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Compile Data Set for Download or QSAR

Found 1346 hits Enz. Inhib. hit(s) with Target = 'acyl coa-diacylglycerol acyl transferase 1 (dgat1)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM?mit=repeat
Kd
nM
EC50/IC50
nM?mit=repeat
koff
s-1
kon
M-1s-1
pHTemp
°C
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM221023
PNG
(US9302996, 138)
Show SMILES CCC(CC)(COc1cc(C)c(cn1)-c1cnc(-c2ncc([nH]2)C(F)(F)F)c(F)c1)C(O)=O
Show InChI InChI=1S/C22H22F4N4O3/c1-4-21(5-2,20(31)32)11-33-17-6-12(3)14(9-27-17)13-7-15(23)18(28-8-13)19-29-10-16(30-19)22(24,25)26/h6-10H,4-5,11H2,1-3H3,(H,29,30)(H,31,32)
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n/an/a 1.70n/an/an/an/a7.430



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...


US Patent US9302996 (2016)


BindingDB Entry DOI: 10.7270/Q2TM790N
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM221011
PNG
(US9302996, 126)
Show SMILES Cc1cc(OCC(C)(C)C(O)=O)ncc1-c1cnc(nc1)-c1ncc([nH]1)C(F)(F)F
Show InChI InChI=1S/C19H18F3N5O3/c1-10-4-14(30-9-18(2,3)17(28)29)23-7-12(10)11-5-24-15(25-6-11)16-26-8-13(27-16)19(20,21)22/h4-8H,9H2,1-3H3,(H,26,27)(H,28,29)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...


US Patent US9302996 (2016)


BindingDB Entry DOI: 10.7270/Q2TM790N
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM220980
PNG
(US9302996, 95-6)
Show SMILES Cc1cc(OCC(C)(C)C(O)=O)ncc1-c1cnc(cn1)-c1nc(c[nH]1)C(F)(F)F
Show InChI InChI=1S/C19H18F3N5O3/c1-10-4-15(30-9-18(2,3)17(28)29)25-5-11(10)12-6-24-13(7-23-12)16-26-8-14(27-16)19(20,21)22/h4-8H,9H2,1-3H3,(H,26,27)(H,28,29)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...


US Patent US9302996 (2016)


BindingDB Entry DOI: 10.7270/Q2TM790N
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM321161
PNG
(US10174049, Example 28 | US9738658, Example 28)
Show SMILES COc1c(Cl)cccc1-n1ccc2cc(ccc12)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C22H18ClN5O3/c1-30-19-15(23)3-2-4-17(19)28-8-7-13-11-14(5-6-16(13)28)27-9-10-31-21-18(22(27)29)20(24)25-12-26-21/h2-8,11-12H,9-10H2,1H3,(H2,24,25,26)
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Glaxosmithkline LLC

US Patent


Assay Description
For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...


US Patent US10174049 (2019)

More data for this
Ligand-Target Pair
hdgat le


(Homo sapiens (Human))
BDBM321161
PNG
(US10174049, Example 28 | US9738658, Example 28)
Show SMILES COc1c(Cl)cccc1-n1ccc2cc(ccc12)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C22H18ClN5O3/c1-30-19-15(23)3-2-4-17(19)28-8-7-13-11-14(5-6-16(13)28)27-9-10-31-21-18(22(27)29)20(24)25-12-26-21/h2-8,11-12H,9-10H2,1H3,(H2,24,25,26)
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GlaxoSmithKline LLC

US Patent


Assay Description
For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...


US Patent US9738658 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM321145
PNG
(US10174049, Example 12 | US9738658, Example 12)
Show SMILES Nc1ncnc2OCCN(c3ccc4n(ccc4c3)-c3cccc(Cl)c3Cl)C(=O)c12
Show InChI InChI=1S/C21H15Cl2N5O2/c22-14-2-1-3-16(18(14)23)28-7-6-12-10-13(4-5-15(12)28)27-8-9-30-20-17(21(27)29)19(24)25-11-26-20/h1-7,10-11H,8-9H2,(H2,24,25,26)
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Glaxosmithkline LLC

US Patent


Assay Description
For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...


US Patent US10174049 (2019)

More data for this
Ligand-Target Pair
hdgat le


(Homo sapiens (Human))
BDBM321169
PNG
(US10174049, Example 36 | US9738658, Example 36)
Show SMILES COc1cccc(c1Br)-n1ccc2cc(ccc12)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C22H18BrN5O3/c1-30-17-4-2-3-16(19(17)23)28-8-7-13-11-14(5-6-15(13)28)27-9-10-31-21-18(22(27)29)20(24)25-12-26-21/h2-8,11-12H,9-10H2,1H3,(H2,24,25,26)
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GlaxoSmithKline LLC

US Patent


Assay Description
For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...


US Patent US9738658 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM220937
PNG
(US9302996, 52)
Show SMILES Cc1cc(OCC(C)(C)C(O)=O)ncc1-c1ccc(-c2ncc([nH]2)C2(CCC2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C25H25F4N3O3/c1-14-9-20(35-13-23(2,3)22(33)34)30-11-17(14)15-5-6-16(18(26)10-15)21-31-12-19(32-21)24(7-4-8-24)25(27,28)29/h5-6,9-12H,4,7-8,13H2,1-3H3,(H,31,32)(H,33,34)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...


US Patent US9302996 (2016)


BindingDB Entry DOI: 10.7270/Q2TM790N
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM221005
PNG
(US9302996, 120)
Show SMILES CC(C)Cc1cnc([nH]1)-c1ccc(cc1Cl)-c1cnc(OCC(C)(C)C(O)=O)cc1C
Show InChI InChI=1S/C24H28ClN3O3/c1-14(2)8-17-11-27-22(28-17)18-7-6-16(10-20(18)25)19-12-26-21(9-15(19)3)31-13-24(4,5)23(29)30/h6-7,9-12,14H,8,13H2,1-5H3,(H,27,28)(H,29,30)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...


US Patent US9302996 (2016)


BindingDB Entry DOI: 10.7270/Q2TM790N
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM321155
PNG
(US10174049, Example 22)
Show SMILES CCCn1ccc2cc(cc(C3CC3)c12)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C21H23N5O2/c1-2-6-25-7-5-14-10-15(11-16(18(14)25)13-3-4-13)26-8-9-28-20-17(21(26)27)19(22)23-12-24-20/h5,7,10-13H,2-4,6,8-9H2,1H3,(H2,22,23,24)
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Glaxosmithkline LLC

US Patent


Assay Description
For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...


US Patent US10174049 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM321169
PNG
(US10174049, Example 36 | US9738658, Example 36)
Show SMILES COc1cccc(c1Br)-n1ccc2cc(ccc12)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C22H18BrN5O3/c1-30-17-4-2-3-16(19(17)23)28-8-7-13-11-14(5-6-15(13)28)27-9-10-31-21-18(22(27)29)20(24)25-12-26-21/h2-8,11-12H,9-10H2,1H3,(H2,24,25,26)
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n/an/a 1.80n/an/an/an/an/an/a



Glaxosmithkline LLC

US Patent


Assay Description
For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...


US Patent US10174049 (2019)

More data for this
Ligand-Target Pair
hdgat le


(Homo sapiens (Human))
BDBM336140
PNG
(US9738658, Example 22)
Show SMILES CCCn1ccc2cc(cc(C3CC3)c12)N(CCO[Si](C)(C)C(C)(C)C)C(=O)c1c(Cl)ncnc1Cl
Show InChI InChI=1S/C27H36Cl2N4O2Si/c1-7-11-32-12-10-19-15-20(16-21(23(19)32)18-8-9-18)33(13-14-35-36(5,6)27(2,3)4)26(34)22-24(28)30-17-31-25(22)29/h10,12,15-18H,7-9,11,13-14H2,1-6H3
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GlaxoSmithKline LLC

US Patent


Assay Description
For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...


US Patent US9738658 (2017)

More data for this
Ligand-Target Pair
hdgat le


(Homo sapiens (Human))
BDBM321145
PNG
(US10174049, Example 12 | US9738658, Example 12)
Show SMILES Nc1ncnc2OCCN(c3ccc4n(ccc4c3)-c3cccc(Cl)c3Cl)C(=O)c12
Show InChI InChI=1S/C21H15Cl2N5O2/c22-14-2-1-3-16(18(14)23)28-7-6-12-10-13(4-5-15(12)28)27-8-9-30-20-17(21(27)29)19(24)25-11-26-20/h1-7,10-11H,8-9H2,(H2,24,25,26)
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GlaxoSmithKline LLC

US Patent


Assay Description
For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...


US Patent US9738658 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM221021
PNG
(US9302996, 136)
Show SMILES Cc1cc(OCC2(CC2)C(O)=O)ncc1-c1cnc(-c2ncc([nH]2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C20H16F4N4O3/c1-10-4-15(31-9-19(2-3-19)18(29)30)25-7-12(10)11-5-13(21)16(26-6-11)17-27-8-14(28-17)20(22,23)24/h4-8H,2-3,9H2,1H3,(H,27,28)(H,29,30)
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n/an/a 1.90n/an/an/an/a7.430



MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...


US Patent US9302996 (2016)


BindingDB Entry DOI: 10.7270/Q2TM790N
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50437390
PNG
(CHEMBL2408633)
Show SMILES OC(=O)[C@H]1CC[C@@H](CC1)Oc1ccc(cn1)-c1ccc(cn1)-c1nc2ccc(Cl)cc2[nH]1
Show InChI InChI=1S/C24H21ClN4O3/c25-17-5-9-20-21(11-17)29-23(28-20)16-3-8-19(26-13-16)15-4-10-22(27-12-15)32-18-6-1-14(2-7-18)24(30)31/h3-5,8-14,18H,1-2,6-7H2,(H,28,29)(H,30,31)/t14-,18-
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Article
PubMed
n/an/a 2n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human DGAT1


Citation and Details

Article DOI: 10.1021/ml400168h
BindingDB Entry DOI: 10.7270/Q2NG4S28
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50437374
PNG
(CHEMBL2408470)
Show SMILES OC(=O)[C@@H]1CC[C@@H](CC1)Oc1ccc(cn1)-c1ccc(cn1)-c1nc2ccc(F)cc2[nH]1
Show InChI InChI=1S/C24H21FN4O3/c25-17-5-9-20-21(11-17)29-23(28-20)16-3-8-19(26-13-16)15-4-10-22(27-12-15)32-18-6-1-14(2-7-18)24(30)31/h3-5,8-14,18H,1-2,6-7H2,(H,28,29)(H,30,31)/t14-,18+
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TBA

Assay Description
Inhibition of human DGAT1


Citation and Details

Article DOI: 10.1021/ml400168h
BindingDB Entry DOI: 10.7270/Q2NG4S28
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM220950
PNG
(US9302996, 65)
Show SMILES CC(C)(COc1ccc(cc1)-c1ccc(cn1)-c1ncc([nH]1)C(F)(F)F)CC(O)=O
Show InChI InChI=1S/C21H20F3N3O3/c1-20(2,9-18(28)29)12-30-15-6-3-13(4-7-15)16-8-5-14(10-25-16)19-26-11-17(27-19)21(22,23)24/h3-8,10-11H,9,12H2,1-2H3,(H,26,27)(H,28,29)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...


US Patent US9302996 (2016)


BindingDB Entry DOI: 10.7270/Q2TM790N
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM221022
PNG
(US9302996, 137)
Show SMILES Cc1cc(OCC2(CCC2)C(O)=O)ncc1-c1cnc(-c2ncc([nH]2)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C21H18F4N4O3/c1-11-5-16(32-10-20(19(30)31)3-2-4-20)26-8-13(11)12-6-14(22)17(27-7-12)18-28-9-15(29-18)21(23,24)25/h5-9H,2-4,10H2,1H3,(H,28,29)(H,30,31)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...


US Patent US9302996 (2016)


BindingDB Entry DOI: 10.7270/Q2TM790N
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM220889
PNG
(US9302996, 4-2)
Show SMILES CC(C)(COc1ccc(cc1F)-c1ccc(cn1)-c1nc(c[nH]1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C20H17F4N3O3/c1-19(2,18(28)29)10-30-15-6-4-11(7-13(15)21)14-5-3-12(8-25-14)17-26-9-16(27-17)20(22,23)24/h3-9H,10H2,1-2H3,(H,26,27)(H,28,29)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...


US Patent US9302996 (2016)


BindingDB Entry DOI: 10.7270/Q2TM790N
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM220969
PNG
(US9302996, 84)
Show SMILES CC(C)(COc1ncc(cc1F)-c1ccc(-c2ncc([nH]2)C(F)(F)F)c(F)c1)C(O)=O
Show InChI InChI=1S/C20H16F5N3O3/c1-19(2,18(29)30)9-31-17-14(22)6-11(7-27-17)10-3-4-12(13(21)5-10)16-26-8-15(28-16)20(23,24)25/h3-8H,9H2,1-2H3,(H,26,28)(H,29,30)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...


US Patent US9302996 (2016)


BindingDB Entry DOI: 10.7270/Q2TM790N
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM221025
PNG
(US9302996, 140)
Show SMILES CCC(CC)(COc1cc(C)c(cn1)-c1ccc(-c2ncc([nH]2)C(F)(F)F)c(Cl)c1)C(O)=O
Show InChI InChI=1S/C23H23ClF3N3O3/c1-4-22(5-2,21(31)32)12-33-19-8-13(3)16(10-28-19)14-6-7-15(17(24)9-14)20-29-11-18(30-20)23(25,26)27/h6-11H,4-5,12H2,1-3H3,(H,29,30)(H,31,32)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...


US Patent US9302996 (2016)


BindingDB Entry DOI: 10.7270/Q2TM790N
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM220958
PNG
(US9302996, 73)
Show SMILES Cc1cc(OCC(C)(C)C(O)=O)ncc1-c1ccc(cc1)-c1ncc([nH]1)C(F)(F)F
Show InChI InChI=1S/C21H20F3N3O3/c1-12-8-17(30-11-20(2,3)19(28)29)25-9-15(12)13-4-6-14(7-5-13)18-26-10-16(27-18)21(22,23)24/h4-10H,11H2,1-3H3,(H,26,27)(H,28,29)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...


US Patent US9302996 (2016)


BindingDB Entry DOI: 10.7270/Q2TM790N
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM221009
PNG
(US9302996, 124)
Show SMILES Cc1cc(OCC(C)(C)C(O)=O)ncc1-c1ccc(-c2ncc([nH]2)C(F)(F)C(F)(F)F)c(F)c1
Show InChI InChI=1S/C22H19F6N3O3/c1-11-6-17(34-10-20(2,3)19(32)33)29-8-14(11)12-4-5-13(15(23)7-12)18-30-9-16(31-18)21(24,25)22(26,27)28/h4-9H,10H2,1-3H3,(H,30,31)(H,32,33)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...


US Patent US9302996 (2016)


BindingDB Entry DOI: 10.7270/Q2TM790N
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50437391
PNG
(CHEMBL2408632)
Show SMILES OC(=O)[C@@H]1CC[C@@H](CC1)Oc1ccc(cn1)-c1ccc(cn1)-c1nc2ccc(Cl)cc2[nH]1
Show InChI InChI=1S/C24H21ClN4O3/c25-17-5-9-20-21(11-17)29-23(28-20)16-3-8-19(26-13-16)15-4-10-22(27-12-15)32-18-6-1-14(2-7-18)24(30)31/h3-5,8-14,18H,1-2,6-7H2,(H,28,29)(H,30,31)/t14-,18+
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TBA

Assay Description
Inhibition of human DGAT1


Citation and Details

Article DOI: 10.1021/ml400168h
BindingDB Entry DOI: 10.7270/Q2NG4S28
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM221010
PNG
(US9302996, 125)
Show SMILES Cc1cc(OCC(C)(C)C(O)=O)ncc1-c1ccc(-c2ncc([nH]2)C(F)(F)C(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C22H19ClF5N3O3/c1-11-6-17(34-10-20(2,3)19(32)33)29-8-14(11)12-4-5-13(15(23)7-12)18-30-9-16(31-18)21(24,25)22(26,27)28/h4-9H,10H2,1-3H3,(H,30,31)(H,32,33)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...


US Patent US9302996 (2016)


BindingDB Entry DOI: 10.7270/Q2TM790N
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM220994
PNG
(US9302996, 109)
Show SMILES Cc1cc(ccc1-c1ncc(CC2CC2)[nH]1)-c1cnc(OCC(C)(C)C(O)=O)cc1C
Show InChI InChI=1S/C25H29N3O3/c1-15-9-18(7-8-20(15)23-27-12-19(28-23)11-17-5-6-17)21-13-26-22(10-16(21)2)31-14-25(3,4)24(29)30/h7-10,12-13,17H,5-6,11,14H2,1-4H3,(H,27,28)(H,29,30)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...


US Patent US9302996 (2016)


BindingDB Entry DOI: 10.7270/Q2TM790N
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM220960
PNG
(US9302996, 75)
Show SMILES CC(C)(COc1ccc(c(F)c1F)-c1ccc(cn1)-c1ncc([nH]1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C20H16F5N3O3/c1-19(2,18(29)30)9-31-13-6-4-11(15(21)16(13)22)12-5-3-10(7-26-12)17-27-8-14(28-17)20(23,24)25/h3-8H,9H2,1-2H3,(H,27,28)(H,29,30)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...


US Patent US9302996 (2016)


BindingDB Entry DOI: 10.7270/Q2TM790N
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50031506
PNG
(CHEMBL3342772)
Show SMILES OC(=O)[C@@H]1CC[C@@H](CC1)OC1CCN(CC1)c1ccc(cn1)-c1nc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C24H27ClN4O3/c25-17-4-7-20-21(13-17)28-23(27-20)16-3-8-22(26-14-16)29-11-9-19(10-12-29)32-18-5-1-15(2-6-18)24(30)31/h3-4,7-8,13-15,18-19H,1-2,5-6,9-12H2,(H,27,28)(H,30,31)/t15-,18+
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1


ACS Med Chem Lett 5: 1082-7 (2014)


Article DOI: 10.1021/ml5003426
BindingDB Entry DOI: 10.7270/Q2WQ05CX
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM220998
PNG
(US9302996, 113)
Show SMILES Cc1cc(OCC(C)(C)C(O)=O)ncc1-c1ccc(-c2ncc([nH]2)C(F)(F)F)c(c1)[N+]#[C-]
Show InChI InChI=1S/C22H19F3N4O3/c1-12-7-18(32-11-21(2,3)20(30)31)27-9-15(12)13-5-6-14(16(8-13)26-4)19-28-10-17(29-19)22(23,24)25/h5-10H,11H2,1-3H3,(H,28,29)(H,30,31)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...


US Patent US9302996 (2016)


BindingDB Entry DOI: 10.7270/Q2TM790N
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM220898
PNG
(US9302996, 13-3)
Show SMILES CC(C)(COc1ccc(cn1)-c1ccc(cn1)-c1nc(c[nH]1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C19H17F3N4O3/c1-18(2,17(27)28)10-29-15-6-4-11(7-24-15)13-5-3-12(8-23-13)16-25-9-14(26-16)19(20,21)22/h3-9H,10H2,1-2H3,(H,25,26)(H,27,28)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...


US Patent US9302996 (2016)


BindingDB Entry DOI: 10.7270/Q2TM790N
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM220930
PNG
(US9302996, 45)
Show SMILES CC(C)(COc1ccc(cn1)-c1ccc(-c2ncc([nH]2)C2(CC2)C(F)(F)F)c(F)c1)C(O)=O
Show InChI InChI=1S/C23H21F4N3O3/c1-21(2,20(31)32)12-33-18-6-4-14(10-28-18)13-3-5-15(16(24)9-13)19-29-11-17(30-19)22(7-8-22)23(25,26)27/h3-6,9-11H,7-8,12H2,1-2H3,(H,29,30)(H,31,32)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...


US Patent US9302996 (2016)


BindingDB Entry DOI: 10.7270/Q2TM790N
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM220944
PNG
(US9302996, 59)
Show SMILES CC(C)Cc1cnc([nH]1)-c1ccc(nc1)-c1ccc(OCC(C)(C)C(O)=O)nc1
Show InChI InChI=1S/C22H26N4O3/c1-14(2)9-17-12-25-20(26-17)16-5-7-18(23-11-16)15-6-8-19(24-10-15)29-13-22(3,4)21(27)28/h5-8,10-12,14H,9,13H2,1-4H3,(H,25,26)(H,27,28)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...


US Patent US9302996 (2016)


BindingDB Entry DOI: 10.7270/Q2TM790N
More data for this
Ligand-Target Pair
hdgat le


(Homo sapiens (Human))
BDBM321166
PNG
(US10174049, Example 33 | US9738658, Example 33)
Show SMILES CCc1ccccc1-n1ccc2cc(ccc12)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C23H21N5O2/c1-2-15-5-3-4-6-18(15)28-10-9-16-13-17(7-8-19(16)28)27-11-12-30-22-20(23(27)29)21(24)25-14-26-22/h3-10,13-14H,2,11-12H2,1H3,(H2,24,25,26)
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GlaxoSmithKline LLC

US Patent


Assay Description
For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...


US Patent US9738658 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50031502
PNG
(CHEMBL3342774)
Show SMILES OC(=O)[C@@H]1CC[C@@H](CC1)OC1CCN(CC1)c1ccc(cn1)-c1nc2cc(ccc2[nH]1)C(F)(F)F
Show InChI InChI=1S/C25H27F3N4O3/c26-25(27,28)17-4-7-20-21(13-17)31-23(30-20)16-3-8-22(29-14-16)32-11-9-19(10-12-32)35-18-5-1-15(2-6-18)24(33)34/h3-4,7-8,13-15,18-19H,1-2,5-6,9-12H2,(H,30,31)(H,33,34)/t15-,18+
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1


ACS Med Chem Lett 5: 1082-7 (2014)


Article DOI: 10.1021/ml5003426
BindingDB Entry DOI: 10.7270/Q2WQ05CX
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM321166
PNG
(US10174049, Example 33 | US9738658, Example 33)
Show SMILES CCc1ccccc1-n1ccc2cc(ccc12)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C23H21N5O2/c1-2-15-5-3-4-6-18(15)28-10-9-16-13-17(7-8-19(16)28)27-11-12-30-22-20(23(27)29)21(24)25-14-26-22/h3-10,13-14H,2,11-12H2,1H3,(H2,24,25,26)
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Glaxosmithkline LLC

US Patent


Assay Description
For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...


US Patent US10174049 (2019)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50437373
PNG
(CHEMBL2408471)
Show SMILES OC(=O)[C@H]1CC[C@@H](CC1)Oc1ccc(cn1)-c1ccc(cn1)-c1nc2ccc(F)cc2[nH]1
Show InChI InChI=1S/C24H21FN4O3/c25-17-5-9-20-21(11-17)29-23(28-20)16-3-8-19(26-13-16)15-4-10-22(27-12-15)32-18-6-1-14(2-7-18)24(30)31/h3-5,8-14,18H,1-2,6-7H2,(H,28,29)(H,30,31)/t14-,18-
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TBA

Assay Description
Inhibition of human DGAT1


Citation and Details

Article DOI: 10.1021/ml400168h
BindingDB Entry DOI: 10.7270/Q2NG4S28
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM220926
PNG
(US9302996, 41)
Show SMILES Cc1cc(OCC(C)(C)C(O)=O)ncc1-c1ccc(cc1)-c1ncc([nH]1)C1(CCC1)C(F)(F)F
Show InChI InChI=1S/C25H26F3N3O3/c1-15-11-20(34-14-23(2,3)22(32)33)29-12-18(15)16-5-7-17(8-6-16)21-30-13-19(31-21)24(9-4-10-24)25(26,27)28/h5-8,11-13H,4,9-10,14H2,1-3H3,(H,30,31)(H,32,33)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...


US Patent US9302996 (2016)


BindingDB Entry DOI: 10.7270/Q2TM790N
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM221012
PNG
(US9302996, 127)
Show SMILES CCC(CC)(COc1cc(C)c(cn1)-c1ccc(nc1)-c1ncc([nH]1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C22H23F3N4O3/c1-4-21(5-2,20(30)31)12-32-18-8-13(3)15(10-27-18)14-6-7-16(26-9-14)19-28-11-17(29-19)22(23,24)25/h6-11H,4-5,12H2,1-3H3,(H,28,29)(H,30,31)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...


US Patent US9302996 (2016)


BindingDB Entry DOI: 10.7270/Q2TM790N
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM220949
PNG
(US9302996, 64)
Show SMILES CC(C)(COc1ccc(c(F)c1)-c1ccc(cn1)-c1ncc([nH]1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C20H17F4N3O3/c1-19(2,18(28)29)10-30-12-4-5-13(14(21)7-12)15-6-3-11(8-25-15)17-26-9-16(27-17)20(22,23)24/h3-9H,10H2,1-2H3,(H,26,27)(H,28,29)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...


US Patent US9302996 (2016)


BindingDB Entry DOI: 10.7270/Q2TM790N
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM220954
PNG
(US9302996, 69)
Show SMILES CC(C)(COc1ccc(cc1)-c1ccc(cn1)-c1ncc([nH]1)C(F)(F)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C21H18F5N3O3/c1-19(2,18(30)31)11-32-14-6-3-12(4-7-14)15-8-5-13(9-27-15)17-28-10-16(29-17)20(22,23)21(24,25)26/h3-10H,11H2,1-2H3,(H,28,29)(H,30,31)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...


US Patent US9302996 (2016)


BindingDB Entry DOI: 10.7270/Q2TM790N
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM220985
PNG
(US9302996, 100-5)
Show SMILES Cc1cc(OCC2(CC2)C(O)=O)ncc1-c1ccc(-c2nc(c[nH]2)C(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C21H17ClF3N3O3/c1-11-6-17(31-10-20(4-5-20)19(29)30)26-8-14(11)12-2-3-13(15(22)7-12)18-27-9-16(28-18)21(23,24)25/h2-3,6-9H,4-5,10H2,1H3,(H,27,28)(H,29,30)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...


US Patent US9302996 (2016)


BindingDB Entry DOI: 10.7270/Q2TM790N
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM220888
PNG
(US9302996, 3-3)
Show SMILES CC(C)(COc1ccc(cn1)-c1ccc(cc1)-c1nc(c[nH]1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C20H18F3N3O3/c1-19(2,18(27)28)11-29-16-8-7-14(9-24-16)12-3-5-13(6-4-12)17-25-10-15(26-17)20(21,22)23/h3-10H,11H2,1-2H3,(H,25,26)(H,27,28)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...


US Patent US9302996 (2016)


BindingDB Entry DOI: 10.7270/Q2TM790N
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM321141
PNG
(US10174049, Example 8 | US9738658, Example 8)
Show SMILES CC(C)COc1cccc(c1)-n1ccc2cc(ccc12)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C25H25N5O3/c1-16(2)14-33-20-5-3-4-18(13-20)29-9-8-17-12-19(6-7-21(17)29)30-10-11-32-24-22(25(30)31)23(26)27-15-28-24/h3-9,12-13,15-16H,10-11,14H2,1-2H3,(H2,26,27,28)
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n/an/a 2.90n/an/an/an/an/an/a



Glaxosmithkline LLC

US Patent


Assay Description
For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...


US Patent US10174049 (2019)

More data for this
Ligand-Target Pair
hdgat le


(Homo sapiens (Human))
BDBM321141
PNG
(US10174049, Example 8 | US9738658, Example 8)
Show SMILES CC(C)COc1cccc(c1)-n1ccc2cc(ccc12)N1CCOc2ncnc(N)c2C1=O
Show InChI InChI=1S/C25H25N5O3/c1-16(2)14-33-20-5-3-4-18(13-20)29-9-8-17-12-19(6-7-21(17)29)30-10-11-32-24-22(25(30)31)23(26)27-15-28-24/h3-9,12-13,15-16H,10-11,14H2,1-2H3,(H2,26,27,28)
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GlaxoSmithKline LLC

US Patent


Assay Description
For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...


