BindingDB logo
myBDB logout

Patent code US11000528

Compile Data Set for Download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK1 (850-1154)


()
BDBM103737
PNG
(US10206907, Compound 234 | US11000528, Cpd # 11 | ...)
Show SMILES FC1(F)CCN(Cc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)CC1
Show InChI InChI=1S/C22H23F2N5O/c23-22(24)10-12-28(13-11-22)14-15-4-6-16(7-5-15)18-2-1-3-19-25-21(27-29(18)19)26-20(30)17-8-9-17/h1-7,17H,8-14H2,(H,26,27,30)
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 7.69n/an/an/an/an/an/a



GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...


US Patent US11000528 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM103737
PNG
(US10206907, Compound 234 | US11000528, Cpd # 11 | ...)
Show SMILES FC1(F)CCN(Cc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)CC1
Show InChI InChI=1S/C22H23F2N5O/c23-22(24)10-12-28(13-11-22)14-15-4-6-16(7-5-15)18-2-1-3-19-25-21(27-29(18)19)26-20(30)17-8-9-17/h1-7,17H,8-14H2,(H,26,27,30)
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 15.5n/an/an/an/an/an/a



GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w...


US Patent US11000528 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (850-1154)


()
BDBM103736
PNG
(US10206907, Compound 207 | US11000528, Cpd # 10 | ...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)N3CCS(=O)(=O)CC3)n2n1)C1CC1
Show InChI InChI=1S/C21H21N5O4S/c27-19(15-6-7-15)23-21-22-18-3-1-2-17(26(18)24-21)14-4-8-16(9-5-14)20(28)25-10-12-31(29,30)13-11-25/h1-5,8-9,15H,6-7,10-13H2,(H,23,24,27)
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 18.2n/an/an/an/an/an/a



GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...


US Patent US11000528 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM103727
PNG
(US10112907, Example 00033 | US10206907, Compound 2...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(CN4CCS(=O)(=O)CC4)cc3)n2n1)C1CC1
Show InChI InChI=1S/C21H23N5O3S/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-30(28,29)13-11-25/h1-7,17H,8-14H2,(H,23,24,27)
PDB
MMDB

GoogleScholar
Purchase

PC cid
PC sid
PDB
UniChem

Similars

PDB
US Patent
n/an/a 31.4n/an/an/an/an/an/a



GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w...


US Patent US11000528 (2021)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM103728
PNG
(US10206907, Compound 18 | US11000528, Cpd # 2 | US...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(CN4CCOCC4)cc3)n2n1)C1CC1
Show InChI InChI=1S/C21H23N5O2/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-28-13-11-25/h1-7,17H,8-14H2,(H,23,24,27)
PDB
MMDB

GoogleScholar
Purchase

PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 38.7n/an/an/an/an/an/a



GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w...


US Patent US11000528 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (850-1154)


()
BDBM103727
PNG
(US10112907, Example 00033 | US10206907, Compound 2...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(CN4CCS(=O)(=O)CC4)cc3)n2n1)C1CC1
Show InChI InChI=1S/C21H23N5O3S/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-30(28,29)13-11-25/h1-7,17H,8-14H2,(H,23,24,27)
PDB
MMDB

GoogleScholar
Purchase

PC cid
PC sid
PDB
UniChem

Similars

US Patent
n/an/a 47.1n/an/an/an/an/an/a



GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...


US Patent US11000528 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (850-1154)


()
BDBM103728
PNG
(US10206907, Compound 18 | US11000528, Cpd # 2 | US...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(CN4CCOCC4)cc3)n2n1)C1CC1
Show InChI InChI=1S/C21H23N5O2/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-28-13-11-25/h1-7,17H,8-14H2,(H,23,24,27)
PDB
MMDB

GoogleScholar
Purchase

PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 50.9n/an/an/an/an/an/a



GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...


US Patent US11000528 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM103736
PNG
(US10206907, Compound 207 | US11000528, Cpd # 10 | ...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)N3CCS(=O)(=O)CC3)n2n1)C1CC1
Show InChI InChI=1S/C21H21N5O4S/c27-19(15-6-7-15)23-21-22-18-3-1-2-17(26(18)24-21)14-4-8-16(9-5-14)20(28)25-10-12-31(29,30)13-11-25/h1-5,8-9,15H,6-7,10-13H2,(H,23,24,27)
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 65.4n/an/an/an/an/an/a



GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w...


US Patent US11000528 (2021)

More data for this
Ligand-Target Pair
TYK2 (aa 871-1187)


(Homo sapiens (Human))
BDBM103727
PNG
(US10112907, Example 00033 | US10206907, Compound 2...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(CN4CCS(=O)(=O)CC4)cc3)n2n1)C1CC1
Show InChI InChI=1S/C21H23N5O3S/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-30(28,29)13-11-25/h1-7,17H,8-14H2,(H,23,24,27)
PDB

GoogleScholar
Purchase

PC cid
PC sid
PDB
UniChem

Similars

US Patent
n/an/a 72.7n/an/an/an/an/an/a



GALAPAGOS NV

US Patent


Assay Description
Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...


US Patent US11000528 (2021)

More data for this
Ligand-Target Pair
TYK2 (aa 871-1187)


(Homo sapiens (Human))
BDBM103737
PNG
(US10206907, Compound 234 | US11000528, Cpd # 11 | ...)
Show SMILES FC1(F)CCN(Cc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)CC1
Show InChI InChI=1S/C22H23F2N5O/c23-22(24)10-12-28(13-11-22)14-15-4-6-16(7-5-15)18-2-1-3-19-25-21(27-29(18)19)26-20(30)17-8-9-17/h1-7,17H,8-14H2,(H,26,27,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 126n/an/an/an/an/an/a



GALAPAGOS NV

US Patent


Assay Description
Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...


US Patent US11000528 (2021)

More data for this
Ligand-Target Pair
JAK3 (aa 781-1124)


(Homo sapiens (Human))
BDBM103727
PNG
(US10112907, Example 00033 | US10206907, Compound 2...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(CN4CCS(=O)(=O)CC4)cc3)n2n1)C1CC1
Show InChI InChI=1S/C21H23N5O3S/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-30(28,29)13-11-25/h1-7,17H,8-14H2,(H,23,24,27)
PDB

GoogleScholar
Purchase

PC cid
PC sid
PDB
UniChem

Similars

US Patent
n/an/a 149n/an/an/an/an/an/a



GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK3 catalytic domain (amino acids 781-1124; catalog number PV3855) was purchased from Invitrogen. 0.025 mU of JAK3 was incubated w...


US Patent US11000528 (2021)

More data for this
Ligand-Target Pair
JAK3 (aa 781-1124)


(Homo sapiens (Human))
BDBM103737
PNG
(US10206907, Compound 234 | US11000528, Cpd # 11 | ...)
Show SMILES FC1(F)CCN(Cc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)CC1
Show InChI InChI=1S/C22H23F2N5O/c23-22(24)10-12-28(13-11-22)14-15-4-6-16(7-5-15)18-2-1-3-19-25-21(27-29(18)19)26-20(30)17-8-9-17/h1-7,17H,8-14H2,(H,26,27,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 195n/an/an/an/an/an/a



GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK3 catalytic domain (amino acids 781-1124; catalog number PV3855) was purchased from Invitrogen. 0.025 mU of JAK3 was incubated w...


US Patent US11000528 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (850-1154)


()
BDBM103729
PNG
(US10206907, Compound 2 | US11000528, Cpd # 3 | US8...)
Show SMILES O=C(Nc1nc2cccc(-c3cccc(CN4CCOCC4)c3)n2n1)C1CC1
Show InChI InChI=1S/C21H23N5O2/c27-20(16-7-8-16)23-21-22-19-6-2-5-18(26(19)24-21)17-4-1-3-15(13-17)14-25-9-11-28-12-10-25/h1-6,13,16H,7-12,14H2,(H,23,24,27)
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 291n/an/an/an/an/an/a



GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...


