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Found 6 Enz. Inhib. hit(s) with all data for entry = 9556
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM474104(1'-(6-amino-5-((2-amino-3-chloropyridin- 4-yl)thio...)
Affinity DataIC50:  8.30nMAssay Description:IC50 values were estimated using 6,8-difluoro-4-methylumbelliferyl phosphate (DiFMUP) as a substrate, SHP2 samples (diluted to 0.5 nM in reaction buf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM474101(Compound 8 | US10858359, Example 8)
Affinity DataIC50:  21.4nMAssay Description:IC50 values were estimated using 6,8-difluoro-4-methylumbelliferyl phosphate (DiFMUP) as a substrate, SHP2 samples (diluted to 0.5 nM in reaction buf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM474087(Compound 7 | US10858359, Example 7)
Affinity DataIC50:  25.8nMAssay Description:IC50 values were estimated using 6,8-difluoro-4-methylumbelliferyl phosphate (DiFMUP) as a substrate, SHP2 samples (diluted to 0.5 nM in reaction buf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM474102(Compound 10 | US10858359, Example 10)
Affinity DataIC50:  30nMAssay Description:IC50 values were estimated using 6,8-difluoro-4-methylumbelliferyl phosphate (DiFMUP) as a substrate, SHP2 samples (diluted to 0.5 nM in reaction buf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM474103((S)-8-(6-amino-5-((3-fluoro-1H-indol-4-yl) thio)py...)
Affinity DataIC50:  40.6nMAssay Description:IC50 values were estimated using 6,8-difluoro-4-methylumbelliferyl phosphate (DiFMUP) as a substrate, SHP2 samples (diluted to 0.5 nM in reaction buf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM38019(US10093646, Compound 1 | US10301278, Example 00003...)
Affinity DataIC50:  84nMAssay Description:IC50 values were estimated using 6,8-difluoro-4-methylumbelliferyl phosphate (DiFMUP) as a substrate, SHP2 samples (diluted to 0.5 nM in reaction buf...More data for this Ligand-Target Pair