Compile Data Set for Download or QSAR
maximum 50k data
Found 72 Enz. Inhib. hit(s) with all data for entry = 9759
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486444(6-((Z)-2-(3-((4R,5R)-2-amino-4-methyl-5-(2,2,2-tri...)
Affinity DataIC50:  14nMAssay Description:The cell-based assay measures inhibition or reduction of Aβ40 in conditioned medium of test compound treated cells expressing amyloid precursor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Amgen

US Patent
LigandPNGBDBM486437((2R,5R)-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fluor...)
Affinity DataIC50:  17nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486438(6-((Z)-2-(3-((3R,6R)-5-amino-3,6-dimethyl-6-(trifl...)
Affinity DataIC50:  26nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486448(5-((Z)-2-(3-((4R,5R)-2-amino-4-methyl-5-(2,2,2-tri...)
Affinity DataIC50:  27nMAssay Description:The cell-based assay measures inhibition or reduction of Aβ40 in conditioned medium of test compound treated cells expressing amyloid precursor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Amgen

US Patent
LigandPNGBDBM486443((2R,5R)-5-(5-((Z)-2-(5-chloropyrazin-2-yl)-2-fluor...)
Affinity DataIC50:  33nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486439(5-((Z)-2-(3-((3R,6R)-5-amino-3,6-dimethyl-6-(trifl...)
Affinity DataIC50:  46nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486449((4R,5R)-4-(5-((Z)-2-(5-(but-2-yn-1-yloxy)pyrazin-2...)
Affinity DataIC50:  48nMAssay Description:The cell-based assay measures inhibition or reduction of Aβ40 in conditioned medium of test compound treated cells expressing amyloid precursor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486442((2R,5R)-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-y...)
Affinity DataIC50:  50nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486449((4R,5R)-4-(5-((Z)-2-(5-(but-2-yn-1-yloxy)pyrazin-2...)
Affinity DataIC50:  52nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486446((4R,5R)-4-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-y...)
Affinity DataIC50:  59nMAssay Description:The cell-based assay measures inhibition or reduction of Aβ40 in conditioned medium of test compound treated cells expressing amyloid precursor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486437((2R,5R)-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fluor...)
Affinity DataIC50:  65nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486453(6-((Z)-2-(6-((3R,6R)-5-amino-3,6-dimethyl-6-(trifl...)
Affinity DataIC50:  90nMAssay Description:The cell-based assay measures inhibition or reduction of Aβ40 in conditioned medium of test compound treated cells expressing amyloid precursor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486445((4R,5R)-4-(5-((Z)-2-(5-chloropyrazin-2-yl)-2-fluor...)
Affinity DataIC50:  90nMAssay Description:The cell-based assay measures inhibition or reduction of Aβ40 in conditioned medium of test compound treated cells expressing amyloid precursor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Amgen

US Patent
LigandPNGBDBM486438(6-((Z)-2-(3-((3R,6R)-5-amino-3,6-dimethyl-6-(trifl...)
Affinity DataIC50:  95nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486442((2R,5R)-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-y...)
Affinity DataIC50:  112nMAssay Description:The cell-based assay measures inhibition or reduction of Aβ40 in conditioned medium of test compound treated cells expressing amyloid precursor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486443((2R,5R)-5-(5-((Z)-2-(5-chloropyrazin-2-yl)-2-fluor...)
Affinity DataIC50:  118nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486448(5-((Z)-2-(3-((4R,5R)-2-amino-4-methyl-5-(2,2,2-tri...)
Affinity DataIC50:  119nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486444(6-((Z)-2-(3-((4R,5R)-2-amino-4-methyl-5-(2,2,2-tri...)
Affinity DataIC50:  125nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486439(5-((Z)-2-(3-((3R,6R)-5-amino-3,6-dimethyl-6-(trifl...)
Affinity DataIC50:  130nMAssay Description:The cell-based assay measures inhibition or reduction of Aβ40 in conditioned medium of test compound treated cells expressing amyloid precursor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486453(6-((Z)-2-(6-((3R,6R)-5-amino-3,6-dimethyl-6-(trifl...)
Affinity DataIC50:  149nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486438(6-((Z)-2-(3-((3R,6R)-5-amino-3,6-dimethyl-6-(trifl...)
Affinity DataIC50:  152nMAssay Description:The cell-based assay measures inhibition or reduction of Aβ40 in conditioned medium of test compound treated cells expressing amyloid precursor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486436(6-((Z)-2-(3-((1R,5S,6R)-3-amino-5-(difluoromethyl)...)
Affinity DataIC50:  152nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486446((4R,5R)-4-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-y...)
Affinity DataIC50:  152nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486450((R,Z)-6-(2-(3-(2-amino-5,5-difluoro-4-methyl-5,6-d...)
Affinity DataIC50:  256nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486434((1R,5S,6R)-5-(5-((Z)-2-(5-bromopyridin-2-yl)-2-flu...)
Affinity DataIC50:  257nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Amgen

