Compile Data Set for Download or QSAR
maximum 50k data
Found 28 Enz. Inhib. hit(s) with all data for entry = 9284
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM455334(7-(4-Fluorophenyl)-N4,5,5-trimethyl-N2-((1R,5S,8s)...)
Affinity DataEC50:  14nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
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TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM455364(7-(2,3-Difluorophenyl)-N4,5,5-trimethyl-N2-((1R,5S...)
Affinity DataEC50:  10nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
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TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM455336(7-(4-Fluorophenyl)-N2-((1R,5S,8s)-3-(6-methoxypyri...)
Affinity DataEC50:  12nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
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TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM455337(7-(4-Fluorophenyl)-N2-((1R,5S,8s)-3-(2-methoxypyri...)
Affinity DataEC50:  23nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
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TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM455338(N2-((1R,5S,8s)-3-(6-Chloropyrimidin-4-yl)-3-azabic...)
Affinity DataEC50:  31nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
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TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM455339(7-(4-Fluorophenyl)-N2-((1R,5S,8s)-3-(6-methoxypyri...)
Affinity DataEC50:  46nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
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TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM455341(N2-((1R,5S,8s)-3-(6-Chloropyridazin-4-yl)-3-azabic...)
Affinity DataEC50:  11nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
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TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM455342(7-(3,4-Difluorophenyl)-N4,5,5-trimethyl-N2-((1R,5S...)
Affinity DataEC50:  33nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
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TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM455343(7-(3,4-Difluorophenyl)-N4,5,5-trimethyl-N2-((1R,5S...)
Affinity DataEC50:  24nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
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TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM455344(7-(4-Fluorophenyl)-N4-methyl-N2-((1R,5S,8s)-3-(6-m...)
Affinity DataEC50:  12nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM455345(7-(3,4-Difluorophenyl)-N2-((1R,5S,8s)-3-(6-methoxy...)
Affinity DataEC50:  16nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM455346(7-(4-Fluorophenyl)-N4,5,5-trimethyl-N2-((1R,5S,8s)...)
Affinity DataEC50:  19nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
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TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM455347(7-(3,3-Difluorocyclobutyl)-N4,5,5-trimethyl-N2-((1...)
Affinity DataEC50:  36nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM455348(7-(3,3-Difluorocyclobutyl)-N4,5,5-trimethyl-N2-((1...)
Affinity DataEC50:  104nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM455349(7-(2,4-Difluorophenyl)-N4,5,5-trimethyl-N2-((1R,5S...)
Affinity DataEC50:  14nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM455350(7-(2,4-Difluorophenyl)-N4,5,5-trimethyl-N2-((1R,5S...)
Affinity DataEC50:  31nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM455351(N4,5,5-Trimethyl-N2-((1R,5S,8s)-3-(6-methylpyrimid...)
Affinity DataEC50:  111nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM455352(N2-((1R,5S,8s)-3-(6-Methoxypyridazin-4-yl)-3-azabi...)
Affinity DataEC50:  53nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM455353(7-(2,4-Difluorophenyl)-N2-((1R,5S,8s)-3-(6-methoxy...)
Affinity DataEC50:  9nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM455354(2-((7-(4-Fluorophenyl)-5,5-dimethyl-2-(((1R,5S,8s)...)
Affinity DataEC50:  12nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM455355(2-((7-(4-Fluorophenyl)-2-(((1R,5S,8s)-3-(6-methoxy...)
Affinity DataEC50:  9nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM455356(8-(4-Fluorophenyl)-N4,5,5-trimethyl-N2-((1R,5S,8s)...)
Affinity DataEC50:  35nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM455357(8-(4-Fluorophenyl)-N2-((1R,5S,8s)-3-(6-methoxypyri...)
Affinity DataEC50:  24nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM455358(7-(2,3-Difluorophenyl)-N4,5,5-trimethyl-N2-((1R,5S...)
Affinity DataEC50:  9nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM455359((S)- or (R)-7-(4-Fluorophenyl)-N4,5-dimethyl-N2-((...)
Affinity DataEC50:  16nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM455360((R)- or (S)-7-(4-Fluorophenyl)-N4,5-dimethyl-N2-((...)
Affinity DataEC50:  17nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM455363(7-(2,3-Difluorophenyl)-N4,5,5-trimethyl-N2-((1R,5S...)
Affinity DataEC50:  6nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM455335(7-(4-Fluorophenyl)-N4,5,5-trimethyl-N2-((1R,5S,8s)...)
Affinity DataEC50:  34nMAssay Description:Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent