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Found 37 Enz. Inhib. hit(s) with all data for entry = 9217
LigandPNGBDBM246893(5-{3-[1-(4-amino-3- methyl-1H-pyrazolo[3,4 d]pyrim...)
Affinity DataIC50: <50nMAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from Perking Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (P...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
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US Patent
LigandPNGBDBM246873(US10053465, 12 | US10065963, Compound 12 | US10125...)
Affinity DataIC50: <50nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM262166(5-{3-(cyanomethyl)- 3-[4-(1H-pyrrolo[2,3- b]pyridi...)
Affinity DataIC50: <50nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246877(4-{3-(cyanomethyl)- 3-[4-(7H-pyrrolo[2,3- d]pyrimi...)
Affinity DataIC50: <50nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246876(5-{3-(cyanomethyl)- 3-[4-(7H-pyrrolo[2,3- d]pyrimi...)
Affinity DataIC50: <50nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM261245(4-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Affinity DataIC50: <50nMAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from Perking Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (P...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM272572(US10065963, Compound 32b | US10376513, Example 347...)
Affinity DataIC50: <50nMAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from Perking Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (P...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM272573(US10065963, 32c | US10376513, Example 346 | US1064...)
Affinity DataIC50: <50nMAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from Perking Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (P...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50004539(CHEMBL2216867 | US10065963, Compound 33 | US105191...)
Affinity DataIC50: <50nMAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from Perking Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (P...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246861(3-[1-(6- chloropyridin-2- yl)pyrrolidin-3-yl]-3- [...)
Affinity DataIC50: <50nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246864(3-(1- [1,3]oxazolo[5,4- b]pyridin-2- ylpyrrolidin-...)
Affinity DataIC50: <50nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM285696(4-[(4-{3-cyano-2-[3- (7H-pyrrolo[2,3- d]pyrimidin-...)
Affinity DataIC50: <50nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246867(4-[(4-{3-cyano-2-[3- (7H-pyrrolo[2,3- d]pyrimidin-...)
Affinity DataIC50: <50nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246868(US10053465, 7 | US10065963, Compound 7 | US1012515...)
Affinity DataIC50: <50nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246869(4-{3-(Cyanomethyl)- 3-[4-(7H-pyrrolo[2,3- d]pyrimi...)
Affinity DataIC50: <50nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246870(US10053465, 9 | US10065963, Compound 9 | US1012515...)
Affinity DataIC50: <50nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
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US Patent
LigandPNGBDBM246871(US10053465, 10 | US10065963, Compound 10 | US10125...)
Affinity DataIC50: <50nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246872(US10053465, 11 | US10065963, Compound 11 | US10125...)
Affinity DataIC50: <50nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246879(US10053465, 18 | US10065963, Compound 18 | US10125...)
Affinity DataIC50: <50nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246874(US10053465, 13 | US10065963, Compound 13 | US10125...)
Affinity DataIC50: <50nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246875(4-(4-{3- [(dimethylamino) methyl]-5- fluorophenoxy...)
Affinity DataIC50: <50nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246880(US10053465, 19 | US10065963, Compound 19 | US10125...)
Affinity DataIC50: <50nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246881(US10053465, 20 | US10065963, Compound 20 | US10125...)
Affinity DataIC50: <50nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
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US Patent
LigandPNGBDBM246882(US10053465, 21 | US10065963, Compound 21 | US10125...)
Affinity DataIC50: <50nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
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US Patent
LigandPNGBDBM246883(US10005788, 1 (2nd peak, cis-) | US10053465, 22 | ...)
Affinity DataIC50: <50nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
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US Patent
LigandPNGBDBM246884(US10053465, 23 | US10065963, Compound 23 | US10125...)
Affinity DataIC50: <50nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246885(US10053465, 24 | US10065963, Compound 25 | US10125...)
Affinity DataIC50: <50nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246886(US10053465, 25 | US10077277, Example 25 | US101251...)
Affinity DataIC50: <50nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246888(US10053465, 26 | US10065963, Compound 26 | US10125...)
Affinity DataIC50: <50nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM246889(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Affinity DataIC50: <50nMAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from Perking Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (P...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
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LigandPNGBDBM50004547(CHEMBL2216863 | US10065963, Compound 28 | US104280...)
Affinity DataIC50: <50nMAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from Perking Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (P...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM261246(4-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Affinity DataIC50: <50nMAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from Perking Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (P...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM246853(4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...)
Affinity DataIC50:  75nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM246896(4-chloro-3'-fluoro-3- methyl-6-[1-(9H-purin-6-...)
Affinity DataIC50:  75nMAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from Perking Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (P...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
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LigandPNGBDBM272574(US10065963, Compound 32d | US10376513, Example 348...)
Affinity DataIC50:  125nMAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from Perking Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (P...More data for this Ligand-Target Pair
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TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
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US Patent
LigandPNGBDBM246852(((2R,5S)-5-{2-[(1R)- 1-hydroxyethyl]-1H- imidazo[4...)
Affinity DataIC50:  125nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM272571(US10065963, Compound 32a | US10376513, Example 345...)
Affinity DataIC50:  125nMAssay Description:[γ-33P]ATP (10 mCi/mL) was purchased from Perking Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (P...More data for this Ligand-Target Pair
In DepthDetails US Patent