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Found 19 Enz. Inhib. hit(s) with all data for entry = 5813
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405268(1-(4-(7-(2,6-difluorobenzyl)-3-((dimethylamino)met...)
Affinity DataIC50:  0.110nMAssay Description:Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetG_PROTEIN_RECEP_F1_2 domain-containing protein(Oryctolagus cuniculus (Rabbit))
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405272(1-(4-(7-(2,6-difluorobenzyl)-3-((dimethylamino)met...)
Affinity DataIC50:  0.240nMAssay Description:Rabbit: This assay was used to determine the inhibition effect of the present compounds on the activity of rabbit GnRHr protein expressed by rabbit G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetG_PROTEIN_RECEP_F1_2 domain-containing protein(Oryctolagus cuniculus (Rabbit))
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405271(1-(4-(3-((dimethylamino)methyl)-5-(2-fluoro-3-meth...)
Affinity DataIC50:  0.270nMAssay Description:Rabbit: This assay was used to determine the inhibition effect of the present compounds on the activity of rabbit GnRHr protein expressed by rabbit G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405272(1-(4-(7-(2,6-difluorobenzyl)-3-((dimethylamino)met...)
Affinity DataIC50:  0.420nMAssay Description:Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405278(1-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)met...)
Affinity DataIC50:  0.430nMAssay Description:Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405270(1-(4-(3-((dimethylamino)methyl)-5-(2-fluoro-3-meth...)
Affinity DataIC50:  0.490nMAssay Description:Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetG_PROTEIN_RECEP_F1_2 domain-containing protein(Oryctolagus cuniculus (Rabbit))
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405274(1-(4-(7-(2,6-difluorobenzyl)-3-((dimethylamino)met...)
Affinity DataIC50:  0.570nMAssay Description:Rabbit: This assay was used to determine the inhibition effect of the present compounds on the activity of rabbit GnRHr protein expressed by rabbit G...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405271(1-(4-(3-((dimethylamino)methyl)-5-(2-fluoro-3-meth...)
Affinity DataIC50:  0.600nMAssay Description:Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405268(1-(4-(7-(2,6-difluorobenzyl)-3-((dimethylamino)met...)
Affinity DataIC50:  0.660nMAssay Description:Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405273(1-(4-(7-(2,6-difluorobenzyl)-3-((dimethylamino)met...)
Affinity DataIC50:  0.660nMAssay Description:Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405267(1-(4-(7-(2,6-difluorobenzyl)-3-((dimethylamino)met...)
Affinity DataIC50:  0.900nMAssay Description:Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405276(1-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)met...)
Affinity DataIC50:  0.920nMAssay Description:Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405269(1-(4-(3-((dimethylamino)methyl)-5-(2-fluoro-3-meth...)
Affinity DataIC50:  0.960nMAssay Description:Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405266(1-(4-(7-(2,6-difluorobenzyl)-3-((dimethylamino)met...)
Affinity DataIC50:  1.46nMAssay Description:Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405275(1-(4-(3-((dimethylamino)methyl)-7-(2-fluoro-6-(tri...)
Affinity DataIC50:  2.24nMAssay Description:Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405279(1-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)met...)
Affinity DataIC50:  2.32nMAssay Description:Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405274(1-(4-(7-(2,6-difluorobenzyl)-3-((dimethylamino)met...)
Affinity DataIC50:  4.95nMAssay Description:Human: Test Example 1. Human GnRHr (GnRH Receptor) Activity Assay of the Present Compounds.In vitro GnRHr protein activity was tested by the followin...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGonadotropin releasing hormone receptor(Macaca fascicularis (Crab-eating macaque) (Cynomol...)
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405272(1-(4-(7-(2,6-difluorobenzyl)-3-((dimethylamino)met...)
Affinity DataIC50:  23.2nMAssay Description:Monkey: This assay was used to determine the inhibition effect of the present compounds on the activity of monkey GnRHr protein expressed by monkey G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGonadotropin releasing hormone receptor(Macaca fascicularis (Crab-eating macaque) (Cynomol...)
Shanghai Hengrui Pharmaceutical

US Patent
LigandPNGBDBM405274(1-(4-(7-(2,6-difluorobenzyl)-3-((dimethylamino)met...)
Affinity DataIC50:  78.6nMAssay Description:Monkey: This assay was used to determine the inhibition effect of the present compounds on the activity of monkey GnRHr protein expressed by monkey G...More data for this Ligand-Target Pair
In DepthDetails US Patent