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Compile Data Set for Download or QSAR

Found 1623 hits Enz. Inhib. hit(s) with Target = 'Protein arginine N-methyltransferase 5'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM415557
PNG
(US10428104, Example 88)
Show SMILES Nc1ncnc2n(ccc12)[C@@H]1O[C@H]([C@H](O)c2ccc(Cl)c(F)c2)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C17H16ClFN4O4/c18-9-2-1-7(5-10(9)19)11(24)14-12(25)13(26)17(27-14)23-4-3-8-15(20)21-6-22-16(8)23/h1-6,11-14,17,24-26H,(H2,20,21,22)/t11-,12+,13-,14-,17-/m1/s1
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0.0200n/an/an/an/an/an/an/an/a



Prelude Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of PRMT5 (unknown origin)


Bioorg Med Chem Lett 29: 1264-1269 (2019)


Article DOI: 10.1016/j.bmcl.2019.03.042
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50431676
PNG
(CHEMBL2349526)
Show SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(Br)c2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C15H20BrN5O5S/c16-6-3-21(13-9(6)12(18)19-5-20-13)14-11(23)10(22)8(26-14)4-27-2-1-7(17)15(24)25/h3,5,7-8,10-11,14,22-23H,1-2,4,17H2,(H,24,25)(H2,18,19,20)/t7-,8+,10+,11+,14+/m0/s1
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1.15E+3n/an/an/an/an/an/an/an/a



EntreMed Inc.

Curated by ChEMBL


Assay Description
Inhibition of PRMT5 (unknown origin) using [3H]SAM after 1 hr by scintillation proximity assay


Bioorg Med Chem 21: 1787-94 (2013)


Article DOI: 10.1016/j.bmc.2013.01.049
BindingDB Entry DOI: 10.7270/Q24F1S41
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50462572
PNG
(CHEMBL4249337)
Show SMILES Nc1nc2cc(CC[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3ccc4c(N)ncnc34)ccc2cc1Br
Show InChI InChI=1S/C22H23BrN6O2/c23-15-8-12-3-1-11(7-16(12)28-21(15)25)2-4-13-9-17(19(31)18(13)30)29-6-5-14-20(24)26-10-27-22(14)29/h1,3,5-8,10,13,17-19,30-31H,2,4,9H2,(H2,25,28)(H2,24,26,27)/t13-,17+,18+,19-/m0/s1
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n/an/a 0.140n/an/an/an/an/an/a



University of Jinan

Curated by ChEMBL


Assay Description
Inhibition of full-length human N-terminal FLAG-tagged PRMT5 expressed in Sf9 insect cells using histone H2A as peptide after 120 mins in presence of...


Bioorg Med Chem Lett 28: 3693-3699 (2018)


Article DOI: 10.1016/j.bmcl.2018.10.026
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50523646
PNG
(CHEMBL4541714)
Show SMILES Nc1ccc2ccc(CC[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3ccc4c(N)ncnc34)cc2n1
Show InChI InChI=1S/C22H24N6O2/c23-18-6-5-13-3-1-12(9-16(13)27-18)2-4-14-10-17(20(30)19(14)29)28-8-7-15-21(24)25-11-26-22(15)28/h1,3,5-9,11,14,17,19-20,29-30H,2,4,10H2,(H2,23,27)(H2,24,25,26)/t14-,17+,19+,20-/m0/s1
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n/an/a 0.160n/an/an/an/an/an/a



Prelude Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of PRMT5 in human A549 cells assessed as reduction in sDMA production after 48 hrs by Hoechst Stain/HCS CellMask Deep Red Stain based immu...


Bioorg Med Chem Lett 29: 1264-1269 (2019)


Article DOI: 10.1016/j.bmcl.2019.03.042
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50462572
PNG
(CHEMBL4249337)
Show SMILES Nc1nc2cc(CC[C@H]3C[C@H]([C@H](O)[C@@H]3O)n3ccc4c(N)ncnc34)ccc2cc1Br
Show InChI InChI=1S/C22H23BrN6O2/c23-15-8-12-3-1-11(7-16(12)28-21(15)25)2-4-13-9-17(19(31)18(13)30)29-6-5-14-20(24)26-10-27-22(14)29/h1,3,5-8,10,13,17-19,30-31H,2,4,9H2,(H2,25,28)(H2,24,26,27)/t13-,17+,18+,19-/m0/s1
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n/an/a 0.25n/an/an/an/an/an/a



Prelude Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of PRMT5 in human A549 cells assessed as reduction in sDMA production after 48 hrs by Hoechst Stain/HCS CellMask Deep Red Stain based immu...


Bioorg Med Chem Lett 29: 1264-1269 (2019)


Article DOI: 10.1016/j.bmcl.2019.03.042
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50523641
PNG
(CHEMBL4543007)
Show SMILES Nc1ncnc2n(ccc12)[C@@H]1C[C@H](CCc2ccc3ccc(NCC4CC4)nc3c2)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C26H30N6O2/c27-25-19-9-10-32(26(19)30-14-29-25)21-12-18(23(33)24(21)34)6-4-15-3-5-17-7-8-22(31-20(17)11-15)28-13-16-1-2-16/h3,5,7-11,14,16,18,21,23-24,33-34H,1-2,4,6,12-13H2,(H,28,31)(H2,27,29,30)/t18-,21+,23+,24-/m0/s1
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n/an/a 0.400n/an/an/an/an/an/a



Prelude Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of PRMT5 in human A549 cells assessed as reduction in sDMA production after 48 hrs by Hoechst Stain/HCS CellMask Deep Red Stain based immu...


Bioorg Med Chem Lett 29: 1264-1269 (2019)


Article DOI: 10.1016/j.bmcl.2019.03.042
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM435525
PNG
((2R,3S,4R,5R)-2-(((2-amino-3- bromoquinolin-7-yl)o...)
Show SMILES C[C@@]1(O)[C@@H](COc2ccc3cc(Br)c(N)nc3c2)O[C@H]([C@@H]1O)n1ccc2c(N)ncnc12
Show InChI InChI=1S/C21H21BrN6O4/c1-21(30)15(8-31-11-3-2-10-6-13(22)18(24)27-14(10)7-11)32-20(16(21)29)28-5-4-12-17(23)25-9-26-19(12)28/h2-7,9,15-16,20,29-30H,8H2,1H3,(H2,24,27)(H2,23,25,26)/t15-,16+,20-,21-/m1/s1
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n/an/a 0.5n/an/an/an/an/an/a



Prelude Therapeutics, Incorporated

US Patent


Assay Description
Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...


US Patent US11078205 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM435509
PNG
((2R,3S,4R,5R)-5-(4-amino-7H- pyrrolo[2,3-d]pyrimid...)
Show SMILES C[C@@]1(O)[C@@H](COc2ccc3ccc(N)nc3c2)O[C@H]([C@@H]1O)n1ccc2c(N)ncnc12
Show InChI InChI=1S/C21H22N6O4/c1-21(29)15(9-30-12-4-2-11-3-5-16(22)26-14(11)8-12)31-20(17(21)28)27-7-6-13-18(23)24-10-25-19(13)27/h2-8,10,15,17,20,28-29H,9H2,1H3,(H2,22,26)(H2,23,24,25)/t15-,17+,20-,21-/m1/s1
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n/an/a 0.75n/an/an/an/an/an/a



Prelude Therapeutics, Incorporated

US Patent


Assay Description
Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...


US Patent US11078205 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM435657
PNG
((2R,3S,4R,5R)-2-(((2-amino-3- bromoquinolin-7-yl)o...)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1O[C@H](COc2ccc3cc(Br)c(N)nc3c2)[C@@](C)(O)[C@H]1O
Show InChI InChI=1S/C22H22BrN5O4/c1-11-14-5-6-28(20(14)26-10-25-11)21-18(29)22(2,30)17(32-21)9-31-13-4-3-12-7-15(23)19(24)27-16(12)8-13/h3-8,10,17-18,21,29-30H,9H2,1-2H3,(H2,24,27)/t17-,18+,21-,22-/m1/s1
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n/an/a 0.800n/an/an/an/an/an/a



Prelude Therapeutics, Incorporated

US Patent


Assay Description
Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...


US Patent US11078205 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM435523
PNG
((2R,3S,4R,5R)-5-(4-amino-5-fluoro-7H- pyrrolo[2,3-...)
Show SMILES C[C@@]1(O)[C@@H](COc2ccc3ccc(N)nc3c2)O[C@H]([C@@H]1O)n1cc(F)c2c(N)ncnc12
Show InChI InChI=1S/C21H21FN6O4/c1-21(30)14(8-31-11-4-2-10-3-5-15(23)27-13(10)6-11)32-20(17(21)29)28-7-12(22)16-18(24)25-9-26-19(16)28/h2-7,9,14,17,20,29-30H,8H2,1H3,(H2,23,27)(H2,24,25,26)/t14-,17+,20-,21-/m1/s1
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n/an/a 0.850n/an/an/an/an/an/a



Prelude Therapeutics, Incorporated

US Patent


Assay Description
Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...


US Patent US11078205 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM435710
PNG
((2R,3S,4R,5R)-5-(4-amino-7H- pyrrolo[2,3-d]pyrimid...)
Show SMILES Cc1cnc2cc(OC[C@H]3O[C@H]([C@H](O)[C@]3(C)O)n3ccc4c(N)ncnc34)ccn12
Show InChI InChI=1S/C20H22N6O4/c1-11-8-22-15-7-12(3-5-25(11)15)29-9-14-20(2,28)16(27)19(30-14)26-6-4-13-17(21)23-10-24-18(13)26/h3-8,10,14,16,19,27-28H,9H2,1-2H3,(H2,21,23,24)/t14-,16+,19-,20-/m1/s1
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n/an/a 0.900n/an/an/an/an/an/a



Prelude Therapeutics, Incorporated

US Patent


Assay Description
Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...


US Patent US11078205 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM451298
PNG
(US10709709, Example 125)
Show SMILES Nc1ncnc2n(cc(Br)c12)[C@@H]1C[C@H](Oc2cc(F)c(F)c3CCNCc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C20H20BrF2N5O3/c21-10-6-28(20-15(10)19(24)26-7-27-20)12-4-14(18(30)17(12)29)31-13-3-11(22)16(23)8-1-2-25-5-9(8)13/h3,6-7,12,14,17-18,25,29-30H,1-2,4-5H2,(H2,24,26,27)/t12-,14+,17+,18-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...


US Patent US10709709 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM451299
PNG
(US10709709, Example 126)
Show SMILES Cc1nc(N)c2c(F)cn([C@@H]3C[C@H](Oc4ccc(F)c5CCNCc45)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C21H23F2N5O3/c1-9-26-20(24)17-13(23)8-28(21(17)27-9)14-6-16(19(30)18(14)29)31-15-3-2-12(22)10-4-5-25-7-11(10)15/h2-3,8,14,16,18-19,25,29-30H,4-7H2,1H3,(H2,24,26,27)/t14-,16+,18+,19-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...


US Patent US10709709 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM451301
PNG
(US10709709, Example 128)
Show SMILES Nc1ncnc2n(cc(Cl)c12)[C@@H]1C[C@H](Oc2cc(F)c(F)c3CCNCc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C20H20ClF2N5O3/c21-10-6-28(20-15(10)19(24)26-7-27-20)12-4-14(18(30)17(12)29)31-13-3-11(22)16(23)8-1-2-25-5-9(8)13/h3,6-7,12,14,17-18,25,29-30H,1-2,4-5H2,(H2,24,26,27)/t12-,14+,17+,18-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...


US Patent US10709709 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM451302
PNG
(US10709709, Example 129)
Show SMILES Cc1cc2CCNCc2c(O[C@H]2C[C@H]([C@H](O)[C@@H]2O)n2cc(Cl)c3c(N)ncnc23)c1
Show InChI InChI=1S/C21H24ClN5O3/c1-10-4-11-2-3-24-7-12(11)15(5-10)30-16-6-14(18(28)19(16)29)27-8-13(22)17-20(23)25-9-26-21(17)27/h4-5,8-9,14,16,18-19,24,28-29H,2-3,6-7H2,1H3,(H2,23,25,26)/t14-,16+,18+,19-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...


US Patent US10709709 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM451303
PNG
(US10709709, Example 130)
Show SMILES Nc1ncnc2n(cc(Cl)c12)[C@@H]1C[C@H](Oc2cc(Cl)cc3CCNCc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C20H21Cl2N5O3/c21-10-3-9-1-2-24-6-11(9)14(4-10)30-15-5-13(17(28)18(15)29)27-7-12(22)16-19(23)25-8-26-20(16)27/h3-4,7-8,13,15,17-18,24,28-29H,1-2,5-6H2,(H2,23,25,26)/t13-,15+,17+,18-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...


US Patent US10709709 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM451304
PNG
(US10709709, Example 131)
Show SMILES Nc1ncnc2n(cc(Br)c12)[C@@H]1C[C@H](Oc2cc(Cl)cc3CCNCc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C20H21BrClN5O3/c21-12-7-27(20-16(12)19(23)25-8-26-20)13-5-15(18(29)17(13)28)30-14-4-10(22)3-9-1-2-24-6-11(9)14/h3-4,7-8,13,15,17-18,24,28-29H,1-2,5-6H2,(H2,23,25,26)/t13-,15+,17+,18-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...


US Patent US10709709 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM451306
PNG
(US10709709, Example 133)
Show SMILES Nc1ncnc2n(cc(Cl)c12)[C@@H]1C[C@H](Oc2ccc(F)c3CCNCc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C20H21ClFN5O3/c21-11-7-27(20-16(11)19(23)25-8-26-20)13-5-15(18(29)17(13)28)30-14-2-1-12(22)9-3-4-24-6-10(9)14/h1-2,7-8,13,15,17-18,24,28-29H,3-6H2,(H2,23,25,26)/t13-,15+,17+,18-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...


US Patent US10709709 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM451307
PNG
(US10709709, Example 134)
Show SMILES Nc1ncnc2n(cc(Br)c12)[C@@H]1C[C@H](Oc2ccc(F)c3CCNCc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C20H21BrFN5O3/c21-11-7-27(20-16(11)19(23)25-8-26-20)13-5-15(18(29)17(13)28)30-14-2-1-12(22)9-3-4-24-6-10(9)14/h1-2,7-8,13,15,17-18,24,28-29H,3-6H2,(H2,23,25,26)/t13-,15+,17+,18-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...


US Patent US10709709 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM452998
PNG
((2R,3R,4S,5S)-2-(4-amino- 7H-pyrrolo[2,3-d]pyrimid...)
Show SMILES Nc1ncnc2n(ccc12)[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)[C@@H]1OCc2ccc(Cl)cc12
Show InChI InChI=1S/C18H17ClN4O4/c19-9-2-1-8-6-26-14(11(8)5-9)15-12(24)13(25)18(27-15)23-4-3-10-16(20)21-7-22-17(10)23/h1-5,7,12-15,18,24-25H,6H2,(H2,20,21,22)/t12-,13+,14+,15-,18+/m0/s1
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Prelude Therapeutics Incorporated

US Patent


Assay Description
Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0,...


US Patent US11254683 (2022)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM452999
PNG
((2S,3S,4R,5R)-2-((R)-6- chloro-1,3- dihydroisobenz...)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)[C@@H]1OCc2ccc(Cl)cc12
Show InChI InChI=1S/C19H18ClN3O4/c1-9-12-4-5-23(18(12)22-8-21-9)19-15(25)14(24)17(27-19)16-13-6-11(20)3-2-10(13)7-26-16/h2-6,8,14-17,19,24-25H,7H2,1H3/t14-,15+,16+,17-,19+/m0/s1
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Prelude Therapeutics Incorporated

US Patent


Assay Description
Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (20 mM Tris-HCl, pH 8.0,...


US Patent US11254683 (2022)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM435709
PNG
((2R,3S,4R,5R)-3-methyl-5-(4-methyl-7H- pyrrolo[2,3...)
Show SMILES Cc1cnc2cc(OC[C@H]3O[C@H]([C@H](O)[C@]3(C)O)n3ccc4c(C)ncnc34)ccn12
Show InChI InChI=1S/C21H23N5O4/c1-12-9-22-17-8-14(4-6-25(12)17)29-10-16-21(3,28)18(27)20(30-16)26-7-5-15-13(2)23-11-24-19(15)26/h4-9,11,16,18,20,27-28H,10H2,1-3H3/t16-,18+,20-,21-/m1/s1
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Prelude Therapeutics, Incorporated

US Patent


Assay Description
Compounds were solubilized and 3-fold diluted in 100% DMSO. These diluted compounds were further diluted in the assay buffer (50 mM Tris-HCl, pH 8.5,...


US Patent US11078205 (2021)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM451375
PNG
(US10709709, Example 205)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(cc3OCCNCc23)C(F)F)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C22H24F2N4O4/c1-11-13-2-4-28(22(13)27-10-26-11)15-8-18(20(30)19(15)29)32-17-7-12(21(23)24)6-16-14(17)9-25-3-5-31-16/h2,4,6-7,10,15,18-21,25,29-30H,3,5,8-9H2,1H3/t15-,18+,19+,20-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...


US Patent US10709709 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM415557
PNG
(US10428104, Example 88)
Show SMILES Nc1ncnc2n(ccc12)[C@@H]1O[C@H]([C@H](O)c2ccc(Cl)c(F)c2)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C17H16ClFN4O4/c18-9-2-1-7(5-10(9)19)11(24)14-12(25)13(26)17(27-14)23-4-3-8-15(20)21-6-22-16(8)23/h1-6,11-14,17,24-26H,(H2,20,21,22)/t11-,12+,13-,14-,17-/m1/s1
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University of Jinan

Curated by ChEMBL


Assay Description
Inhibition of PRMT5 (unknown origin)


Bioorg Med Chem Lett 28: 3693-3699 (2018)


Article DOI: 10.1016/j.bmcl.2018.10.026
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50523631
PNG
(CHEMBL4585734)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cccc3CCNCc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C21H24N4O3/c1-12-14-6-8-25(21(14)24-11-23-12)16-9-18(20(27)19(16)26)28-17-4-2-3-13-5-7-22-10-15(13)17/h2-4,6,8,11,16,18-20,22,26-27H,5,7,9-10H2,1H3/t16-,18+,19+,20-/m1/s1
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Prelude Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of PRMT5 (unknown origin)


Bioorg Med Chem Lett 29: 1264-1269 (2019)


Article DOI: 10.1016/j.bmcl.2019.03.042
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50523638
PNG
(CHEMBL4470815 | US10709709, Example 200)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(OC(F)F)c(F)c3CCNCc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C22H23F3N4O4/c1-10-11-3-5-29(21(11)28-9-27-10)14-6-17(20(31)19(14)30)32-15-7-16(33-22(24)25)18(23)12-2-4-26-8-13(12)15/h3,5,7,9,14,17,19-20,22,26,30-31H,2,4,6,8H2,1H3/t14-,17+,19+,20-/m1/s1
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Prelude Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of PRMT5 (unknown origin)


Bioorg Med Chem Lett 29: 1264-1269 (2019)


Article DOI: 10.1016/j.bmcl.2019.03.042
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50523649
PNG
(CHEMBL4448266 | US10709709, Example 198)
Show SMILES COc1cc(O[C@H]2C[C@H]([C@H](O)[C@@H]2O)n2ccc3c(C)ncnc23)c2CNCCc2c1F
Show InChI InChI=1S/C22H25FN4O4/c1-11-12-4-6-27(22(12)26-10-25-11)15-7-18(21(29)20(15)28)31-16-8-17(30-2)19(23)13-3-5-24-9-14(13)16/h4,6,8,10,15,18,20-21,24,28-29H,3,5,7,9H2,1-2H3/t15-,18+,20+,21-/m1/s1
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Prelude Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of PRMT5 (unknown origin)


Bioorg Med Chem Lett 29: 1264-1269 (2019)


Article DOI: 10.1016/j.bmcl.2019.03.042
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50523650
PNG
(CHEMBL4541232 | US10709709, Example 91)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(cc3CCNCc23)C#N)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C22H23N5O3/c1-12-15-3-5-27(22(15)26-11-25-12)17-8-19(21(29)20(17)28)30-18-7-13(9-23)6-14-2-4-24-10-16(14)18/h3,5-7,11,17,19-21,24,28-29H,2,4,8,10H2,1H3/t17-,19+,20+,21-/m1/s1
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Prelude Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of PRMT5 (unknown origin)


Bioorg Med Chem Lett 29: 1264-1269 (2019)


Article DOI: 10.1016/j.bmcl.2019.03.042
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50523652
PNG
(CHEMBL4445368 | US10709709, Example 89)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(Br)cc3CCNCc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C21H23BrN4O3/c1-11-14-3-5-26(21(14)25-10-24-11)16-8-18(20(28)19(16)27)29-17-7-13(22)6-12-2-4-23-9-15(12)17/h3,5-7,10,16,18-20,23,27-28H,2,4,8-9H2,1H3/t16-,18+,19+,20-/m1/s1
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Prelude Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of PRMT5 (unknown origin)


Bioorg Med Chem Lett 29: 1264-1269 (2019)


Article DOI: 10.1016/j.bmcl.2019.03.042
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM415582
PNG
(US10428104, Example 112)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1O[C@H]([C@H](O)c2cccc3CCNCc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C21H24N4O4/c1-11-13-6-8-25(20(13)24-10-23-11)21-18(28)17(27)19(29-21)16(26)14-4-2-3-12-5-7-22-9-15(12)14/h2-4,6,8,10,16-19,21-22,26-28H,5,7,9H2,1H3/t16-,17+,18-,19-,21-/m1/s1
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Prelude Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of PRMT5 (unknown origin)


Bioorg Med Chem Lett 29: 1264-1269 (2019)


Article DOI: 10.1016/j.bmcl.2019.03.042
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM415554
PNG
((2R,3R,4S,5R)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidi...)
Show SMILES Nc1ncnc2n(ccc12)[C@@H]1O[C@H]([C@H](O)c2ccc(F)c(F)c2)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C17H16F2N4O4/c18-9-2-1-7(5-10(9)19)11(24)14-12(25)13(26)17(27-14)23-4-3-8-15(20)21-6-22-16(8)23/h1-6,11-14,17,24-26H,(H2,20,21,22)/t11-,12+,13-,14-,17-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...


US Patent US10428104 (2019)


BindingDB Entry DOI: 10.7270/Q2PG1V45
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM415556
PNG
(US10428104, Example 87)
Show SMILES Nc1ncnc2n(ccc12)[C@@H]1O[C@H]([C@H](O)c2ccc(Cl)cc2)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C17H17ClN4O4/c18-9-3-1-8(2-4-9)11(23)14-12(24)13(25)17(26-14)22-6-5-10-15(19)20-7-21-16(10)22/h1-7,11-14,17,23-25H,(H2,19,20,21)/t11-,12+,13-,14-,17-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...


US Patent US10428104 (2019)


BindingDB Entry DOI: 10.7270/Q2PG1V45
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM415557
PNG
(US10428104, Example 88)
Show SMILES Nc1ncnc2n(ccc12)[C@@H]1O[C@H]([C@H](O)c2ccc(Cl)c(F)c2)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C17H16ClFN4O4/c18-9-2-1-7(5-10(9)19)11(24)14-12(25)13(26)17(27-14)23-4-3-8-15(20)21-6-22-16(8)23/h1-6,11-14,17,24-26H,(H2,20,21,22)/t11-,12+,13-,14-,17-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...


US Patent US10428104 (2019)


BindingDB Entry DOI: 10.7270/Q2PG1V45
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM415582
PNG
(US10428104, Example 112)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1O[C@H]([C@H](O)c2cccc3CCNCc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C21H24N4O4/c1-11-13-6-8-25(20(13)24-10-23-11)21-18(28)17(27)19(29-21)16(26)14-4-2-3-12-5-7-22-9-15(12)14/h2-4,6,8,10,16-19,21-22,26-28H,5,7,9H2,1H3/t16-,17+,18-,19-,21-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...


US Patent US10428104 (2019)


BindingDB Entry DOI: 10.7270/Q2PG1V45
More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM451261
PNG
(US10709709, Example 88)
Show SMILES Cc1cc2CCNCc2c(O[C@H]2C[C@H]([C@H](O)[C@@H]2O)n2ccc3c(C)ncnc23)c1
Show InChI InChI=1S/C22H26N4O3/c1-12-7-14-3-5-23-10-16(14)18(8-12)29-19-9-17(20(27)21(19)28)26-6-4-15-13(2)24-11-25-22(15)26/h4,6-8,11,17,19-21,23,27-28H,3,5,9-10H2,1-2H3/t17-,19+,20+,21-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...


US Patent US10709709 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50523652
PNG
(CHEMBL4445368 | US10709709, Example 89)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(Br)cc3CCNCc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C21H23BrN4O3/c1-11-14-3-5-26(21(14)25-10-24-11)16-8-18(20(28)19(16)27)29-17-7-13(22)6-12-2-4-23-9-15(12)17/h3,5-7,10,16,18-20,23,27-28H,2,4,8-9H2,1H3/t16-,18+,19+,20-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...


US Patent US10709709 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM50523650
PNG
(CHEMBL4541232 | US10709709, Example 91)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(cc3CCNCc23)C#N)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C22H23N5O3/c1-12-15-3-5-27(22(15)26-11-25-12)17-8-19(21(29)20(17)28)30-18-7-13(9-23)6-14-2-4-24-10-16(14)18/h3,5-7,11,17,19-21,24,28-29H,2,4,8,10H2,1H3/t17-,19+,20+,21-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...


US Patent US10709709 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM451265
PNG
(US10709709, Example 92)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(F)c(F)c3CCNCc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C21H22F2N4O3/c1-10-11-3-5-27(21(11)26-9-25-10)15-7-17(20(29)19(15)28)30-16-6-14(22)18(23)12-2-4-24-8-13(12)16/h3,5-6,9,15,17,19-20,24,28-29H,2,4,7-8H2,1H3/t15-,17+,19+,20-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...


US Patent US10709709 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM451266
PNG
(US10709709, Example 93)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(Cl)c(F)c3CCNCc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C21H22ClFN4O3/c1-10-11-3-5-27(21(11)26-9-25-10)15-7-17(20(29)19(15)28)30-16-6-14(22)18(23)12-2-4-24-8-13(12)16/h3,5-6,9,15,17,19-20,24,28-29H,2,4,7-8H2,1H3/t15-,17+,19+,20-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...


US Patent US10709709 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM451267
PNG
(US10709709, Example 94)
Show SMILES Cc1ncnc2n(ccc12)[C@@H]1C[C@H](Oc2cc(Br)c(F)c3CCNCc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C21H22BrFN4O3/c1-10-11-3-5-27(21(11)26-9-25-10)15-7-17(20(29)19(15)28)30-16-6-14(22)18(23)12-2-4-24-8-13(12)16/h3,5-6,9,15,17,19-20,24,28-29H,2,4,7-8H2,1H3/t15-,17+,19+,20-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...


US Patent US10709709 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM451273
PNG
(US10709709, Example 100)
Show SMILES Nc1ncnc2n(cc(F)c12)[C@@H]1C[C@H](Oc2ccc(F)c3CCNCc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C20H21F2N5O3/c21-11-1-2-14(10-6-24-4-3-9(10)11)30-15-5-13(17(28)18(15)29)27-7-12(22)16-19(23)25-8-26-20(16)27/h1-2,7-8,13,15,17-18,24,28-29H,3-6H2,(H2,23,25,26)/t13-,15+,17+,18-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...


US Patent US10709709 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM451274
PNG
(US10709709, Example 101)
Show SMILES Nc1ncnc2n(cc(F)c12)[C@@H]1C[C@H](Oc2cc(Br)cc3CCNCc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C20H21BrFN5O3/c21-10-3-9-1-2-24-6-11(9)14(4-10)30-15-5-13(17(28)18(15)29)27-7-12(22)16-19(23)25-8-26-20(16)27/h3-4,7-8,13,15,17-18,24,28-29H,1-2,5-6H2,(H2,23,25,26)/t13-,15+,17+,18-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...


US Patent US10709709 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM451275
PNG
(US10709709, Example 102)
Show SMILES Nc1ncnc2n(cc(F)c12)[C@@H]1C[C@H](Oc2cc(Cl)cc3CCNCc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C20H21ClFN5O3/c21-10-3-9-1-2-24-6-11(9)14(4-10)30-15-5-13(17(28)18(15)29)27-7-12(22)16-19(23)25-8-26-20(16)27/h3-4,7-8,13,15,17-18,24,28-29H,1-2,5-6H2,(H2,23,25,26)/t13-,15+,17+,18-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...