US Patent US9738658 (2017)

More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50031501
PNG
(CHEMBL3342773)
Show SMILES OC(=O)[C@H]1CC[C@@H](CC1)OC1CCN(CC1)c1ccc(cn1)-c1nc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C24H27ClN4O3/c25-17-4-7-20-21(13-17)28-23(27-20)16-3-8-22(26-14-16)29-11-9-19(10-12-29)32-18-5-1-15(2-6-18)24(30)31/h3-4,7-8,13-15,18-19H,1-2,5-6,9-12H2,(H,27,28)(H,30,31)/t15-,18-
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n/an/a 2.90n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human DGAT1


ACS Med Chem Lett 5: 1082-7 (2014)


Article DOI: 10.1021/ml5003426
BindingDB Entry DOI: 10.7270/Q2WQ05CX
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50003815
PNG
(CHEMBL3235321)
Show SMILES CC1(C)Oc2nc(nc(N)c2N=C1c1ccc2c(CC[C@@]22CC[C@H](CC(O)=O)CC2)c1)C(F)(F)F
Show InChI InChI=1S/C25H27F3N4O3/c1-23(2)19(30-18-20(29)31-22(25(26,27)28)32-21(18)35-23)15-3-4-16-14(12-15)7-10-24(16)8-5-13(6-9-24)11-17(33)34/h3-4,12-13H,5-11H2,1-2H3,(H,33,34)(H2,29,31,32)/t13-,24-
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n/an/a 3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 (unknown origin) by cell-based assay


J Med Chem 57: 3464-83 (2014)


Article DOI: 10.1021/jm500135c
BindingDB Entry DOI: 10.7270/Q23X886W
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM50437392
PNG
(CHEMBL2408631)
Show SMILES OC(=O)[C@H]1CC[C@@H](CC1)Oc1ccc(cn1)-c1ccc(cn1)-c1nc2ccc(cc2[nH]1)C(F)(F)F
Show InChI InChI=1S/C25H21F3N4O3/c26-25(27,28)17-5-9-20-21(11-17)32-23(31-20)16-3-8-19(29-13-16)15-4-10-22(30-12-15)35-18-6-1-14(2-7-18)24(33)34/h3-5,8-14,18H,1-2,6-7H2,(H,31,32)(H,33,34)/t14-,18-
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TBA

Assay Description
Inhibition of human DGAT1


Citation and Details

Article DOI: 10.1021/ml400168h
BindingDB Entry DOI: 10.7270/Q2NG4S28
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM220967
PNG
(US9302996, 82)
Show SMILES CC(C)(COc1ncc(cc1F)-c1ccc(-c2ncc([nH]2)C(F)(F)F)c(Cl)c1)C(O)=O
Show InChI InChI=1S/C20H16ClF4N3O3/c1-19(2,18(29)30)9-31-17-14(22)6-11(7-27-17)10-3-4-12(13(21)5-10)16-26-8-15(28-16)20(23,24)25/h3-8H,9H2,1-2H3,(H,26,28)(H,29,30)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...


US Patent US9302996 (2016)


BindingDB Entry DOI: 10.7270/Q2TM790N
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM220965
PNG
(US9302996, 80)
Show SMILES CC(C)(COc1ccc(cn1)-c1ccc(-c2ncc([nH]2)C(F)(F)F)c(F)c1F)C(O)=O
Show InChI InChI=1S/C20H16F5N3O3/c1-19(2,18(29)30)9-31-14-6-3-10(7-26-14)11-4-5-12(16(22)15(11)21)17-27-8-13(28-17)20(23,24)25/h3-8H,9H2,1-2H3,(H,27,28)(H,29,30)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...


US Patent US9302996 (2016)


BindingDB Entry DOI: 10.7270/Q2TM790N
More data for this
Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (DGAT1)


(Homo sapiens (Human))
BDBM220957
PNG
(US9302996, 72)
Show SMILES Cc1cc(OCC(C)(C)C(O)=O)ncc1-c1ccc(cn1)-c1ncc([nH]1)C(F)(F)F
Show InChI InChI=1S/C20H19F3N4O3/c1-11-6-16(30-10-19(2,3)18(28)29)25-8-13(11)14-5-4-12(7-24-14)17-26-9-15(27-17)20(21,22)23/h4-9H,10H2,1-3H3,(H,26,27)(H,28,29)
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MITSUBISHI TANABE PHARMA CORPORATION

US Patent


Assay Description
As a buffer to be used in the enzymatic reaction of DGAT1, 100 mM Tris-HCl (pH 7.4), 200 mM Sucrose, 20 mM MgCl2, 0.125% Bovine Serum Albumin (BSA) w...


US Patent US9302996 (2016)


BindingDB Entry DOI: 10.7270/Q2TM790N
More data for this
Ligand-Target Pair
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