US Patent US11000528 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (850-1154)


()
BDBM103735
PNG
(US10206907, Compound 141 | US11000528, Cpd # 9 | U...)
Show SMILES CC(=O)N1CCN(Cc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)CC1
Show InChI InChI=1S/C23H26N6O2/c1-16(30)28-13-11-27(12-14-28)15-17-5-7-18(8-6-17)20-3-2-4-21-24-23(26-29(20)21)25-22(31)19-9-10-19/h2-8,19H,9-15H2,1H3,(H,25,26,31)
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 334n/an/an/an/an/an/a



GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...


US Patent US11000528 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (850-1154)


()
BDBM103734
PNG
(US10206907, Compound 140 | US11000528, Cpd # 8 | U...)
Show SMILES NC(=O)C1CCN(Cc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)CC1
Show InChI InChI=1S/C23H26N6O2/c24-21(30)17-10-12-28(13-11-17)14-15-4-6-16(7-5-15)19-2-1-3-20-25-23(27-29(19)20)26-22(31)18-8-9-18/h1-7,17-18H,8-14H2,(H2,24,30)(H,26,27,31)
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 435n/an/an/an/an/an/a



GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...


US Patent US11000528 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (850-1154)


()
BDBM103733
PNG
(US10206907, Compound 139 | US11000528, Cpd # 7 | U...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(CN4CCCCC4)cc3)n2n1)C1CC1
Show InChI InChI=1S/C22H25N5O/c28-21(18-11-12-18)24-22-23-20-6-4-5-19(27(20)25-22)17-9-7-16(8-10-17)15-26-13-2-1-3-14-26/h4-10,18H,1-3,11-15H2,(H,24,25,28)
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 504n/an/an/an/an/an/a



GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...


US Patent US11000528 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM103735
PNG
(US10206907, Compound 141 | US11000528, Cpd # 9 | U...)
Show SMILES CC(=O)N1CCN(Cc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)CC1
Show InChI InChI=1S/C23H26N6O2/c1-16(30)28-13-11-27(12-14-28)15-17-5-7-18(8-6-17)20-3-2-4-21-24-23(26-29(20)21)25-22(31)19-9-10-19/h2-8,19H,9-15H2,1H3,(H,25,26,31)
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 849n/an/an/an/an/an/a



GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w...


US Patent US11000528 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (850-1154)


()
BDBM103730
PNG
(US10206907, Compound 6 | US11000528, Cpd # 4 | US8...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(nc3)N3CCOCC3)n2n1)C1CC1
Show InChI InChI=1S/C19H20N6O2/c26-18(13-4-5-13)22-19-21-17-3-1-2-15(25(17)23-19)14-6-7-16(20-12-14)24-8-10-27-11-9-24/h1-3,6-7,12-13H,4-5,8-11H2,(H,22,23,26)
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.03E+3n/an/an/an/an/an/a



GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...


US Patent US11000528 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (850-1154)


()
BDBM103731
PNG
(US10206907, Compound 129 | US11000528, Cpd # 5 | U...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(cc3)N3CCOCC3)n2n1)C1CC1
Show InChI InChI=1S/C20H21N5O2/c26-19(15-4-5-15)22-20-21-18-3-1-2-17(25(18)23-20)14-6-8-16(9-7-14)24-10-12-27-13-11-24/h1-3,6-9,15H,4-5,10-13H2,(H,22,23,26)
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.45E+3n/an/an/an/an/an/a



GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...


US Patent US11000528 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM103731
PNG
(US10206907, Compound 129 | US11000528, Cpd # 5 | U...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(cc3)N3CCOCC3)n2n1)C1CC1
Show InChI InChI=1S/C20H21N5O2/c26-19(15-4-5-15)22-20-21-18-3-1-2-17(25(18)23-20)14-6-8-16(9-7-14)24-10-12-27-13-11-24/h1-3,6-9,15H,4-5,10-13H2,(H,22,23,26)
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.76E+3n/an/an/an/an/an/a



GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w...


US Patent US11000528 (2021)

More data for this
Ligand-Target Pair
TYK2 (aa 871-1187)


(Homo sapiens (Human))
BDBM103728
PNG
(US10206907, Compound 18 | US11000528, Cpd # 2 | US...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(CN4CCOCC4)cc3)n2n1)C1CC1
Show InChI InChI=1S/C21H23N5O2/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-28-13-11-25/h1-7,17H,8-14H2,(H,23,24,27)
PDB

GoogleScholar
Purchase

PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.10E+3n/an/an/an/an/an/a



GALAPAGOS NV

US Patent


Assay Description
Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...


US Patent US11000528 (2021)

More data for this
Ligand-Target Pair
JAK3 (aa 781-1124)


(Homo sapiens (Human))
BDBM103728
PNG
(US10206907, Compound 18 | US11000528, Cpd # 2 | US...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(CN4CCOCC4)cc3)n2n1)C1CC1
Show InChI InChI=1S/C21H23N5O2/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-28-13-11-25/h1-7,17H,8-14H2,(H,23,24,27)
PDB

GoogleScholar
Purchase

PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.84E+3n/an/an/an/an/an/a



GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK3 catalytic domain (amino acids 781-1124; catalog number PV3855) was purchased from Invitrogen. 0.025 mU of JAK3 was incubated w...


US Patent US11000528 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 (850-1154)


()
BDBM103732
PNG
(US10206907, Compound 130 | US11000528, Cpd # 6 | U...)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)CC1
Show InChI InChI=1S/C22H26N6O/c1-26-11-13-27(14-12-26)15-16-5-7-17(8-6-16)19-3-2-4-20-23-22(25-28(19)20)24-21(29)18-9-10-18/h2-8,18H,9-15H2,1H3,(H,24,25,29)
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.45E+3n/an/an/an/an/an/a



GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...


US Patent US11000528 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM103732
PNG
(US10206907, Compound 130 | US11000528, Cpd # 6 | U...)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)CC1
Show InChI InChI=1S/C22H26N6O/c1-26-11-13-27(14-12-26)15-16-5-7-17(8-6-16)19-3-2-4-20-23-22(25-28(19)20)24-21(29)18-9-10-18/h2-8,18H,9-15H2,1H3,(H,24,25,29)
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5.07E+3n/an/an/an/an/an/a



GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w...


US Patent US11000528 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM103733
PNG
(US10206907, Compound 139 | US11000528, Cpd # 7 | U...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(CN4CCCCC4)cc3)n2n1)C1CC1
Show InChI InChI=1S/C22H25N5O/c28-21(18-11-12-18)24-22-23-20-6-4-5-19(27(20)25-22)17-9-7-16(8-10-17)15-26-13-2-1-3-14-26/h4-10,18H,1-3,11-15H2,(H,24,25,28)
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6.45E+3n/an/an/an/an/an/a



GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w...


US Patent US11000528 (2021)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM103734
PNG
(US10206907, Compound 140 | US11000528, Cpd # 8 | U...)
Show SMILES NC(=O)C1CCN(Cc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)CC1
Show InChI InChI=1S/C23H26N6O2/c24-21(30)17-10-12-28(13-11-17)14-15-4-6-16(7-5-15)19-2-1-3-20-25-23(27-29(19)20)26-22(31)18-8-9-18/h1-7,17-18H,8-14H2,(H2,24,30)(H,26,27,31)
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 7.73E+3n/an/an/an/an/an/a



GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w...


US Patent US11000528 (2021)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%