Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Replicase polyprotein 1ab (BtCoV) | BDBM420298![]() (PF-00835231 | PF-0835231 | WO2005113580-Ex-02 | WO...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase PDB UniChem | WIPO WO2021205298 | 0.0300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. WIPO | Assay Description Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV... | WIPO WO2021205298 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (BtCoV) | BDBM420298![]() (PF-00835231 | PF-0835231 | WO2005113580-Ex-02 | WO...) | UniProtKB/SwissProt GoogleScholar | Purchase PDB UniChem | WIPO WO2021205298 | 0.0300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. WIPO | Assay Description Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV... | WIPO WO2021205298 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (BtCoV) | BDBM420298![]() (PF-00835231 | PF-0835231 | WO2005113580-Ex-02 | WO...) | UniProtKB/SwissProt GoogleScholar | Purchase PDB UniChem | Article PubMed | 0.0330 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. | Assay Description PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc... | bioRxiv (2020) Article DOI: 10.1101/2020.09.12.293498 BindingDB Entry DOI: 10.7270/Q2VQ352Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (BtCoV) | BDBM420298![]() (PF-00835231 | PF-0835231 | WO2005113580-Ex-02 | WO...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase PDB UniChem | Article PubMed | 0.0340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. | Assay Description PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc... | bioRxiv (2020) Article DOI: 10.1101/2020.09.12.293498 BindingDB Entry DOI: 10.7270/Q2VQ352Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (Feline coronavirus (strain FIPV WSU-79/1146) (FCoV...) | BDBM420298![]() (PF-00835231 | PF-0835231 | WO2005113580-Ex-02 | WO...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase PDB UniChem | WIPO WO2021205298 | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. WIPO | Assay Description Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV... | WIPO WO2021205298 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (Feline coronavirus (strain FIPV WSU-79/1146) (FCoV...) | BDBM420298![]() (PF-00835231 | PF-0835231 | WO2005113580-Ex-02 | WO...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase PDB UniChem | Article PubMed | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. | Assay Description PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc... | bioRxiv (2020) Article DOI: 10.1101/2020.09.12.293498 BindingDB Entry DOI: 10.7270/Q2VQ352Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (2019-nCoV) | BDBM420298![]() (PF-00835231 | PF-0835231 | WO2005113580-Ex-02 | WO...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar | Purchase PDB UniChem | Article PubMed | 0.270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. | Assay Description PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc... | bioRxiv (2020) Article DOI: 10.1101/2020.09.12.293498 BindingDB Entry DOI: 10.7270/Q2VQ352Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (2019-nCoV) | BDBM420298![]() (PF-00835231 | PF-0835231 | WO2005113580-Ex-02 | WO...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar | Purchase PDB UniChem | 0.270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
Pfizer | Assay Description The respective human coronavirus Mpro in assay buffer (20 mM Tris-HCl, pH 7.3, 100 mM NaCl, 1 mM EDTA, 5 mM TCEP) and 0.1% BSA was added to assay-rea... | Science 374: 1-13 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (PEDV) | BDBM420298![]() (PF-00835231 | PF-0835231 | WO2005113580-Ex-02 | WO...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase PDB UniChem | WIPO WO2021205298 | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. WIPO | Assay Description Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV... | WIPO WO2021205298 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (PEDV) | BDBM420298![]() (PF-00835231 | PF-0835231 | WO2005113580-Ex-02 | WO...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase PDB UniChem | Article PubMed | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. | Assay Description PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc... | bioRxiv (2020) Article DOI: 10.1101/2020.09.12.293498 BindingDB Entry DOI: 10.7270/Q2VQ352Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM420298![]() (PF-00835231 | PF-0835231 | WO2005113580-Ex-02 | WO...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase PDB UniChem | WIPO WO2021205298 | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. WIPO | Assay Description Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV... | WIPO WO2021205298 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-OC43) | BDBM420298![]() (PF-00835231 | PF-0835231 | WO2005113580-Ex-02 | WO...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase PDB UniChem | Article PubMed | 0.510 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. | Assay Description PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc... | bioRxiv (2020) Article DOI: 10.1101/2020.09.12.293498 BindingDB Entry DOI: 10.7270/Q2VQ352Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (BtCoV) | BDBM420298![]() (PF-00835231 | PF-0835231 | WO2005113580-Ex-02 | WO...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase PDB UniChem | Article PubMed | 0.740 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. | Assay Description PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc... | bioRxiv (2020) Article DOI: 10.1101/2020.09.12.293498 BindingDB Entry DOI: 10.7270/Q2VQ352Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-NL63) | BDBM420298![]() (PF-00835231 | PF-0835231 | WO2005113580-Ex-02 | WO...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase PDB UniChem | Article PubMed | 0.770 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. | Assay Description PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc... | bioRxiv (2020) Article DOI: 10.1101/2020.09.12.293498 BindingDB Entry DOI: 10.7270/Q2VQ352Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (BtCoV) | BDBM420298![]() (PF-00835231 | PF-0835231 | WO2005113580-Ex-02 | WO...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase PDB UniChem | WIPO WO2021205298 | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. WIPO | Assay Description Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV... | WIPO WO2021205298 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-NL63) | BDBM420298![]() (PF-00835231 | PF-0835231 | WO2005113580-Ex-02 | WO...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase PDB UniChem | WIPO WO2021205298 | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. WIPO | Assay Description Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV... | WIPO WO2021205298 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-HKU1) | BDBM420298![]() (PF-00835231 | PF-0835231 | WO2005113580-Ex-02 | WO...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase PDB UniChem | Article PubMed | 0.850 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. | Assay Description PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc... | bioRxiv (2020) Article DOI: 10.1101/2020.09.12.293498 BindingDB Entry DOI: 10.7270/Q2VQ352Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-HKU1) | BDBM420298![]() (PF-00835231 | PF-0835231 | WO2005113580-Ex-02 | WO...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase PDB UniChem | WIPO WO2021205298 | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. WIPO | Assay Description Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV... | WIPO WO2021205298 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (MHV-A59) | BDBM420298![]() (PF-00835231 | PF-0835231 | WO2005113580-Ex-02 | WO...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase PDB UniChem | WIPO WO2021205298 | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. WIPO | Assay Description Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV... | WIPO WO2021205298 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (MHV-A59) | BDBM420298![]() (PF-00835231 | PF-0835231 | WO2005113580-Ex-02 | WO...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase PDB UniChem | Article PubMed | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. | Assay Description PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc... | bioRxiv (2020) Article DOI: 10.1101/2020.09.12.293498 BindingDB Entry DOI: 10.7270/Q2VQ352Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-229E) | BDBM420298![]() (PF-00835231 | PF-0835231 | WO2005113580-Ex-02 | WO...) | PDB MMDB KEGG UniProtKB/SwissProt GoogleScholar | Purchase PDB UniChem | Article PubMed | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. | Assay Description PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc... | bioRxiv (2020) Article DOI: 10.1101/2020.09.12.293498 BindingDB Entry DOI: 10.7270/Q2VQ352Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (HCoV-229E) | BDBM420298![]() (PF-00835231 | PF-0835231 | WO2005113580-Ex-02 | WO...) | PDB MMDB KEGG UniProtKB/SwissProt GoogleScholar | Purchase PDB UniChem | WIPO WO2021205298 | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. WIPO | Assay Description Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV... | WIPO WO2021205298 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (2019-nCoV) | BDBM535166![]() (WO2022013684, Example 18) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar | UniChem | WIPO WO2022013684 | 1.55 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
PFIZER INC. WIPO | Assay Description The proteolytic activity of the main protease, 3CLpro, of SARS-CoV-2 was monitored using a continuous fluorescence resonance energy transfer (FRET) a... | WIPO WO2022013684 (2022) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (Human SARS coronavirus (SARS-CoV) (Severe acute re...) | BDBM429243![]() (jm5b01461, Compound 60) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar | PC cid PC sid UniChem | Article PubMed | 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn | Assay Description This is a review article. | Med Res Rev (2020) Article DOI: 10.1002/med.21724 BindingDB Entry DOI: 10.7270/Q2JS9ST6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (Human SARS coronavirus (SARS-CoV) (Severe acute re...) | BDBM512405![]() (acs.jmedchem.1c00409_ST.2) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar | PC cid PC sid UniChem | PubMed | 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Michigan State University | Assay Description This is a review article. Please point to the original journal. | J Med Chem 64: 16922-16955 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (Human SARS coronavirus (SARS-CoV) (Severe acute re...) | BDBM429243![]() (jm5b01461, Compound 60) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar | PC cid PC sid UniChem | Article PubMed | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn | Assay Description This is a review article. | J Med Chem 59: 6595-628 (2016) Article DOI: 10.1021/acs.jmedchem.5b01461 BindingDB Entry DOI: 10.7270/Q2PK0JH1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (2019-nCoV) | BDBM496902![]() (PF-07321332 | WO2021250648, Example 13 | science.a...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar | Purchase PC cid PC sid UniChem | 3.11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
Pfizer | Assay Description The respective human coronavirus Mpro in assay buffer (20 mM Tris-HCl, pH 7.3, 100 mM NaCl, 1 mM EDTA, 5 mM TCEP) and 0.1% BSA was added to assay-rea... | Science 374: 1-13 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (IBV) | BDBM420298![]() (PF-00835231 | PF-0835231 | WO2005113580-Ex-02 | WO...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase PDB UniChem | WIPO WO2021205298 | 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. WIPO | Assay Description Proteolytic activity of SARS-CoV-2 Coronavirus 3CL protease is measured using a continuous fluorescence resonance energy transfer assay. The SARS-CoV... | WIPO WO2021205298 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (IBV) | BDBM420298![]() (PF-00835231 | PF-0835231 | WO2005113580-Ex-02 | WO...) | PDB UniProtKB/SwissProt GoogleScholar | Purchase PDB UniChem | Article PubMed | 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. | Assay Description PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc... | bioRxiv (2020) Article DOI: 10.1101/2020.09.12.293498 BindingDB Entry DOI: 10.7270/Q2VQ352Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (Human SARS coronavirus (SARS-CoV) (Severe acute re...) | BDBM512406![]() (acs.jmedchem.1c00409_ST.3) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar | PC cid PC sid UniChem | PubMed | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Michigan State University | Assay Description This is a review article. Please point to the original journal. | J Med Chem 64: 16922-16955 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (Human SARS coronavirus (SARS-CoV) (Severe acute re...) | BDBM512689![]() (acs.jmedchem.1c00409_ST.283) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar | PC cid PC sid UniChem | PubMed | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Michigan State University | Assay Description This is a review article. Please point to the original journal. | J Med Chem 64: 16922-16955 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (Human SARS coronavirus (SARS-CoV) (Severe acute re...) | BDBM429242![]() (acs.jmedchem.1c00409_ST.4 | jm5b01461, Compound 59) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar | Purchase PC cid PC sid PDB UniChem | Article PubMed | 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn | Assay Description This is a review article. | Med Res Rev (2020) Article DOI: 10.1002/med.21724 BindingDB Entry DOI: 10.7270/Q2JS9ST6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (Human SARS coronavirus (SARS-CoV) (Severe acute re...) | BDBM429242![]() (acs.jmedchem.1c00409_ST.4 | jm5b01461, Compound 59) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar | Purchase PC cid PC sid PDB UniChem | Article PubMed | 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn | Assay Description This is a review article. | J Med Chem 59: 6595-628 (2016) Article DOI: 10.1021/acs.jmedchem.5b01461 BindingDB Entry DOI: 10.7270/Q2PK0JH1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (2019-nCoV) | BDBM535159![]() (WO2022013684, Example 14) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar | UniChem | WIPO WO2022013684 | 6.02 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
PFIZER INC. WIPO | Assay Description The proteolytic activity of the main protease, 3CLpro, of SARS-CoV-2 was monitored using a continuous fluorescence resonance energy transfer (FRET) a... | WIPO WO2022013684 (2022) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (2019-nCoV) | BDBM535160![]() (WO2022013684, Example 15) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar | UniChem | WIPO WO2022013684 | 6.14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
PFIZER INC. WIPO | Assay Description The proteolytic activity of the main protease, 3CLpro, of SARS-CoV-2 was monitored using a continuous fluorescence resonance energy transfer (FRET) a... | WIPO WO2022013684 (2022) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (Human SARS coronavirus (SARS-CoV) (Severe acute re...) | BDBM429242![]() (acs.jmedchem.1c00409_ST.4 | jm5b01461, Compound 59) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar | Purchase PC cid PC sid PDB UniChem | PubMed | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Michigan State University | Assay Description This is a review article. Please point to the original journal. | J Med Chem 64: 16922-16955 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (2019-nCoV) | BDBM535290![]() (WO2022021841, 37) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar | UniChem | WIPO WO2022021841 | 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SICHUAN UNIVERSITY WIPO | Assay Description SARS-CoV-2 Mpro (final concentration 750 nM) plus every compound in 25 uL of buffer (20 mM Tris-HCl, pH 7.5, 150mM NaCl,1mM EDTA,2mM DT... | WIPO WO2022021841 (2022) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (Human SARS coronavirus (SARS-CoV) (Severe acute re...) | BDBM59242![]() (Benzotriazole ester, 8 | acs.jmedchem.1c00409_ST.6...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar | PC cid PC sid PDB UniChem | Article PubMed | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a | 7.5 | n/a |
Academia Sinica | Assay Description Inhibition assay against SARS-CoV 3CL protease, a fluorometric assay was utilized to determine the inhibition constants of the samples. | Chem Biol 13: 261-8 (2006) Article DOI: 10.1016/j.chembiol.2005.12.008 BindingDB Entry DOI: 10.7270/Q21C1V9G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (Human SARS coronavirus (SARS-CoV) (Severe acute re...) | BDBM59242![]() (Benzotriazole ester, 8 | acs.jmedchem.1c00409_ST.6...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar | PC cid PC sid PDB UniChem | Article PubMed | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn | Assay Description This is a review article. | Med Res Rev (2020) Article DOI: 10.1002/med.21724 BindingDB Entry DOI: 10.7270/Q2JS9ST6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (Human SARS coronavirus (SARS-CoV) (Severe acute re...) | BDBM59242![]() (Benzotriazole ester, 8 | acs.jmedchem.1c00409_ST.6...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar | PC cid PC sid PDB UniChem | PubMed | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Michigan State University | Assay Description This is a review article. Please point to the original journal. | J Med Chem 64: 16922-16955 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (Human SARS coronavirus (SARS-CoV) (Severe acute re...) | BDBM429296![]() (jm5b01461, Compound 116) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar | PC cid PC sid UniChem | Article PubMed | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn | Assay Description This is a review article. | J Med Chem 59: 6595-628 (2016) Article DOI: 10.1021/acs.jmedchem.5b01461 BindingDB Entry DOI: 10.7270/Q2PK0JH1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (2019-nCoV) | BDBM535126![]() ((1R,2S,5S)-6,6-Dimethyl-3-[N-(methylsulfonyl)-L-va...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar | UniChem | WIPO WO2022013684 | 7.74 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
PFIZER INC. WIPO | Assay Description The proteolytic activity of the main protease, 3CLpro, of SARS-CoV-2 was monitored using a continuous fluorescence resonance energy transfer (FRET) a... | WIPO WO2022013684 (2022) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (2019-nCoV) | BDBM496900![]() (science.abl4784, 4) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar | PC cid PC sid UniChem | 7.93 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
Pfizer | Assay Description The respective human coronavirus Mpro in assay buffer (20 mM Tris-HCl, pH 7.3, 100 mM NaCl, 1 mM EDTA, 5 mM TCEP) and 0.1% BSA was added to assay-rea... | Science 374: 1-13 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (2019-nCoV) | BDBM423466![]() (WO2006061714, P39.1 | WO2006061714-ID-11 | cmdc.20...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar | PC cid PC sid UniChem | Article PubMed | 8.30 | n/a | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Texas A&M University | Assay Description The assays were carried out with 20 nM enzyme (except for MPI3, for which 10 nM enzyme was used) and 10 μM substrate at 37oC with continuous sha... | ChemMedChem (2020) Article DOI: 10.1002/cmdc.202000924 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (2019-nCoV) | BDBM535192![]() (WO2022021841, 6) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar | UniChem | WIPO WO2022021841 | 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SICHUAN UNIVERSITY WIPO | Assay Description SARS-CoV-2 Mpro (final concentration 750 nM) plus every compound in 25 uL of buffer (20 mM Tris-HCl, pH 7.5, 150mM NaCl,1mM EDTA,2mM DT... | WIPO WO2022021841 (2022) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (2019-nCoV) | BDBM535264![]() (WO2022021841, 26) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar | UniChem | WIPO WO2022021841 | 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SICHUAN UNIVERSITY WIPO | Assay Description SARS-CoV-2 Mpro (final concentration 750 nM) plus every compound in 25 uL of buffer (20 mM Tris-HCl, pH 7.5, 150mM NaCl,1mM EDTA,2mM DT... | WIPO WO2022021841 (2022) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (2019-nCoV) | BDBM535324![]() (WO2022021841, 43) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar | UniChem | WIPO WO2022021841 | 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SICHUAN UNIVERSITY WIPO | Assay Description SARS-CoV-2 Mpro (final concentration 750 nM) plus every compound in 25 uL of buffer (20 mM Tris-HCl, pH 7.5, 150mM NaCl,1mM EDTA,2mM DT... | WIPO WO2022021841 (2022) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (2019-nCoV) | BDBM535168![]() (WO2022013684, Example 19) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar | UniChem | WIPO WO2022013684 | 9.77 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
PFIZER INC. WIPO | Assay Description The proteolytic activity of the main protease, 3CLpro, of SARS-CoV-2 was monitored using a continuous fluorescence resonance energy transfer (FRET) a... | WIPO WO2022013684 (2022) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (2019-nCoV) | BDBM535331![]() (WO2022021841, 44) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar | UniChem | WIPO WO2022021841 | 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SICHUAN UNIVERSITY WIPO | Assay Description SARS-CoV-2 Mpro (final concentration 750 nM) plus every compound in 25 uL of buffer (20 mM Tris-HCl, pH 7.5, 150mM NaCl,1mM EDTA,2mM DT... | WIPO WO2022021841 (2022) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Replicase polyprotein 1ab (2019-nCoV) | BDBM535164![]() (WO2022013684, Example 16) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank GoogleScholar | UniChem | WIPO WO2022013684 | 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
PFIZER INC. WIPO | Assay Description The proteolytic activity of the main protease, 3CLpro, of SARS-CoV-2 was monitored using a continuous fluorescence resonance energy transfer (FRET) a... | WIPO WO2022013684 (2022) | |||||||||||
More data for this Ligand-Target Pair |
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