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Patent code US10995099

Compile Data Set for Download or QSAR
Found 93 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM496979
PNG
(US10995099, Example 69)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(c(C)c2c(=O)n(C2CCC2C(O)=O)c1=O)-c1ncco1)OC1CCOCC1
Show InChI InChI=1S/C29H31N3O8S/c1-16-23-26(33)32(20-8-7-18(20)28(34)35)29(36)31(27(23)41-24(16)25-30-11-14-39-25)15-22(40-17-9-12-38-13-10-17)19-5-3-4-6-21(19)37-2/h3-6,11,14,17-18,20,22H,7-10,12-13,15H2,1-2H3,(H,34,35)/t18?,20?,22-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM489782
PNG
(US10995099, Example 26 | US10995099, Example 37)
Show SMILES COc1ccccc1C(Cn1c2sc(c(C)c2c(=O)n(c1=O)C1(CCC1)C(O)=O)-c1ncco1)OC1CCOCC1
Show InChI InChI=1S/C29H31N3O8S/c1-17-22-25(33)32(29(27(34)35)10-5-11-29)28(36)31(26(22)41-23(17)24-30-12-15-39-24)16-21(40-18-8-13-38-14-9-18)19-6-3-4-7-20(19)37-2/h3-4,6-7,12,15,18,21H,5,8-11,13-14,16H2,1-2H3,(H,34,35)
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM489789
PNG
(US10995099, Example 33)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(c(C)c2c(=O)n(c1=O)C1(CC1)C(O)=O)-c1ncco1)OC1CCOCC1
Show InChI InChI=1S/C28H29N3O8S/c1-16-21-24(32)31(28(9-10-28)26(33)34)27(35)30(25(21)40-22(16)23-29-11-14-38-23)15-20(39-17-7-12-37-13-8-17)18-5-3-4-6-19(18)36-2/h3-6,11,14,17,20H,7-10,12-13,15H2,1-2H3,(H,33,34)/t20-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM496904
PNG
(US10995099, Example 42)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(c(C)c2c(=O)n(c1=O)C(C)(C)C(N)=O)-c1ncco1)OC1CCOCC1
Show InChI InChI=1S/C28H32N4O7S/c1-16-21-24(33)32(28(2,3)26(29)34)27(35)31(25(21)40-22(16)23-30-11-14-38-23)15-20(39-17-9-12-37-13-10-17)18-7-5-6-8-19(18)36-4/h5-8,11,14,17,20H,9-10,12-13,15H2,1-4H3,(H2,29,34)/t20-/m0/s1
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n/an/a<1n/an/an/an/an/an/a



Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM496965
PNG
(US10995099, Example 55)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(c(C)c2c(=O)n(c1=O)C1(CCCC1)C(O)=O)-n1nccn1)OC1CCOCC1
Show InChI InChI=1S/C29H33N5O7S/c1-18-23-24(35)33(29(27(36)37)11-5-6-12-29)28(38)32(26(23)42-25(18)34-30-13-14-31-34)17-22(41-19-9-15-40-16-10-19)20-7-3-4-8-21(20)39-2/h3-4,7-8,13-14,19,22H,5-6,9-12,15-17H2,1-2H3,(H,36,37)/t22-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM50069756
PNG
(CHEMBL3407547 | US10995099, Example 38)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(c(C)c2c(=O)n(c1=O)C(C)(C)C(O)=O)-c1ncco1)OC1CCOCC1
Show InChI InChI=1S/C28H31N3O8S/c1-16-21-24(32)31(28(2,3)26(33)34)27(35)30(25(21)40-22(16)23-29-11-14-38-23)15-20(39-17-9-12-37-13-10-17)18-7-5-6-8-19(18)36-4/h5-8,11,14,17,20H,9-10,12-13,15H2,1-4H3,(H,33,34)/t20-/m0/s1
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PC sid
UniChem

Similars

US Patent
n/an/a<1n/an/an/an/an/an/a



Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM496913
PNG
(US10995099, Example 47)
Show SMILES CNC(=O)C1(CC1)n1c(=O)n(CC(OC2CCOCC2)c2ccccc2OC)c2sc(c(C)c2c1=O)-c1ncco1
Show InChI InChI=1S/C29H32N4O7S/c1-17-22-25(34)33(29(10-11-29)27(35)30-2)28(36)32(26(22)41-23(17)24-31-12-15-39-24)16-21(40-18-8-13-38-14-9-18)19-6-4-5-7-20(19)37-3/h4-7,12,15,18,21H,8-11,13-14,16H2,1-3H3,(H,30,35)
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM496905
PNG
(US10995099, Example 43)
Show SMILES COc1ccccc1C(Cn1c2sc(c(C)c2c(=O)n(c1=O)C1(CCCC1)C(N)=O)-c1ncco1)OC1CCOCC1
Show InChI InChI=1S/C30H34N4O7S/c1-18-23-26(35)34(30(28(31)36)11-5-6-12-30)29(37)33(27(23)42-24(18)25-32-13-16-40-25)17-22(41-19-9-14-39-15-10-19)20-7-3-4-8-21(20)38-2/h3-4,7-8,13,16,19,22H,5-6,9-12,14-15,17H2,1-2H3,(H2,31,36)
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM496976
PNG
(US10995099, Example 66)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(c(C)c2c(=O)n(c1=O)C(C)(C)C(=O)OC(C)(C)C)-c1ncco1)OC1CCOCC1
Show InChI InChI=1S/C32H39N3O8S/c1-19-24-27(36)35(32(5,6)29(37)43-31(2,3)4)30(38)34(28(24)44-25(19)26-33-14-17-41-26)18-23(42-20-12-15-40-16-13-20)21-10-8-9-11-22(21)39-7/h8-11,14,17,20,23H,12-13,15-16,18H2,1-7H3/t23-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM496964
PNG
(US10995099, Example 54)
Show SMILES COc1ccccc1C(Cn1c2sc(c(C)c2c(=O)n(c1=O)C1(CCC1)C(N)=O)-c1ncco1)OC1CCOCC1
Show InChI InChI=1S/C29H32N4O7S/c1-17-22-25(34)33(29(27(30)35)10-5-11-29)28(36)32(26(22)41-23(17)24-31-12-15-39-24)16-21(40-18-8-13-38-14-9-18)19-6-3-4-7-20(19)37-2/h3-4,6-7,12,15,18,21H,5,8-11,13-14,16H2,1-2H3,(H2,30,35)
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM496974
PNG
(US10995099, Example 64)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(c(C)c2c(=O)n(c1=O)C1(CC(N)=O)CC1)-c1ncco1)OC1CCOCC1
Show InChI InChI=1S/C29H32N4O7S/c1-17-23-26(35)33(29(9-10-29)15-22(30)34)28(36)32(27(23)41-24(17)25-31-11-14-39-25)16-21(40-18-7-12-38-13-8-18)19-5-3-4-6-20(19)37-2/h3-6,11,14,18,21H,7-10,12-13,15-16H2,1-2H3,(H2,30,34)/t21-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM496909
PNG
(US10995099, Example 44)
Show SMILES CNC(=O)C1(CCCC1)n1c(=O)n(CC(OC2CCOCC2)c2ccccc2OC)c2sc(c(C)c2c1=O)-c1ncco1
Show InChI InChI=1S/C31H36N4O7S/c1-19-24-27(36)35(31(29(37)32-2)12-6-7-13-31)30(38)34(28(24)43-25(19)26-33-14-17-41-26)18-23(42-20-10-15-40-16-11-20)21-8-4-5-9-22(21)39-3/h4-5,8-9,14,17,20,23H,6-7,10-13,15-16,18H2,1-3H3,(H,32,37)
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM496972
PNG
(US10995099, Example 62)
Show SMILES CNC(=O)CC1(CC1)n1c(=O)n(C[C@H](OC2CCOCC2)c2ccccc2OC)c2sc(Br)c(C)c2c1=O
Show InChI InChI=1S/C27H32BrN3O6S/c1-16-22-24(33)31(27(10-11-27)14-21(32)29-2)26(34)30(25(22)38-23(16)28)15-20(37-17-8-12-36-13-9-17)18-6-4-5-7-19(18)35-3/h4-7,17,20H,8-15H2,1-3H3,(H,29,32)/t20-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM489785
PNG
(US10995099, Example 29)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(Br)c(C)c2c(=O)n(c1=O)C1(CC1)C(O)=O)OC1CCOCC1
Show InChI InChI=1S/C25H27BrN2O7S/c1-14-19-21(29)28(25(9-10-25)23(30)31)24(32)27(22(19)36-20(14)26)13-18(35-15-7-11-34-12-8-15)16-5-3-4-6-17(16)33-2/h3-6,15,18H,7-13H2,1-2H3,(H,30,31)/t18-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM496973
PNG
(US10995099, Example 63)
Show SMILES CNC(=O)CC1(CC1)n1c(=O)n(C[C@H](OC2CCOCC2)c2ccccc2OC)c2sc(c(C)c2c1=O)-c1ncco1
Show InChI InChI=1S/C30H34N4O7S/c1-18-24-27(36)34(30(10-11-30)16-23(35)31-2)29(37)33(28(24)42-25(18)26-32-12-15-40-26)17-22(41-19-8-13-39-14-9-19)20-6-4-5-7-21(20)38-3/h4-7,12,15,19,22H,8-11,13-14,16-17H2,1-3H3,(H,31,35)/t22-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM496921
PNG
(US10995099, Example 53)
Show SMILES CNC(=O)C1(CCC1)n1c(=O)n(CC(OC2CCOCC2)c2ccccc2OC)c2sc(c(C)c2c1=O)-c1ncco1
Show InChI InChI=1S/C30H34N4O7S/c1-18-23-26(35)34(30(11-6-12-30)28(36)31-2)29(37)33(27(23)42-24(18)25-32-13-16-40-25)17-22(41-19-9-14-39-15-10-19)20-7-4-5-8-21(20)38-3/h4-5,7-8,13,16,19,22H,6,9-12,14-15,17H2,1-3H3,(H,31,36)
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM496912
PNG
(US10995099, Example 46)
Show SMILES COc1ccccc1C(Cn1c2sc(c(C)c2c(=O)n(c1=O)C1(CC1)C(N)=O)-c1ncco1)OC1CCOCC1
Show InChI InChI=1S/C28H30N4O7S/c1-16-21-24(33)32(28(9-10-28)26(29)34)27(35)31(25(21)40-22(16)23-30-11-14-38-23)15-20(39-17-7-12-37-13-8-17)18-5-3-4-6-19(18)36-2/h3-6,11,14,17,20H,7-10,12-13,15H2,1-2H3,(H2,29,34)
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM489781
PNG
(US10995099, Example 25 | US10995099, Example 36)
Show SMILES COc1ccccc1C(Cn1c2sc(c(C)c2c(=O)n(c1=O)C1(CCCC1)C(O)=O)-c1ncco1)OC1CCOCC1
Show InChI InChI=1S/C30H33N3O8S/c1-18-23-26(34)33(30(28(35)36)11-5-6-12-30)29(37)32(27(23)42-24(18)25-31-13-16-40-25)17-22(41-19-9-14-39-15-10-19)20-7-3-4-8-21(20)38-2/h3-4,7-8,13,16,19,22H,5-6,9-12,14-15,17H2,1-2H3,(H,35,36)
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM489787
PNG
(US10995099, Example 31)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(Br)c(C)c2c(=O)n(c1=O)C1(CCC1)C(O)=O)OC1CCOCC1
Show InChI InChI=1S/C26H29BrN2O7S/c1-15-20-22(30)29(26(24(31)32)10-5-11-26)25(33)28(23(20)37-21(15)27)14-19(36-16-8-12-35-13-9-16)17-6-3-4-7-18(17)34-2/h3-4,6-7,16,19H,5,8-14H2,1-2H3,(H,31,32)/t19-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM489786
PNG
(US10995099, Example 30)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(Br)c(C)c2c(=O)n(c1=O)C1(CCCC1)C(O)=O)OC1CCOCC1
Show InChI InChI=1S/C27H31BrN2O7S/c1-16-21-23(31)30(27(25(32)33)11-5-6-12-27)26(34)29(24(21)38-22(16)28)15-20(37-17-9-13-36-14-10-17)18-7-3-4-8-19(18)35-2/h3-4,7-8,17,20H,5-6,9-15H2,1-2H3,(H,32,33)/t20-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM496974
PNG
(US10995099, Example 64)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(c(C)c2c(=O)n(c1=O)C1(CC(N)=O)CC1)-c1ncco1)OC1CCOCC1
Show InChI InChI=1S/C29H32N4O7S/c1-17-23-26(35)33(29(9-10-29)15-22(30)34)28(36)32(27(23)41-24(17)25-31-11-14-39-25)16-21(40-18-7-12-38-13-8-18)19-5-3-4-6-20(19)37-2/h3-6,11,14,18,21H,7-10,12-13,15-16H2,1-2H3,(H2,30,34)/t21-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM496914
PNG
(US10995099, Example 48)
Show SMILES COc1ccccc1C(Cn1c2sc(Br)c(C)c2c(=O)n(c1=O)C1(CCCC1)C(N)=O)OC1CCOCC1
Show InChI InChI=1S/C27H32BrN3O6S/c1-16-21-23(32)31(27(25(29)33)11-5-6-12-27)26(34)30(24(21)38-22(16)28)15-20(37-17-9-13-36-14-10-17)18-7-3-4-8-19(18)35-2/h3-4,7-8,17,20H,5-6,9-15H2,1-2H3,(H2,29,33)
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM496921
PNG
(US10995099, Example 53)
Show SMILES CNC(=O)C1(CCC1)n1c(=O)n(CC(OC2CCOCC2)c2ccccc2OC)c2sc(c(C)c2c1=O)-c1ncco1
Show InChI InChI=1S/C30H34N4O7S/c1-18-23-26(35)34(30(11-6-12-30)28(36)31-2)29(37)33(27(23)42-24(18)25-32-13-16-40-25)17-22(41-19-9-14-39-15-10-19)20-7-4-5-8-21(20)38-3/h4-5,7-8,13,16,19,22H,6,9-12,14-15,17H2,1-3H3,(H,31,36)
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM496915
PNG
(US10995099, Example 49)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(c(C)c2c(=O)n(c1=O)C1(CC1)C(O)=O)-n1nccn1)OC1CCOCC1
Show InChI InChI=1S/C27H29N5O7S/c1-16-21-22(33)31(27(9-10-27)25(34)35)26(36)30(24(21)40-23(16)32-28-11-12-29-32)15-20(39-17-7-13-38-14-8-17)18-5-3-4-6-19(18)37-2/h3-6,11-12,17,20H,7-10,13-15H2,1-2H3,(H,34,35)/t20-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM496979
PNG
(US10995099, Example 69)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(c(C)c2c(=O)n(C2CCC2C(O)=O)c1=O)-c1ncco1)OC1CCOCC1
Show InChI InChI=1S/C29H31N3O8S/c1-16-23-26(33)32(20-8-7-18(20)28(34)35)29(36)31(27(23)41-24(16)25-30-11-14-39-25)15-22(40-17-9-12-38-13-10-17)19-5-3-4-6-21(19)37-2/h3-6,11,14,17-18,20,22H,7-10,12-13,15H2,1-2H3,(H,34,35)/t18?,20?,22-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM496910
PNG
(US10995099, Example 45)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(c(C)c2c(=O)n(c1=O)C1(CC1)C(O)=O)-n1cccn1)OC1CCOCC1
Show InChI InChI=1S/C28H30N4O7S/c1-17-22-23(33)32(28(10-11-28)26(34)35)27(36)30(25(22)40-24(17)31-13-5-12-29-31)16-21(39-18-8-14-38-15-9-18)19-6-3-4-7-20(19)37-2/h3-7,12-13,18,21H,8-11,14-16H2,1-2H3,(H,34,35)/t21-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM489781
PNG
(US10995099, Example 25 | US10995099, Example 36)
Show SMILES COc1ccccc1C(Cn1c2sc(c(C)c2c(=O)n(c1=O)C1(CCCC1)C(O)=O)-c1ncco1)OC1CCOCC1
Show InChI InChI=1S/C30H33N3O8S/c1-18-23-26(34)33(30(28(35)36)11-5-6-12-30)29(37)32(27(23)42-24(18)25-31-13-16-40-25)17-22(41-19-9-14-39-15-10-19)20-7-3-4-8-21(20)38-2/h3-4,7-8,13,16,19,22H,5-6,9-12,14-15,17H2,1-2H3,(H,35,36)
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM489787
PNG
(US10995099, Example 31)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(Br)c(C)c2c(=O)n(c1=O)C1(CCC1)C(O)=O)OC1CCOCC1
Show InChI InChI=1S/C26H29BrN2O7S/c1-15-20-22(30)29(26(24(31)32)10-5-11-26)25(33)28(23(20)37-21(15)27)14-19(36-16-8-12-35-13-9-16)17-6-3-4-7-18(17)34-2/h3-4,6-7,16,19H,5,8-14H2,1-2H3,(H,31,32)/t19-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM489785
PNG
(US10995099, Example 29)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(Br)c(C)c2c(=O)n(c1=O)C1(CC1)C(O)=O)OC1CCOCC1
Show InChI InChI=1S/C25H27BrN2O7S/c1-14-19-21(29)28(25(9-10-25)23(30)31)24(32)27(22(19)36-20(14)26)13-18(35-15-7-11-34-12-8-15)16-5-3-4-6-17(16)33-2/h3-6,15,18H,7-13H2,1-2H3,(H,30,31)/t18-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM496904
PNG
(US10995099, Example 42)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(c(C)c2c(=O)n(c1=O)C(C)(C)C(N)=O)-c1ncco1)OC1CCOCC1
Show InChI InChI=1S/C28H32N4O7S/c1-16-21-24(33)32(28(2,3)26(29)34)27(35)31(25(21)40-22(16)23-30-11-14-38-23)15-20(39-17-9-12-37-13-10-17)18-7-5-6-8-19(18)36-4/h5-8,11,14,17,20H,9-10,12-13,15H2,1-4H3,(H2,29,34)/t20-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM496905
PNG
(US10995099, Example 43)
Show SMILES COc1ccccc1C(Cn1c2sc(c(C)c2c(=O)n(c1=O)C1(CCCC1)C(N)=O)-c1ncco1)OC1CCOCC1
Show InChI InChI=1S/C30H34N4O7S/c1-18-23-26(35)34(30(28(31)36)11-5-6-12-30)29(37)33(27(23)42-24(18)25-32-13-16-40-25)17-22(41-19-9-14-39-15-10-19)20-7-3-4-8-21(20)38-2/h3-4,7-8,13,16,19,22H,5-6,9-12,14-15,17H2,1-2H3,(H2,31,36)
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM496903
PNG
(US10995099, Example 41)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(c(C)c2c(=O)n(c1=O)C1(CC1)C(=O)NS(C)(=O)=O)-c1ncco1)OC1CCOCC1
Show InChI InChI=1S/C29H32N4O9S2/c1-17-22-25(34)33(29(10-11-29)27(35)31-44(3,37)38)28(36)32(26(22)43-23(17)24-30-12-15-41-24)16-21(42-18-8-13-40-14-9-18)19-6-4-5-7-20(19)39-2/h4-7,12,15,18,21H,8-11,13-14,16H2,1-3H3,(H,31,35)/t21-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM50069756
PNG
(CHEMBL3407547 | US10995099, Example 38)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(c(C)c2c(=O)n(c1=O)C(C)(C)C(O)=O)-c1ncco1)OC1CCOCC1
Show InChI InChI=1S/C28H31N3O8S/c1-16-21-24(32)31(28(2,3)26(33)34)27(35)30(25(21)40-22(16)23-29-11-14-38-23)15-20(39-17-9-12-37-13-10-17)18-7-5-6-8-19(18)36-4/h5-8,11,14,17,20H,9-10,12-13,15H2,1-4H3,(H,33,34)/t20-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM496965
PNG
(US10995099, Example 55)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(c(C)c2c(=O)n(c1=O)C1(CCCC1)C(O)=O)-n1nccn1)OC1CCOCC1
Show InChI InChI=1S/C29H33N5O7S/c1-18-23-24(35)33(29(27(36)37)11-5-6-12-29)28(38)32(26(23)42-25(18)34-30-13-14-31-34)17-22(41-19-9-15-40-16-10-19)20-7-3-4-8-21(20)39-2/h3-4,7-8,13-14,19,22H,5-6,9-12,15-17H2,1-2H3,(H,36,37)/t22-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM489782
PNG
(US10995099, Example 26 | US10995099, Example 37)
Show SMILES COc1ccccc1C(Cn1c2sc(c(C)c2c(=O)n(c1=O)C1(CCC1)C(O)=O)-c1ncco1)OC1CCOCC1
Show InChI InChI=1S/C29H31N3O8S/c1-17-22-25(33)32(29(27(34)35)10-5-11-29)28(36)31(26(22)41-23(17)24-30-12-15-39-24)16-21(40-18-8-13-38-14-9-18)19-6-3-4-7-20(19)37-2/h3-4,6-7,12,15,18,21H,5,8-11,13-14,16H2,1-2H3,(H,34,35)
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM489789
PNG
(US10995099, Example 33)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(c(C)c2c(=O)n(c1=O)C1(CC1)C(O)=O)-c1ncco1)OC1CCOCC1
Show InChI InChI=1S/C28H29N3O8S/c1-16-21-24(32)31(28(9-10-28)26(33)34)27(35)30(25(21)40-22(16)23-29-11-14-38-23)15-20(39-17-7-12-37-13-8-17)18-5-3-4-6-19(18)36-2/h3-6,11,14,17,20H,7-10,12-13,15H2,1-2H3,(H,33,34)/t20-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM496971
PNG
(US10995099, Example 61)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(c(C)c2c(=O)n(c1=O)C1(CC(O)=O)CC1)-c1ncco1)OC1CCOCC1
Show InChI InChI=1S/C29H31N3O8S/c1-17-23-26(35)32(29(9-10-29)15-22(33)34)28(36)31(27(23)41-24(17)25-30-11-14-39-25)16-21(40-18-7-12-38-13-8-18)19-5-3-4-6-20(19)37-2/h3-6,11,14,18,21H,7-10,12-13,15-16H2,1-2H3,(H,33,34)/t21-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM489781
PNG
(US10995099, Example 25 | US10995099, Example 36)
Show SMILES COc1ccccc1C(Cn1c2sc(c(C)c2c(=O)n(c1=O)C1(CCCC1)C(O)=O)-c1ncco1)OC1CCOCC1
Show InChI InChI=1S/C30H33N3O8S/c1-18-23-26(34)33(30(28(35)36)11-5-6-12-30)29(37)32(27(23)42-24(18)25-31-13-16-40-25)17-22(41-19-9-14-39-15-10-19)20-7-3-4-8-21(20)38-2/h3-4,7-8,13,16,19,22H,5-6,9-12,14-15,17H2,1-2H3,(H,35,36)
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM489782
PNG
(US10995099, Example 26 | US10995099, Example 37)
Show SMILES COc1ccccc1C(Cn1c2sc(c(C)c2c(=O)n(c1=O)C1(CCC1)C(O)=O)-c1ncco1)OC1CCOCC1
Show InChI InChI=1S/C29H31N3O8S/c1-17-22-25(33)32(29(27(34)35)10-5-11-29)28(36)31(26(22)41-23(17)24-30-12-15-39-24)16-21(40-18-8-13-38-14-9-18)19-6-3-4-7-20(19)37-2/h3-4,6-7,12,15,18,21H,5,8-11,13-14,16H2,1-2H3,(H,34,35)
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM496968
PNG
(US10995099, Example 58)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(Br)c(C)c2c(=O)n(c1=O)C1(CC1)C(N)=O)OC1CCOCC1
Show InChI InChI=1S/C25H28BrN3O6S/c1-14-19-21(30)29(25(9-10-25)23(27)31)24(32)28(22(19)36-20(14)26)13-18(35-15-7-11-34-12-8-15)16-5-3-4-6-17(16)33-2/h3-6,15,18H,7-13H2,1-2H3,(H2,27,31)/t18-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM496917
PNG
(US10995099, Example 51)
Show SMILES COc1ccccc1C(Cn1c2sc(Br)c(C)c2c(=O)n(c1=O)C1(CCC1)C(N)=O)OC1CCOCC1
Show InChI InChI=1S/C26H30BrN3O6S/c1-15-20-22(31)30(26(24(28)32)10-5-11-26)25(33)29(23(20)37-21(15)27)14-19(36-16-8-12-35-13-9-16)17-6-3-4-7-18(17)34-2/h3-4,6-7,16,19H,5,8-14H2,1-2H3,(H2,28,32)
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM496918
PNG
(US10995099, Example 52)
Show SMILES CNC(=O)C1(CCC1)n1c(=O)n(CC(OC2CCOCC2)c2ccccc2OC)c2sc(Br)c(C)c2c1=O
Show InChI InChI=1S/C27H32BrN3O6S/c1-16-21-23(32)31(27(11-6-12-27)25(33)29-2)26(34)30(24(21)38-22(16)28)15-20(37-17-9-13-36-14-10-17)18-7-4-5-8-19(18)35-3/h4-5,7-8,17,20H,6,9-15H2,1-3H3,(H,29,33)
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM496969
PNG
(US10995099, Example 59)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(Br)c(C)c2c(=O)n(c1=O)C1(CC(O)=O)CC1)OC1CCOCC1
Show InChI InChI=1S/C26H29BrN2O7S/c1-15-21-23(32)29(26(9-10-26)13-20(30)31)25(33)28(24(21)37-22(15)27)14-19(36-16-7-11-35-12-8-16)17-5-3-4-6-18(17)34-2/h3-6,16,19H,7-14H2,1-2H3,(H,30,31)/t19-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM496970
PNG
(US10995099, Example 60)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(Br)c(C)c2c(=O)n(c1=O)C1(CC(N)=O)CC1)OC1CCOCC1
Show InChI InChI=1S/C26H30BrN3O6S/c1-15-21-23(32)30(26(9-10-26)13-20(28)31)25(33)29(24(21)37-22(15)27)14-19(36-16-7-11-35-12-8-16)17-5-3-4-6-18(17)34-2/h3-6,16,19H,7-14H2,1-2H3,(H2,28,31)/t19-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM496971
PNG
(US10995099, Example 61)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(c(C)c2c(=O)n(c1=O)C1(CC(O)=O)CC1)-c1ncco1)OC1CCOCC1
Show InChI InChI=1S/C29H31N3O8S/c1-17-23-26(35)32(29(9-10-29)15-22(33)34)28(36)31(27(23)41-24(17)25-30-11-14-39-25)16-21(40-18-7-12-38-13-8-18)19-5-3-4-6-20(19)37-2/h3-6,11,14,18,21H,7-10,12-13,15-16H2,1-2H3,(H,33,34)/t21-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM496977
PNG
(US10995099, Example 67)
Show SMILES COC(=O)C1(CCC1)n1c(=O)n(C[C@H](OC2CCOCC2)c2ccccc2OC)c2sc(Br)c(C)c2c1=O
Show InChI InChI=1S/C27H31BrN2O7S/c1-16-21-23(31)30(27(11-6-12-27)25(32)35-3)26(33)29(24(21)38-22(16)28)15-20(37-17-9-13-36-14-10-17)18-7-4-5-8-19(18)34-2/h4-5,7-8,17,20H,6,9-15H2,1-3H3/t20-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Homo sapiens (Human))
BDBM496978
PNG
(US10995099, Example 68)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(Br)c(C)c2c(=O)n(c1=O)C(C)(C)C(=O)OC(C)(C)C)OC1CCOCC1
Show InChI InChI=1S/C29H37BrN2O7S/c1-17-22-24(33)32(29(5,6)26(34)39-28(2,3)4)27(35)31(25(22)40-23(17)30)16-21(38-18-12-14-37-15-13-18)19-10-8-9-11-20(19)36-7/h8-11,18,21H,12-16H2,1-7H3/t21-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM50069756
PNG
(CHEMBL3407547 | US10995099, Example 38)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(c(C)c2c(=O)n(c1=O)C(C)(C)C(O)=O)-c1ncco1)OC1CCOCC1
Show InChI InChI=1S/C28H31N3O8S/c1-16-21-24(32)31(28(2,3)26(33)34)27(35)30(25(21)40-22(16)23-29-11-14-38-23)15-20(39-17-9-12-37-13-10-17)18-7-5-6-8-19(18)36-4/h5-8,11,14,17,20H,9-10,12-13,15H2,1-4H3,(H,33,34)/t20-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM496969
PNG
(US10995099, Example 59)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(Br)c(C)c2c(=O)n(c1=O)C1(CC(O)=O)CC1)OC1CCOCC1
Show InChI InChI=1S/C26H29BrN2O7S/c1-15-21-23(32)29(26(9-10-26)13-20(30)31)25(33)28(24(21)37-22(15)27)14-19(36-16-7-11-35-12-8-16)17-5-3-4-6-18(17)34-2/h3-6,16,19H,7-14H2,1-2H3,(H,30,31)/t19-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM496913
PNG
(US10995099, Example 47)
Show SMILES CNC(=O)C1(CC1)n1c(=O)n(CC(OC2CCOCC2)c2ccccc2OC)c2sc(c(C)c2c1=O)-c1ncco1
Show InChI InChI=1S/C29H32N4O7S/c1-17-22-25(34)33(29(10-11-29)27(35)30-2)28(36)32(26(22)41-23(17)24-31-12-15-39-24)16-21(40-18-8-13-38-14-9-18)19-6-4-5-7-20(19)37-3/h4-7,12,15,18,21H,8-11,13-14,16H2,1-3H3,(H,30,35)
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM489764
PNG
(US10995099, Example 10)
Show SMILES COc1ccccc1C(Cn1c2sc(Br)c(C)c2c(=O)n(c1=O)C(C)(C)C(O)=O)OC1CCOCC1
Show InChI InChI=1S/C25H29BrN2O7S/c1-14-19-21(29)28(25(2,3)23(30)31)24(32)27(22(19)36-20(14)26)13-18(35-15-9-11-34-12-10-15)16-7-5-6-8-17(16)33-4/h5-8,15,18H,9-13H2,1-4H3,(H,30,31)
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM489765
PNG
(US10995099, Example 82)
Show SMILES COc1ccccc1C(Cn1c2sc(c(C)c2c(=O)n(c1=O)C1(CC(O)=O)CC1)-c1ncco1)OC1CCOCC1
Show InChI InChI=1S/C29H31N3O8S/c1-17-23-26(35)32(29(9-10-29)15-22(33)34)28(36)31(27(23)41-24(17)25-30-11-14-39-25)16-21(40-18-7-12-38-13-8-18)19-5-3-4-6-20(19)37-2/h3-6,11,14,18,21H,7-10,12-13,15-16H2,1-2H3,(H,33,34)
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM496972
PNG
(US10995099, Example 62)
Show SMILES CNC(=O)CC1(CC1)n1c(=O)n(C[C@H](OC2CCOCC2)c2ccccc2OC)c2sc(Br)c(C)c2c1=O
Show InChI InChI=1S/C27H32BrN3O6S/c1-16-22-24(33)31(27(10-11-27)14-21(32)29-2)26(34)30(25(22)38-23(16)28)15-20(37-17-8-12-36-13-9-17)18-6-4-5-7-19(18)35-3/h4-7,17,20H,8-15H2,1-3H3,(H,29,32)/t20-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM496970
PNG
(US10995099, Example 60)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(Br)c(C)c2c(=O)n(c1=O)C1(CC(N)=O)CC1)OC1CCOCC1
Show InChI InChI=1S/C26H30BrN3O6S/c1-15-21-23(32)30(26(9-10-26)13-20(28)31)25(33)29(24(21)37-22(15)27)14-19(36-16-7-11-35-12-8-16)17-5-3-4-6-18(17)34-2/h3-6,16,19H,7-14H2,1-2H3,(H2,28,31)/t19-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM496912
PNG
(US10995099, Example 46)
Show SMILES COc1ccccc1C(Cn1c2sc(c(C)c2c(=O)n(c1=O)C1(CC1)C(N)=O)-c1ncco1)OC1CCOCC1
Show InChI InChI=1S/C28H30N4O7S/c1-16-21-24(33)32(28(9-10-28)26(29)34)27(35)31(25(21)40-22(16)23-30-11-14-38-23)15-20(39-17-7-12-37-13-8-17)18-5-3-4-6-19(18)36-2/h3-6,11,14,17,20H,7-10,12-13,15H2,1-2H3,(H2,29,34)
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM489775
PNG
(US10995099, Example 19)
Show SMILES COc1ccccc1C(Cn1c2sc(c(C)c2c(=O)n(c1=O)C1(CC(N)=O)CC1)-c1ncco1)OC1CCOCC1
Show InChI InChI=1S/C29H32N4O7S/c1-17-23-26(35)33(29(9-10-29)15-22(30)34)28(36)32(27(23)41-24(17)25-31-11-14-39-25)16-21(40-18-7-12-38-13-8-18)19-5-3-4-6-20(19)37-2/h3-6,11,14,18,21H,7-10,12-13,15-16H2,1-2H3,(H2,30,34)
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM496976
PNG
(US10995099, Example 66)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(c(C)c2c(=O)n(c1=O)C(C)(C)C(=O)OC(C)(C)C)-c1ncco1)OC1CCOCC1
Show InChI InChI=1S/C32H39N3O8S/c1-19-24-27(36)35(32(5,6)29(37)43-31(2,3)4)30(38)34(28(24)44-25(19)26-33-14-17-41-26)18-23(42-20-12-15-40-16-13-20)21-10-8-9-11-22(21)39-7/h8-11,14,17,20,23H,12-13,15-16,18H2,1-7H3/t23-/m0/s1
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n/an/a 55n/an/an/an/an/an/a



Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM496909
PNG
(US10995099, Example 44)
Show SMILES CNC(=O)C1(CCCC1)n1c(=O)n(CC(OC2CCOCC2)c2ccccc2OC)c2sc(c(C)c2c1=O)-c1ncco1
Show InChI InChI=1S/C31H36N4O7S/c1-19-24-27(36)35(31(29(37)32-2)12-6-7-13-31)30(38)34(28(24)43-25(19)26-33-14-17-41-26)18-23(42-20-10-15-40-16-11-20)21-8-4-5-9-22(21)39-3/h4-5,8-9,14,17,20,23H,6-7,10-13,15-16,18H2,1-3H3,(H,32,37)
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM496832
PNG
(US10995099, Example 40)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(Cl)c(C)c2c(=O)n(c1=O)C1(CC1)C(O)=O)OC1CCOCC1
Show InChI InChI=1S/C25H27ClN2O7S/c1-14-19-21(29)28(25(9-10-25)23(30)31)24(32)27(22(19)36-20(14)26)13-18(35-15-7-11-34-12-8-15)16-5-3-4-6-17(16)33-2/h3-6,15,18H,7-13H2,1-2H3,(H,30,31)/t18-/m0/s1
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n/an/a 55n/an/an/an/an/an/a



Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM496968
PNG
(US10995099, Example 58)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(Br)c(C)c2c(=O)n(c1=O)C1(CC1)C(N)=O)OC1CCOCC1
Show InChI InChI=1S/C25H28BrN3O6S/c1-14-19-21(30)29(25(9-10-25)23(27)31)24(32)28(22(19)36-20(14)26)13-18(35-15-7-11-34-12-8-15)16-5-3-4-6-17(16)33-2/h3-6,15,18H,7-13H2,1-2H3,(H2,27,31)/t18-/m0/s1
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n/an/a 55n/an/an/an/an/an/a



Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM489774
PNG
(US10995099, Example 80)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(c(C)c2c(=O)n(c1=O)C1(CC1)C(O)=O)-c1cnco1)OC1CCOCC1
Show InChI InChI=1S/C28H29N3O8S/c1-16-22-24(32)31(28(9-10-28)26(33)34)27(35)30(25(22)40-23(16)20-13-29-15-38-20)14-21(39-17-7-11-37-12-8-17)18-5-3-4-6-19(18)36-2/h3-6,13,15,17,21H,7-12,14H2,1-2H3,(H,33,34)/t21-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM496918
PNG
(US10995099, Example 52)
Show SMILES CNC(=O)C1(CCC1)n1c(=O)n(CC(OC2CCOCC2)c2ccccc2OC)c2sc(Br)c(C)c2c1=O
Show InChI InChI=1S/C27H32BrN3O6S/c1-16-21-23(32)31(27(11-6-12-27)25(33)29-2)26(34)30(24(21)38-22(16)28)15-20(37-17-9-13-36-14-10-17)18-7-4-5-8-19(18)35-3/h4-5,7-8,17,20H,6,9-15H2,1-3H3,(H,29,33)
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM496916
PNG
(US10995099, Example 50)
Show SMILES CNC(=O)C1(CCCC1)n1c(=O)n(CC(OC2CCOCC2)c2ccccc2OC)c2sc(Br)c(C)c2c1=O
Show InChI InChI=1S/C28H34BrN3O6S/c1-17-22-24(33)32(28(26(34)30-2)12-6-7-13-28)27(35)31(25(22)39-23(17)29)16-21(38-18-10-14-37-15-11-18)19-8-4-5-9-20(19)36-3/h4-5,8-9,18,21H,6-7,10-16H2,1-3H3,(H,30,34)
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM496975
PNG
(US10995099, Example 65)
Show SMILES COCCNC(=O)CC1(CC1)n1c(=O)n(CC(OC2CCOCC2)c2ccccc2OC)c2sc(c(C)c2c1=O)-c1ncco1
Show InChI InChI=1S/C32H38N4O8S/c1-20-26-29(38)36(32(10-11-32)18-25(37)33-12-16-40-2)31(39)35(30(26)45-27(20)28-34-13-17-43-28)19-24(44-21-8-14-42-15-9-21)22-6-4-5-7-23(22)41-3/h4-7,13,17,21,24H,8-12,14-16,18-19H2,1-3H3,(H,33,37)
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM489761
PNG
(US10995099, Example 18 | US10995099, Example 3)
Show SMILES COc1ccccc1C(Cn1c2sc(c(C)c2c(=O)n(c1=O)C1(CC1)C(O)=O)C(F)(F)F)OC1CCOCC1
Show InChI InChI=1S/C26H27F3N2O7S/c1-14-19-21(32)31(25(9-10-25)23(33)34)24(35)30(22(19)39-20(14)26(27,28)29)13-18(38-15-7-11-37-12-8-15)16-5-3-4-6-17(16)36-2/h3-6,15,18H,7-13H2,1-2H3,(H,33,34)
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM496964
PNG
(US10995099, Example 54)
Show SMILES COc1ccccc1C(Cn1c2sc(c(C)c2c(=O)n(c1=O)C1(CCC1)C(N)=O)-c1ncco1)OC1CCOCC1
Show InChI InChI=1S/C29H32N4O7S/c1-17-22-25(34)33(29(27(30)35)10-5-11-29)28(36)32(26(22)41-23(17)24-31-12-15-39-24)16-21(40-18-8-13-38-14-9-18)19-6-3-4-7-20(19)37-2/h3-4,6-7,12,15,18,21H,5,8-11,13-14,16H2,1-2H3,(H2,30,35)
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM489762
PNG
(US10995099, Example 21 | US10995099, Example 4)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(C(=O)N(C)C)c(C)c2c(=O)n(c1=O)C1(CC1)C(O)=O)OC1CCOCC1
Show InChI InChI=1S/C28H33N3O8S/c1-16-21-23(32)31(28(11-12-28)26(34)35)27(36)30(25(21)40-22(16)24(33)29(2)3)15-20(39-17-9-13-38-14-10-17)18-7-5-6-8-19(18)37-4/h5-8,17,20H,9-15H2,1-4H3,(H,34,35)/t20-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM496973
PNG
(US10995099, Example 63)
Show SMILES CNC(=O)CC1(CC1)n1c(=O)n(C[C@H](OC2CCOCC2)c2ccccc2OC)c2sc(c(C)c2c1=O)-c1ncco1
Show InChI InChI=1S/C30H34N4O7S/c1-18-24-27(36)34(30(10-11-30)16-23(35)31-2)29(37)33(28(24)42-25(18)26-32-12-15-40-26)17-22(41-19-8-13-39-14-9-19)20-6-4-5-7-21(20)38-3/h4-7,12,15,19,22H,8-11,13-14,16-17H2,1-3H3,(H,31,35)/t22-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM496917
PNG
(US10995099, Example 51)
Show SMILES COc1ccccc1C(Cn1c2sc(Br)c(C)c2c(=O)n(c1=O)C1(CCC1)C(N)=O)OC1CCOCC1
Show InChI InChI=1S/C26H30BrN3O6S/c1-15-20-22(31)30(26(24(28)32)10-5-11-26)25(33)29(23(20)37-21(15)27)14-19(36-16-8-12-35-13-9-16)17-6-3-4-7-18(17)34-2/h3-4,6-7,16,19H,5,8-14H2,1-2H3,(H2,28,32)
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM489776
PNG
(US10995099, Example 20)
Show SMILES CNC(=O)CC1(CC1)n1c(=O)n(CC(OC2CCOCC2)c2ccccc2OC)c2sc(c(C)c2c1=O)-c1ncco1
Show InChI InChI=1S/C30H34N4O7S/c1-18-24-27(36)34(30(10-11-30)16-23(35)31-2)29(37)33(28(24)42-25(18)26-32-12-15-40-26)17-22(41-19-8-13-39-14-9-19)20-6-4-5-7-21(20)38-3/h4-7,12,15,19,22H,8-11,13-14,16-17H2,1-3H3,(H,31,35)
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM489784
PNG
(US10995099, Example 28)
Show SMILES COc1ccccc1[C@@H](Cn1c2sc(c(C)c2c(=O)n(c1=O)C1(CC1)C(O)=O)-c1ncco1)OC1CCOCC1
Show InChI InChI=1S/C28H29N3O8S/c1-16-21-24(32)31(28(9-10-28)26(33)34)27(35)30(25(21)40-22(16)23-29-11-14-38-23)15-20(39-17-7-12-37-13-8-17)18-5-3-4-6-19(18)36-2/h3-6,11,14,17,20H,7-10,12-13,15H2,1-2H3,(H,33,34)/t20-/m1/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM489763
PNG
(US10995099, Example 9)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(c(C)c2c(=O)n(c1=O)C(C)(C)C(O)=O)-c1nnco1)OC1CCOCC1
Show InChI InChI=1S/C27H30N4O8S/c1-15-20-23(32)31(27(2,3)25(33)34)26(35)30(24(20)40-21(15)22-29-28-14-38-22)13-19(39-16-9-11-37-12-10-16)17-7-5-6-8-18(17)36-4/h5-8,14,16,19H,9-13H2,1-4H3,(H,33,34)/t19-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM489788
PNG
(US10995099, Example 32)
Show SMILES COc1ccccc1[C@@H](Cn1c2sc(Br)c(C)c2c(=O)n(c1=O)C1(CC1)C(O)=O)OC1CCOCC1
Show InChI InChI=1S/C25H27BrN2O7S/c1-14-19-21(29)28(25(9-10-25)23(30)31)24(32)27(22(19)36-20(14)26)13-18(35-15-7-11-34-12-8-15)16-5-3-4-6-17(16)33-2/h3-6,15,18H,7-13H2,1-2H3,(H,30,31)/t18-/m1/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM489778
PNG
(US10995099, Example 22)
Show SMILES CNC(=O)c1sc2n(C[C@H](OC3CCOCC3)c3ccccc3OC)c(=O)n(c(=O)c2c1C)C1(CC1)C(O)=O
Show InChI InChI=1S/C27H31N3O8S/c1-15-20-23(32)30(27(10-11-27)25(33)34)26(35)29(24(20)39-21(15)22(31)28-2)14-19(38-16-8-12-37-13-9-16)17-6-4-5-7-18(17)36-3/h4-7,16,19H,8-14H2,1-3H3,(H,28,31)(H,33,34)/t19-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM496978
PNG
(US10995099, Example 68)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(Br)c(C)c2c(=O)n(c1=O)C(C)(C)C(=O)OC(C)(C)C)OC1CCOCC1
Show InChI InChI=1S/C29H37BrN2O7S/c1-17-22-24(33)32(29(5,6)26(34)39-28(2,3)4)27(35)31(25(22)40-23(17)30)16-21(38-18-12-14-37-15-13-18)19-10-8-9-11-20(19)36-7/h8-11,18,21H,12-16H2,1-7H3/t21-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM489769
PNG
(US10995099, Example 14)
Show SMILES COc1ccccc1C(Cn1c2sc(C#N)c(C)c2c(=O)n(c1=O)C1(CC1)C(O)=O)OC1CCOCC1
Show InChI InChI=1S/C26H27N3O7S/c1-15-20(13-27)37-23-21(15)22(30)29(26(9-10-26)24(31)32)25(33)28(23)14-19(36-16-7-11-35-12-8-16)17-5-3-4-6-18(17)34-2/h3-6,16,19H,7-12,14H2,1-2H3,(H,31,32)
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n/an/a 550n/an/an/an/an/an/a



Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM489779
PNG
(US10995099, Example 23)
Show SMILES COc1ccccc1C(Cn1c2sc(Br)c(C)c2c(=O)n(c1=O)C1(CC(=O)N2CCOCC2)CC1)OC1CCOCC1
Show InChI InChI=1S/C30H36BrN3O7S/c1-19-25-27(36)34(30(9-10-30)17-24(35)32-11-15-40-16-12-32)29(37)33(28(25)42-26(19)31)18-23(41-20-7-13-39-14-8-20)21-5-3-4-6-22(21)38-2/h3-6,20,23H,7-18H2,1-2H3
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n/an/a 550n/an/an/an/an/an/a



Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM496977
PNG
(US10995099, Example 67)
Show SMILES COC(=O)C1(CCC1)n1c(=O)n(C[C@H](OC2CCOCC2)c2ccccc2OC)c2sc(Br)c(C)c2c1=O
Show InChI InChI=1S/C27H31BrN2O7S/c1-16-21-23(31)30(27(11-6-12-27)25(32)35-3)26(33)29(24(21)38-22(16)28)15-20(37-17-9-13-36-14-10-17)18-7-4-5-8-19(18)34-2/h4-5,7-8,17,20H,6,9-15H2,1-3H3/t20-/m0/s1
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n/an/a 550n/an/an/an/an/an/a



Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM496967
PNG
(US10995099, Example 57)
Show SMILES CNC(=O)C1(CC1)n1c(=O)n(C[C@H](OC2CCOCC2)c2ccccc2OC)c2sc(Br)cc2c1=O
Show InChI InChI=1S/C25H28BrN3O6S/c1-27-23(31)25(9-10-25)29-21(30)17-13-20(26)36-22(17)28(24(29)32)14-19(35-15-7-11-34-12-8-15)16-5-3-4-6-18(16)33-2/h3-6,13,15,19H,7-12,14H2,1-2H3,(H,27,31)/t19-/m0/s1
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n/an/a 550n/an/an/an/an/an/a



Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM496966
PNG
(US10995099, Example 56)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(c(C)c2c(=O)n(c1=O)C1(CC1)C(O)=O)-n1cncn1)OC1CCOCC1
Show InChI InChI=1S/C27H29N5O7S/c1-16-21-22(33)32(27(9-10-27)25(34)35)26(36)30(24(21)40-23(16)31-15-28-14-29-31)13-20(39-17-7-11-38-12-8-17)18-5-3-4-6-19(18)37-2/h3-6,14-15,17,20H,7-13H2,1-2H3,(H,34,35)/t20-/m0/s1
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n/an/a 550n/an/an/an/an/an/a



Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM489780
PNG
(US10995099, Example 24)
Show SMILES COc1ccccc1C(Cn1c2sc(Br)c(C)c2c(=O)n(c1=O)C1(CC(=O)N2CCN(C)CC2)CC1)OC1CCOCC1
Show InChI InChI=1S/C31H39BrN4O6S/c1-20-26-28(38)36(31(10-11-31)18-25(37)34-14-12-33(2)13-15-34)30(39)35(29(26)43-27(20)32)19-24(42-21-8-16-41-17-9-21)22-6-4-5-7-23(22)40-3/h4-7,21,24H,8-19H2,1-3H3
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n/an/a 550n/an/an/an/an/an/a



Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM489770
PNG
(US10995099, Example 15)
Show SMILES COc1ccccc1C(Cn1c2sc(Br)c(C)c2c(=O)n(c1=O)C1(CC1)C(=O)C(O)=O)OC1CCOCC1
Show InChI InChI=1S/C26H27BrN2O8S/c1-14-19-22(31)29(26(9-10-26)20(30)24(32)33)25(34)28(23(19)38-21(14)27)13-18(37-15-7-11-36-12-8-15)16-5-3-4-6-17(16)35-2/h3-6,15,18H,7-13H2,1-2H3,(H,32,33)
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM489768
PNG
(US10995099, Example 13)
Show SMILES COc1ccccc1C(O)Cn1c2cc(-c3ncco3)c(C)cc2c(=O)n(c1=O)C(C)(C)C(O)=O
Show InChI InChI=1S/C25H25N3O7/c1-14-11-17-18(12-16(14)21-26-9-10-35-21)27(13-19(29)15-7-5-6-8-20(15)34-4)24(33)28(22(17)30)25(2,3)23(31)32/h5-12,19,29H,13H2,1-4H3,(H,31,32)
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM489761
PNG
(US10995099, Example 18 | US10995099, Example 3)
Show SMILES COc1ccccc1C(Cn1c2sc(c(C)c2c(=O)n(c1=O)C1(CC1)C(O)=O)C(F)(F)F)OC1CCOCC1
Show InChI InChI=1S/C26H27F3N2O7S/c1-14-19-21(32)31(25(9-10-25)23(33)34)24(35)30(22(19)39-20(14)26(27,28)29)13-18(38-15-7-11-37-12-8-15)16-5-3-4-6-17(16)36-2/h3-6,15,18H,7-13H2,1-2H3,(H,33,34)
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM489771
PNG
(US10995099, Example 16 | US10995099, Example 17)
Show SMILES COc1ccccc1[C@H](Cn1c2scc(C)c2c(=O)n(c1=O)C1(CC1)C(O)=O)OC1CCOCC1
Show InChI InChI=1S/C25H28N2O7S/c1-15-14-35-22-20(15)21(28)27(25(9-10-25)23(29)30)24(31)26(22)13-19(34-16-7-11-33-12-8-16)17-5-3-4-6-18(17)32-2/h3-6,14,16,19H,7-13H2,1-2H3,(H,29,30)/t19-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM489767
PNG
(US10995099, Example 12)
Show SMILES COc1ccccc1C(Cn1c2cc(Br)c(C)cc2c(=O)n(c1=O)C(C)(C)C(O)=O)OC1CCOCC1
Show InChI InChI=1S/C27H31BrN2O7/c1-16-13-19-21(14-20(16)28)29(26(34)30(24(19)31)27(2,3)25(32)33)15-23(37-17-9-11-36-12-10-17)18-7-5-6-8-22(18)35-4/h5-8,13-14,17,23H,9-12,15H2,1-4H3,(H,32,33)
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM489805
PNG
(US10995099, Example 34 | US10995099, Example 35)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(CN)c(C)c2c(=O)n(c1=O)C1(CCC1)C(O)=O)OC1CCOCC1
Show InChI InChI=1S/C27H33N3O7S/c1-16-21(14-28)38-24-22(16)23(31)30(27(25(32)33)10-5-11-27)26(34)29(24)15-20(37-17-8-12-36-13-9-17)18-6-3-4-7-19(18)35-2/h3-4,6-7,17,20H,5,8-15,28H2,1-2H3,(H,32,33)/t20-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM489762
PNG
(US10995099, Example 21 | US10995099, Example 4)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(C(=O)N(C)C)c(C)c2c(=O)n(c1=O)C1(CC1)C(O)=O)OC1CCOCC1
Show InChI InChI=1S/C28H33N3O8S/c1-16-21-23(32)31(28(11-12-28)26(34)35)27(36)30(25(21)40-22(16)24(33)29(2)3)15-20(39-17-9-13-38-14-10-17)18-7-5-6-8-19(18)37-4/h5-8,17,20H,9-15H2,1-4H3,(H,34,35)/t20-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM489805
PNG
(US10995099, Example 34 | US10995099, Example 35)
Show SMILES COc1ccccc1[C@H](Cn1c2sc(CN)c(C)c2c(=O)n(c1=O)C1(CCC1)C(O)=O)OC1CCOCC1
Show InChI InChI=1S/C27H33N3O7S/c1-16-21(14-28)38-24-22(16)23(31)30(27(25(32)33)10-5-11-27)26(34)29(24)15-20(37-17-8-12-36-13-9-17)18-6-3-4-7-19(18)35-2/h3-4,6-7,17,20H,5,8-15,28H2,1-2H3,(H,32,33)/t20-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM489771
PNG
(US10995099, Example 16 | US10995099, Example 17)
Show SMILES COc1ccccc1[C@H](Cn1c2scc(C)c2c(=O)n(c1=O)C1(CC1)C(O)=O)OC1CCOCC1
Show InChI InChI=1S/C25H28N2O7S/c1-15-14-35-22-20(15)21(28)27(25(9-10-25)23(29)30)24(31)26(22)13-19(34-16-7-11-33-12-8-16)17-5-3-4-6-18(17)32-2/h3-6,14,16,19H,7-13H2,1-2H3,(H,29,30)/t19-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM489766
PNG
(US10995099, Example 11)
Show SMILES COc1ccccc1C(Cn1c2cc(-c3ncco3)c(C)cc2c(=O)n(c1=O)C(C)(C)C(O)=O)OC1CCOCC1
Show InChI InChI=1S/C30H33N3O8/c1-18-15-22-23(16-21(18)26-31-11-14-40-26)32(29(37)33(27(22)34)30(2,3)28(35)36)17-25(41-19-9-12-39-13-10-19)20-7-5-6-8-24(20)38-4/h5-8,11,14-16,19,25H,9-10,12-13,17H2,1-4H3,(H,35,36)
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM489783
PNG
(US10995099, Example 27)
Show SMILES COCc1sc2n(C[C@H](CC3CCOCC3)c3ccccc3OC)c(=O)n(c(=O)c2c1C)C1(CCCC1)C(O)=O
Show InChI InChI=1S/C30H38N2O7S/c1-19-24(18-37-2)40-27-25(19)26(33)32(30(28(34)35)12-6-7-13-30)29(36)31(27)17-21(16-20-10-14-39-15-11-20)22-8-4-5-9-23(22)38-3/h4-5,8-9,20-21H,6-7,10-18H2,1-3H3,(H,34,35)/t21-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase


(Homo sapiens (Human))
BDBM496814
PNG
(US10995099, Example 39)
Show SMILES COc1ccccc1[C@H](Cn1c2ccc(cc2c(=O)n(c1=O)C1(CC1)C(O)=O)-c1ncco1)OC1CCOCC1
Show InChI InChI=1S/C29H29N3O8/c1-37-23-5-3-2-4-20(23)24(40-19-8-13-38-14-9-19)17-31-22-7-6-18(25-30-12-15-39-25)16-21(22)26(33)32(28(31)36)29(10-11-29)27(34)35/h2-7,12,15-16,19,24H,8-11,13-14,17H2,1H3,(H,34,35)/t24-/m0/s1
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Nanjing Ruijie Pharmatech Co., Ltd.

US Patent


Assay Description
An exemplary procedure for the in vitro ACC inhibition assay, which can be used to determine the inhibitory action of compounds of the invention towa...


US Patent US10995099 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%