US Patent US10709709 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM451276
PNG
(US10709709, Example 103)
Show SMILES Nc1ncnc2n(cc(F)c12)[C@@H]1C[C@H](Oc2cc(F)c(F)c3CCNCc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C20H20F3N5O3/c21-10-3-13(9-5-25-2-1-8(9)16(10)23)31-14-4-12(17(29)18(14)30)28-6-11(22)15-19(24)26-7-27-20(15)28/h3,6-7,12,14,17-18,25,29-30H,1-2,4-5H2,(H2,24,26,27)/t12-,14+,17+,18-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...


US Patent US10709709 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM451277
PNG
(US10709709, Example 104)
Show SMILES Nc1ncnc2n(cc(F)c12)[C@@H]1C[C@H](Oc2cc(cc3CCNCc23)C(F)(F)F)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C21H21F4N5O3/c22-12-7-30(20-16(12)19(26)28-8-29-20)13-5-15(18(32)17(13)31)33-14-4-10(21(23,24)25)3-9-1-2-27-6-11(9)14/h3-4,7-8,13,15,17-18,27,31-32H,1-2,5-6H2,(H2,26,28,29)/t13-,15+,17+,18-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...


US Patent US10709709 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM451278
PNG
(US10709709, Example 105)
Show SMILES Cc1cc2CCNCc2c(O[C@H]2C[C@H]([C@H](O)[C@@H]2O)n2cc(F)c3c(N)ncnc23)c1
Show InChI InChI=1S/C21H24FN5O3/c1-10-4-11-2-3-24-7-12(11)15(5-10)30-16-6-14(18(28)19(16)29)27-8-13(22)17-20(23)25-9-26-21(17)27/h4-5,8-9,14,16,18-19,24,28-29H,2-3,6-7H2,1H3,(H2,23,25,26)/t14-,16+,18+,19-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...


US Patent US10709709 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM451280
PNG
(US10709709, Example 107)
Show SMILES Nc1ncnc2n(cc(F)c12)[C@@H]1C[C@H](Oc2cc(F)cc3CCNCc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C20H21F2N5O3/c21-10-3-9-1-2-24-6-11(9)14(4-10)30-15-5-13(17(28)18(15)29)27-7-12(22)16-19(23)25-8-26-20(16)27/h3-4,7-8,13,15,17-18,24,28-29H,1-2,5-6H2,(H2,23,25,26)/t13-,15+,17+,18-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...


US Patent US10709709 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM451281
PNG
(US10709709, Example 108)
Show SMILES Nc1ncnc2n(cc(F)c12)[C@@H]1C[C@H](Oc2cc(Cl)c(F)c3CCNCc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C20H20ClF2N5O3/c21-10-3-13(9-5-25-2-1-8(9)16(10)23)31-14-4-12(17(29)18(14)30)28-6-11(22)15-19(24)26-7-27-20(15)28/h3,6-7,12,14,17-18,25,29-30H,1-2,4-5H2,(H2,24,26,27)/t12-,14+,17+,18-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...


US Patent US10709709 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM451282
PNG
(US10709709, Example 109)
Show SMILES Nc1ncnc2n(cc(F)c12)[C@@H]1C[C@H](Oc2cc(Br)c(F)c3CCNCc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C20H20BrF2N5O3/c21-10-3-13(9-5-25-2-1-8(9)16(10)23)31-14-4-12(17(29)18(14)30)28-6-11(22)15-19(24)26-7-27-20(15)28/h3,6-7,12,14,17-18,25,29-30H,1-2,4-5H2,(H2,24,26,27)/t12-,14+,17+,18-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...


US Patent US10709709 (2020)

More data for this
Ligand-Target Pair
Protein arginine N-methyltransferase 5


(Homo sapiens (Human))
BDBM451286
PNG
(US10709709, Example 113)
Show SMILES Cc1cc(O[C@H]2C[C@H]([C@H](O)[C@@H]2O)n2cc(F)c3c(N)ncnc23)c2CNCCc2c1F
Show InChI InChI=1S/C21H23F2N5O3/c1-9-4-14(11-6-25-3-2-10(11)17(9)23)31-15-5-13(18(29)19(15)30)28-7-12(22)16-20(24)26-8-27-21(16)28/h4,7-8,13,15,18-19,25,29-30H,2-3,5-6H2,1H3,(H2,24,26,27)/t13-,15+,18+,19-/m1/s1
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Pfizer Inc.

US Patent


Assay Description
Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...


US Patent US10709709 (2020)

More data for this
Ligand-Target Pair
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