US Patent
LigandPNGBDBM486439(5-((Z)-2-(3-((3R,6R)-5-amino-3,6-dimethyl-6-(trifl...)
Affinity DataIC50:  273nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486451((R,Z)-5,5-difluoro-4-(2-fluoro-5-(2-fluoro-2-(5-(p...)
Affinity DataIC50:  283nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486445((4R,5R)-4-(5-((Z)-2-(5-chloropyrazin-2-yl)-2-fluor...)
Affinity DataIC50:  341nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486436(6-((Z)-2-(3-((1R,5S,6R)-3-amino-5-(difluoromethyl)...)
Affinity DataIC50:  344nMAssay Description:The cell-based assay measures inhibition or reduction of Aβ40 in conditioned medium of test compound treated cells expressing amyloid precursor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Amgen

US Patent
LigandPNGBDBM486442((2R,5R)-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(prop-2-y...)
Affinity DataIC50:  375nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Amgen

US Patent
LigandPNGBDBM486435((1R,5S,6R)-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fl...)
Affinity DataIC50:  421nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Amgen

US Patent
LigandPNGBDBM486434((1R,5S,6R)-5-(5-((Z)-2-(5-bromopyridin-2-yl)-2-flu...)
Affinity DataIC50:  564nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486443((2R,5R)-5-(5-((Z)-2-(5-chloropyrazin-2-yl)-2-fluor...)
Affinity DataIC50:  663nMAssay Description:The cell-based assay measures inhibition or reduction of Aβ40 in conditioned medium of test compound treated cells expressing amyloid precursor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486441((2R,5R)-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(2,2,3,3-...)
Affinity DataIC50:  666nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486452((R,Z)-6-(2-(6-(2-amino-5,5-difluoro-4-methyl-5,6-d...)
Affinity DataIC50:  676nMAssay Description:The cell-based assay measures inhibition or reduction of Aβ40 in conditioned medium of test compound treated cells expressing amyloid precursor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486437((2R,5R)-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fluor...)
Affinity DataIC50:  693nMAssay Description:The cell-based assay measures inhibition or reduction of Aβ40 in conditioned medium of test compound treated cells expressing amyloid precursor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Amgen

US Patent
LigandPNGBDBM486453(6-((Z)-2-(6-((3R,6R)-5-amino-3,6-dimethyl-6-(trifl...)
Affinity DataIC50:  853nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486434((1R,5S,6R)-5-(5-((Z)-2-(5-bromopyridin-2-yl)-2-flu...)
Affinity DataIC50:  948nMAssay Description:The cell-based assay measures inhibition or reduction of Aβ40 in conditioned medium of test compound treated cells expressing amyloid precursor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486435((1R,5S,6R)-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fl...)
Affinity DataIC50:  954nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486452((R,Z)-6-(2-(6-(2-amino-5,5-difluoro-4-methyl-5,6-d...)
Affinity DataIC50:  1.05E+3nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486435((1R,5S,6R)-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fl...)
Affinity DataIC50:  1.12E+3nMAssay Description:The cell-based assay measures inhibition or reduction of Aβ40 in conditioned medium of test compound treated cells expressing amyloid precursor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Amgen

US Patent
LigandPNGBDBM486445((4R,5R)-4-(5-((Z)-2-(5-chloropyrazin-2-yl)-2-fluor...)
Affinity DataIC50:  1.51E+3nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Amgen

US Patent
LigandPNGBDBM486441((2R,5R)-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(2,2,3,3-...)
Affinity DataIC50:  1.59E+3nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Amgen

US Patent
LigandPNGBDBM486436(6-((Z)-2-(3-((1R,5S,6R)-3-amino-5-(difluoromethyl)...)
Affinity DataIC50:  1.62E+3nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486450((R,Z)-6-(2-(3-(2-amino-5,5-difluoro-4-methyl-5,6-d...)
Affinity DataIC50:  2.66E+3nMAssay Description:The cell-based assay measures inhibition or reduction of Aβ40 in conditioned medium of test compound treated cells expressing amyloid precursor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Amgen

US Patent
LigandPNGBDBM486450((R,Z)-6-(2-(3-(2-amino-5,5-difluoro-4-methyl-5,6-d...)
Affinity DataIC50:  2.73E+3nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Amgen

US Patent
LigandPNGBDBM486444(6-((Z)-2-(3-((4R,5R)-2-amino-4-methyl-5-(2,2,2-tri...)
Affinity DataIC50:  3.87E+3nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486441((2R,5R)-5-(2-fluoro-5-((Z)-2-fluoro-2-(5-(2,2,3,3-...)
Affinity DataIC50:  4.13E+3nMAssay Description:The cell-based assay measures inhibition or reduction of Aβ40 in conditioned medium of test compound treated cells expressing amyloid precursor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM486451((R,Z)-5,5-difluoro-4-(2-fluoro-5-(2-fluoro-2-(5-(p...)
Affinity DataIC50:  4.67E+3nMAssay Description:The cell-based assay measures inhibition or reduction of Aβ40 in conditioned medium of test compound treated cells expressing amyloid precursor ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Mus musculus (Mouse))
Amgen

US Patent
LigandPNGBDBM486451((R,Z)-5,5-difluoro-4-(2-fluoro-5-(2-fluoro-2-(5-(p...)
Affinity DataIC50:  5.84E+3nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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