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Found 40 Enz. Inhib. hit(s) with all data for entry = 871
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  0.75nMpH: 7.4Assay Description:The half inhibition concentrations (IC50 values) of the compounds disclosed herein on Btk were determined at both enzymatic level and cellular level:...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295019(US10112922, Compound 9)
Affinity DataIC50:  1.90nMAssay Description:In vitro activity in inhibiting ITK kinase was determined similar to that in respect of BTK kinase.The inhibitory activity of the compound of Example...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  75.3nMAssay Description:In vitro activity in inhibiting ITK kinase was determined similar to that in respect of BTK kinase.The inhibitory activity of the compound of Example...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295013(US10112922, Compound 3)
Affinity DataIC50: <100nMpH: 7.4Assay Description:The half inhibition concentrations (IC50 values) of the compounds disclosed herein on Btk were determined at both enzymatic level and cellular level:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295014(US10112922, Compound 4)
Affinity DataIC50: <100nMpH: 7.4Assay Description:The half inhibition concentrations (IC50 values) of the compounds disclosed herein on Btk were determined at both enzymatic level and cellular level:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295015(US10112922, Compound 5)
Affinity DataIC50: <100nMpH: 7.4Assay Description:The half inhibition concentrations (IC50 values) of the compounds disclosed herein on Btk were determined at both enzymatic level and cellular level:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295012(US10112922, Compound 2)
Affinity DataIC50: <100nMAssay Description:In vitro activity in inhibiting ITK kinase was determined similar to that in respect of BTK kinase.The inhibitory activity of the compound of Example...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295012(US10112922, Compound 2)
Affinity DataIC50: <100nMpH: 7.4Assay Description:The half inhibition concentrations (IC50 values) of the compounds disclosed herein on Btk were determined at both enzymatic level and cellular level:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295011(US10112922, Compound 1 | US9926299, 27 (R-isomer))
Affinity DataIC50: <100nMpH: 7.4Assay Description:The half inhibition concentrations (IC50 values) of the compounds disclosed herein on Btk were determined at both enzymatic level and cellular level:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295011(US10112922, Compound 1 | US9926299, 27 (R-isomer))
Affinity DataIC50: <100nMAssay Description:In vitro activity in inhibiting ITK kinase was determined similar to that in respect of BTK kinase.The inhibitory activity of the compound of Example...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295028(US10112922, Compound 18)
Affinity DataIC50: <100nMpH: 7.4Assay Description:The half inhibition concentrations (IC50 values) of the compounds disclosed herein on Btk were determined at both enzymatic level and cellular level:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295027(US10112922, Compound 17)
Affinity DataIC50: <100nMAssay Description:In vitro activity in inhibiting ITK kinase was determined similar to that in respect of BTK kinase.The inhibitory activity of the compound of Example...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295027(US10112922, Compound 17)
Affinity DataIC50: <100nMpH: 7.4Assay Description:The half inhibition concentrations (IC50 values) of the compounds disclosed herein on Btk were determined at both enzymatic level and cellular level:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295026(US10112922, Compound 16)
Affinity DataIC50: <100nMpH: 7.4Assay Description:The half inhibition concentrations (IC50 values) of the compounds disclosed herein on Btk were determined at both enzymatic level and cellular level:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295025(US10112922, Compound 15)
Affinity DataIC50: <100nMpH: 7.4Assay Description:The half inhibition concentrations (IC50 values) of the compounds disclosed herein on Btk were determined at both enzymatic level and cellular level:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295024(US10112922, Compound 14)
Affinity DataIC50: <100nMpH: 7.4Assay Description:The half inhibition concentrations (IC50 values) of the compounds disclosed herein on Btk were determined at both enzymatic level and cellular level:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295023(US10112922, Compound 13)
Affinity DataIC50: <100nMpH: 7.4Assay Description:The half inhibition concentrations (IC50 values) of the compounds disclosed herein on Btk were determined at both enzymatic level and cellular level:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295022(US10112922, Compound 12)
Affinity DataIC50: <100nMpH: 7.4Assay Description:The half inhibition concentrations (IC50 values) of the compounds disclosed herein on Btk were determined at both enzymatic level and cellular level:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295021(US10112922, Compound 11)
Affinity DataIC50: <100nMpH: 7.4Assay Description:The half inhibition concentrations (IC50 values) of the compounds disclosed herein on Btk were determined at both enzymatic level and cellular level:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295020(US10112922, Compound 10)
Affinity DataIC50: <100nMpH: 7.4Assay Description:The half inhibition concentrations (IC50 values) of the compounds disclosed herein on Btk were determined at both enzymatic level and cellular level:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295019(US10112922, Compound 9)
