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Found 6 Enz. Inhib. hit(s) with all data for entry = 9574
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Daiichi Sankyo

US Patent
LigandPNGBDBM475604(US10851092, Example 5)
Affinity DataIC50:  2.20nMAssay Description:A reaction buffer (100 mM HEPES (pH 7.4), 10 mM MgCl2, 0.003% Brij-35, 0.004% Tween-20, and 1 mM DTT) was mixed with a RET recombinant protein (RET—w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804L](Homo sapiens (Human))
Daiichi Sankyo

US Patent
LigandPNGBDBM475604(US10851092, Example 5)
Affinity DataIC50:  2.70nMAssay Description:A reaction buffer (100 mM HEPES (pH 7.4), 10 mM MgCl2, 0.003% Brij-35, 0.004% Tween-20, and 1 mM DTT) was mixed with a RET recombinant protein (RET—w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Daiichi Sankyo

US Patent
LigandPNGBDBM475603(US10851092, Example 3)
Affinity DataIC50:  4.60nMAssay Description:A reaction buffer (100 mM HEPES (pH 7.4), 10 mM MgCl2, 0.003% Brij-35, 0.004% Tween-20, and 1 mM DTT) was mixed with a RET recombinant protein (RET—w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804L](Homo sapiens (Human))
Daiichi Sankyo

US Patent
LigandPNGBDBM475603(US10851092, Example 3)
Affinity DataIC50:  6.30nMAssay Description:A reaction buffer (100 mM HEPES (pH 7.4), 10 mM MgCl2, 0.003% Brij-35, 0.004% Tween-20, and 1 mM DTT) was mixed with a RET recombinant protein (RET—w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Daiichi Sankyo

US Patent
LigandPNGBDBM50362781(1256580-46-7 | AF802 | Alecensa | Alectinib | CH54...)
Affinity DataIC50:  52nMAssay Description:A reaction buffer (100 mM HEPES (pH 7.4), 10 mM MgCl2, 0.003% Brij-35, 0.004% Tween-20, and 1 mM DTT) was mixed with a RET recombinant protein (RET—w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804L](Homo sapiens (Human))
Daiichi Sankyo

US Patent
LigandPNGBDBM50362781(1256580-46-7 | AF802 | Alecensa | Alectinib | CH54...)
Affinity DataIC50:  811nMAssay Description:A reaction buffer (100 mM HEPES (pH 7.4), 10 mM MgCl2, 0.003% Brij-35, 0.004% Tween-20, and 1 mM DTT) was mixed with a RET recombinant protein (RET—w...More data for this Ligand-Target Pair
In DepthDetails US Patent