21-12-23(32)24(33)13-22(21)31(2,3)14-26(29)39/h4-13,15,26,29,38-39H,14,16H2,1-3H3,(H2,35,37,40)/t26-,29-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM445331
PNG
(US10669239, Compound 56 | US10927079, Compound 56)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1-c1ccnc(CO)c1)-c1ccccc1
Show InChI InChI=1S/C31H30F2N4O3/c1-17-11-25(28(18-7-5-4-6-8-18)36-27(17)19-9-10-34-20(12-19)16-38)35-30(40)37-29-21-13-23(32)24(33)14-22(21)31(2,3)15-26(29)39/h4-14,26,29,38-39H,15-16H2,1-3H3,(H2,35,37,40)/t26-,29-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412262
PNG
(US10399945, Example 1 | US10669239, Compound 1 | U...)
Show SMILES CC1(C)C[C@@H](O)[C@H](NC(=O)Nc2cccnc2-c2ccccc2)c2ccccc12
Show InChI InChI=1S/C24H25N3O2/c1-24(2)15-20(28)22(17-11-6-7-12-18(17)24)27-23(29)26-19-13-8-14-25-21(19)16-9-4-3-5-10-16/h3-14,20,22,28H,15H2,1-2H3,(H2,26,27,29)/t20-,22-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412263
PNG
(US10399945, Example 2 | US10399945, Example 7 | US...)
Show SMILES Cc1cnc(c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c1)-c1ccccc1
Show InChI InChI=1S/C25H27N3O2/c1-16-13-20(22(26-15-16)17-9-5-4-6-10-17)27-24(30)28-23-18-11-7-8-12-19(18)25(2,3)14-21(23)29/h4-13,15,21,23,29H,14H2,1-3H3,(H2,27,28,30)/t21-,23-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412264
PNG
(US10399945, Example 3 | US10399945, Example 9 | US...)
Show SMILES Cc1ncc(cn1)-c1nc(c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)cc1C)-c1ccccc1
Show InChI InChI=1S/C30H31N5O2/c1-18-14-24(27(20-10-6-5-7-11-20)34-26(18)21-16-31-19(2)32-17-21)33-29(37)35-28-22-12-8-9-13-23(22)30(3,4)15-25(28)36/h5-14,16-17,25,28,36H,15H2,1-4H3,(H2,33,35,37)/t25-,28-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412265
PNG
(US10399945, Example 10 | US10399945, Example 4 | U...)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C29H31N5O2/c1-18-14-23(26(19-10-6-5-7-11-19)32-25(18)20-16-30-34(4)17-20)31-28(36)33-27-21-12-8-9-13-22(21)29(2,3)15-24(27)35/h5-14,16-17,24,27,35H,15H2,1-4H3,(H2,31,33,36)/t24-,27-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412266
PNG
(US10399945, Example 18 | US10399945, Example 5 | U...)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1cn[nH]c1)-c1ccccc1
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MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412267
PNG
(US10399945, Example 6 | US10669239, Compound 20 | ...)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1ccc(O)nc1)-c1ccccc1
Show InChI InChI=1S/C30H30N4O3/c1-18-15-23(27(19-9-5-4-6-10-19)33-26(18)20-13-14-25(36)31-17-20)32-29(37)34-28-21-11-7-8-12-22(21)30(2,3)16-24(28)35/h4-15,17,24,28,35H,16H2,1-3H3,(H,31,36)(H2,32,34,37)/t24-,28-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412263
PNG
(US10399945, Example 2 | US10399945, Example 7 | US...)
Show SMILES Cc1cnc(c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c1)-c1ccccc1
Show InChI InChI=1S/C25H27N3O2/c1-16-13-20(22(26-15-16)17-9-5-4-6-10-17)27-24(30)28-23-18-11-7-8-12-19(18)25(2,3)14-21(23)29/h4-13,15,21,23,29H,14H2,1-3H3,(H2,27,28,30)/t21-,23-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412269
PNG
(US10399945, Example 8 | US10669239, Compound 8 | U...)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1CO)-c1ccccc1
Show InChI InChI=1S/C26H29N3O3/c1-16-13-20(23(27-21(16)15-30)17-9-5-4-6-10-17)28-25(32)29-24-18-11-7-8-12-19(18)26(2,3)14-22(24)31/h4-13,22,24,30-31H,14-15H2,1-3H3,(H2,28,29,32)/t22-,24-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412264
PNG
(US10399945, Example 3 | US10399945, Example 9 | US...)
Show SMILES Cc1ncc(cn1)-c1nc(c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)cc1C)-c1ccccc1
Show InChI InChI=1S/C30H31N5O2/c1-18-14-24(27(20-10-6-5-7-11-20)34-26(18)21-16-31-19(2)32-17-21)33-29(37)35-28-22-12-8-9-13-23(22)30(3,4)15-25(28)36/h5-14,16-17,25,28,36H,15H2,1-4H3,(H2,33,35,37)/t25-,28-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412265
PNG
(US10399945, Example 10 | US10399945, Example 4 | U...)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1cnn(C)c1)-c1ccccc1
Show InChI InChI=1S/C29H31N5O2/c1-18-14-23(26(19-10-6-5-7-11-19)32-25(18)20-16-30-34(4)17-20)31-28(36)33-27-21-12-8-9-13-22(21)29(2,3)15-24(27)35/h5-14,16-17,24,27,35H,15H2,1-4H3,(H2,31,33,36)/t24-,27-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412272
PNG
(US10399945, Example 11 | US10927079, Compound 11)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1cncc(c1)C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C31H29F3N4O2/c1-18-13-24(36-29(40)38-28-22-11-7-8-12-23(22)30(2,3)15-25(28)39)27(19-9-5-4-6-10-19)37-26(18)20-14-21(17-35-16-20)31(32,33)34/h4-14,16-17,25,28,39H,15H2,1-3H3,(H2,36,38,40)/t25-,28-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412273
PNG
(US10399945, Example 12 | US10927079, Compound 12)
Show SMILES Cc1ccc(cn1)-c1nc(c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)cc1C)-c1ccccc1
Show InChI InChI=1S/C31H32N4O2/c1-19-16-25(28(21-10-6-5-7-11-21)34-27(19)22-15-14-20(2)32-18-22)33-30(37)35-29-23-12-8-9-13-24(23)31(3,4)17-26(29)36/h5-16,18,26,29,36H,17H2,1-4H3,(H2,33,35,37)/t26-,29-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM483547
PNG
(US10927079, Compound 13)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1ccc(nc1)C#N)-c1ccccc1
Show InChI InChI=1S/C31H29N5O2/c1-19-15-25(34-30(38)36-29-23-11-7-8-12-24(23)31(2,3)16-26(29)37)28(20-9-5-4-6-10-20)35-27(19)21-13-14-22(17-32)33-18-21/h4-15,18,26,29,37H,16H2,1-3H3,(H2,34,36,38)/t26-,29-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412275
PNG
(US10399945, Example 14 | US10927079, Compound 14)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1ccc(nc1)S(C)(=O)=O)-c1ccccc1
Show InChI InChI=1S/C31H32N4O4S/c1-19-16-24(33-30(37)35-29-22-12-8-9-13-23(22)31(2,3)17-25(29)36)28(20-10-6-5-7-11-20)34-27(19)21-14-15-26(32-18-21)40(4,38)39/h5-16,18,25,29,36H,17H2,1-4H3,(H2,33,35,37)/t25-,29-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412276
PNG
(US10399945, Example 15 | US10927079, Compound 15)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1cnc(nc1)C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C30H28F3N5O2/c1-17-13-22(36-28(40)38-26-20-11-7-8-12-21(20)29(2,3)14-23(26)39)25(18-9-5-4-6-10-18)37-24(17)19-15-34-27(35-16-19)30(31,32)33/h4-13,15-16,23,26,39H,14H2,1-3H3,(H2,36,38,40)/t23-,26-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412277
PNG
(US10399945, Example 16 | US10669239, Compound 16 |...)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1ccc(cc1)C#N)-c1ccccc1
Show InChI InChI=1S/C32H30N4O2/c1-20-17-26(34-31(38)36-30-24-11-7-8-12-25(24)32(2,3)18-27(30)37)29(22-9-5-4-6-10-22)35-28(20)23-15-13-21(19-33)14-16-23/h4-17,27,30,37H,18H2,1-3H3,(H2,34,36,38)/t27-,30-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412278
PNG
(US10399945, Example 17 | US10669239, Compound 17 |...)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1ccnc(c1)C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C31H29F3N4O2/c1-18-15-23(36-29(40)38-28-21-11-7-8-12-22(21)30(2,3)17-24(28)39)27(19-9-5-4-6-10-19)37-26(18)20-13-14-35-25(16-20)31(32,33)34/h4-16,24,28,39H,17H2,1-3H3,(H2,36,38,40)/t24-,28-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM412266
PNG
(US10399945, Example 18 | US10399945, Example 5 | U...)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1cn[nH]c1)-c1ccccc1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...


US Patent US10927079 (2021)

More data for this
Ligand-Target Pair
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