Affinity DataIC50: <100nMpH: 7.4Assay Description:The half inhibition concentrations (IC50 values) of the compounds disclosed herein on Btk were determined at both enzymatic level and cellular level:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295018(US10112922, Compound 8)
Affinity DataIC50: <100nMpH: 7.4Assay Description:The half inhibition concentrations (IC50 values) of the compounds disclosed herein on Btk were determined at both enzymatic level and cellular level:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295017(US10112922, Compound 7)
Affinity DataIC50: <100nMpH: 7.4Assay Description:The half inhibition concentrations (IC50 values) of the compounds disclosed herein on Btk were determined at both enzymatic level and cellular level:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295016(US10112922, Compound 6)
Affinity DataIC50: <100nMpH: 7.4Assay Description:The half inhibition concentrations (IC50 values) of the compounds disclosed herein on Btk were determined at both enzymatic level and cellular level:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295014(US10112922, Compound 4)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro activity in inhibiting ITK kinase was determined similar to that in respect of BTK kinase.The inhibitory activity of the compound of Example...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295015(US10112922, Compound 5)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro activity in inhibiting ITK kinase was determined similar to that in respect of BTK kinase.The inhibitory activity of the compound of Example...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295026(US10112922, Compound 16)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro activity in inhibiting ITK kinase was determined similar to that in respect of BTK kinase.The inhibitory activity of the compound of Example...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295021(US10112922, Compound 11)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro activity in inhibiting ITK kinase was determined similar to that in respect of BTK kinase.The inhibitory activity of the compound of Example...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295028(US10112922, Compound 18)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro activity in inhibiting ITK kinase was determined similar to that in respect of BTK kinase.The inhibitory activity of the compound of Example...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295020(US10112922, Compound 10)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro activity in inhibiting ITK kinase was determined similar to that in respect of BTK kinase.The inhibitory activity of the compound of Example...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295025(US10112922, Compound 15)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro activity in inhibiting ITK kinase was determined similar to that in respect of BTK kinase.The inhibitory activity of the compound of Example...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295019(US10112922, Compound 9)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro activity in inhibiting ITK kinase was determined similar to that in respect of BTK kinase.The inhibitory activity of the compound of Example...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295019(US10112922, Compound 9)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro activity in inhibiting ITK kinase was determined similar to that in respect of BTK kinase.The inhibitory activity of the compound of Example...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295018(US10112922, Compound 8)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro activity in inhibiting ITK kinase was determined similar to that in respect of BTK kinase.The inhibitory activity of the compound of Example...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295024(US10112922, Compound 14)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro activity in inhibiting ITK kinase was determined similar to that in respect of BTK kinase.The inhibitory activity of the compound of Example...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295017(US10112922, Compound 7)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro activity in inhibiting ITK kinase was determined similar to that in respect of BTK kinase.The inhibitory activity of the compound of Example...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295013(US10112922, Compound 3)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro activity in inhibiting ITK kinase was determined similar to that in respect of BTK kinase.The inhibitory activity of the compound of Example...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295016(US10112922, Compound 6)
Affinity DataIC50: >1.00E+3nMpH: 7.4Assay Description:The half inhibition concentrations (IC50 values) of the compounds disclosed herein on Btk were determined at both enzymatic level and cellular level:...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295023(US10112922, Compound 13)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro activity in inhibiting ITK kinase was determined similar to that in respect of BTK kinase.The inhibitory activity of the compound of Example...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Centaurus Biopharma

US Patent
LigandPNGBDBM295022(US10112922, Compound 12)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro activity in inhibiting ITK kinase was determined similar to that in respect of BTK kinase.The inhibitory activity of the compound of Example...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent