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Found 20 Enz. Inhib. hit(s) with all data for entry = 669
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Yang Ji Chemical

US Patent
LigandPNGBDBM286099(N-(5-(ethylsulfonyl)-5-azaspiro[2.4]heptan-7-yl)-N...)
Affinity DataIC50:  2.80nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Yang Ji Chemical

US Patent
LigandPNGBDBM286098((R)-3-((7-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)...)
Affinity DataIC50:  5.80nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Yang Ji Chemical

US Patent
LigandPNGBDBM286095((R)-3-(7-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)a...)
Affinity DataIC50:  8.5nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Yang Ji Chemical

US Patent
LigandPNGBDBM286098((R)-3-((7-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)...)
Affinity DataIC50:  24.7nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Yang Ji Chemical

US Patent
LigandPNGBDBM286096(3-(7-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino...)
Affinity DataIC50:  29.3nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Yang Ji Chemical

US Patent
LigandPNGBDBM286096(3-(7-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino...)
Affinity DataIC50:  40.4nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Yang Ji Chemical

US Patent
LigandPNGBDBM286098((R)-3-((7-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)...)
Affinity DataIC50:  58.6nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Yang Ji Chemical

US Patent
LigandPNGBDBM286098((R)-3-((7-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)...)
Affinity DataIC50:  110nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Yang Ji Chemical

US Patent
LigandPNGBDBM286096(3-(7-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino...)
Affinity DataIC50:  148nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Yang Ji Chemical

US Patent
LigandPNGBDBM286099(N-(5-(ethylsulfonyl)-5-azaspiro[2.4]heptan-7-yl)-N...)
Affinity DataIC50:  198nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Yang Ji Chemical

US Patent
LigandPNGBDBM286095((R)-3-(7-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)a...)
Affinity DataIC50:  252nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Yang Ji Chemical

US Patent
LigandPNGBDBM286095((R)-3-(7-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)a...)
Affinity DataIC50:  412nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Yang Ji Chemical

US Patent
LigandPNGBDBM286099(N-(5-(ethylsulfonyl)-5-azaspiro[2.4]heptan-7-yl)-N...)
Affinity DataIC50:  422nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Yang Ji Chemical

US Patent
LigandPNGBDBM286096(3-(7-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino...)
Affinity DataIC50:  694nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Yang Ji Chemical

US Patent
LigandPNGBDBM286097((S)-3-(7-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)a...)
Affinity DataIC50:  787nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Yang Ji Chemical

US Patent
LigandPNGBDBM286097((S)-3-(7-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)a...)
Affinity DataIC50: >1.00E+3nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Yang Ji Chemical

US Patent
LigandPNGBDBM286097((S)-3-(7-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)a...)
Affinity DataIC50: >1.00E+3nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Yang Ji Chemical

US Patent
LigandPNGBDBM286097((S)-3-(7-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)a...)
Affinity DataIC50: >1.00E+3nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Yang Ji Chemical

US Patent
LigandPNGBDBM286099(N-(5-(ethylsulfonyl)-5-azaspiro[2.4]heptan-7-yl)-N...)
Affinity DataIC50: >1.00E+3nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Yang Ji Chemical

US Patent
LigandPNGBDBM286095((R)-3-(7-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)a...)
Affinity DataIC50:  1.09E+3nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent