Found 64 Enz. Inhib. hit(s) with all data for entry = 2759 TargetDNA topoisomerase 1(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 240nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 240nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 240nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 480nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 480nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 480nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 480nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 725nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 725nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 970nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 970nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 1.95E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 1.95E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 1.95E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 2.93E+3nMAssay Description:Human Topoisomerase IIα assays were carried out by adding the compounds to 185 ng of kinetoplast DNA (kDNA, from TopoGen) in the buffer supplied...More data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 2.93E+3nMAssay Description:Human Topoisomerase IIα assays were carried out by adding the compounds to 185 ng of kinetoplast DNA (kDNA, from TopoGen) in the buffer supplied...More data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 2.93E+3nMAssay Description:Human Topoisomerase IIα assays were carried out by adding the compounds to 185 ng of kinetoplast DNA (kDNA, from TopoGen) in the buffer supplied...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 3.90E+3nMAssay Description:Human topoisomerase I relaxation assays were carried out with 0.5 U of enzyme in reaction buffer supplied by the manufacturer. The enzyme was mixed w...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 3.90E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 3.90E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 3.90E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 3.90E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 3.90E+3nMAssay Description:DNA gyrase supercoiling assays were carried out by mixing the compounds and the enzyme in a similar manner as above (EcTopI relaxation inhibition ass...More data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 3.90E+3nMAssay Description:DNA gyrase supercoiling assays were carried out by mixing the compounds and the enzyme in a similar manner as above (EcTopI relaxation inhibition ass...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 3.90E+3nMAssay Description:Human topoisomerase I relaxation assays were carried out with 0.5 U of enzyme in reaction buffer supplied by the manufacturer. The enzyme was mixed w...More data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 3.90E+3nMAssay Description:DNA gyrase supercoiling assays were carried out by mixing the compounds and the enzyme in a similar manner as above (EcTopI relaxation inhibition ass...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 3.90E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 3.90E+3nMAssay Description:Human Topoisomerase IIα assays were carried out by adding the compounds to 185 ng of kinetoplast DNA (kDNA, from TopoGen) in the buffer supplied...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 3.90E+3nMAssay Description:Human topoisomerase I relaxation assays were carried out with 0.5 U of enzyme in reaction buffer supplied by the manufacturer. The enzyme was mixed w...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 3.90E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 5.85E+3nMAssay Description:Human Topoisomerase IIα assays were carried out by adding the compounds to 185 ng of kinetoplast DNA (kDNA, from TopoGen) in the buffer supplied...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 5.85E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 5.85E+3nMAssay Description:Human Topoisomerase IIα assays were carried out by adding the compounds to 185 ng of kinetoplast DNA (kDNA, from TopoGen) in the buffer supplied...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 7.80E+3nMAssay Description:Human topoisomerase I relaxation assays were carried out with 0.5 U of enzyme in reaction buffer supplied by the manufacturer. The enzyme was mixed w...More data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 7.80E+3nMAssay Description:DNA gyrase supercoiling assays were carried out by mixing the compounds and the enzyme in a similar manner as above (EcTopI relaxation inhibition ass...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 7.80E+3nMAssay Description:Human topoisomerase I relaxation assays were carried out with 0.5 U of enzyme in reaction buffer supplied by the manufacturer. The enzyme was mixed w...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 7.80E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 1.17E+4nMAssay Description:Human topoisomerase I relaxation assays were carried out with 0.5 U of enzyme in reaction buffer supplied by the manufacturer. The enzyme was mixed w...More data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 1.17E+4nMAssay Description:DNA gyrase supercoiling assays were carried out by mixing the compounds and the enzyme in a similar manner as above (EcTopI relaxation inhibition ass...More data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 1.56E+4nMAssay Description:Human Topoisomerase IIα assays were carried out by adding the compounds to 185 ng of kinetoplast DNA (kDNA, from TopoGen) in the buffer supplied...More data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 1.56E+4nMAssay Description:DNA gyrase supercoiling assays were carried out by mixing the compounds and the enzyme in a similar manner as above (EcTopI relaxation inhibition ass...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 1.56E+4nMAssay Description:Human topoisomerase I relaxation assays were carried out with 0.5 U of enzyme in reaction buffer supplied by the manufacturer. The enzyme was mixed w...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 1.56E+4nMAssay Description:Human topoisomerase I relaxation assays were carried out with 0.5 U of enzyme in reaction buffer supplied by the manufacturer. The enzyme was mixed w...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 1.56E+4nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 1.56E+4nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 1.56E+4nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 1.56E+4nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 2.34E+4nMAssay Description:DNA gyrase supercoiling assays were carried out by mixing the compounds and the enzyme in a similar manner as above (EcTopI relaxation inhibition ass...More data for this Ligand-Target Pair
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 2.34E+4nMAssay Description:DNA gyrase supercoiling assays were carried out by mixing the compounds and the enzyme in a similar manner as above (EcTopI relaxation inhibition ass...More data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board Of Trustees
US Patent
The Florida International University Board Of Trustees
US Patent
Affinity DataIC50: 3.13E+4nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
