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Found 24 Enz. Inhib. hit(s) with all data for entry = 3373
TargetProteinase-activated receptor 1(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM50197614(CHEMBL3939323 | US10322140, Example 12)
Affinity DataIC50:  0.990nMAssay Description:Frozen HEK 293 Cells were plated in 384-well PDL coated plates at 12000 cells/well in 50 uL of DMEM media containing 10% FBS, pen/strep/L-Glutamine a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM398052(2-(6-((E)-2- ((3R,3aS,4R,5S,7aR)- 7a-(5-amino-1,3,...)
Affinity DataIC50:  1.22nMAssay Description:Frozen HEK 293 Cells were plated in 384-well PDL coated plates at 12000 cells/well in 50 uL of DMEM media containing 10% FBS, pen/strep/L-Glutamine a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM398050(2-(6-((E)-2- ((3R,3aS,4R,5S,7aR)- 6,6-difluoro-3,5...)
Affinity DataIC50:  1.34nMAssay Description:Frozen HEK 293 Cells were plated in 384-well PDL coated plates at 12000 cells/well in 50 uL of DMEM media containing 10% FBS, pen/strep/L-Glutamine a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM398061(2-(6-((E)-2- ((3R,3aS,4R,5S,7aR)- 7a-(5-cyclopropy...)
Affinity DataIC50:  2.07nMAssay Description:Frozen HEK 293 Cells were plated in 384-well PDL coated plates at 12000 cells/well in 50 uL of DMEM media containing 10% FBS, pen/strep/L-Glutamine a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM50197581(CHEMBL3929336 | US10322140, Example 4)
Affinity DataIC50:  3.08nMAssay Description:Frozen HEK 293 Cells were plated in 384-well PDL coated plates at 12000 cells/well in 50 uL of DMEM media containing 10% FBS, pen/strep/L-Glutamine a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM398062(2-(6-((E)-2- ((3R,3aS,4R,5S,7aR)- 6,6-difluoro-3,5...)
Affinity DataIC50:  5.01nMAssay Description:Frozen HEK 293 Cells were plated in 384-well PDL coated plates at 12000 cells/well in 50 uL of DMEM media containing 10% FBS, pen/strep/L-Glutamine a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM398049(US10322140, Example 13)
Affinity DataIC50:  6.20nMAssay Description:Frozen HEK 293 Cells were plated in 384-well PDL coated plates at 12000 cells/well in 50 uL of DMEM media containing 10% FBS, pen/strep/L-Glutamine a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM398064(2-(6-((E)-2- ((3R,3aS,4R,5S,7aR)- 7a-(1,5-dimethyl...)
Affinity DataIC50:  6.30nMAssay Description:Frozen HEK 293 Cells were plated in 384-well PDL coated plates at 12000 cells/well in 50 uL of DMEM media containing 10% FBS, pen/strep/L-Glutamine a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM398044(US10322140, Example 9)
Affinity DataIC50:  14.5nMAssay Description:Frozen HEK 293 Cells were plated in 384-well PDL coated plates at 12000 cells/well in 50 uL of DMEM media containing 10% FBS, pen/strep/L-Glutamine a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM398063(2-(6-((E)-2- ((3R,3aS,4R,5S,7aR)- 7a-(5-(tert-buty...)
Affinity DataIC50:  25.3nMAssay Description:Frozen HEK 293 Cells were plated in 384-well PDL coated plates at 12000 cells/well in 50 uL of DMEM media containing 10% FBS, pen/strep/L-Glutamine a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM50197612(CHEMBL3968866 | US10322140, Example 8)
Affinity DataIC50:  28.7nMAssay Description:Frozen HEK 293 Cells were plated in 384-well PDL coated plates at 12000 cells/well in 50 uL of DMEM media containing 10% FBS, pen/strep/L-Glutamine a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM50197614(CHEMBL3939323 | US10322140, Example 12)
Affinity DataIC50:  2.40E+3nMAssay Description:Compound dilutions and assay-ready plates were prepared on a TTP Labtech mosquito HTS. Assay conduction was fully automated on a customized Screening...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM398049(US10322140, Example 13)
Affinity DataIC50:  8.80E+3nMAssay Description:Compound dilutions and assay-ready plates were prepared on a TTP Labtech mosquito HTS. Assay conduction was fully automated on a customized Screening...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM50197581(CHEMBL3929336 | US10322140, Example 4)
Affinity DataIC50:  9.90E+3nMAssay Description:Compound dilutions and assay-ready plates were prepared on a TTP Labtech mosquito HTS. Assay conduction was fully automated on a customized Screening...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM398052(2-(6-((E)-2- ((3R,3aS,4R,5S,7aR)- 7a-(5-amino-1,3,...)
Affinity DataIC50:  1.04E+4nMAssay Description:Compound dilutions and assay-ready plates were prepared on a TTP Labtech mosquito HTS. Assay conduction was fully automated on a customized Screening...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM398067(US10322140, Example 5)
Affinity DataIC50:  1.69E+4nMAssay Description:Compound dilutions and assay-ready plates were prepared on a TTP Labtech mosquito HTS. Assay conduction was fully automated on a customized Screening...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM398064(2-(6-((E)-2- ((3R,3aS,4R,5S,7aR)- 7a-(1,5-dimethyl...)
Affinity DataIC50:  1.76E+4nMAssay Description:Compound dilutions and assay-ready plates were prepared on a TTP Labtech mosquito HTS. Assay conduction was fully automated on a customized Screening...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM50197613(CHEMBL3940415 | US10322140, Example 1)
Affinity DataIC50:  2.18E+4nMAssay Description:Compound dilutions and assay-ready plates were prepared on a TTP Labtech mosquito HTS. Assay conduction was fully automated on a customized Screening...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM398050(2-(6-((E)-2- ((3R,3aS,4R,5S,7aR)- 6,6-difluoro-3,5...)
Affinity DataIC50:  2.28E+4nMAssay Description:Compound dilutions and assay-ready plates were prepared on a TTP Labtech mosquito HTS. Assay conduction was fully automated on a customized Screening...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM398063(2-(6-((E)-2- ((3R,3aS,4R,5S,7aR)- 7a-(5-(tert-buty...)
Affinity DataIC50:  5.00E+4nMAssay Description:Compound dilutions and assay-ready plates were prepared on a TTP Labtech mosquito HTS. Assay conduction was fully automated on a customized Screening...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM398044(US10322140, Example 9)
Affinity DataIC50:  5.00E+4nMAssay Description:Compound dilutions and assay-ready plates were prepared on a TTP Labtech mosquito HTS. Assay conduction was fully automated on a customized Screening...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM50197612(CHEMBL3968866 | US10322140, Example 8)
Affinity DataIC50:  5.00E+4nMAssay Description:Compound dilutions and assay-ready plates were prepared on a TTP Labtech mosquito HTS. Assay conduction was fully automated on a customized Screening...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM398061(2-(6-((E)-2- ((3R,3aS,4R,5S,7aR)- 7a-(5-cyclopropy...)
Affinity DataIC50:  5.00E+4nMAssay Description:Compound dilutions and assay-ready plates were prepared on a TTP Labtech mosquito HTS. Assay conduction was fully automated on a customized Screening...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM398062(2-(6-((E)-2- ((3R,3aS,4R,5S,7aR)- 6,6-difluoro-3,5...)
Affinity DataIC50:  5.00E+4nMAssay Description:Compound dilutions and assay-ready plates were prepared on a TTP Labtech mosquito HTS. Assay conduction was fully automated on a customized Screening...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent